| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | L-Eflornithine (monohydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.17455 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.156974 |
| EGFR | epidermal growth factor receptor | 0.144716 |
| LMO7 | LIM domain 7 | 0.131074 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.124676 |
| ANXA1 | annexin A1 | 0.114144 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.110905 |
| EZR | ezrin | 0.0868146 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0832845 |
| PTMA | prothymosin, alpha | 0.0810244 |
| OXR1 | oxidation resistance 1 | 0.080489 |
| FAT1 | FAT atypical cadherin 1 | 0.0797768 |
| DSPP | dentin sialophosphoprotein | 0.0783756 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0776364 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.075774 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0729378 |
| ATXN1 | ataxin 1 | 0.0700523 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0681577 |
| LDHA | lactate dehydrogenase A | 0.0624012 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0619735 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0603308 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0584737 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0578988 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0575144 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0552695 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0542679 |
| KITLG | KIT ligand | 0.0538924 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0538808 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0537622 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0523745 |
| LAMC2 | laminin, gamma 2 | 0.0521704 |
| TOP1 | topoisomerase (DNA) I | 0.0501123 |
| GOLGA4 | golgin A4 | 0.0485211 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0477676 |
| RNF43 | ring finger protein 43 | 0.0472175 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0471998 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0446324 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0444896 |
| RPL3 | ribosomal protein L3 | 0.0436792 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0431942 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0428447 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0424117 |
| EREG | epiregulin | 0.0417835 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0417079 |
| AXIN2 | axin 2 | 0.0412688 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0408931 |
| RPS3 | ribosomal protein S3 | 0.0406649 |
| ENO1 | enolase 1, (alpha) | 0.0398239 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0395434 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0393661 |
| SERINC5 | serine incorporator 5 | 0.0392264 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0392186 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0390531 |
| YAP1 | Yes-associated protein 1 | 0.03898 |
| LAMB3 | laminin, beta 3 | 0.0389159 |
| RUNX2 | runt-related transcription factor 2 | 0.0387525 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0386967 |
| PRRC2C | proline-rich coiled-coil 2C | 0.038283 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.038 |
| ACTN4 | actinin, alpha 4 | 0.0379876 |
| RAD51B | RAD51 paralog B | 0.0377964 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0375829 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0375802 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0370876 |
| RBM25 | RNA binding motif protein 25 | 0.0369224 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0367129 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0366257 |
| TXNRD1 | thioredoxin reductase 1 | 0.0359759 |
| VMP1 | vacuole membrane protein 1 | 0.0357228 |
| IER3 | immediate early response 3 | 0.0357173 |
| CPOX | coproporphyrinogen oxidase | 0.0352666 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0347412 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0347257 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0345362 |
| USP6NL | USP6 N-terminal like | 0.0341001 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0340164 |
| UBC | ubiquitin C | 0.0339513 |
| BBX | bobby sox homolog (Drosophila) | 0.0338336 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0334779 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0334778 |
| ITGA6 | integrin, alpha 6 | 0.0333782 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0332807 |
| ATL2 | atlastin GTPase 2 | 0.0332351 |
| RPS4X | ribosomal protein S4, X-linked | 0.0332045 |
| MT2A | metallothionein 2A | 0.0328344 |
| DUSP4 | dual specificity phosphatase 4 | 0.0325583 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0323277 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.032286 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0321235 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.031851 |
| EVA1C | eva-1 homolog C (C. elegans) | 0.0316738 |
| TJP1 | tight junction protein 1 | 0.0315485 |
| TMSB10 | thymosin beta 10 | 0.0314623 |
| ZNRF3 | zinc and ring finger 3 | 0.031207 |
| PKM | pyruvate kinase, muscle | 0.0309036 |
| COG5 | component of oligomeric golgi complex 5 | 0.0307896 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0307122 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0301882 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0299651 |
| OGA | O-GlcNAcase | 0.029776 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.048552 |
| GPC5 | glypican 5 | -0.026293 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0260499 |
| ACTG1 | actin gamma 1 | -0.02465 |
| ITGB4 | integrin, beta 4 | -0.0236653 |
| RPL35A | ribosomal protein L35a | -0.0187496 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0174019 |
| HMGA2 | high mobility group AT-hook 2 | -0.0171503 |
| FHIT | fragile histidine triad | -0.0163473 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.0149076 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.0148513 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0144643 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.013267 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0129515 |
| RASAL2 | RAS protein activator like 2 | -0.0121535 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0118598 |
| KLK6 | kallikrein-related peptidase 6 | -0.0105981 |
| CDHR3 | cadherin-related family member 3 | -0.0103696 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0102091 |
| TENM3 | teneurin transmembrane protein 3 | -0.0100164 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.00983362 |
| S100A2 | S100 calcium binding protein A2 | -0.0096582 |
| KRT19 | keratin 19, type I | -0.00961988 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.00950575 |
| CCND1 | cyclin D1 | -0.00939958 |
| RPS21 | ribosomal protein S21 | -0.00929101 |
| LSMEM2 | leucine-rich single-pass membrane protein 2 | -0.00917521 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.00853778 |
| CPNE7 | copine VII | -0.00840032 |
| IGF1R | insulin-like growth factor 1 receptor | -0.00791321 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.00781197 |
| VKORC1L1 | vitamin K epoxide reductase complex, subunit 1-like 1 | -0.00780513 |
| VIM | vimentin | -0.00780146 |
| RPL9 | ribosomal protein L9 | -0.00779979 |
| DNAJC9 | DnaJ (Hsp40) homolog, subfamily C, member 9 | -0.00773932 |
| PYGB | phosphorylase, glycogen; brain | -0.0075977 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.00756547 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0074897 |
| CREB5 | cAMP responsive element binding protein 5 | -0.00744776 |
| ADAP1 | ArfGAP with dual PH domains 1 | -0.00734664 |
| KRT16 | keratin 16, type I | -0.00727829 |
| CHRM3 | cholinergic receptor, muscarinic 3 | -0.00701384 |
| CLCF1 | cardiotrophin-like cytokine factor 1 | -0.00699118 |
| HLCS | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) | -0.0069086 |
| ZMYM4 | zinc finger, MYM-type 4 | -0.00686678 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.00679634 |
| BRI3BP | BRI3 binding protein | -0.00677052 |
| CFAP161 | cilia and flagella associated protein 161 | -0.00673241 |
| FOXN3 | forkhead box N3 | -0.00672782 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.00663563 |
| KIF26B | kinesin family member 26B | -0.00663494 |
| PILRA | paired immunoglobin-like type 2 receptor alpha | -0.00655843 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.00646985 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.00646109 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | -0.00644976 |
| RPL37A | ribosomal protein L37a | -0.00636146 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.00625611 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.00621329 |
| FOXK1 | forkhead box K1 | -0.00619488 |
| RPS25 | ribosomal protein S25 | -0.00618086 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.00616334 |
| RPS26 | ribosomal protein S26 | -0.00615006 |
| SH3RF3 | SH3 domain containing ring finger 3 | -0.00614933 |
| AEBP2 | AE binding protein 2 | -0.00607852 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.00602987 |
| POLN | polymerase (DNA directed) nu | -0.00601596 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.00598489 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.00598338 |
| LCN2 | lipocalin 2 | -0.00596676 |
| COMMD10 | COMM domain containing 10 | -0.00596274 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.00595288 |
| EPHB2 | EPH receptor B2 | -0.00593633 |
| IER5 | immediate early response 5 | -0.00593592 |
| FUT10 | fucosyltransferase 10 (alpha (1,3) fucosyltransferase) | -0.00591882 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.00591535 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.00588133 |
| MACROD1 | MACRO domain containing 1 | -0.00583227 |
| SH3PXD2B | SH3 and PX domains 2B | -0.00583185 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.00583109 |
| DIMT1 | DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) | -0.00582411 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0058018 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.00580142 |
| ARHGAP39 | Rho GTPase activating protein 39 | -0.0057879 |
| NEK10 | NIMA-related kinase 10 | -0.00572157 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | -0.00571124 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.00569407 |
| INTS6 | integrator complex subunit 6 | -0.00567793 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | -0.00563693 |
| MTCL1 | microtubule crosslinking factor 1 | -0.00563051 |
| TMEM241 | transmembrane protein 241 | -0.0055965 |
| SNED1 | sushi, nidogen and EGF-like domains 1 | -0.00558018 |
| ENOSF1 | enolase superfamily member 1 | -0.00557285 |
| EXOC6 | exocyst complex component 6 | -0.00556858 |
| ALMS1 | Alstrom syndrome protein 1 | -0.0055664 |
| RAD9A | RAD9 homolog A (S. pombe) | -0.00548832 |
| NRARP | NOTCH-regulated ankyrin repeat protein | -0.00547922 |
| CEP170B | centrosomal protein 170B | -0.00545898 |
| SULF2 | sulfatase 2 | -0.00544571 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.00544172 |
| SKI | SKI proto-oncogene | -0.00544108 |
