| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | L-Thyroxine (sodium salt pentahydrate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.173366 |
| MT2A | metallothionein 2A | 0.116058 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0904695 |
| STC1 | stanniocalcin 1 | 0.0843452 |
| MSN | moesin | 0.0798942 |
| POTEF | POTE ankyrin domain family, member F | 0.075991 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0759302 |
| NDRG1 | N-myc downstream regulated 1 | 0.074957 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0652317 |
| RPS6 | ribosomal protein S6 | 0.0644753 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0611909 |
| EGFR | epidermal growth factor receptor | 0.0603907 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0524319 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0523336 |
| PCBP2 | poly(rC) binding protein 2 | 0.0489199 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.047457 |
| MCL1 | myeloid cell leukemia 1 | 0.0472405 |
| RPS2 | ribosomal protein S2 | 0.0464003 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0460824 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0452301 |
| FRMD6 | FERM domain containing 6 | 0.0437708 |
| FLNB | filamin B, beta | 0.043703 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0435142 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0428282 |
| AXL | AXL receptor tyrosine kinase | 0.0418242 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0404991 |
| LAMC2 | laminin, gamma 2 | 0.0388321 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0386475 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0384582 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0365954 |
| PRRC2C | proline-rich coiled-coil 2C | 0.036251 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0354897 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0344963 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0339549 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0338138 |
| USP47 | ubiquitin specific peptidase 47 | 0.033807 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0337147 |
| ZFP36 | ZFP36 ring finger protein | 0.0327604 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0324602 |
| SMAD3 | SMAD family member 3 | 0.0314217 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0313722 |
| OPTN | optineurin | 0.0313219 |
| FAM13A | family with sequence similarity 13, member A | 0.031307 |
| PKM | pyruvate kinase, muscle | 0.0311106 |
| ADM | adrenomedullin | 0.0309317 |
| FA2H | fatty acid 2-hydroxylase | 0.0304855 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0303692 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0301268 |
| USP34 | ubiquitin specific peptidase 34 | 0.0299414 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0298031 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0296369 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0296094 |
| DUSP5 | dual specificity phosphatase 5 | 0.0288779 |
| MAP7 | microtubule-associated protein 7 | 0.0284439 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | 0.0282928 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0280532 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0279559 |
| PXYLP1 | 2-phosphoxylose phosphatase 1 | 0.0278035 |
| DSPP | dentin sialophosphoprotein | 0.0277126 |
| VCL | vinculin | 0.0275537 |
| RPL3 | ribosomal protein L3 | 0.0274515 |
| HDGF | hepatoma-derived growth factor | 0.0274232 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0272029 |
| TNS1 | tensin 1 | 0.0272006 |
| FOSL1 | FOS-like antigen 1 | 0.0271998 |
| RPL21 | ribosomal protein L21 | 0.0269074 |
| SMYD3 | SET and MYND domain containing 3 | 0.0267308 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0266901 |
| RPL7 | ribosomal protein L7 | 0.0259447 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0257765 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0257736 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0254647 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0254398 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.025438 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0249867 |
| CCNL1 | cyclin L1 | 0.0248838 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0246806 |
| FMNL2 | formin-like 2 | 0.0245047 |
| GOLGA4 | golgin A4 | 0.0242525 |
| FAM13B | family with sequence similarity 13, member B | 0.0241054 |
| GPC6 | glypican 6 | 0.024041 |
| ANGPTL4 | angiopoietin-like 4 | 0.0237973 |
| CCNY | cyclin Y | 0.0236819 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0234344 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0233347 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0231898 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0230792 |
| PRKCE | protein kinase C, epsilon | 0.022951 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0229305 |
| CNTN1 | contactin 1 | 0.0227276 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0226329 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0225922 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0225675 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0225446 |
| FOXP1 | forkhead box P1 | 0.0223035 |
| VPS35 | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.0222756 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.022008 |
| VEGFA | vascular endothelial growth factor A | 0.0218243 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0216594 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0215982 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.129046 |
| ANXA2 | annexin A2 | -0.110702 |
| TMSB10 | thymosin beta 10 | -0.109505 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.102108 |
| TXNRD1 | thioredoxin reductase 1 | -0.0905998 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0865993 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.082527 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0820508 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0787535 |
| FTL | ferritin, light polypeptide | -0.0721341 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0716804 |
| RPS24 | ribosomal protein S24 | -0.070742 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0700355 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0681477 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0615541 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0592367 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0584446 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0582496 |
| OSMR | oncostatin M receptor | -0.0566283 |
| ACTG1 | actin gamma 1 | -0.0557989 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0557975 |
| S100A10 | S100 calcium binding protein A10 | -0.0535996 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0516162 |
| RRBP1 | ribosome binding protein 1 | -0.0511962 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0502187 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0483577 |
| KRT7 | keratin 7, type II | -0.0481261 |
| KYNU | kynureninase | -0.0476818 |
| RNF213 | ring finger protein 213 | -0.0472182 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.046947 |
| RPL23 | ribosomal protein L23 | -0.0468791 |
| USP3 | ubiquitin specific peptidase 3 | -0.0461581 |
| TMSB4X | thymosin beta 4, X-linked | -0.045977 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0459762 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0455187 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0452689 |
| TNS3 | tensin 3 | -0.0443049 |
| PTMA | prothymosin, alpha | -0.0431647 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0422233 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0421292 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0410628 |
| ANXA1 | annexin A1 | -0.0410141 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0408515 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.040742 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0401212 |
| AOPEP | aminopeptidase O (putative) | -0.0400468 |
| AHNAK | AHNAK nucleoprotein | -0.0392403 |
| EHBP1 | EH domain binding protein 1 | -0.0390223 |
| TKT | transketolase | -0.0386678 |
| KRT81 | keratin 81, type II | -0.038232 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0377166 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0376978 |
| ACTN4 | actinin, alpha 4 | -0.0375951 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0372049 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0372047 |
| PGK1 | phosphoglycerate kinase 1 | -0.0365475 |
| PLSCR1 | phospholipid scramblase 1 | -0.0365458 |
| ATG7 | autophagy related 7 | -0.0362446 |
| GLIS3 | GLIS family zinc finger 3 | -0.0354074 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0349937 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0346552 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0343564 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0340985 |
| NRP1 | neuropilin 1 | -0.0330931 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0325683 |
| DENND4A | DENN/MADD domain containing 4A | -0.0324365 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0322674 |
| KLF6 | Kruppel-like factor 6 | -0.0322224 |
| TFG | TRK-fused gene | -0.0319438 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0317996 |
| RPS21 | ribosomal protein S21 | -0.0317205 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0315045 |
| RAI14 | retinoic acid induced 14 | -0.0313509 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0308742 |
| SBF2 | SET binding factor 2 | -0.0307445 |
| VIM | vimentin | -0.0306023 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0305701 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0305162 |
| ARF1 | ADP-ribosylation factor 1 | -0.0298354 |
| MT1X | metallothionein 1X | -0.0294815 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0289531 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0288183 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0284709 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0284555 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0283398 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0283385 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0283353 |
| RPL4 | ribosomal protein L4 | -0.0283075 |
| SRGN | serglycin | -0.0282017 |
| RPS27A | ribosomal protein S27a | -0.0279325 |
| LMNA | lamin A/C | -0.0274936 |
| OLA1 | Obg-like ATPase 1 | -0.0274038 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0272854 |
| CANX | calnexin | -0.0270552 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0267558 |
| RBM39 | RNA binding motif protein 39 | -0.0267311 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0266214 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0263788 |
| UBC | ubiquitin C | -0.0262188 |
| KRT18 | keratin 18, type I | -0.0262016 |
