L-Eflornithine (monohydrochloride)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Eflornithine (monohydrochloride) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.221943
CD109 CD109 molecule 0.0825819
NAMPT nicotinamide phosphoribosyltransferase 0.0796728
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.071037
MT2A metallothionein 2A 0.0682225
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0656211
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0641781
ICAM1 intercellular adhesion molecule 1 0.0640948
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0635981
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0582876
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0549802
DSCAM Down syndrome cell adhesion molecule 0.0531348
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0530766
ESYT2 extended synaptotagmin-like protein 2 0.0523627
PRELID2 PRELI domain containing 2 0.0522152
PI15 peptidase inhibitor 15 0.0505913
APP amyloid beta (A4) precursor protein 0.0478379
VMP1 vacuole membrane protein 1 0.0472014
RNF145 ring finger protein 145 0.0465996
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0457492
APLP2 amyloid beta (A4) precursor-like protein 2 0.0441247
SPRED1 sprouty-related, EVH1 domain containing 1 0.0438105
AHR aryl hydrocarbon receptor 0.0421428
KMT2E lysine (K)-specific methyltransferase 2E 0.0414096
WWTR1 WW domain containing transcription regulator 1 0.040524
CDC73 cell division cycle 73 0.0405032
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0390144
KMT2C lysine (K)-specific methyltransferase 2C 0.0388206
UBC ubiquitin C 0.0387034
EPS8 epidermal growth factor receptor pathway substrate 8 0.0386573
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0382947
RTN4 reticulon 4 0.038229
CDK19 cyclin-dependent kinase 19 0.0374696
NAV2 neuron navigator 2 0.0369431
GOLGA4 golgin A4 0.0364795
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0363135
LEF1 lymphoid enhancer-binding factor 1 0.0362262
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0361873
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0358253
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0355854
COPA coatomer protein complex, subunit alpha 0.0345139
RBM33 RNA binding motif protein 33 0.0336193
ARRDC3 arrestin domain containing 3 0.033475
UHMK1 U2AF homology motif (UHM) kinase 1 0.0334647
OGA O-GlcNAcase 0.0334452
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0327457
MT1X metallothionein 1X 0.0321872
SRPK2 SRSF protein kinase 2 0.0313894
TPR translocated promoter region, nuclear basket protein 0.0311546
ZNF654 zinc finger protein 654 0.030885
AFDN afadin, adherens junction formation factor 0.0306731
TMEM178B transmembrane protein 178B 0.0305323
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0302122
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.030087
HELZ helicase with zinc finger 0.0297679
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0296112
ENO1 enolase 1, (alpha) 0.0289099
BIRC2 baculoviral IAP repeat containing 2 0.0287793
ZNF292 zinc finger protein 292 0.0277265
SPAG9 sperm associated antigen 9 0.0274795
CTNND1 catenin (cadherin-associated protein), delta 1 0.0274346
TSC22D1 TSC22 domain family, member 1 0.0269133
ZC3H11A zinc finger CCCH-type containing 11A 0.0268169
SPRED2 sprouty-related, EVH1 domain containing 2 0.026258
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0259194
IL1RAP interleukin 1 receptor accessory protein 0.0254413
CCNL1 cyclin L1 0.0253191
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0252549
ZYX zyxin 0.0252033
ASPH aspartate beta-hydroxylase 0.0250758
UBE2H ubiquitin-conjugating enzyme E2H 0.0249539
SUCO SUN domain containing ossification factor 0.0248604
IL6ST interleukin 6 signal transducer 0.0247628
RNMT RNA (guanine-7-) methyltransferase 0.0243088
AKAP13 A kinase (PRKA) anchor protein 13 0.0241848
CSNK1A1 casein kinase 1, alpha 1 0.0240806
MRTFA myocardin related transcription factor A 0.0240234
WDR45B WD repeat domain 45B 0.0238778
WASL Wiskott-Aldrich syndrome-like 0.0237999
TOP1 topoisomerase (DNA) I 0.0237687
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0234231
KTN1 kinectin 1 (kinesin receptor) 0.0233975
MED13L mediator complex subunit 13-like 0.0233598
CHD1 chromodomain helicase DNA binding protein 1 0.0233394
STOM stomatin 0.0233004
VCL vinculin 0.0232805
HBP1 HMG-box transcription factor 1 0.0232108
CUL3 cullin 3 0.0229764
YAP1 Yes-associated protein 1 0.0229581
RB1CC1 RB1-inducible coiled-coil 1 0.0229046
ETNK1 ethanolamine kinase 1 0.0228498
RAP1B RAP1B, member of RAS oncogene family 0.0226877
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.022619
RCAN1 regulator of calcineurin 1 0.0224735
PRRC2C proline-rich coiled-coil 2C 0.0223672
FOXJ3 forkhead box J3 0.0223318
FNDC3B fibronectin type III domain containing 3B 0.0222627
RBM39 RNA binding motif protein 39 0.0221427
ARHGAP5 Rho GTPase activating protein 5 0.0220853
TNNC1 troponin C type 1 (slow) 0.0219854

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.149939
IGFBP5 insulin-like growth factor binding protein 5 -0.13898
VGF VGF nerve growth factor inducible -0.137846
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.129718
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.118167
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.103288
NLGN1 neuroligin 1 -0.0774125
TMSB10 thymosin beta 10 -0.0710054
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0707937
NAV3 neuron navigator 3 -0.0673869
NDRG1 N-myc downstream regulated 1 -0.0664898
HLA-B major histocompatibility complex, class I, B -0.0641897
S100A6 S100 calcium binding protein A6 -0.0515258
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0483133
MAML3 mastermind-like 3 (Drosophila) -0.0462084
FRMD4A FERM domain containing 4A -0.0458413
LMNA lamin A/C -0.0456685
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0451641
CDK14 cyclin-dependent kinase 14 -0.0440308
EHBP1 EH domain binding protein 1 -0.0435258
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0434227
CUX1 cut-like homeobox 1 -0.0412899
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0407181
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0405108
HMGA2 high mobility group AT-hook 2 -0.0384355
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0383236
VIM vimentin -0.0374045
HMCN1 hemicentin 1 -0.0373554
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0363948
ZNF704 zinc finger protein 704 -0.035271
LRRC23 leucine rich repeat containing 23 -0.0347121
SCFD2 sec1 family domain containing 2 -0.0344821
ACTG1 actin gamma 1 -0.0341149
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0340695
CTTNBP2 cortactin binding protein 2 -0.0338549
LSAMP limbic system-associated membrane protein -0.0327463
PTCHD4 patched domain containing 4 -0.0323392
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0322157
SOX5 SRY (sex determining region Y)-box 5 -0.0321541
MACROD2 MACRO domain containing 2 -0.0318193
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0302479
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0293229
NEGR1 neuronal growth regulator 1 -0.0293194
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0291991
PTMA prothymosin, alpha -0.029004
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0279031
NPAS2 neuronal PAS domain protein 2 -0.0277983
AHNAK AHNAK nucleoprotein -0.0275359
GPC6 glypican 6 -0.0274433
DCT dopachrome tautomerase -0.0274016
TPT1 tumor protein, translationally-controlled 1 -0.0272542
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0272325
GDF15 growth differentiation factor 15 -0.0268225
RPL37A ribosomal protein L37a -0.0268023
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0264978
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0264929
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0264848
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0262748
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0258948
PCDH7 protocadherin 7 -0.025872
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0255455
FRMD5 FERM domain containing 5 -0.0254859
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0250875
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0248914
BACE2 beta-site APP-cleaving enzyme 2 -0.0247508
EBF1 early B-cell factor 1 -0.0247507
PTPRD protein tyrosine phosphatase, receptor type, D -0.0243992
CTSD cathepsin D -0.0241521
RNF24 ring finger protein 24 -0.0241491
LINGO2 leucine rich repeat and Ig domain containing 2 -0.02394
TPI1 triosephosphate isomerase 1 -0.0238339
VDAC1 voltage-dependent anion channel 1 -0.0234968
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0234095
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0229588
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.02285
RRBP1 ribosome binding protein 1 -0.0228484
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0228359
CCND1 cyclin D1 -0.0224397
GNAS GNAS complex locus -0.022375
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0220603
NAV1 neuron navigator 1 -0.0216222
RUNX1 runt-related transcription factor 1 -0.0215914
RPL35A ribosomal protein L35a -0.0215201
IFRD1 interferon-related developmental regulator 1 -0.021255
HSPG2 heparan sulfate proteoglycan 2 -0.0211837
CALU calumenin -0.021101
RPTOR regulatory associated protein of MTOR, complex 1 -0.0209125
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0209022
FBXL7 F-box and leucine-rich repeat protein 7 -0.0208551
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.020781
HSPB1 heat shock 27kDa protein 1 -0.0206905
NRCAM neuronal cell adhesion molecule -0.020423
WSB1 WD repeat and SOCS box containing 1 -0.0204092
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0203468
PDE4B phosphodiesterase 4B, cAMP-specific -0.0201981
TBC1D22A TBC1 domain family, member 22A -0.020196
CAVIN1 caveolae associated protein 1 -0.0199659
MYO1E myosin IE -0.0199429
HILPDA hypoxia inducible lipid droplet-associated -0.0196913
RPLP1 ribosomal protein, large, P1 -0.0196622