L-Eflornithine (monohydrochloride)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Eflornithine (monohydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.141441
CDH10 cadherin 10, type 2 (T2-cadherin) 0.135128
CENPF centromere protein F, 350/400kDa 0.104079
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0845642
COL5A2 collagen, type V, alpha 2 0.08084
ZEB2 zinc finger E-box binding homeobox 2 0.0766114
CSDE1 cold shock domain containing E1, RNA-binding 0.070839
PEG10 paternally expressed 10 0.0691975
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0647815
ZNF292 zinc finger protein 292 0.0627422
PGAP1 post-GPI attachment to proteins 1 0.0621137
MRPS30 mitochondrial ribosomal protein S30 0.0596681
TSC22D2 TSC22 domain family, member 2 0.0580689
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0564506
NIPBL Nipped-B homolog (Drosophila) 0.0562063
MKI67 marker of proliferation Ki-67 0.055264
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0550491
TRPS1 trichorhinophalangeal syndrome I 0.054245
H1-0 H1.0 linker histone 0.0504946
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0501925
RAB1A RAB1A, member RAS oncogene family 0.0493375
GPC3 glypican 3 0.0481861
UBC ubiquitin C 0.0463224
NUSAP1 nucleolar and spindle associated protein 1 0.0445276
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.044401
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0434495
XPO1 exportin 1 0.0433632
DSCAM Down syndrome cell adhesion molecule 0.0433251
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0425401
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.041894
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0414431
RASAL2 RAS protein activator like 2 0.0411435
SMC4 structural maintenance of chromosomes 4 0.0407546
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.0401041
STAG2 stromal antigen 2 0.0399251
PDGFC platelet derived growth factor C 0.0394431
NOP58 NOP58 ribonucleoprotein 0.0393911
ZNF608 zinc finger protein 608 0.039241
RAD21 RAD21 homolog (S. pombe) 0.0385444
TPX2 TPX2, microtubule-associated 0.03814
APLP2 amyloid beta (A4) precursor-like protein 2 0.0379348
TMSB4X thymosin beta 4, X-linked 0.0377666
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0376715
ANXA1 annexin A1 0.0355125
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.035413
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0353895
CKAP5 cytoskeleton associated protein 5 0.0353086
TEX11 testis expressed 11 0.0350528
RBM39 RNA binding motif protein 39 0.0347827
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0346431
NPR2 natriuretic peptide receptor 2 0.0346386
USP9X ubiquitin specific peptidase 9, X-linked 0.0345337
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.033753
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0335521
STMN1 stathmin 1 0.0333837
BRMS1L breast cancer metastasis-suppressor 1-like 0.0332681
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0331634
MED13L mediator complex subunit 13-like 0.0331513
HP1BP3 heterochromatin protein 1, binding protein 3 0.0330268
RSRC2 arginine/serine-rich coiled-coil 2 0.0329985
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0329298
HDAC9 histone deacetylase 9 0.0328706
SET SET nuclear proto-oncogene 0.0327446
PHIP pleckstrin homology domain interacting protein 0.0327031
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0326523
CENPE centromere protein E, 312kDa 0.0325233
TLK1 tousled-like kinase 1 0.0321085
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0319789
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0319599
KAT6A K(lysine) acetyltransferase 6A 0.031882
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0316382
CEP350 centrosomal protein 350kDa 0.0312197
ECT2 epithelial cell transforming 2 0.031092
CKAP2 cytoskeleton associated protein 2 0.031066
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0309529
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0305679
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0302778
HMGB2 high mobility group box 2 0.030097
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0300533
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.029891
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0297169
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0295689
LIN28B lin-28 homolog B (C. elegans) 0.029517
CALU calumenin 0.0294398
SLC38A2 solute carrier family 38, member 2 0.0289329
FBXO11 F-box protein 11 0.0286917
MATR3 matrin 3 0.0285068
RBM27 RNA binding motif protein 27 0.0283492
ZDHHC20 zinc finger, DHHC-type containing 20 0.0282867
EMP1 epithelial membrane protein 1 0.0281895
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0279531
MEF2C myocyte enhancer factor 2C 0.0278668
CLSPN claspin 0.0278239
RTN4 reticulon 4 0.0274691
DENND4A DENN/MADD domain containing 4A 0.0273541
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0271784
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0271139
TMEM39A transmembrane protein 39A 0.0270706
TPM3 tropomyosin 3 0.0270377
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0270223

decreased expression

Symbol Name Standardized Value
CADM2 cell adhesion molecule 2 -0.194948
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.152079
COL11A1 collagen, type XI, alpha 1 -0.123724
VIM vimentin -0.115514
TMSB10 thymosin beta 10 -0.106526
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.101817
RPS6 ribosomal protein S6 -0.0973603
RPL35A ribosomal protein L35a -0.0822403
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0804617
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0740066
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0730499
RPS16 ribosomal protein S16 -0.0715001
RPS8 ribosomal protein S8 -0.0705286
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0682556
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0635819
PARD3B par-3 family cell polarity regulator beta -0.0616776
COL1A2 collagen, type I, alpha 2 -0.0552766
SLIT2 slit homolog 2 (Drosophila) -0.0546726
RPS12 ribosomal protein S12 -0.0532793
ISG15 ISG15 ubiquitin-like modifier -0.0529681
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0515245
SNX6 sorting nexin 6 -0.0493229
HMCN1 hemicentin 1 -0.0483037
MDK midkine (neurite growth-promoting factor 2) -0.0478735
HSPB1 heat shock 27kDa protein 1 -0.047813
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0474995
ADGRL3 adhesion G protein-coupled receptor L3 -0.0467342
RPL11 ribosomal protein L11 -0.0460299
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0448841
NPAS3 neuronal PAS domain protein 3 -0.0430654
FTL ferritin, light polypeptide -0.0407113
ANKRD33B ankyrin repeat domain 33B -0.0395147
RPL37A ribosomal protein L37a -0.0390825
ZFPM2 zinc finger protein, FOG family member 2 -0.0367751
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.036293
DST dystonin -0.0354369
CSMD3 CUB and Sushi multiple domains 3 -0.0342435
EEF2 eukaryotic translation elongation factor 2 -0.0340514
MAP4 microtubule-associated protein 4 -0.0338055
RPLP1 ribosomal protein, large, P1 -0.0337751
NRG1 neuregulin 1 -0.03302
CABLES1 Cdk5 and Abl enzyme substrate 1 -0.0324221
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0322368
PCDH7 protocadherin 7 -0.0321636
RPL5 ribosomal protein L5 -0.0320418
BPTF bromodomain PHD finger transcription factor -0.0310885
MRPS6 mitochondrial ribosomal protein S6 -0.0310561
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0310199
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0309165
ACTG1 actin gamma 1 -0.0305371
RPS27A ribosomal protein S27a -0.0303045
B2M beta-2-microglobulin -0.0302974
FAM177A1 family with sequence similarity 177, member A1 -0.0300253
GNAS GNAS complex locus -0.0294305
FGF13 fibroblast growth factor 13 -0.0293215
KPNB1 karyopherin (importin) beta 1 -0.0292488
RPL31 ribosomal protein L31 -0.0291801
DLG1 discs, large homolog 1 (Drosophila) -0.0290826
TPT1 tumor protein, translationally-controlled 1 -0.0290547
CTBP2 C-terminal binding protein 2 -0.0290192
CUX1 cut-like homeobox 1 -0.0286677
RPL36A ribosomal protein L36a -0.028635
ZBTB20 zinc finger and BTB domain containing 20 -0.0283472
NAP1L1 nucleosome assembly protein 1-like 1 -0.0283085
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0283074
RIMS2 regulating synaptic membrane exocytosis 2 -0.0281911
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0280614
S100A10 S100 calcium binding protein A10 -0.0279773
FBXO17 F-box protein 17 -0.0278765
SAMD4A sterile alpha motif domain containing 4A -0.0277501
RPS10 ribosomal protein S10 -0.0276078
HSPE1 heat shock 10kDa protein 1 -0.0271631
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0271281
LYST lysosomal trafficking regulator -0.02712
EXOC4 exocyst complex component 4 -0.0270983
RPL23 ribosomal protein L23 -0.0269019
RPS17 ribosomal protein S17 -0.0267856
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0267655
RPL32 ribosomal protein L32 -0.0267279
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0265311
RIGI RNA sensor RIG-I -0.026495
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0263473
GAB2 GRB2-associated binding protein 2 -0.0262781
UBE2K ubiquitin-conjugating enzyme E2K -0.0262444
RPS29 ribosomal protein S29 -0.0262209
RAD51B RAD51 paralog B -0.0261181
RPS19 ribosomal protein S19 -0.0259844
PRTG protogenin -0.0259602
NCAM2 neural cell adhesion molecule 2 -0.0258776
RPL34 ribosomal protein L34 -0.0258461
SYT1 synaptotagmin I -0.0255686
ESYT2 extended synaptotagmin-like protein 2 -0.0254641
RPS13 ribosomal protein S13 -0.0253778
TPM4 tropomyosin 4 -0.0253665
SLC38A9 solute carrier family 38, member 9 -0.0251784
PCDH9 protocadherin 9 -0.0250039
GSE1 Gse1 coiled-coil protein -0.0247539
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0246407
FOXG1 forkhead box G1 -0.0245572
TBL1X transducin (beta)-like 1X-linked -0.0242596