L-Thyroxine (sodium salt pentahydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Thyroxine (sodium salt pentahydrate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.0780599
ATP13A3 ATPase type 13A3 0.0660601
ASPH aspartate beta-hydroxylase 0.0652136
CD44 CD44 molecule (Indian blood group) 0.0617305
RPS2 ribosomal protein S2 0.0590147
MSN moesin 0.0553268
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0539989
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0511823
GPC6 glypican 6 0.0506587
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0474439
CCL2 chemokine (C-C motif) ligand 2 0.047007
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0469981
UBA6 ubiquitin-like modifier activating enzyme 6 0.0428363
MARCHF6 membrane associated ring-CH-type finger 6 0.0418816
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0417999
TRIO trio Rho guanine nucleotide exchange factor 0.0400265
RBM39 RNA binding motif protein 39 0.0398861
APP amyloid beta (A4) precursor protein 0.0391897
PTBP3 polypyrimidine tract binding protein 3 0.0390736
FNDC3B fibronectin type III domain containing 3B 0.0383338
WAC WW domain containing adaptor with coiled-coil 0.0381533
SMAD3 SMAD family member 3 0.0380873
TPM3 tropomyosin 3 0.0374538
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0374094
FMNL2 formin-like 2 0.0372385
XPO1 exportin 1 0.0371842
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0369417
ADAM9 ADAM metallopeptidase domain 9 0.0365059
NRIP1 nuclear receptor interacting protein 1 0.0357692
VCAM1 vascular cell adhesion molecule 1 0.0355164
UGCG UDP-glucose ceramide glucosyltransferase 0.0352323
QKI QKI, KH domain containing, RNA binding 0.0347186
DDIT4 DNA-damage-inducible transcript 4 0.0346718
ZFP36L1 ZFP36 ring finger protein-like 1 0.0333848
UBQLN1 ubiquilin 1 0.0316298
SRPK2 SRSF protein kinase 2 0.0312532
USP3 ubiquitin specific peptidase 3 0.0309878
ANKRD33B ankyrin repeat domain 33B 0.030837
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0302785
MYO10 myosin X 0.0300113
CSF1 colony stimulating factor 1 (macrophage) 0.0295353
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0291489
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0291338
PDLIM5 PDZ and LIM domain 5 0.0290924
OSBPL3 oxysterol binding protein-like 3 0.0285204
RAB10 RAB10, member RAS oncogene family 0.0279939
GLS2 glutaminase 2 (liver, mitochondrial) 0.0276086
HIP1 huntingtin interacting protein 1 0.0273844
RAB8B RAB8B, member RAS oncogene family 0.0271945
SLTM SAFB-like, transcription modulator 0.0271686
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0271514
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0271278
ARHGAP26 Rho GTPase activating protein 26 0.0269738
KMT2C lysine (K)-specific methyltransferase 2C 0.0268812
CADM1 cell adhesion molecule 1 0.0265233
ADAM17 ADAM metallopeptidase domain 17 0.0264075
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0259925
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0259765
NCKAP1 NCK-associated protein 1 0.0259677
PTK2 protein tyrosine kinase 2 0.0257713
SPAG9 sperm associated antigen 9 0.0257252
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0255827
OPTN optineurin 0.0253151
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0252167
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.025194
PUM2 pumilio RNA-binding family member 2 0.0246123
ADM adrenomedullin 0.0245174
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0243189
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0242996
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0242721
AKAP13 A kinase (PRKA) anchor protein 13 0.0241689
TNIP1 TNFAIP3 interacting protein 1 0.0240687
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0239488
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0239305
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0236425
USP12 ubiquitin specific peptidase 12 0.0234576
ELOVL5 ELOVL fatty acid elongase 5 0.0233925
SET SET nuclear proto-oncogene 0.0233394
ZFAND3 zinc finger, AN1-type domain 3 0.0231992
RAI14 retinoic acid induced 14 0.0231659
PDE8A phosphodiesterase 8A 0.0229605
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0229417
ARHGAP17 Rho GTPase activating protein 17 0.0229304
FXR1 fragile X mental retardation, autosomal homolog 1 0.0227769
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0227097
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.022599
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0225956
TFG TRK-fused gene 0.0225706
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0224212
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0223932
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0223097
OSBPL9 oxysterol binding protein-like 9 0.0222632
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0221649
ARRDC3 arrestin domain containing 3 0.0220688
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0219649
DENND2B DENN domain containing 2B 0.0219312
NKTR natural killer cell triggering receptor 0.0218729
GOLT1B golgi transport 1B 0.0215891
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0211104
COPA coatomer protein complex, subunit alpha 0.0209588

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.227509
TMSB10 thymosin beta 10 -0.168886
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.145305
FTL ferritin, light polypeptide -0.134928
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.126565
IGFBP3 insulin-like growth factor binding protein 3 -0.106126
FRMD4A FERM domain containing 4A -0.101968
TXNRD1 thioredoxin reductase 1 -0.0925068
RPL35A ribosomal protein L35a -0.079113
RPL23 ribosomal protein L23 -0.0740928
HLA-B major histocompatibility complex, class I, B -0.0654969
RPS19 ribosomal protein S19 -0.0635086
RPS8 ribosomal protein S8 -0.0619439
RPLP1 ribosomal protein, large, P1 -0.061034
PLIN2 perilipin 2 -0.0582231
EIF1 eukaryotic translation initiation factor 1 -0.0581008
TPT1 tumor protein, translationally-controlled 1 -0.0573439
RPL34 ribosomal protein L34 -0.0539662
RPL19 ribosomal protein L19 -0.0514708
HSPB1 heat shock 27kDa protein 1 -0.0507026
MT2A metallothionein 2A -0.0506423
RPLP2 ribosomal protein, large, P2 -0.0504845
RPS6 ribosomal protein S6 -0.0483627
CP ceruloplasmin (ferroxidase) -0.0481764
VCL vinculin -0.046976
RPS24 ribosomal protein S24 -0.046176
PTMA prothymosin, alpha -0.0459999
RPS4X ribosomal protein S4, X-linked -0.0452499
RPL12 ribosomal protein L12 -0.0447549
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0423518
RPL31 ribosomal protein L31 -0.0415973
PDE4D phosphodiesterase 4D, cAMP-specific -0.0406167
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0401795
AHNAK AHNAK nucleoprotein -0.0400673
RPS23 ribosomal protein S23 -0.0385045
ACTG1 actin gamma 1 -0.0374762
CMIP c-Maf inducing protein -0.0365802
HM13 histocompatibility (minor) 13 -0.0357583
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0357366
RPL9 ribosomal protein L9 -0.0352203
NAV2 neuron navigator 2 -0.0347523
RPL8 ribosomal protein L8 -0.034548
RPS17 ribosomal protein S17 -0.0344629
TPM4 tropomyosin 4 -0.033594
CREB5 cAMP responsive element binding protein 5 -0.0335422
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0332593
RPS13 ribosomal protein S13 -0.0330212
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0326699
RIGI RNA sensor RIG-I -0.0319841
RPS14 ribosomal protein S14 -0.0317335
MGST1 microsomal glutathione S-transferase 1 -0.0315855
RPS20 ribosomal protein S20 -0.0313705
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0312374
ARL4C ADP-ribosylation factor-like 4C -0.031123
RPS21 ribosomal protein S21 -0.0307243
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0305815
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0305453
B2M beta-2-microglobulin -0.0302953
RPL36 ribosomal protein L36 -0.0301886
CUX1 cut-like homeobox 1 -0.030058
RPL35 ribosomal protein L35 -0.0297376
IARS1 isoleucyl-tRNA synthetase 1 -0.0294111
GARS1 glycyl-tRNA synthetase 1 -0.0289891
RPS16 ribosomal protein S16 -0.028934
HMGB1 high mobility group box 1 -0.0286573
RPS15 ribosomal protein S15 -0.0286099
KPNB1 karyopherin (importin) beta 1 -0.0284465
RPL5 ribosomal protein L5 -0.0284307
RPL37A ribosomal protein L37a -0.0283321
RPL28 ribosomal protein L28 -0.0281556
MKI67 marker of proliferation Ki-67 -0.0280107
EXT1 exostosin glycosyltransferase 1 -0.0277234
OSMR oncostatin M receptor -0.0272879
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0272171
IFITM3 interferon induced transmembrane protein 3 -0.0270707
IFI16 interferon, gamma-inducible protein 16 -0.0268383
COTL1 coactosin-like F-actin binding protein 1 -0.0264979
RPL27A ribosomal protein L27a -0.0262994
SPDYA speedy/RINGO cell cycle regulator family member A -0.0261668
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0257367
RPL26 ribosomal protein L26 -0.0257014
RPS11 ribosomal protein S11 -0.0256745
LOC102724023 ES1 protein homolog, mitochondrial -0.0255436
S100A10 S100 calcium binding protein A10 -0.0252918
S100A11 S100 calcium binding protein A11 -0.0252598
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0249099
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0248623
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0247189
GNAS GNAS complex locus -0.0245098
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.024436
TSHZ2 teashirt zinc finger homeobox 2 -0.0243625
EGR1 early growth response 1 -0.0242736
INTS6 integrator complex subunit 6 -0.023789
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0237638
HLA-E major histocompatibility complex, class I, E -0.0237456
HLA-C major histocompatibility complex, class I, C -0.0234814
GOLGB1 golgin B1 -0.0234433
IFIH1 interferon induced with helicase C domain 1 -0.0231825
ZMYND8 zinc finger, MYND-type containing 8 -0.0231341
UBC ubiquitin C -0.0230944