L-Eflornithine (monohydrochloride)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Eflornithine (monohydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.163134
FNDC3B fibronectin type III domain containing 3B 0.14903
GRB10 growth factor receptor-bound protein 10 0.123467
KDM2A lysine (K)-specific demethylase 2A 0.108177
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.100923
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0991377
SDK1 sidekick cell adhesion molecule 1 0.097999
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0922887
RICTOR RPTOR independent companion of MTOR, complex 2 0.0919931
PCBP2 poly(rC) binding protein 2 0.0904049
GOLGA4 golgin A4 0.0893529
SOD2 superoxide dismutase 2, mitochondrial 0.0868868
SIK3 SIK family kinase 3 0.078484
APLP2 amyloid beta (A4) precursor-like protein 2 0.0766888
VEGFA vascular endothelial growth factor A 0.0762838
RAB1A RAB1A, member RAS oncogene family 0.0757721
P4HB prolyl 4-hydroxylase, beta polypeptide 0.075419
AKAP13 A kinase (PRKA) anchor protein 13 0.0715736
ATP13A3 ATPase type 13A3 0.0714569
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0709363
LOX lysyl oxidase 0.0706462
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0696754
TRIO trio Rho guanine nucleotide exchange factor 0.0684061
RBM39 RNA binding motif protein 39 0.0653296
IGFBP3 insulin-like growth factor binding protein 3 0.0640336
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0640115
FAM13A family with sequence similarity 13, member A 0.0629157
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.061538
MEF2A myocyte enhancer factor 2A 0.0613056
ZEB2 zinc finger E-box binding homeobox 2 0.0611457
USP34 ubiquitin specific peptidase 34 0.0609179
SPAG9 sperm associated antigen 9 0.0606417
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0603539
UBA6 ubiquitin-like modifier activating enzyme 6 0.059062
WAC WW domain containing adaptor with coiled-coil 0.0588252
FTH1 ferritin, heavy polypeptide 1 0.0579706
ITCH itchy E3 ubiquitin protein ligase 0.0569147
UBC ubiquitin C 0.0554526
COPA coatomer protein complex, subunit alpha 0.0551736
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0534752
SETD5 SET domain containing 5 0.0528937
HELZ helicase with zinc finger 0.0510195
PIAS2 protein inhibitor of activated STAT, 2 0.0507428
ELL2 elongation factor, RNA polymerase II, 2 0.0507108
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0503117
VMP1 vacuole membrane protein 1 0.0500894
RAP1B RAP1B, member of RAS oncogene family 0.0499485
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0498725
SEC31A SEC31 homolog A (S. cerevisiae) 0.0487963
CD44 CD44 molecule (Indian blood group) 0.0480375
NGLY1 N-glycanase 1 0.0477866
KTN1 kinectin 1 (kinesin receptor) 0.0472073
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0467843
FLNB filamin B, beta 0.0466522
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0463194
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0455581
KMT2C lysine (K)-specific methyltransferase 2C 0.0450528
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0440316
PDIA6 protein disulfide isomerase family A, member 6 0.0436579
PDIA3 protein disulfide isomerase family A, member 3 0.0435371
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0429914
PICALM phosphatidylinositol binding clathrin assembly protein 0.0423403
LDHA lactate dehydrogenase A 0.0421792
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0420758
DOCK5 dedicator of cytokinesis 5 0.0420465
JMJD1C jumonji domain containing 1C 0.0418691
ADD3 adducin 3 (gamma) 0.0414593
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0412412
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0404358
STK38L serine/threonine kinase 38 like 0.0404225
MYH9 myosin, heavy chain 9, non-muscle 0.0398955
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0397731
UBE2H ubiquitin-conjugating enzyme E2H 0.0397539
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.039651
CANX calnexin 0.0389556
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0385454
SRP54 signal recognition particle 54kDa 0.0384553
SEC23A Sec23 homolog A (S. cerevisiae) 0.0380704
OGA O-GlcNAcase 0.0380163
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0378879
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.037432
ARHGAP5 Rho GTPase activating protein 5 0.0372209
ANKRD11 ankyrin repeat domain 11 0.036777
STRN3 striatin, calmodulin binding protein 3 0.0366498
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0366
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.036406
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0362082
SUCO SUN domain containing ossification factor 0.0361581
USP3 ubiquitin specific peptidase 3 0.0360562
HILPDA hypoxia inducible lipid droplet-associated 0.0360244
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0359174
MBNL1 muscleblind-like splicing regulator 1 0.035681
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0354785
PTK2 protein tyrosine kinase 2 0.0352862
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0352377
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0351739
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0349732
PDGFA platelet-derived growth factor alpha polypeptide 0.0341658
IQGAP1 IQ motif containing GTPase activating protein 1 0.0339359
MYO1B myosin IB 0.0335405

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.13459
TMSB10 thymosin beta 10 -0.128202
VIM vimentin -0.109726
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0835098
RPLP1 ribosomal protein, large, P1 -0.0782472
RPL35A ribosomal protein L35a -0.0687672
RPS19 ribosomal protein S19 -0.0536671
RPS21 ribosomal protein S21 -0.0477313
RPL36 ribosomal protein L36 -0.0467204
RPL32 ribosomal protein L32 -0.0465148
RPLP2 ribosomal protein, large, P2 -0.0464045
RPS29 ribosomal protein S29 -0.0433074
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0432481
ZBTB20 zinc finger and BTB domain containing 20 -0.0419881
DPYD dihydropyrimidine dehydrogenase -0.0407816
RPL34 ribosomal protein L34 -0.0392969
RPS24 ribosomal protein S24 -0.0391949
C15ORF48 chromosome 15 open reading frame 48 -0.038817
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0362395
IER3 immediate early response 3 -0.0348738
TPT1 tumor protein, translationally-controlled 1 -0.0342944
FTL ferritin, light polypeptide -0.0333798
RPL11 ribosomal protein L11 -0.0321863
RPL37A ribosomal protein L37a -0.032103
SYT1 synaptotagmin I -0.0319541
RPL12 ribosomal protein L12 -0.0315861
RPL23 ribosomal protein L23 -0.0315122
RPS6 ribosomal protein S6 -0.0313275
HLA-B major histocompatibility complex, class I, B -0.0307743
LRMDA leucine rich melanocyte differentiation associated -0.0305221
EIF1 eukaryotic translation initiation factor 1 -0.0292344
SLC38A1 solute carrier family 38, member 1 -0.0285488
VDAC1 voltage-dependent anion channel 1 -0.0280445
RPS16 ribosomal protein S16 -0.0278703
MBD5 methyl-CpG binding domain protein 5 -0.0275884
RPL31 ribosomal protein L31 -0.0275814
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0273141
RPL19 ribosomal protein L19 -0.0267252
EXOC4 exocyst complex component 4 -0.026346
PDE4D phosphodiesterase 4D, cAMP-specific -0.0260039
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0258854
RPL9 ribosomal protein L9 -0.0255986
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0251647
RPL38 ribosomal protein L38 -0.0251126
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.024597
RPLP0 ribosomal protein, large, P0 -0.0243903
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0240657
ZNF804A zinc finger protein 804A -0.0237831
BCAS3 breast carcinoma amplified sequence 3 -0.0236672
RPS25 ribosomal protein S25 -0.0236013
CDH13 cadherin 13 -0.0234417
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0228847
SEC61G Sec61 gamma subunit -0.0227474
RPS8 ribosomal protein S8 -0.0227005
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0224258
SUMF1 sulfatase modifying factor 1 -0.0223512
SAMD9 sterile alpha motif domain containing 9 -0.0223416
RPS13 ribosomal protein S13 -0.0219659
TBL1X transducin (beta)-like 1X-linked -0.021905
MECOM MDS1 and EVI1 complex locus -0.0218886
PHF14 PHD finger protein 14 -0.0218847
ENOSF1 enolase superfamily member 1 -0.0218061
RPL28 ribosomal protein L28 -0.021664
NRG1 neuregulin 1 -0.0213115
MIPOL1 mirror-image polydactyly 1 -0.0212978
TBC1D5 TBC1 domain family, member 5 -0.0212098
IFITM3 interferon induced transmembrane protein 3 -0.0210563
RPS10 ribosomal protein S10 -0.020948
RPS20 ribosomal protein S20 -0.0209001
NAMPT nicotinamide phosphoribosyltransferase -0.0208338
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0206182
RPS3 ribosomal protein S3 -0.0205085
NCOA7 nuclear receptor coactivator 7 -0.0204902
GSTP1 glutathione S-transferase pi 1 -0.0203165
RPS12 ribosomal protein S12 -0.0200356
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0197145
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0196289
RPL30 ribosomal protein L30 -0.0194998
RPL18 ribosomal protein L18 -0.019388
ATG7 autophagy related 7 -0.0189344
ZMYND8 zinc finger, MYND-type containing 8 -0.0187219
EIF5B eukaryotic translation initiation factor 5B -0.0186358
TFPI2 tissue factor pathway inhibitor 2 -0.0184429
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0182975
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0181063
MYO9A myosin IXA -0.0180669
RPL7A ribosomal protein L7a -0.0180477
RPS23 ribosomal protein S23 -0.0180317
CAVIN1 caveolae associated protein 1 -0.0177933
GCC2 GRIP and coiled-coil domain containing 2 -0.0176522
RPS5 ribosomal protein S5 -0.0175169
CDK13 cyclin-dependent kinase 13 -0.0174091
RPS15 ribosomal protein S15 -0.0173414
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0171795
ISG15 ISG15 ubiquitin-like modifier -0.0171206
RPS11 ribosomal protein S11 -0.0170881
RPL13A ribosomal protein L13a -0.0170811
IFIH1 interferon induced with helicase C domain 1 -0.0170099
IFI6 interferon, alpha-inducible protein 6 -0.016996
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0169863