L-Eflornithine (monohydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Eflornithine (monohydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.166571
GPC6 glypican 6 0.149327
CD44 CD44 molecule (Indian blood group) 0.109749
NRP2 neuropilin 2 0.0886007
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0826912
MYH9 myosin, heavy chain 9, non-muscle 0.0817284
EXT1 exostosin glycosyltransferase 1 0.0810364
CALU calumenin 0.0763725
NRIP1 nuclear receptor interacting protein 1 0.0717576
FRMD4A FERM domain containing 4A 0.06991
NAV2 neuron navigator 2 0.0684826
RAI14 retinoic acid induced 14 0.0680388
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0670624
VEGFA vascular endothelial growth factor A 0.0655993
CALR calreticulin 0.0635201
FNDC3B fibronectin type III domain containing 3B 0.0622616
VCL vinculin 0.0615896
TRIO trio Rho guanine nucleotide exchange factor 0.0615868
AKAP9 A kinase (PRKA) anchor protein 9 0.0597998
PLK2 polo-like kinase 2 0.0574092
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0565709
B2M beta-2-microglobulin 0.0558941
P3H2 prolyl 3-hydroxylase 2 0.0535566
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0517631
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0511404
SKAP2 src kinase associated phosphoprotein 2 0.0508416
APLP2 amyloid beta (A4) precursor-like protein 2 0.0500887
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0500113
MYOF myoferlin 0.0496823
ZFP36L1 ZFP36 ring finger protein-like 1 0.0492736
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0484617
SMAD3 SMAD family member 3 0.048276
ADAM9 ADAM metallopeptidase domain 9 0.0481272
SEPTIN9 septin 9 0.0478594
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.047108
ZBTB20 zinc finger and BTB domain containing 20 0.0462513
BIRC6 baculoviral IAP repeat containing 6 0.0436308
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0434464
APP amyloid beta (A4) precursor protein 0.0432907
ADAM10 ADAM metallopeptidase domain 10 0.0430246
CA12 carbonic anhydrase XII 0.0413004
PAX8 paired box 8 0.0411481
MSN moesin 0.0408286
CENPF centromere protein F, 350/400kDa 0.0403222
GOLGA4 golgin A4 0.0400902
CMIP c-Maf inducing protein 0.0400493
TTC3 tetratricopeptide repeat domain 3 0.0398598
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0397996
ARRDC3 arrestin domain containing 3 0.039585
CANX calnexin 0.0389552
DLG1 discs, large homolog 1 (Drosophila) 0.0389351
PBX1 pre-B-cell leukemia homeobox 1 0.0383279
UGCG UDP-glucose ceramide glucosyltransferase 0.0381956
APOL1 apolipoprotein L, 1 0.0380039
TOP2A topoisomerase (DNA) II alpha 170kDa 0.037985
PRRC2C proline-rich coiled-coil 2C 0.0378195
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0377126
TPM3 tropomyosin 3 0.0366495
GLS2 glutaminase 2 (liver, mitochondrial) 0.0361693
GOLGB1 golgin B1 0.0353164
IQGAP1 IQ motif containing GTPase activating protein 1 0.0352334
ZCCHC7 zinc finger, CCHC domain containing 7 0.0349406
ACBD3 acyl-CoA binding domain containing 3 0.0343356
MT2A metallothionein 2A 0.0342651
SEC31A SEC31 homolog A (S. cerevisiae) 0.03416
RTN4 reticulon 4 0.0338237
SRRM2 serine/arginine repetitive matrix 2 0.0337863
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0336578
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0334996
EGFR epidermal growth factor receptor 0.0334153
UBC ubiquitin C 0.0329042
AKAP13 A kinase (PRKA) anchor protein 13 0.0323784
RNF220 ring finger protein 220 0.0322482
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0322227
TNS3 tensin 3 0.0320746
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0319379
BIRC3 baculoviral IAP repeat containing 3 0.0318408
SPAG9 sperm associated antigen 9 0.0317414
ITGAV integrin, alpha V 0.0314918
UBE2H ubiquitin-conjugating enzyme E2H 0.031461
LDHA lactate dehydrogenase A 0.0313279
FNIP1 folliculin interacting protein 1 0.0309779
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0308748
DOCK5 dedicator of cytokinesis 5 0.0308374
ADAR adenosine deaminase, RNA-specific 0.0307203
COG5 component of oligomeric golgi complex 5 0.0304398
TPST1 tyrosylprotein sulfotransferase 1 0.0304047
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0303192
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0299682
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0299451
PDIA6 protein disulfide isomerase family A, member 6 0.0297991
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0295844
TPR translocated promoter region, nuclear basket protein 0.0294397
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0293876
PTBP3 polypyrimidine tract binding protein 3 0.0289165
RPL3 ribosomal protein L3 0.0287062
RNF216 ring finger protein 216 0.0286006
MSH6 mutS homolog 6 0.0285688
MACF1 microtubule-actin crosslinking factor 1 0.0284289
KMT2C lysine (K)-specific methyltransferase 2C 0.0282023

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.063293
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0418735
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0370044
TMSB10 thymosin beta 10 -0.0367019
HSPB1 heat shock 27kDa protein 1 -0.0352569
G0S2 G0/G1 switch 2 -0.0322143
RPS19 ribosomal protein S19 -0.0282404
RPL35A ribosomal protein L35a -0.0271117
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0267909
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0250986
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0227405
RPS20 ribosomal protein S20 -0.0221569
CXCL2 chemokine (C-X-C motif) ligand 2 -0.0216887
QKI QKI, KH domain containing, RNA binding -0.0204949
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0203902
RPL19 ribosomal protein L19 -0.0201773
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0185289
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0181109
FTL ferritin, light polypeptide -0.0178091
ATF3 activating transcription factor 3 -0.0173346
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0171189
CD70 CD70 molecule -0.016331
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0162899
JUN jun proto-oncogene -0.0152325
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -0.0151945
RPLP1 ribosomal protein, large, P1 -0.0148002
IRF1 interferon regulatory factor 1 -0.0145724
FLNA filamin A, alpha -0.0142879
GDF15 growth differentiation factor 15 -0.0137523
RPLP2 ribosomal protein, large, P2 -0.0133985
KLF6 Kruppel-like factor 6 -0.0132677
GNAS GNAS complex locus -0.0129505
ARF1 ADP-ribosylation factor 1 -0.0128075
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -0.0126909
RPS16 ribosomal protein S16 -0.0125531
RPS8 ribosomal protein S8 -0.0123113
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0122496
LMNA lamin A/C -0.0119644
NAMPT nicotinamide phosphoribosyltransferase -0.011858
UBB ubiquitin B -0.0118286
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0116661
IER3 immediate early response 3 -0.0116599
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.011578
GLIS3 GLIS family zinc finger 3 -0.0113734
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0112412
RPS6 ribosomal protein S6 -0.0111219
ABI1 abl-interactor 1 -0.0111137
ICAM1 intercellular adhesion molecule 1 -0.0110549
RPS5 ribosomal protein S5 -0.011
RPS27A ribosomal protein S27a -0.0108805
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.010873
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0108647
HMGB1 high mobility group box 1 -0.010841
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.0107978
MARCHF6 membrane associated ring-CH-type finger 6 -0.0107537
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0106475
RPS21 ribosomal protein S21 -0.0106191
FSCN1 fascin actin-bundling protein 1 -0.0105462
MLF1 myeloid leukemia factor 1 -0.0105233
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.010484
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0104198
RPL28 ribosomal protein L28 -0.0103191
TPT1 tumor protein, translationally-controlled 1 -0.0103124
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0103058
UBE2B ubiquitin-conjugating enzyme E2B -0.0102056
RPL30 ribosomal protein L30 -0.0100976
FLNC filamin C, gamma -0.00993826
RPS14 ribosomal protein S14 -0.00988885
RPLP0 ribosomal protein, large, P0 -0.00982151
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G -0.009742
USP3 ubiquitin specific peptidase 3 -0.00965851
RPL11 ribosomal protein L11 -0.00951362
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.00936681
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.00933559
NOP58 NOP58 ribonucleoprotein -0.00932013
RPL32 ribosomal protein L32 -0.00927096
UBE2I ubiquitin-conjugating enzyme E2I -0.00912086
DENND2B DENN domain containing 2B -0.00901419
RPL8 ribosomal protein L8 -0.00896584
TSC22D2 TSC22 domain family, member 2 -0.00875559
FOS FBJ murine osteosarcoma viral oncogene homolog -0.00872823
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0086799
RPL5 ribosomal protein L5 -0.00853453
ELL2 elongation factor, RNA polymerase II, 2 -0.00848773
HMGA1 high mobility group AT-hook 1 -0.00838082
RRAD Ras-related associated with diabetes -0.00826158
RPS2 ribosomal protein S2 -0.00821434
RPL9 ribosomal protein L9 -0.00811389
RPL36 ribosomal protein L36 -0.00809478
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.00802077
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.00799611
ZNF207 zinc finger protein 207 -0.00799016
INSIG1 insulin induced gene 1 -0.00796263
JAG1 jagged 1 -0.00794258
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.00793609
MLF2 myeloid leukemia factor 2 -0.00780507
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.00772926
RPL38 ribosomal protein L38 -0.00767939
AKR1C1 aldo-keto reductase family 1, member C1 -0.00767833
RPL18 ribosomal protein L18 -0.00767265