L-Eflornithine (monohydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Eflornithine (monohydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.189296
FLNB filamin B, beta 0.157283
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.124367
TPT1 tumor protein, translationally-controlled 1 0.12434
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.100119
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0980692
PABPC1 poly(A) binding protein, cytoplasmic 1 0.097524
EZR ezrin 0.0966161
VCL vinculin 0.0953433
ACTN4 actinin, alpha 4 0.0911456
DSPP dentin sialophosphoprotein 0.087991
TMSB10 thymosin beta 10 0.08736
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0868687
EEF2 eukaryotic translation elongation factor 2 0.0860709
RPL3 ribosomal protein L3 0.0856095
LDHA lactate dehydrogenase A 0.0794966
ACTG1 actin gamma 1 0.0790916
ENO1 enolase 1, (alpha) 0.0786986
KRT8 keratin 8, type II 0.0736862
PTMA prothymosin, alpha 0.0704945
CALB1 calbindin 1, 28kDa 0.0703317
MSI2 musashi RNA-binding protein 2 0.0692458
SEC31A SEC31 homolog A (S. cerevisiae) 0.0690155
ITGA6 integrin, alpha 6 0.0689436
UBC ubiquitin C 0.0688829
ANXA2 annexin A2 0.0670563
CANX calnexin 0.0668235
AKAP13 A kinase (PRKA) anchor protein 13 0.0647611
PKM pyruvate kinase, muscle 0.0643108
LAMB3 laminin, beta 3 0.0639255
RPL4 ribosomal protein L4 0.0636912
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0626794
RPLP1 ribosomal protein, large, P1 0.0571749
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0564686
CALU calumenin 0.0562366
F3 coagulation factor III (thromboplastin, tissue factor) 0.0554442
PGK1 phosphoglycerate kinase 1 0.0537495
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0520928
IQGAP1 IQ motif containing GTPase activating protein 1 0.051652
RPL23 ribosomal protein L23 0.0515399
ANXA11 annexin A11 0.0503141
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0497648
RPL34 ribosomal protein L34 0.0483105
MYH9 myosin, heavy chain 9, non-muscle 0.0476454
RRBP1 ribosome binding protein 1 0.0473416
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.0472798
TSPAN8 tetraspanin 8 0.0462803
BAIAP2L1 BAI1-associated protein 2-like 1 0.0462062
RPL31 ribosomal protein L31 0.0453778
RPS3 ribosomal protein S3 0.0439311
TTC3 tetratricopeptide repeat domain 3 0.0439308
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0434943
EIF4B eukaryotic translation initiation factor 4B 0.0433634
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0424665
ITPRID2 ITPR interacting domain containing 2 0.0420439
CTNND1 catenin (cadherin-associated protein), delta 1 0.0416862
KRT18 keratin 18, type I 0.0416772
MYO6 myosin VI 0.0411079
CLDN4 claudin 4 0.040775
DSCAM Down syndrome cell adhesion molecule 0.0407036
ESYT2 extended synaptotagmin-like protein 2 0.0406509
VEGFA vascular endothelial growth factor A 0.0405741
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0404371
NCOR2 nuclear receptor corepressor 2 0.0401124
CSDE1 cold shock domain containing E1, RNA-binding 0.0395496
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0395264
EEF1G eukaryotic translation elongation factor 1 gamma 0.0388603
CALR calreticulin 0.0386985
RPL37 ribosomal protein L37 0.0386155
SLK STE20-like kinase 0.0384068
PLAC8 placenta-specific 8 0.038319
GMDS GDP-mannose 4,6-dehydratase 0.0381147
KRT19 keratin 19, type I 0.0374904
EIF4A2 eukaryotic translation initiation factor 4A2 0.0374422
RPLP0 ribosomal protein, large, P0 0.0372609
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0372363
SRRM2 serine/arginine repetitive matrix 2 0.0370684
MYH14 myosin, heavy chain 14, non-muscle 0.0364524
EMP1 epithelial membrane protein 1 0.0364139
INSIG1 insulin induced gene 1 0.0360846
ETNK1 ethanolamine kinase 1 0.0357068
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0354278
AHNAK AHNAK nucleoprotein 0.0353687
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0352211
UBE2H ubiquitin-conjugating enzyme E2H 0.0350882
RAB1A RAB1A, member RAS oncogene family 0.0345397
S100A6 S100 calcium binding protein A6 0.0345326
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.034403
CD9 CD9 molecule 0.0342356
GOLGA4 golgin A4 0.0341823
RBM25 RNA binding motif protein 25 0.0337021
GOLGB1 golgin B1 0.0332638
RPL27A ribosomal protein L27a 0.033133
PERP PERP, TP53 apoptosis effector 0.0331299
EPHA2 EPH receptor A2 0.0330693
GOLGA3 golgin A3 0.0322225
RPS11 ribosomal protein S11 0.0321085
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0320732
RPL14 ribosomal protein L14 0.0320288
RACK1 receptor for activated C kinase 1 0.0319302

decreased expression

Symbol Name Standardized Value
RPS2 ribosomal protein S2 -0.0989973
PDE4D phosphodiesterase 4D, cAMP-specific -0.0695716
TXNRD1 thioredoxin reductase 1 -0.0660129
PTPRG protein tyrosine phosphatase, receptor type, G -0.0497043
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0485627
ATXN1 ataxin 1 -0.0418406
RNF145 ring finger protein 145 -0.0383039
NAMPT nicotinamide phosphoribosyltransferase -0.0352177
CCSER1 coiled-coil serine-rich protein 1 -0.0321937
CCND2 cyclin D2 -0.0300635
ARL15 ADP-ribosylation factor-like 15 -0.0298586
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.029143
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0283711
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0280114
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0262723
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.0262718
EXT1 exostosin glycosyltransferase 1 -0.02432
TAS2R14 taste receptor, type 2, member 14 -0.0241104
WWOX WW domain containing oxidoreductase -0.0235693
ARHGAP29 Rho GTPase activating protein 29 -0.02347
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0225394
TCF12 transcription factor 12 -0.0224446
NCOA7 nuclear receptor coactivator 7 -0.0215237
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0209834
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0209826
RPL9 ribosomal protein L9 -0.0205767
BTBD9 BTB (POZ) domain containing 9 -0.0205273
SMYD3 SET and MYND domain containing 3 -0.0194929
IL6ST interleukin 6 signal transducer -0.0193166
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0185529
GCLC glutamate-cysteine ligase, catalytic subunit -0.0182479
NEBL nebulette -0.0180627
PARD3B par-3 family cell polarity regulator beta -0.0180582
CCPG1 cell cycle progression 1 -0.0179973
GPHN gephyrin -0.0176151
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.0175479
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0173194
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0172501
EREG epiregulin -0.0170435
SAMD5 sterile alpha motif domain containing 5 -0.0169395
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0167247
NRXN3 neurexin 3 -0.0165878
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0165228
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) -0.0165097
NKTR natural killer cell triggering receptor -0.0164066
MAN1A2 mannosidase, alpha, class 1A, member 2 -0.0162888
FOXP1 forkhead box P1 -0.0162464
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0162459
GOLM2 golgi membrane protein 2 -0.0158483
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.0157211
CNTNAP2 contactin associated protein-like 2 -0.0156804
SPIDR scaffolding protein involved in DNA repair -0.0156756
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0156184
KLF5 Kruppel-like factor 5 (intestinal) -0.0155818
NIBAN1 niban apoptosis regulator 1 -0.0155172
MX2 MX dynamin-like GTPase 2 -0.0154624
RPS12 ribosomal protein S12 -0.0154522
TBC1D5 TBC1 domain family, member 5 -0.0153841
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.015304
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0152715
RIMKLB ribosomal modification protein rimK-like family member B -0.0151092
LOC105378220 macrophage receptor MARCO-like -0.0150956
BLTP1 bridge-like lipid transfer protein family member 1 -0.014957
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0149521
FAF1 Fas (TNFRSF6) associated factor 1 -0.0149479
SCLT1 sodium channel and clathrin linker 1 -0.0149346
NFIB nuclear factor I/B -0.0147571
BICD1 bicaudal D homolog 1 (Drosophila) -0.014699
FBXL17 F-box and leucine-rich repeat protein 17 -0.0146812
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0146069
TTC17 tetratricopeptide repeat domain 17 -0.0145575
SOS1 son of sevenless homolog 1 (Drosophila) -0.0145228
PDZD8 PDZ domain containing 8 -0.0144805
ZNF407 zinc finger protein 407 -0.0144562
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0144277
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0143937
RPL23A ribosomal protein L23a -0.0143817
ICE1 interactor of little elongation complex ELL subunit 1 -0.0143629
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0142415
DPY19L1 dpy-19-like 1 (C. elegans) -0.0142013
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0140558
BCAS3 breast carcinoma amplified sequence 3 -0.0140348
FER fer (fps/fes related) tyrosine kinase -0.0139358
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0139237
KIAA1328 KIAA1328 -0.0138661
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0137982
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0136176
ELOVL7 ELOVL fatty acid elongase 7 -0.0134708
FBXO32 F-box protein 32 -0.0134479
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0134059
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0133858
TARS1 threonyl-tRNA synthetase 1 -0.0132959
UBE2B ubiquitin-conjugating enzyme E2B -0.013287
SQSTM1 sequestosome 1 -0.0132796
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0131499
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0130016
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0129853
CAMKMT calmodulin-lysine N-methyltransferase -0.0129807
RUNX1 runt-related transcription factor 1 -0.0129752
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0129399