| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | L-Eflornithine (monohydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.431486 |
| PEG10 | paternally expressed 10 | 0.141693 |
| CENPF | centromere protein F, 350/400kDa | 0.124609 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0997672 |
| TENM1 | teneurin transmembrane protein 1 | 0.0943437 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0803028 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.078904 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0739152 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0732974 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0718805 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0706197 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0646794 |
| PCM1 | pericentriolar material 1 | 0.0633982 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0631996 |
| ZNF292 | zinc finger protein 292 | 0.0610966 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0592111 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0587254 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0560461 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0559888 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0555546 |
| MT2A | metallothionein 2A | 0.054298 |
| IRS2 | insulin receptor substrate 2 | 0.0530089 |
| MKI67 | marker of proliferation Ki-67 | 0.0520937 |
| HMGB3 | high mobility group box 3 | 0.0520257 |
| CADM1 | cell adhesion molecule 1 | 0.0508516 |
| RAD51B | RAD51 paralog B | 0.0499215 |
| NIPSNAP2 | nipsnap homolog 2 | 0.0489271 |
| FAT1 | FAT atypical cadherin 1 | 0.0478729 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0469804 |
| SMAD9 | SMAD family member 9 | 0.0457948 |
| SET | SET nuclear proto-oncogene | 0.0456445 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0453912 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0447696 |
| AOPEP | aminopeptidase O (putative) | 0.0443915 |
| INHBA | inhibin, beta A | 0.0434136 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0423255 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0422553 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0421223 |
| SIK2 | salt-inducible kinase 2 | 0.0411525 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0408874 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.040659 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0402399 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0400878 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0394357 |
| TOX | thymocyte selection-associated high mobility group box | 0.0387998 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0386021 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0375777 |
| MTMR7 | myotubularin related protein 7 | 0.0374308 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0372278 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0366702 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0366069 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.0362398 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0354437 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.0351276 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0350773 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0350139 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0349217 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0348143 |
| NLGN1 | neuroligin 1 | 0.034774 |
| XPO1 | exportin 1 | 0.0347468 |
| SYT4 | synaptotagmin IV | 0.033371 |
| ENO1 | enolase 1, (alpha) | 0.0331564 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0330802 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0325103 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0323361 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0320123 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0319408 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0316455 |
| VEGFA | vascular endothelial growth factor A | 0.0312586 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0311604 |
| UBE2QL1 | ubiquitin-conjugating enzyme E2Q family-like 1 | 0.0310547 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | 0.0310463 |
| RIT2 | Ras-like without CAAX 2 | 0.0309621 |
| TPX2 | TPX2, microtubule-associated | 0.0308818 |
| PRKD1 | protein kinase D1 | 0.0308396 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0307142 |
| H1-0 | H1.0 linker histone | 0.0302902 |
| GRAMD4 | GRAM domain containing 4 | 0.0301632 |
| UBAC2 | UBA domain containing 2 | 0.0301353 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0299775 |
| DST | dystonin | 0.0298816 |
| ECT2 | epithelial cell transforming 2 | 0.0298386 |
| CCDC88A | coiled-coil domain containing 88A | 0.0296564 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0295941 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0295757 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0290437 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0286411 |
| HMGB2 | high mobility group box 2 | 0.0284458 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0282213 |
| CA8 | carbonic anhydrase VIII | 0.0282183 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0281162 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0277426 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0275946 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0275768 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0274829 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.0271681 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0267513 |
| NUF2 | NUF2, NDC80 kinetochore complex component | 0.0267449 |
| RTN4 | reticulon 4 | 0.026706 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0266874 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | -0.0968897 |
| NDRG1 | N-myc downstream regulated 1 | -0.09438 |
| NRG1 | neuregulin 1 | -0.0893802 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0642057 |
| SNTG1 | syntrophin, gamma 1 | -0.0626671 |
| RORA | RAR-related orphan receptor A | -0.061928 |
| MCL1 | myeloid cell leukemia 1 | -0.060674 |
| GPC5 | glypican 5 | -0.0601391 |
| KIF26B | kinesin family member 26B | -0.0594216 |
| ACTG1 | actin gamma 1 | -0.0592788 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0529085 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0508436 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0500931 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0473628 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0466721 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0438535 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.043609 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0433269 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0424131 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0420076 |
| MAP1B | microtubule-associated protein 1B | -0.0414687 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0406935 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0382002 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0373368 |
| RPL37A | ribosomal protein L37a | -0.0368133 |
| HOMER1 | homer scaffolding protein 1 | -0.0351343 |
| PAEP | progestagen-associated endometrial protein | -0.0339679 |
| RPS25 | ribosomal protein S25 | -0.033595 |
| CDK13 | cyclin-dependent kinase 13 | -0.0330633 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0330021 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.03295 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0327791 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0324151 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.030904 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.030653 |
| JUN | jun proto-oncogene | -0.0294985 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0294527 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0294482 |
| GDAP1 | ganglioside induced differentiation associated protein 1 | -0.0285908 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | -0.0281942 |
| RPL38 | ribosomal protein L38 | -0.0281727 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.02817 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.0276665 |
| GNAS | GNAS complex locus | -0.0276148 |
| EGR1 | early growth response 1 | -0.027403 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0273698 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.0268019 |
| CHGA | chromogranin A | -0.0263302 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0256558 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0255587 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0252023 |
| NBEA | neurobeachin | -0.0251638 |
| KLHL29 | kelch-like family member 29 | -0.024734 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0244515 |
| RPL11 | ribosomal protein L11 | -0.0236217 |
| RPS21 | ribosomal protein S21 | -0.0236194 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0234362 |
| CNTNAP2 | contactin associated protein-like 2 | -0.0232911 |
| MYT1L | myelin transcription factor 1-like | -0.0231562 |
| STC1 | stanniocalcin 1 | -0.0231558 |
| GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like | -0.0230775 |
| RPS6 | ribosomal protein S6 | -0.0229755 |
| RPL31 | ribosomal protein L31 | -0.0229566 |
| RPLP1 | ribosomal protein, large, P1 | -0.0227336 |
| RPS8 | ribosomal protein S8 | -0.0226711 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0226114 |
| UBB | ubiquitin B | -0.0222286 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 | -0.0221961 |
| SCG2 | secretogranin II | -0.0221886 |
| HM13 | histocompatibility (minor) 13 | -0.0221118 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0218573 |
| RPL30 | ribosomal protein L30 | -0.0218151 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0215859 |
| TMSB10 | thymosin beta 10 | -0.0214339 |
| LSAMP | limbic system-associated membrane protein | -0.0212368 |
| NANOS1 | nanos homolog 1 (Drosophila) | -0.0210164 |
| RPS15 | ribosomal protein S15 | -0.0208982 |
| SEC11C | SEC11 homolog C (S. cerevisiae) | -0.0206507 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0205477 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0205065 |
| PTCHD4 | patched domain containing 4 | -0.0202815 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | -0.0202721 |
| APP | amyloid beta (A4) precursor protein | -0.0201641 |
| RPS24 | ribosomal protein S24 | -0.0199558 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0199106 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.019799 |
| RPL35A | ribosomal protein L35a | -0.0197715 |
| SLC35F4 | solute carrier family 35, member F4 | -0.019758 |
| SQSTM1 | sequestosome 1 | -0.0195151 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0188631 |
| LRFN2 | leucine rich repeat and fibronectin type III domain containing 2 | -0.0186997 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0183648 |
| RPL7A | ribosomal protein L7a | -0.0182893 |
| ARFGEF3 | ARFGEF family member 3 | -0.0181325 |
| SVIL | supervillin | -0.0181137 |
| VIM | vimentin | -0.0180216 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0179237 |
| ABR | active BCR-related | -0.017483 |
| IER3 | immediate early response 3 | -0.0173793 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0172324 |
