L-Eflornithine (monohydrochloride)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Eflornithine (monohydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.255054
FN1 fibronectin 1 0.145985
AKAP12 A kinase (PRKA) anchor protein 12 0.136257
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.13165
VIM vimentin 0.113711
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.111047
NDRG1 N-myc downstream regulated 1 0.0984187
MT2A metallothionein 2A 0.0940439
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0912192
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0899713
DSCAM Down syndrome cell adhesion molecule 0.0890517
GPC6 glypican 6 0.0853902
FTL ferritin, light polypeptide 0.0762157
ELL2 elongation factor, RNA polymerase II, 2 0.0747047
EIF1 eukaryotic translation initiation factor 1 0.0736296
TMSB10 thymosin beta 10 0.0732857
ENO1 enolase 1, (alpha) 0.0729943
RTN4 reticulon 4 0.0729584
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0702401
ACTG1 actin gamma 1 0.0677168
ERRFI1 ERBB receptor feedback inhibitor 1 0.0644336
LDHA lactate dehydrogenase A 0.06397
NAMPT nicotinamide phosphoribosyltransferase 0.0634745
ZNF292 zinc finger protein 292 0.0623557
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0620707
TPT1 tumor protein, translationally-controlled 1 0.0609052
RPS16 ribosomal protein S16 0.0531059
PRKCA protein kinase C, alpha 0.0523343
ATXN1 ataxin 1 0.0523147
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0498906
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0482348
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0462934
VCL vinculin 0.0462032
NAP1L1 nucleosome assembly protein 1-like 1 0.0460584
RPLP1 ribosomal protein, large, P1 0.0458721
CD44 CD44 molecule (Indian blood group) 0.0455569
DIAPH2 diaphanous-related formin 2 0.0438497
MCTP1 multiple C2 domains, transmembrane 1 0.0435409
KMT2E lysine (K)-specific methyltransferase 2E 0.0421995
TRIO trio Rho guanine nucleotide exchange factor 0.0420783
BIRC6 baculoviral IAP repeat containing 6 0.0414259
RBM39 RNA binding motif protein 39 0.0408036
APP amyloid beta (A4) precursor protein 0.0405627
STC1 stanniocalcin 1 0.0405235
PLAUR plasminogen activator, urokinase receptor 0.0405051
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0384701
GARS1 glycyl-tRNA synthetase 1 0.0383451
IQGAP1 IQ motif containing GTPase activating protein 1 0.0382265
FAM162A family with sequence similarity 162, member A 0.0370655
OGA O-GlcNAcase 0.0367824
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0366412
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0362927
GOLGA4 golgin A4 0.0361344
YBX1 Y box binding protein 1 0.0361313
ANO6 anoctamin 6 0.0360825
CXCL8 chemokine (C-X-C motif) ligand 8 0.0356577
PDE10A phosphodiesterase 10A 0.0355494
CANX calnexin 0.0354122
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0353868
SFTPA2 surfactant protein A2 0.0351044
RPS6 ribosomal protein S6 0.0349218
PRRC2C proline-rich coiled-coil 2C 0.0341895
KDM5B lysine (K)-specific demethylase 5B 0.0340276
NALF1 NALCN channel auxiliary factor 1 0.0339199
PGK1 phosphoglycerate kinase 1 0.0338667
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0337657
PDIA3 protein disulfide isomerase family A, member 3 0.0337044
SND1 staphylococcal nuclease and tudor domain containing 1 0.0335567
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0332607
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0331329
RPS3 ribosomal protein S3 0.0327663
PNISR PNN-interacting serine/arginine-rich protein 0.0326855
PKM pyruvate kinase, muscle 0.0326159
WDR45B WD repeat domain 45B 0.0324236
FNDC3B fibronectin type III domain containing 3B 0.0322509
KMT2C lysine (K)-specific methyltransferase 2C 0.0319979
HOOK2 hook microtubule-tethering protein 2 0.0318271
EIF4A1 eukaryotic translation initiation factor 4A1 0.0317131
DSTN destrin (actin depolymerizing factor) 0.0317103
FAM13A family with sequence similarity 13, member A 0.0315984
RPLP2 ribosomal protein, large, P2 0.0310481
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0310375
FBXO11 F-box protein 11 0.030962
RPL23 ribosomal protein L23 0.0303338
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0297033
SIK3 SIK family kinase 3 0.0297003
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0296731
RAB7A RAB7A, member RAS oncogene family 0.0293089
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0292497
KDM3A lysine (K)-specific demethylase 3A 0.0292234
RPL12 ribosomal protein L12 0.029179
SEC31A SEC31 homolog A (S. cerevisiae) 0.0291236
RAB1A RAB1A, member RAS oncogene family 0.0290751
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0289674
RLF rearranged L-myc fusion 0.0286935
TPI1 triosephosphate isomerase 1 0.0285801
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.028387
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0280412
MORF4L2 mortality factor 4 like 2 0.027704
MYO10 myosin X 0.0276265

decreased expression

Symbol Name Standardized Value
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.139873
GRB10 growth factor receptor-bound protein 10 -0.0874851
MUC16 mucin 16, cell surface associated -0.0783574
ATOSA atos homolog A -0.076184
CEMIP cell migration inducing protein, hyaluronan binding -0.07617
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0634075
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0632454
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0631377
KRT17 keratin 17, type I -0.0605462
BACE2 beta-site APP-cleaving enzyme 2 -0.0566364
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0556863
ANTXR2 anthrax toxin receptor 2 -0.0546668
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0541326
SAMD4A sterile alpha motif domain containing 4A -0.0519934
KIF13B kinesin family member 13B -0.0518359
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0505311
LMO7 LIM domain 7 -0.0501745
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0485381
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0472536
KYNU kynureninase -0.0469182
RBM47 RNA binding motif protein 47 -0.0456522
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0456224
LAMB3 laminin, beta 3 -0.0451872
ANKRD36C ankyrin repeat domain 36C -0.044925
EIF4A3 eukaryotic translation initiation factor 4A3 -0.0431478
PNN pinin, desmosome associated protein -0.0429375
STEAP4 STEAP family member 4 -0.0425506
TGFA transforming growth factor, alpha -0.0425334
SCEL sciellin -0.0421723
F3 coagulation factor III (thromboplastin, tissue factor) -0.0418969
AKR1C1 aldo-keto reductase family 1, member C1 -0.0418929
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0415609
NEBL nebulette -0.041523
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0410223
TMPRSS4 transmembrane protease, serine 4 -0.0409605
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0404848
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0401459
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0396573
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.039291
FAM107B family with sequence similarity 107, member B -0.038813
TJP2 tight junction protein 2 -0.0387493
LAMC2 laminin, gamma 2 -0.0385246
EXOC6B exocyst complex component 6B -0.0384946
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0384921
SPNS2 spinster homolog 2 (Drosophila) -0.0383405
CXXC1 CXXC finger protein 1 -0.0382792
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0381784
ISG20 interferon stimulated exonuclease gene 20kDa -0.037984
TMOD3 tropomodulin 3 (ubiquitous) -0.0377403
VEZT vezatin, adherens junctions transmembrane protein -0.0372403
GCC2 GRIP and coiled-coil domain containing 2 -0.0364991
RNF213 ring finger protein 213 -0.0359887
SLK STE20-like kinase -0.0358099
STX18 syntaxin 18 -0.0355345
CLDN7 claudin 7 -0.0351663
SOX4 SRY (sex determining region Y)-box 4 -0.0351632
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0350448
SYT1 synaptotagmin I -0.0348047
NEMF nuclear export mediator factor -0.0346571
SQSTM1 sequestosome 1 -0.034639
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma -0.0346305
AGFG1 ArfGAP with FG repeats 1 -0.0346156
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0345709
GPATCH2L G patch domain containing 2-like -0.0345582
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0344997
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0344728
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0343151
CATSPERB catsper channel auxiliary subunit beta -0.034241
PDE4D phosphodiesterase 4D, cAMP-specific -0.0341618
PLEC plectin -0.0340913
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0337961
TXNRD1 thioredoxin reductase 1 -0.0335403
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0333787
SAMD9 sterile alpha motif domain containing 9 -0.0331311
CA12 carbonic anhydrase XII -0.0330215
SPPL3 signal peptide peptidase like 3 -0.0330161
SVIL supervillin -0.0329976
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0328878
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0328296
RCOR1 REST corepressor 1 -0.0327399
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0326605
RIGI RNA sensor RIG-I -0.0325405
JUN jun proto-oncogene -0.0322792
ARL15 ADP-ribosylation factor-like 15 -0.0320552
ARHGAP21 Rho GTPase activating protein 21 -0.0318876
IRAK2 interleukin-1 receptor-associated kinase 2 -0.0318874
USP34 ubiquitin specific peptidase 34 -0.031789
SAMD12 sterile alpha motif domain containing 12 -0.0316359
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -0.0313569
MYO1D myosin ID -0.0313276
ADAR adenosine deaminase, RNA-specific -0.0311003
NSD1 nuclear receptor binding SET domain protein 1 -0.0305375
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0305118
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0304979
S100A9 S100 calcium binding protein A9 -0.0304565
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0302935
C6ORF132 chromosome 6 open reading frame 132 -0.0301044
GLCCI1 glucocorticoid induced 1 -0.0300842
BCAS3 breast carcinoma amplified sequence 3 -0.0300322
OSBPL10 oxysterol binding protein-like 10 -0.0298673