| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | L-Eflornithine (monohydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.198106 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.187385 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0964792 |
| MMP12 | matrix metallopeptidase 12 | 0.0937041 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.091738 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0856791 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.083302 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0784841 |
| TMEM41B | transmembrane protein 41B | 0.066974 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0647559 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0642822 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0641481 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0631028 |
| PDGFC | platelet derived growth factor C | 0.061847 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0614774 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0604784 |
| TENM3 | teneurin transmembrane protein 3 | 0.0592953 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0574546 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0540204 |
| YAP1 | Yes-associated protein 1 | 0.053461 |
| DST | dystonin | 0.0510705 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.04916 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0470502 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0468449 |
| ANXA1 | annexin A1 | 0.0465797 |
| TXNRD1 | thioredoxin reductase 1 | 0.0464629 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0453823 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0452328 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0448172 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0443545 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0434234 |
| CLDN1 | claudin 1 | 0.0413637 |
| OXR1 | oxidation resistance 1 | 0.0410019 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0406269 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.040429 |
| CCN2 | cellular communication network factor 2 | 0.0399883 |
| XPO1 | exportin 1 | 0.0390968 |
| ASPH | aspartate beta-hydroxylase | 0.0389239 |
| NEK7 | NIMA-related kinase 7 | 0.038819 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.038748 |
| PCDH7 | protocadherin 7 | 0.0386925 |
| ECT2 | epithelial cell transforming 2 | 0.0383718 |
| VMP1 | vacuole membrane protein 1 | 0.038333 |
| ATP11A | ATPase, class VI, type 11A | 0.0372037 |
| MED13L | mediator complex subunit 13-like | 0.0367518 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.036366 |
| RPL3 | ribosomal protein L3 | 0.0362342 |
| EXOC6B | exocyst complex component 6B | 0.0360461 |
| AXIN2 | axin 2 | 0.0356744 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0333856 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0329884 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0328312 |
| DSPP | dentin sialophosphoprotein | 0.0328127 |
| ETNK1 | ethanolamine kinase 1 | 0.0326426 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0323926 |
| NEBL | nebulette | 0.0319888 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0310998 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0310209 |
| PTMS | parathymosin | 0.0310198 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0301618 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0297853 |
| PEG10 | paternally expressed 10 | 0.0297017 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0294637 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0293686 |
| MYPN | myopalladin | 0.0293393 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0288729 |
| CEP95 | centrosomal protein 95kDa | 0.0286449 |
| RRM2 | ribonucleotide reductase M2 | 0.0282943 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0282739 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0281525 |
| LMO7 | LIM domain 7 | 0.0280545 |
| RNF13 | ring finger protein 13 | 0.0277947 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0273694 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | 0.0272568 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0271551 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0270272 |
| CLDND1 | claudin domain containing 1 | 0.0268266 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.0266513 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0265594 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0260987 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.02609 |
| EFNA5 | ephrin-A5 | 0.0259739 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0258568 |
| KIF5B | kinesin family member 5B | 0.0257104 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0255624 |
| CDK19 | cyclin-dependent kinase 19 | 0.0248383 |
| USP34 | ubiquitin specific peptidase 34 | 0.0248315 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0243644 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0243112 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.024307 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0242889 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0242609 |
| EDARADD | EDAR-associated death domain | 0.0241781 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0240367 |
| SP3 | Sp3 transcription factor | 0.0240272 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0238946 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0237636 |
| IPO7 | importin 7 | 0.0237072 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0236532 |
| ZNF217 | zinc finger protein 217 | 0.0232719 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.244239 |
| VIM | vimentin | -0.178386 |
| TMSB10 | thymosin beta 10 | -0.124498 |
| FTL | ferritin, light polypeptide | -0.0881793 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0801435 |
| PTMA | prothymosin, alpha | -0.0777296 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0775941 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0766366 |
| RPL35A | ribosomal protein L35a | -0.0751525 |
| ACTG1 | actin gamma 1 | -0.0717328 |
| RPS6 | ribosomal protein S6 | -0.0703443 |
| RPS8 | ribosomal protein S8 | -0.0578766 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.056638 |
| HMGA1 | high mobility group AT-hook 1 | -0.0538348 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0523198 |
| RPS27A | ribosomal protein S27a | -0.0471442 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0464809 |
| RPL37A | ribosomal protein L37a | -0.044937 |
| RPLP1 | ribosomal protein, large, P1 | -0.0439171 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0434972 |
| RPL38 | ribosomal protein L38 | -0.0402675 |
| RPL12 | ribosomal protein L12 | -0.0398668 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0391068 |
| RPS19 | ribosomal protein S19 | -0.0389308 |
| KPNB1 | karyopherin (importin) beta 1 | -0.038151 |
| RPL19 | ribosomal protein L19 | -0.0381063 |
| HMGB1 | high mobility group box 1 | -0.0374181 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0371147 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0366766 |
| EGR1 | early growth response 1 | -0.0352884 |
| RPL23 | ribosomal protein L23 | -0.0351769 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0349914 |
| RPL9 | ribosomal protein L9 | -0.0348818 |
| TPM4 | tropomyosin 4 | -0.0345448 |
| RPL11 | ribosomal protein L11 | -0.0328094 |
| S100A10 | S100 calcium binding protein A10 | -0.0324547 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0319675 |
| RPLP2 | ribosomal protein, large, P2 | -0.0318064 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0315649 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0306919 |
| RPL34 | ribosomal protein L34 | -0.030683 |
| GNAS | GNAS complex locus | -0.0306756 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0303329 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0301292 |
| S100A6 | S100 calcium binding protein A6 | -0.0298373 |
| RBM39 | RNA binding motif protein 39 | -0.0296692 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0296213 |
| RPS27 | ribosomal protein S27 | -0.0293314 |
| TPI1 | triosephosphate isomerase 1 | -0.0289864 |
| RPS21 | ribosomal protein S21 | -0.0287303 |
| TUBA1B | tubulin, alpha 1b | -0.0281953 |
| RPL36 | ribosomal protein L36 | -0.0281632 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0274776 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0270993 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0269762 |
| RPS12 | ribosomal protein S12 | -0.0265779 |
| RPL10A | ribosomal protein L10a | -0.026536 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0262018 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0260304 |
| S100A11 | S100 calcium binding protein A11 | -0.0255183 |
| HMGA2 | high mobility group AT-hook 2 | -0.02541 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0253859 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0249171 |
| CUX1 | cut-like homeobox 1 | -0.0243452 |
| RPL31 | ribosomal protein L31 | -0.0242938 |
| LRRC23 | leucine rich repeat containing 23 | -0.0241557 |
| RPL5 | ribosomal protein L5 | -0.023931 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.023697 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0236213 |
| NOP58 | NOP58 ribonucleoprotein | -0.0226 |
| ADIPOR2 | adiponectin receptor 2 | -0.0224126 |
| RPS13 | ribosomal protein S13 | -0.0215376 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0211899 |
| RPL32 | ribosomal protein L32 | -0.0209734 |
| RPS14 | ribosomal protein S14 | -0.0209517 |
| RPS29 | ribosomal protein S29 | -0.0208389 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0206 |
| RPL37 | ribosomal protein L37 | -0.0205534 |
| RPS10 | ribosomal protein S10 | -0.0204993 |
| RPS16 | ribosomal protein S16 | -0.0203207 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0200358 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0200161 |
| RPS23 | ribosomal protein S23 | -0.0199363 |
| PCDH9 | protocadherin 9 | -0.0199226 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.019284 |
| RPS5 | ribosomal protein S5 | -0.0191927 |
| RPS25 | ribosomal protein S25 | -0.0191651 |
| NAV3 | neuron navigator 3 | -0.0190805 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0189851 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0186877 |
| RPL36A | ribosomal protein L36a | -0.0186631 |
| RPS24 | ribosomal protein S24 | -0.0184474 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | -0.0183129 |
| LDHB | lactate dehydrogenase B | -0.0182772 |
| GCG | glucagon | -0.0182344 |
| ANXA2 | annexin A2 | -0.0181288 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.017865 |
| RPL7 | ribosomal protein L7 | -0.0178173 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0177978 |
| INTS6 | integrator complex subunit 6 | -0.0177012 |
