| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | L-Thyroxine (sodium salt pentahydrate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.112649 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0861321 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0806847 |
| JMJD1C | jumonji domain containing 1C | 0.058152 |
| MMP12 | matrix metallopeptidase 12 | 0.0555254 |
| YAP1 | Yes-associated protein 1 | 0.0537664 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0518376 |
| RPS2 | ribosomal protein S2 | 0.0492275 |
| AREG | amphiregulin | 0.0477353 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0463736 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0444231 |
| PCBP2 | poly(rC) binding protein 2 | 0.0415619 |
| TPM3 | tropomyosin 3 | 0.0359253 |
| RPL3 | ribosomal protein L3 | 0.0345565 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0338446 |
| VMP1 | vacuole membrane protein 1 | 0.0334784 |
| XPOT | exportin, tRNA | 0.0324379 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.032404 |
| ASPH | aspartate beta-hydroxylase | 0.0312351 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0301684 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0300321 |
| POTEF | POTE ankyrin domain family, member F | 0.0298333 |
| RTN4 | reticulon 4 | 0.0294138 |
| CCNL1 | cyclin L1 | 0.0288583 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0287609 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0287251 |
| RSF1 | remodeling and spacing factor 1 | 0.0287087 |
| RPS12 | ribosomal protein S12 | 0.0273399 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0272179 |
| SESN2 | sestrin 2 | 0.0270658 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.026971 |
| HMGA2 | high mobility group AT-hook 2 | 0.0265343 |
| NEBL | nebulette | 0.0260246 |
| PRELID2 | PRELI domain containing 2 | 0.0259398 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0253395 |
| HDGF | hepatoma-derived growth factor | 0.0252882 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0248599 |
| EGR1 | early growth response 1 | 0.0245654 |
| PCM1 | pericentriolar material 1 | 0.0244636 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.024444 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0243806 |
| BRD2 | bromodomain containing 2 | 0.0236508 |
| INTS6 | integrator complex subunit 6 | 0.0230085 |
| SETD5 | SET domain containing 5 | 0.022985 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0227316 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0225473 |
| RBM25 | RNA binding motif protein 25 | 0.0225127 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.022122 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0219668 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0216022 |
| PTEN | phosphatase and tensin homolog | 0.0214316 |
| MCL1 | myeloid cell leukemia 1 | 0.021394 |
| MANBA | mannosidase, beta A, lysosomal | 0.0208286 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0207272 |
| SNX14 | sorting nexin 14 | 0.0206456 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0205495 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0203862 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0203754 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0202384 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0201676 |
| RPS18 | ribosomal protein S18 | 0.0194646 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | 0.0193922 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0192526 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0190462 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0189794 |
| PRKCE | protein kinase C, epsilon | 0.0189004 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.018816 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0187732 |
| CEP57 | centrosomal protein 57kDa | 0.0185556 |
| NRDC | nardilysin convertase | 0.0184956 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0181081 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.017842 |
| TMEM41B | transmembrane protein 41B | 0.0177521 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0177153 |
| NRXN3 | neurexin 3 | 0.0177064 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0176802 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0176486 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.0175838 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0175516 |
| RPL37A | ribosomal protein L37a | 0.0174929 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0174848 |
| USP34 | ubiquitin specific peptidase 34 | 0.0174335 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | 0.0173918 |
| EDARADD | EDAR-associated death domain | 0.0173848 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0170674 |
| ZNF407 | zinc finger protein 407 | 0.0170042 |
| SET | SET nuclear proto-oncogene | 0.0169839 |
| RNF13 | ring finger protein 13 | 0.0168521 |
| MSN | moesin | 0.0167839 |
| VCL | vinculin | 0.0165628 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0163958 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0163934 |
| RCOR1 | REST corepressor 1 | 0.0163513 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.016336 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | 0.0162922 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0162276 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0160528 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0160272 |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.0159839 |
| WWOX | WW domain containing oxidoreductase | 0.0158183 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.256695 |
| TMSB10 | thymosin beta 10 | -0.151904 |
| PCDH7 | protocadherin 7 | -0.12406 |
| MYL12B | myosin, light chain 12B, regulatory | -0.106203 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.10568 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.105562 |
| NLGN1 | neuroligin 1 | -0.100997 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0842708 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0829897 |
| CLDN1 | claudin 1 | -0.0777354 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.075236 |
| AHNAK | AHNAK nucleoprotein | -0.0747729 |
| DST | dystonin | -0.0739381 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0714714 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0664609 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0652899 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0639493 |
| CDK6 | cyclin-dependent kinase 6 | -0.060122 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0545436 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0520811 |
| RPS24 | ribosomal protein S24 | -0.0516096 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0511589 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0498699 |
| LMO7 | LIM domain 7 | -0.0493388 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.049077 |
| H1-0 | H1.0 linker histone | -0.0467664 |
| RASAL2 | RAS protein activator like 2 | -0.046728 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0463742 |
| CCND1 | cyclin D1 | -0.0450174 |
| ZNF804A | zinc finger protein 804A | -0.0441046 |
| KLF6 | Kruppel-like factor 6 | -0.0438228 |
| RPLP1 | ribosomal protein, large, P1 | -0.0435457 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0433593 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.042912 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0413728 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0403895 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0398896 |
| GNAS | GNAS complex locus | -0.0394519 |
| EDN1 | endothelin 1 | -0.0388509 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0382881 |
| ACTG1 | actin gamma 1 | -0.0382666 |
| ECT2 | epithelial cell transforming 2 | -0.0382377 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0380522 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0378268 |
| TMEM123 | transmembrane protein 123 | -0.0376851 |
| SYT1 | synaptotagmin I | -0.0373968 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0363048 |
| NF1 | neurofibromin 1 | -0.0360724 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0353822 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0351871 |
| RPL12 | ribosomal protein L12 | -0.034196 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0339094 |
| HDLBP | high density lipoprotein binding protein | -0.032821 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.032547 |
| KIF5B | kinesin family member 5B | -0.0324971 |
| TUBB | tubulin, beta class I | -0.0324249 |
| RPS19 | ribosomal protein S19 | -0.0323678 |
| RPL8 | ribosomal protein L8 | -0.0319648 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.031619 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0312071 |
| ANXA1 | annexin A1 | -0.0308177 |
| RPL35A | ribosomal protein L35a | -0.0298005 |
| RPLP0 | ribosomal protein, large, P0 | -0.0291062 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0288404 |
| CALR | calreticulin | -0.0287548 |
| RPL34 | ribosomal protein L34 | -0.0286438 |
| FTL | ferritin, light polypeptide | -0.0281254 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0279817 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0278105 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0276846 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0275414 |
| CCDC47 | coiled-coil domain containing 47 | -0.0273528 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0273518 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0271547 |
| RPL11 | ribosomal protein L11 | -0.0270427 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0267871 |
| RPL32 | ribosomal protein L32 | -0.0267499 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.0265847 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0265625 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0264531 |
| RPS3 | ribosomal protein S3 | -0.0263891 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.026153 |
| TGM2 | transglutaminase 2 | -0.0261253 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0258474 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0256995 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0255813 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0254811 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0253245 |
| SRP72 | signal recognition particle 72kDa | -0.0253055 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0253018 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0252829 |
| RPL26 | ribosomal protein L26 | -0.0251155 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0250233 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.0249662 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0249643 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0249583 |
| FOXK2 | forkhead box K2 | -0.024925 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0248484 |
| RPS21 | ribosomal protein S21 | -0.0248285 |
| BRCA1 | breast cancer 1, early onset | -0.0248214 |
