L-Eflornithine (monohydrochloride)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Eflornithine (monohydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.207696
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.133726
MT1X metallothionein 1X 0.0989922
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0935874
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0935868
APLP2 amyloid beta (A4) precursor-like protein 2 0.0931289
FNDC3B fibronectin type III domain containing 3B 0.0903859
UBC ubiquitin C 0.0711052
BACE2 beta-site APP-cleaving enzyme 2 0.0704559
CTNND1 catenin (cadherin-associated protein), delta 1 0.0685816
AKAP12 A kinase (PRKA) anchor protein 12 0.0668474
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0656794
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0639026
RTN4 reticulon 4 0.0574657
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0519655
FTL ferritin, light polypeptide 0.0493657
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0493035
AKAP9 A kinase (PRKA) anchor protein 9 0.0489715
FNIP1 folliculin interacting protein 1 0.0482757
DSCAM Down syndrome cell adhesion molecule 0.0481502
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0478089
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0475845
EIF1 eukaryotic translation initiation factor 1 0.0452837
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0446895
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0446215
DOCK5 dedicator of cytokinesis 5 0.0445538
NDRG1 N-myc downstream regulated 1 0.0438483
TOP1 topoisomerase (DNA) I 0.043675
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0433751
ERRFI1 ERBB receptor feedback inhibitor 1 0.0428622
SAMD4A sterile alpha motif domain containing 4A 0.0409635
ASPH aspartate beta-hydroxylase 0.0403808
SPAG9 sperm associated antigen 9 0.0399547
FTH1 ferritin, heavy polypeptide 1 0.0394642
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0390803
DTNA dystrobrevin, alpha 0.0389337
TMEM51 transmembrane protein 51 0.0385496
KLF6 Kruppel-like factor 6 0.0381502
ANXA1 annexin A1 0.0376805
AKAP13 A kinase (PRKA) anchor protein 13 0.0375098
YTHDC1 YTH domain containing 1 0.0372129
RNF149 ring finger protein 149 0.0370987
MEF2A myocyte enhancer factor 2A 0.0369561
OGA O-GlcNAcase 0.0369337
TTC3 tetratricopeptide repeat domain 3 0.0367446
MCL1 myeloid cell leukemia 1 0.0366327
SEC31A SEC31 homolog A (S. cerevisiae) 0.0363623
PDZD8 PDZ domain containing 8 0.0360601
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.035883
MT1E metallothionein 1E 0.0356937
MACF1 microtubule-actin crosslinking factor 1 0.0355671
ANO6 anoctamin 6 0.034807
ENO1 enolase 1, (alpha) 0.0345723
ARHGAP5 Rho GTPase activating protein 5 0.0345591
ADAM9 ADAM metallopeptidase domain 9 0.0342505
CDCP1 CUB domain containing protein 1 0.0332919
GOLGB1 golgin B1 0.0332412
RB1CC1 RB1-inducible coiled-coil 1 0.0331451
NRIP1 nuclear receptor interacting protein 1 0.0330073
PRRC2C proline-rich coiled-coil 2C 0.0329654
AREG amphiregulin 0.0328796
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0325951
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0322058
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0321639
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0314894
CANX calnexin 0.0311692
SMAD3 SMAD family member 3 0.0307442
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.030232
ESYT2 extended synaptotagmin-like protein 2 0.0301659
SCFD1 sec1 family domain containing 1 0.0298726
GLRX glutaredoxin (thioltransferase) 0.0298168
OPTN optineurin 0.0294113
CD2AP CD2-associated protein 0.0291443
FBXL5 F-box and leucine-rich repeat protein 5 0.0290365
UBA6 ubiquitin-like modifier activating enzyme 6 0.0287271
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.028634
EMP1 epithelial membrane protein 1 0.0280007
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.027199
MYH9 myosin, heavy chain 9, non-muscle 0.0269925
FAM13A family with sequence similarity 13, member A 0.026915
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0268724
SLC38A2 solute carrier family 38, member 2 0.0268319
CCNL1 cyclin L1 0.02657
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0264902
ARRDC3 arrestin domain containing 3 0.0264576
LDHA lactate dehydrogenase A 0.0261956
RAP2B RAP2B, member of RAS oncogene family 0.0255663
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0255445
HELZ helicase with zinc finger 0.0255363
WWTR1 WW domain containing transcription regulator 1 0.0254239
YEATS2 YEATS domain containing 2 0.0253215
TMCC3 transmembrane and coiled-coil domain family 3 0.0252338
SEC23A Sec23 homolog A (S. cerevisiae) 0.02509
COPA coatomer protein complex, subunit alpha 0.0250614
SECISBP2L SECIS binding protein 2-like 0.0247123
MAP2K1 mitogen-activated protein kinase kinase 1 0.024694
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0246392
COG5 component of oligomeric golgi complex 5 0.0245154
TOGARAM1 TOG array regulator of axonemal microtubules 1 0.0244649
MYOF myoferlin 0.0244336

decreased expression

Symbol Name Standardized Value
MMP7 matrix metallopeptidase 7 -0.209962
CP ceruloplasmin (ferroxidase) -0.17689
IGFBP3 insulin-like growth factor binding protein 3 -0.141866
TMSB10 thymosin beta 10 -0.108237
APOL1 apolipoprotein L, 1 -0.0973883
PTMA prothymosin, alpha -0.0959459
EFNA5 ephrin-A5 -0.0725432
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0695203
PCDH7 protocadherin 7 -0.0679535
LMO7 LIM domain 7 -0.0636224
NRG3 neuregulin 3 -0.062712
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0613973
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0605964
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0588508
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0579294
ANXA2 annexin A2 -0.0557215
MAML2 mastermind-like 2 (Drosophila) -0.0551967
ARHGAP26 Rho GTPase activating protein 26 -0.0549604
HLA-B major histocompatibility complex, class I, B -0.0527176
TMSB4X thymosin beta 4, X-linked -0.0525093
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0524089
F3 coagulation factor III (thromboplastin, tissue factor) -0.0515815
PARD3 par-3 family cell polarity regulator -0.0508175
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0493967
LPP LIM domain containing preferred translocation partner in lipoma -0.0480254
EXT1 exostosin glycosyltransferase 1 -0.0480159
PLAT plasminogen activator, tissue -0.0470057
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0456221
RNF213 ring finger protein 213 -0.0450651
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -0.0445982
MX2 MX dynamin-like GTPase 2 -0.0433225
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0426176
LAMB3 laminin, beta 3 -0.0422511
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0421909
LMNA lamin A/C -0.0420878
LCN2 lipocalin 2 -0.0419133
NCKAP5 NCK-associated protein 5 -0.0409306
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0399435
CDK6 cyclin-dependent kinase 6 -0.0392705
ISG15 ISG15 ubiquitin-like modifier -0.0390266
AHNAK AHNAK nucleoprotein -0.0379897
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0374307
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0368992
IER3 immediate early response 3 -0.036628
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0365527
KLF5 Kruppel-like factor 5 (intestinal) -0.0357192
CATSPERB catsper channel auxiliary subunit beta -0.035549
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.034688
PDLIM5 PDZ and LIM domain 5 -0.0346364
ANTXR2 anthrax toxin receptor 2 -0.034458
RASAL2 RAS protein activator like 2 -0.0338518
AHNAK2 AHNAK nucleoprotein 2 -0.0337438
IFI27 interferon, alpha-inducible protein 27 -0.0336331
PRKCA protein kinase C, alpha -0.0334424
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0330032
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0327173
PDE4D phosphodiesterase 4D, cAMP-specific -0.0326188
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0321419
TMC5 transmembrane channel-like 5 -0.0320345
HMGA2 high mobility group AT-hook 2 -0.0316716
CNRIP1 cannabinoid receptor interacting protein 1 -0.0308408
VCAN versican -0.0308103
ITGA6 integrin, alpha 6 -0.0307841
RAI14 retinoic acid induced 14 -0.0307087
RIGI RNA sensor RIG-I -0.0305552
H1-0 H1.0 linker histone -0.0305429
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0304282
S100A6 S100 calcium binding protein A6 -0.030227
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0301876
PTPRK protein tyrosine phosphatase, receptor type, K -0.0299711
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0299483
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.028507
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0280932
ITGB4 integrin, beta 4 -0.0279665
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -0.0279141
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0273685
KRT19 keratin 19, type I -0.0273555
MUC16 mucin 16, cell surface associated -0.0270467
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0268749
CFLAR CASP8 and FADD-like apoptosis regulator -0.0266525
GABRP gamma-aminobutyric acid (GABA) A receptor, pi -0.0263557
CFB complement factor B -0.0262745
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0249967
GLIS3 GLIS family zinc finger 3 -0.024904
STRN3 striatin, calmodulin binding protein 3 -0.0246468
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0245916
TM4SF4 transmembrane 4 L six family member 4 -0.0244537
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0242718
KRT23 keratin 23, type I -0.0242259
PMP22 peripheral myelin protein 22 -0.0241501
XAF1 XIAP associated factor 1 -0.0240494
TPT1 tumor protein, translationally-controlled 1 -0.0239292
EHBP1 EH domain binding protein 1 -0.0238013
RCOR1 REST corepressor 1 -0.023788
UTRN utrophin -0.0237812
ANXA4 annexin A4 -0.0234517
WARS1 tryptophanyl-tRNA synthetase 1 -0.0233207
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0232211
RPS21 ribosomal protein S21 -0.0231192
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.022919