L-Eflornithine (monohydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Eflornithine (monohydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.159519
DSCAM Down syndrome cell adhesion molecule 0.147796
FNDC3B fibronectin type III domain containing 3B 0.139405
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.139203
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.137339
ASPH aspartate beta-hydroxylase 0.133347
UBC ubiquitin C 0.123971
POTEF POTE ankyrin domain family, member F 0.123
APLP2 amyloid beta (A4) precursor-like protein 2 0.103868
ELL2 elongation factor, RNA polymerase II, 2 0.101447
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0963895
MYO6 myosin VI 0.095737
VEGFA vascular endothelial growth factor A 0.0857189
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0822569
AKAP13 A kinase (PRKA) anchor protein 13 0.0802495
TRIO trio Rho guanine nucleotide exchange factor 0.075959
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0742178
GRB10 growth factor receptor-bound protein 10 0.0670544
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0666124
ADAM9 ADAM metallopeptidase domain 9 0.0656423
CCNL1 cyclin L1 0.0611794
KMT2E lysine (K)-specific methyltransferase 2E 0.0610928
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0610791
MSN moesin 0.0600993
SDC4 syndecan 4 0.0582583
TSC22D2 TSC22 domain family, member 2 0.0561089
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0553375
COPA coatomer protein complex, subunit alpha 0.0552271
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0542222
SPAG9 sperm associated antigen 9 0.053563
GOLGA4 golgin A4 0.0534603
UBA6 ubiquitin-like modifier activating enzyme 6 0.0531621
ITCH itchy E3 ubiquitin protein ligase 0.0526564
KDM6A lysine (K)-specific demethylase 6A 0.0520785
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0517906
NRIP1 nuclear receptor interacting protein 1 0.0512635
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.051064
DTNA dystrobrevin, alpha 0.0499663
ERBIN erbb2 interacting protein 0.0498493
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0496239
RCOR1 REST corepressor 1 0.0495994
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0494692
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0490282
CD109 CD109 molecule 0.0487181
FAM3C family with sequence similarity 3, member C 0.0482732
FLNB filamin B, beta 0.0478672
RNF145 ring finger protein 145 0.0471317
MYO5B myosin VB 0.047025
MARCHF6 membrane associated ring-CH-type finger 6 0.0467811
CDCP1 CUB domain containing protein 1 0.0466054
PPARD peroxisome proliferator-activated receptor delta 0.0462187
CALR calreticulin 0.0447152
SETD5 SET domain containing 5 0.0446536
LDHA lactate dehydrogenase A 0.0441597
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0436156
PARD3 par-3 family cell polarity regulator 0.0432922
TMF1 TATA element modulatory factor 1 0.0432611
SEC23A Sec23 homolog A (S. cerevisiae) 0.0429882
YTHDC1 YTH domain containing 1 0.0426785
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0424376
ANXA1 annexin A1 0.042269
NPEPPS aminopeptidase puromycin sensitive 0.0421986
RBM39 RNA binding motif protein 39 0.0421705
MYH9 myosin, heavy chain 9, non-muscle 0.0414781
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0414161
RASA2 RAS p21 protein activator 2 0.0412328
PTK2 protein tyrosine kinase 2 0.0411933
GPBP1 GC-rich promoter binding protein 1 0.0410527
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0410309
FAM13A family with sequence similarity 13, member A 0.040949
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0408184
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0407848
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0402504
ARRDC3 arrestin domain containing 3 0.0399527
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0391065
NAMPT nicotinamide phosphoribosyltransferase 0.0386665
RTN4 reticulon 4 0.0385034
STRN3 striatin, calmodulin binding protein 3 0.0384215
DUSP10 dual specificity phosphatase 10 0.0379066
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0377956
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0377918
TENT2 terminal nucleotidyltransferase 2 0.0374016
RAB1A RAB1A, member RAS oncogene family 0.0372122
ZNF148 zinc finger protein 148 0.0369338
TFG TRK-fused gene 0.0367977
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.03642
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0356075
CDC73 cell division cycle 73 0.0354797
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0349654
PRRC2C proline-rich coiled-coil 2C 0.0348445
SLMAP sarcolemma associated protein 0.0348128
VMP1 vacuole membrane protein 1 0.0346618
RBM25 RNA binding motif protein 25 0.0341484
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0341414
ZNF654 zinc finger protein 654 0.0337761
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0335251
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0335176
AREG amphiregulin 0.0332225
EEF2 eukaryotic translation elongation factor 2 0.0331022
MAP2K1 mitogen-activated protein kinase kinase 1 0.0330773

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0996827
LPP LIM domain containing preferred translocation partner in lipoma -0.0977324
TMSB10 thymosin beta 10 -0.0948453
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0770154
TPT1 tumor protein, translationally-controlled 1 -0.0749891
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0679317
RPL35A ribosomal protein L35a -0.0655848
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0628188
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0605457
IFI16 interferon, gamma-inducible protein 16 -0.0591513
CCND1 cyclin D1 -0.0589965
RPLP1 ribosomal protein, large, P1 -0.057423
FBXO32 F-box protein 32 -0.0557478
AHNAK AHNAK nucleoprotein -0.0543474
SQSTM1 sequestosome 1 -0.0463135
ISG15 ISG15 ubiquitin-like modifier -0.046177
RNF213 ring finger protein 213 -0.0449747
RPL19 ribosomal protein L19 -0.0439784
SOX4 SRY (sex determining region Y)-box 4 -0.0439772
RPLP2 ribosomal protein, large, P2 -0.0433632
IFI27 interferon, alpha-inducible protein 27 -0.0425517
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0413945
RPS8 ribosomal protein S8 -0.0409501
RPL34 ribosomal protein L34 -0.0408155
MX2 MX dynamin-like GTPase 2 -0.0402951
LMNA lamin A/C -0.0390823
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0387471
H1-0 H1.0 linker histone -0.0384815
ZBTB20 zinc finger and BTB domain containing 20 -0.0382099
FTL ferritin, light polypeptide -0.0378872
RPS29 ribosomal protein S29 -0.0367093
RPS19 ribosomal protein S19 -0.0359799
RIGI RNA sensor RIG-I -0.0350644
RPS6 ribosomal protein S6 -0.0333134
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0320666
ETV6 ets variant 6 -0.0314589
AHNAK2 AHNAK nucleoprotein 2 -0.0302881
RPLP0 ribosomal protein, large, P0 -0.0299076
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0294412
RPL12 ribosomal protein L12 -0.0294368
RPS21 ribosomal protein S21 -0.029257
KRT7 keratin 7, type II -0.0291904
RPL23 ribosomal protein L23 -0.0288811
RPS27A ribosomal protein S27a -0.0287907
EXT1 exostosin glycosyltransferase 1 -0.0287842
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0286941
IFI6 interferon, alpha-inducible protein 6 -0.028557
CAVIN1 caveolae associated protein 1 -0.0285202
MDK midkine (neurite growth-promoting factor 2) -0.0282799
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0276115
CSTB cystatin B (stefin B) -0.0274033
SP100 SP100 nuclear antigen -0.0271939
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0267245
RRBP1 ribosome binding protein 1 -0.0260329
LIMCH1 LIM and calponin homology domains 1 -0.0259772
RPL30 ribosomal protein L30 -0.0253806
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0252782
RAI14 retinoic acid induced 14 -0.0247724
RPL8 ribosomal protein L8 -0.024754
RPS23 ribosomal protein S23 -0.0246038
LY6E lymphocyte antigen 6 complex, locus E -0.0245937
RPS10 ribosomal protein S10 -0.0245896
RPS25 ribosomal protein S25 -0.0245836
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0245278
RPL32 ribosomal protein L32 -0.0243523
WARS1 tryptophanyl-tRNA synthetase 1 -0.0239592
RPS24 ribosomal protein S24 -0.0239328
ZNF217 zinc finger protein 217 -0.023645
RAD51B RAD51 paralog B -0.0235825
RPL11 ribosomal protein L11 -0.023564
IFIH1 interferon induced with helicase C domain 1 -0.0233557
RPS16 ribosomal protein S16 -0.023208
TBCA tubulin folding cofactor A -0.0230612
MX1 MX dynamin-like GTPase 1 -0.0229152
RBM47 RNA binding motif protein 47 -0.0228554
HLA-B major histocompatibility complex, class I, B -0.0226372
DSG2 desmoglein 2 -0.0224886
S100A9 S100 calcium binding protein A9 -0.0220698
HMGB1 high mobility group box 1 -0.0219468
GNAS GNAS complex locus -0.0214605
RPS13 ribosomal protein S13 -0.0214335
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0214071
CUX1 cut-like homeobox 1 -0.0211895
ARF1 ADP-ribosylation factor 1 -0.0209977
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0209837
VIM vimentin -0.0206437
RPL28 ribosomal protein L28 -0.0205232
RPL38 ribosomal protein L38 -0.0204095
KRT18 keratin 18, type I -0.020046
ARHGAP20 Rho GTPase activating protein 20 -0.0200422
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0199659
RPS14 ribosomal protein S14 -0.0199314
TPM4 tropomyosin 4 -0.0198318
RPL36 ribosomal protein L36 -0.0198106
LAP3 leucine aminopeptidase 3 -0.0196729
TMEM123 transmembrane protein 123 -0.0196701
RPL27 ribosomal protein L27 -0.0194225
HSPB1 heat shock 27kDa protein 1 -0.019311
PMP22 peripheral myelin protein 22 -0.0192054
F3 coagulation factor III (thromboplastin, tissue factor) -0.0190541