L-Eflornithine (monohydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Eflornithine (monohydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.236491
BAIAP2L1 BAI1-associated protein 2-like 1 0.202517
UBC ubiquitin C 0.167607
POTEF POTE ankyrin domain family, member F 0.147084
APLP2 amyloid beta (A4) precursor-like protein 2 0.122526
FLNB filamin B, beta 0.119303
PSD3 pleckstrin and Sec7 domain containing 3 0.116015
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.114796
EFNA5 ephrin-A5 0.113672
VIM vimentin 0.0969663
NDRG1 N-myc downstream regulated 1 0.0933266
SLC38A2 solute carrier family 38, member 2 0.093072
S100A10 S100 calcium binding protein A10 0.093002
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0893699
ITGA6 integrin, alpha 6 0.0875709
LDHA lactate dehydrogenase A 0.0829376
ZSWIM6 zinc finger, SWIM-type containing 6 0.0810163
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0805123
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0752248
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0746695
AKAP13 A kinase (PRKA) anchor protein 13 0.0726737
EZR ezrin 0.0708477
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0665108
UBA6 ubiquitin-like modifier activating enzyme 6 0.0634599
DSPP dentin sialophosphoprotein 0.063023
ERBIN erbb2 interacting protein 0.0609131
MCL1 myeloid cell leukemia 1 0.059719
LAMA4 laminin, alpha 4 0.0580693
TPM3 tropomyosin 3 0.0563701
VCL vinculin 0.0539543
PTMA prothymosin, alpha 0.0517886
ASPH aspartate beta-hydroxylase 0.0517665
RCOR1 REST corepressor 1 0.0515976
ARHGAP42 Rho GTPase activating protein 42 0.0492869
KTN1 kinectin 1 (kinesin receptor) 0.0482075
ZFP36L1 ZFP36 ring finger protein-like 1 0.048154
EGFR epidermal growth factor receptor 0.0480359
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0477986
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0474843
TRIO trio Rho guanine nucleotide exchange factor 0.0474208
MPRIP myosin phosphatase Rho interacting protein 0.0468315
RASAL2 RAS protein activator like 2 0.0464348
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.045861
FAM107B family with sequence similarity 107, member B 0.0456406
EGR1 early growth response 1 0.0454877
PKM pyruvate kinase, muscle 0.04539
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0451226
S100A11 S100 calcium binding protein A11 0.0448488
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0443276
PERP PERP, TP53 apoptosis effector 0.0438912
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0433242
DIAPH1 diaphanous-related formin 1 0.0429686
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0423182
FNDC3B fibronectin type III domain containing 3B 0.0420155
B2M beta-2-microglobulin 0.0407593
EMP1 epithelial membrane protein 1 0.0407181
RIOK3 RIO kinase 3 0.0401518
MYOF myoferlin 0.0390403
MBNL1 muscleblind-like splicing regulator 1 0.0376153
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0375846
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.037368
GRB10 growth factor receptor-bound protein 10 0.0371137
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0370649
DOCK5 dedicator of cytokinesis 5 0.036609
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0364846
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0363753
SRRM2 serine/arginine repetitive matrix 2 0.0362947
CTBP2 C-terminal binding protein 2 0.0362912
ITPRID2 ITPR interacting domain containing 2 0.0361245
NCOR2 nuclear receptor corepressor 2 0.035538
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0354938
CD9 CD9 molecule 0.035239
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0349286
MKI67 marker of proliferation Ki-67 0.0347391
BCL2L1 BCL2-like 1 0.0347176
ENO1 enolase 1, (alpha) 0.0340861
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0336026
MACF1 microtubule-actin crosslinking factor 1 0.0335621
ESYT2 extended synaptotagmin-like protein 2 0.0335426
VEZT vezatin, adherens junctions transmembrane protein 0.0335102
PGK1 phosphoglycerate kinase 1 0.0332699
PICALM phosphatidylinositol binding clathrin assembly protein 0.0330418
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0327351
MYO1E myosin IE 0.0324437
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0319652
FBXO11 F-box protein 11 0.0315474
TIMP2 TIMP metallopeptidase inhibitor 2 0.0307999
ERRFI1 ERBB receptor feedback inhibitor 1 0.0307467
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.030636
OPTN optineurin 0.0305084
FTL ferritin, light polypeptide 0.0304785
SEC31A SEC31 homolog A (S. cerevisiae) 0.0297058
GOLGB1 golgin B1 0.0295472
LAMC2 laminin, gamma 2 0.0293721
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0292512
SGMS2 sphingomyelin synthase 2 0.0290954
S100A6 S100 calcium binding protein A6 0.0290057
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0289504
AKAP9 A kinase (PRKA) anchor protein 9 0.0289307
SDC4 syndecan 4 0.0288639

decreased expression

Symbol Name Standardized Value
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.125085
LAMB3 laminin, beta 3 -0.125018
LMTK2 lemur tyrosine kinase 2 -0.10123
TXNRD1 thioredoxin reductase 1 -0.0864098
TPT1 tumor protein, translationally-controlled 1 -0.0711534
IGFBP3 insulin-like growth factor binding protein 3 -0.0652998
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0578291
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0557794
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0498994
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0420537
NAMPT nicotinamide phosphoribosyltransferase -0.0400474
TRRAP transformation/transcription domain-associated protein -0.0399472
PRSS3 protease, serine, 3 -0.037969
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0376095
RRBP1 ribosome binding protein 1 -0.0352005
AHNAK2 AHNAK nucleoprotein 2 -0.0342529
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0321706
AK1 adenylate kinase 1 -0.0314436
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0313552
ZMYND8 zinc finger, MYND-type containing 8 -0.0306766
FAM3C family with sequence similarity 3, member C -0.0306237
NDFIP1 Nedd4 family interacting protein 1 -0.0301089
ANTXR2 anthrax toxin receptor 2 -0.0300439
LMO7 LIM domain 7 -0.0300132
PLEC plectin -0.0298691
PLAUR plasminogen activator, urokinase receptor -0.0286412
F3 coagulation factor III (thromboplastin, tissue factor) -0.0274983
TPM4 tropomyosin 4 -0.0258759
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0258367
RPS21 ribosomal protein S21 -0.0252162
ARF1 ADP-ribosylation factor 1 -0.0248805
MARCHF6 membrane associated ring-CH-type finger 6 -0.0247829
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0242705
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0240436
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.02341
GNAS GNAS complex locus -0.0217964
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0217796
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0214513
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.0214482
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0213428
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0209784
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0209526
RESF1 retroelement silencing factor 1 -0.0197204
SAMD9 sterile alpha motif domain containing 9 -0.0196083
RHEB Ras homolog enriched in brain -0.019553
KDM3A lysine (K)-specific demethylase 3A -0.0194389
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0190364
UPP1 uridine phosphorylase 1 -0.0188279
RBM25 RNA binding motif protein 25 -0.0182508
TUFT1 tuftelin 1 -0.0182164
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.0174939
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0174054
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0172804
S100A4 S100 calcium binding protein A4 -0.0168799
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0168326
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0166075
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0165
CEP95 centrosomal protein 95kDa -0.0163422
IFI16 interferon, gamma-inducible protein 16 -0.0162072
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0161847
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -0.0160848
AGO2 argonaute RISC catalytic component 2 -0.0159207
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.0156272
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0155686
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0155531
TM4SF1 transmembrane 4 L six family member 1 -0.0155167
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0152079
PTK2 protein tyrosine kinase 2 -0.0151834
APOL2 apolipoprotein L, 2 -0.0149155
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0148878
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0147417
VCAN versican -0.0146055
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0145873
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 -0.0142292
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0142113
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0140938
GLCCI1 glucocorticoid induced 1 -0.0140872
AFF4 AF4/FMR2 family, member 4 -0.014061
ZEB1 zinc finger E-box binding homeobox 1 -0.0140159
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -0.0139119
AMBRA1 autophagy/beclin-1 regulator 1 -0.0138858
ANKRD10 ankyrin repeat domain 10 -0.0138779
HMGA1 high mobility group AT-hook 1 -0.0137994
TMCC3 transmembrane and coiled-coil domain family 3 -0.0137655
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 -0.0137417
TRA2A transformer 2 alpha homolog (Drosophila) -0.0136479
WDR43 WD repeat domain 43 -0.0135896
ZNF292 zinc finger protein 292 -0.0135189
ATM ATM serine/threonine kinase -0.0133735
DENND5B DENN/MADD domain containing 5B -0.0133623
NUB1 negative regulator of ubiquitin-like proteins 1 -0.01332
EIF4H eukaryotic translation initiation factor 4H -0.0132922
EXT1 exostosin glycosyltransferase 1 -0.0132905
SACK1A scaffolding CK1 anchoring protein A -0.013272
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0132683
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0132376
NAV3 neuron navigator 3 -0.0130307
BMERB1 bMERB domain containing 1 -0.0129828
SCFD2 sec1 family domain containing 2 -0.0129533
CFLAR CASP8 and FADD-like apoptosis regulator -0.0128702