| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | L-Eflornithine (monohydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.153766 |
| PM20D1 | peptidase M20 domain containing 1 | 0.127462 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.115914 |
| GRAMD1B | GRAM domain containing 1B | 0.112425 |
| TXNRD1 | thioredoxin reductase 1 | 0.0813292 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0800612 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0757254 |
| SLC38A2 | solute carrier family 38, member 2 | 0.073886 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0687871 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0603862 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0580774 |
| RTN4 | reticulon 4 | 0.0540105 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0521097 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0519841 |
| ERBIN | erbb2 interacting protein | 0.0515997 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0506688 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0505718 |
| VMP1 | vacuole membrane protein 1 | 0.049268 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.04795 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0469225 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0466142 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0450568 |
| POTEF | POTE ankyrin domain family, member F | 0.0441181 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0436817 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0433239 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0430841 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0420609 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0410317 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0403475 |
| TPM3 | tropomyosin 3 | 0.0386649 |
| FGB | fibrinogen beta chain | 0.0369098 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0364378 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0362082 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0361996 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.0355232 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0347438 |
| WDR43 | WD repeat domain 43 | 0.0339926 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0336897 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0332756 |
| RBM25 | RNA binding motif protein 25 | 0.0332077 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0331447 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0327128 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0325624 |
| JMJD1C | jumonji domain containing 1C | 0.0319523 |
| RASAL2 | RAS protein activator like 2 | 0.0311192 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.031112 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0311092 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0310253 |
| PDE8A | phosphodiesterase 8A | 0.030249 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0301954 |
| MKI67 | marker of proliferation Ki-67 | 0.0296035 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0295238 |
| RPL3 | ribosomal protein L3 | 0.0292595 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0288899 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0288566 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0284682 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0276448 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0274632 |
| PLS3 | plastin 3 | 0.0272376 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0268444 |
| COG5 | component of oligomeric golgi complex 5 | 0.0264283 |
| USP34 | ubiquitin specific peptidase 34 | 0.026372 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.026363 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.026055 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0257972 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0257319 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0255225 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0254025 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0252452 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0248531 |
| BMP6 | bone morphogenetic protein 6 | 0.0246862 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0246417 |
| COPA | coatomer protein complex, subunit alpha | 0.0243878 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.023861 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0238375 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.023836 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0237522 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0234988 |
| KLF6 | Kruppel-like factor 6 | 0.0234788 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0231722 |
| CENPF | centromere protein F, 350/400kDa | 0.0229975 |
| FMNL2 | formin-like 2 | 0.0228914 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0228114 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0227748 |
| RCOR1 | REST corepressor 1 | 0.022772 |
| RBM39 | RNA binding motif protein 39 | 0.0226059 |
| ECT2 | epithelial cell transforming 2 | 0.0225813 |
| PCNX1 | pecanex 1 | 0.0222513 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0221416 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0220929 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0219998 |
| CFDP1 | craniofacial development protein 1 | 0.0219504 |
| TOP1 | topoisomerase (DNA) I | 0.0219109 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0217612 |
| NUP58 | nucleoporin 58 | 0.0216775 |
| UBE3A | ubiquitin protein ligase E3A | 0.0213453 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0212384 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0209685 |
| NUP153 | nucleoporin 153kDa | 0.0208992 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 0.0207862 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.115204 |
| IGF2 | insulin-like growth factor 2 | -0.0803324 |
| TMSB10 | thymosin beta 10 | -0.0765615 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0642947 |
| IER3 | immediate early response 3 | -0.0610589 |
| VIM | vimentin | -0.0587926 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0579744 |
| CAVIN1 | caveolae associated protein 1 | -0.05604 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0549666 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0542994 |
| PTMA | prothymosin, alpha | -0.0468079 |
| S100A10 | S100 calcium binding protein A10 | -0.0441793 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0425578 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0418915 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0409237 |
| LMNA | lamin A/C | -0.0384989 |
| RPS21 | ribosomal protein S21 | -0.0313999 |
| S100A6 | S100 calcium binding protein A6 | -0.031351 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0312069 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0309101 |
| PYGL | phosphorylase, glycogen, liver | -0.0308859 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0308127 |
| ACTG1 | actin gamma 1 | -0.0307321 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0291088 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0287675 |
| ANXA2 | annexin A2 | -0.0282497 |
| HMGA2 | high mobility group AT-hook 2 | -0.0274909 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0274504 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0272917 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0268532 |
| EGFR | epidermal growth factor receptor | -0.0262295 |
| NEGR1 | neuronal growth regulator 1 | -0.0253265 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0240631 |
| RPL35A | ribosomal protein L35a | -0.024023 |
| RPL23 | ribosomal protein L23 | -0.0239932 |
| RPS25 | ribosomal protein S25 | -0.0232524 |
| BICC1 | BicC family RNA binding protein 1 | -0.0229719 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0228353 |
| EHBP1 | EH domain binding protein 1 | -0.0227843 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0217679 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0217197 |
| RPS8 | ribosomal protein S8 | -0.0212247 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0210154 |
| RNF213 | ring finger protein 213 | -0.0207913 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0207387 |
| HLA-B | major histocompatibility complex, class I, B | -0.0202471 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0201881 |
| TNS3 | tensin 3 | -0.0198245 |
| LRRC23 | leucine rich repeat containing 23 | -0.0194367 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | -0.0191698 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0190428 |
| PGK1 | phosphoglycerate kinase 1 | -0.0184092 |
| RIOK3 | RIO kinase 3 | -0.0180819 |
| RPLP1 | ribosomal protein, large, P1 | -0.0179888 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0178948 |
| AHNAK | AHNAK nucleoprotein | -0.0176961 |
| STC1 | stanniocalcin 1 | -0.017292 |
| ANGPTL4 | angiopoietin-like 4 | -0.016966 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0168175 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0167569 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0163852 |
| RPS29 | ribosomal protein S29 | -0.0163076 |
| UBB | ubiquitin B | -0.016165 |
| NDRG1 | N-myc downstream regulated 1 | -0.0161117 |
| FTL | ferritin, light polypeptide | -0.0161001 |
| RPS11 | ribosomal protein S11 | -0.0160969 |
| SRGN | serglycin | -0.0158857 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0158799 |
| SP100 | SP100 nuclear antigen | -0.0157608 |
| CDK13 | cyclin-dependent kinase 13 | -0.0154731 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0153569 |
| SERF2 | small EDRK-rich factor 2 | -0.0153223 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0152428 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0152396 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0151986 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0151474 |
| GNAS | GNAS complex locus | -0.0151458 |
| INTS6 | integrator complex subunit 6 | -0.0150914 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0150119 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.0149218 |
| MT2A | metallothionein 2A | -0.0149101 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0148583 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0148306 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.01475 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0147169 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0146536 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0146425 |
| HLA-E | major histocompatibility complex, class I, E | -0.0145693 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0145639 |
| RPL37A | ribosomal protein L37a | -0.014521 |
| RPL38 | ribosomal protein L38 | -0.0144949 |
| SQSTM1 | sequestosome 1 | -0.0144571 |
| DCAF5 | DDB1 and CUL4 associated factor 5 | -0.0143554 |
| RPS6 | ribosomal protein S6 | -0.014344 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0142383 |
| B2M | beta-2-microglobulin | -0.0142102 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0141728 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0141508 |
| MYO1E | myosin IE | -0.0140885 |
| CCDC7 | coiled-coil domain containing 7 | -0.014032 |
