L-Eflornithine (monohydrochloride)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Eflornithine (monohydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
STC1 stanniocalcin 1 0.254046
FN1 fibronectin 1 0.181131
VIM vimentin 0.141761
PGK1 phosphoglycerate kinase 1 0.10967
MT2A metallothionein 2A 0.106075
CD44 CD44 molecule (Indian blood group) 0.104917
ENO1 enolase 1, (alpha) 0.0971104
GOLGA4 golgin A4 0.090486
VEGFA vascular endothelial growth factor A 0.0858385
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0831267
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0817709
DSCAM Down syndrome cell adhesion molecule 0.0706801
FAM20C family with sequence similarity 20, member C 0.06963
CALR calreticulin 0.0690636
LDHA lactate dehydrogenase A 0.0656343
B2M beta-2-microglobulin 0.0645786
MYH9 myosin, heavy chain 9, non-muscle 0.0628665
ASPH aspartate beta-hydroxylase 0.0599242
TFPI2 tissue factor pathway inhibitor 2 0.0595948
COL1A2 collagen, type I, alpha 2 0.0569527
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0568311
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0552211
CANX calnexin 0.0551198
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0546815
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0535255
CEMIP cell migration inducing protein, hyaluronan binding 0.0530825
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0512934
DOCK5 dedicator of cytokinesis 5 0.0504972
CENPF centromere protein F, 350/400kDa 0.0495376
NAV2 neuron navigator 2 0.0473194
IQGAP1 IQ motif containing GTPase activating protein 1 0.0470686
HMGB2 high mobility group box 2 0.0463499
SDC4 syndecan 4 0.0457837
ICAM1 intercellular adhesion molecule 1 0.0449778
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0447706
H1-0 H1.0 linker histone 0.0441847
CALU calumenin 0.0440349
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0435562
SEPTIN7 septin 7 0.0429081
INHBA inhibin, beta A 0.042831
WWTR1 WW domain containing transcription regulator 1 0.0427532
MCTP2 multiple C2 domains, transmembrane 2 0.0427197
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.041105
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0403675
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0402416
JARID2 jumonji, AT rich interactive domain 2 0.0395149
YEATS2 YEATS domain containing 2 0.0393713
PRRC2C proline-rich coiled-coil 2C 0.0392103
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0391994
FLNB filamin B, beta 0.0388402
PSD3 pleckstrin and Sec7 domain containing 3 0.0387318
SMC4 structural maintenance of chromosomes 4 0.0386486
MKI67 marker of proliferation Ki-67 0.038595
NRIP1 nuclear receptor interacting protein 1 0.0382395
TPM4 tropomyosin 4 0.0376964
KMT2E lysine (K)-specific methyltransferase 2E 0.0375171
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0357057
MMP12 matrix metallopeptidase 12 0.0353181
ESYT2 extended synaptotagmin-like protein 2 0.0351546
ANKRD28 ankyrin repeat domain 28 0.0344624
UBC ubiquitin C 0.0343256
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0335728
DNAAF9 dynein axonemal assembly factor 9 0.0333677
OGA O-GlcNAcase 0.033221
PTMA prothymosin, alpha 0.0328889
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0325636
TPX2 TPX2, microtubule-associated 0.0324222
FMNL2 formin-like 2 0.0323146
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0319683
BIRC6 baculoviral IAP repeat containing 6 0.0316699
AKAP13 A kinase (PRKA) anchor protein 13 0.031501
NAMPT nicotinamide phosphoribosyltransferase 0.0314916
PCBP3 poly(rC) binding protein 3 0.0309284
ANGPTL4 angiopoietin-like 4 0.0308552
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0307038
AFAP1 actin filament associated protein 1 0.0306002
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0305595
DLG1 discs, large homolog 1 (Drosophila) 0.0303946
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.030203
RAD21 RAD21 homolog (S. pombe) 0.0301458
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0300974
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0299877
NPAS2 neuronal PAS domain protein 2 0.0299866
SEC31A SEC31 homolog A (S. cerevisiae) 0.0298776
MSN moesin 0.0295054
COL7A1 collagen, type VII, alpha 1 0.0292322
FNDC3B fibronectin type III domain containing 3B 0.0291991
APP amyloid beta (A4) precursor protein 0.0291019
FNIP1 folliculin interacting protein 1 0.0288913
ANLN anillin, actin binding protein 0.0288473
MACF1 microtubule-actin crosslinking factor 1 0.0286814
CSDE1 cold shock domain containing E1, RNA-binding 0.0285212
CENPE centromere protein E, 312kDa 0.0285061
CTSB cathepsin B 0.0282559
RB1CC1 RB1-inducible coiled-coil 1 0.0280244
TMF1 TATA element modulatory factor 1 0.0278423
SPTBN1 spectrin, beta, non-erythrocytic 1 0.027764
AKAP9 A kinase (PRKA) anchor protein 9 0.0276543
CORO1C coronin, actin binding protein, 1C 0.0274719
GSK3B glycogen synthase kinase 3 beta 0.0272516

decreased expression

Symbol Name Standardized Value
EGR1 early growth response 1 -0.0452652
FBXO32 F-box protein 32 -0.0399848
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0390708
CDH13 cadherin 13 -0.0351113
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.033854
SLIT2 slit homolog 2 (Drosophila) -0.0318777
RAB7A RAB7A, member RAS oncogene family -0.0302862
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0300751
PTPRG protein tyrosine phosphatase, receptor type, G -0.0285511
COL1A1 collagen, type I, alpha 1 -0.0273044
TGFBI transforming growth factor, beta-induced, 68kDa -0.0260504
GLIS3 GLIS family zinc finger 3 -0.024952
BZW2 basic leucine zipper and W2 domains 2 -0.024685
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0240324
LOC102724023 ES1 protein homolog, mitochondrial -0.0237487
NABP1 nucleic acid binding protein 1 -0.0208824
TENT5A terminal nucleotidyltransferase 5A -0.0205324
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0202123
LRRC23 leucine rich repeat containing 23 -0.0195563
LPCAT2 lysophosphatidylcholine acyltransferase 2 -0.0191531
NDRG1 N-myc downstream regulated 1 -0.0190939
CAV1 caveolin 1, caveolae protein, 22kDa -0.0189621
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0177455
TEX14 testis expressed 14 -0.0172986
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0169518
FHIT fragile histidine triad -0.0169085
IER2 immediate early response 2 -0.0166354
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0164849
PARD3 par-3 family cell polarity regulator -0.0163737
TNNC1 troponin C type 1 (slow) -0.0161674
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0161121
FAM53C family with sequence similarity 53, member C -0.0153989
NCOA7 nuclear receptor coactivator 7 -0.0153237
EPAS1 endothelial PAS domain protein 1 -0.0152672
WDFY2 WD repeat and FYVE domain containing 2 -0.0151542
FRMD4A FERM domain containing 4A -0.0150767
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0150363
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0149322
ADM adrenomedullin -0.0147969
EPSTI1 epithelial stromal interaction 1 (breast) -0.0146588
ATP5F1E ATP synthase F1 subunit epsilon -0.0145317
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.014453
USP3 ubiquitin specific peptidase 3 -0.0144303
JUN jun proto-oncogene -0.014365
TMSB10 thymosin beta 10 -0.0142735
CCBE1 collagen and calcium binding EGF domains 1 -0.0142729
TLE4 transducin-like enhancer of split 4 -0.0142605
PMP22 peripheral myelin protein 22 -0.0142527
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0142297
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0142063
MAP4 microtubule-associated protein 4 -0.0141255
SOX5 SRY (sex determining region Y)-box 5 -0.0139337
RYBP RING1 and YY1 binding protein -0.0137874
DIAPH2 diaphanous-related formin 2 -0.0137001
AFF3 AF4/FMR2 family, member 3 -0.0135571
FGFR1 fibroblast growth factor receptor 1 -0.0135436
SYNE1 spectrin repeat containing, nuclear envelope 1 -0.0132756
RNASEH2A ribonuclease H2, subunit A -0.0132585
PFN1 profilin 1 -0.012874
PRKCE protein kinase C, epsilon -0.01287
IFITM3 interferon induced transmembrane protein 3 -0.0128498
RPS20 ribosomal protein S20 -0.0128215
TWIST2 twist family bHLH transcription factor 2 -0.0127368
TRA2A transformer 2 alpha homolog (Drosophila) -0.0126365
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.012627
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0126251
LAP3 leucine aminopeptidase 3 -0.0126177
PDE8A phosphodiesterase 8A -0.0125488
RPS6 ribosomal protein S6 -0.0124994
SSBP2 single-stranded DNA binding protein 2 -0.0124181
EHD2 EH-domain containing 2 -0.0123412
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -0.0121977
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0121137
PCDHGA2 protocadherin gamma subfamily A, 2 -0.0119513
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0118863
DENND1A DENN/MADD domain containing 1A -0.0118617
UGCG UDP-glucose ceramide glucosyltransferase -0.0118318
RND3 Rho family GTPase 3 -0.0116395
NAV1 neuron navigator 1 -0.011634
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0114652
KLHL15 kelch-like family member 15 -0.0114554
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.011395
CADM1 cell adhesion molecule 1 -0.0113648
EGFR epidermal growth factor receptor -0.0113264
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0113222
IRF1 interferon regulatory factor 1 -0.011313
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0111595
BICC1 BicC family RNA binding protein 1 -0.0110681
RPS12 ribosomal protein S12 -0.011012
RIGI RNA sensor RIG-I -0.0109781
TTYH3 tweety family member 3 -0.0109116
BRD4 bromodomain containing 4 -0.0108326
CKS2 CDC28 protein kinase regulatory subunit 2 -0.0108034
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0107974
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0107614
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) -0.0107455
CEMIP2 cell migration inducing hyaluronidase 2 -0.0107334
NOCT nocturnin -0.010733
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0107195
CNTNAP2 contactin associated protein-like 2 -0.0107175