L-Thyroxine (sodium salt pentahydrate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Thyroxine (sodium salt pentahydrate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein 0.136406
NALF1 NALCN channel auxiliary factor 1 0.103515
AKAP12 A kinase (PRKA) anchor protein 12 0.103238
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.102859
NRG1 neuregulin 1 0.0896281
LINGO2 leucine rich repeat and Ig domain containing 2 0.0750927
PTPRD protein tyrosine phosphatase, receptor type, D 0.0747461
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0690192
KLHL13 kelch-like family member 13 0.0623493
EXT1 exostosin glycosyltransferase 1 0.0606558
FMN1 formin 1 0.0513001
CEMIP cell migration inducing protein, hyaluronan binding 0.0483661
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0480756
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0471974
NREP neuronal regeneration related protein 0.0466456
MEF2A myocyte enhancer factor 2A 0.0462762
FNDC3B fibronectin type III domain containing 3B 0.0457748
PLAT plasminogen activator, tissue 0.0455563
GPC5 glypican 5 0.0447208
PCBP3 poly(rC) binding protein 3 0.0395595
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0385702
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.037713
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0366275
ZBTB20 zinc finger and BTB domain containing 20 0.0353005
SMYD3 SET and MYND domain containing 3 0.0347507
FLT1 fms-related tyrosine kinase 1 0.0345772
TPST1 tyrosylprotein sulfotransferase 1 0.0340131
NPAS2 neuronal PAS domain protein 2 0.0337229
PTEN phosphatase and tensin homolog 0.0336782
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0334972
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0330157
CADM2 cell adhesion molecule 2 0.0328928
SLIT2 slit homolog 2 (Drosophila) 0.0325712
COL18A1 collagen, type XVIII, alpha 1 0.0312955
PDE10A phosphodiesterase 10A 0.0302699
TCF12 transcription factor 12 0.0299157
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0291662
AFF3 AF4/FMR2 family, member 3 0.0289061
SLITRK6 SLIT and NTRK-like family, member 6 0.0275178
MAPK10 mitogen-activated protein kinase 10 0.0274377
PACS1 phosphofurin acidic cluster sorting protein 1 0.0269825
SIK2 salt-inducible kinase 2 0.0267465
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0266663
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0266275
COL4A2 collagen, type IV, alpha 2 0.0264824
SDK1 sidekick cell adhesion molecule 1 0.0260323
PTPRG protein tyrosine phosphatase, receptor type, G 0.0259731
FAM13A family with sequence similarity 13, member A 0.0258664
BPTF bromodomain PHD finger transcription factor 0.0258634
USP34 ubiquitin specific peptidase 34 0.0256848
FRMD6 FERM domain containing 6 0.0256062
ADGRB3 adhesion G protein-coupled receptor B3 0.0254845
TET1 tet methylcytosine dioxygenase 1 0.0251051
ADARB1 adenosine deaminase, RNA-specific, B1 0.0249105
CSNK1A1 casein kinase 1, alpha 1 0.024762
ELL2 elongation factor, RNA polymerase II, 2 0.0246767
ANTXR1 anthrax toxin receptor 1 0.0246381
PRKCA protein kinase C, alpha 0.024115
TRIO trio Rho guanine nucleotide exchange factor 0.0234401
FAM107B family with sequence similarity 107, member B 0.0233703
FNDC3A fibronectin type III domain containing 3A 0.0227456
SYTL3 synaptotagmin-like 3 0.0223773
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0223089
USP9Y ubiquitin specific peptidase 9, Y-linked 0.0222068
ARHGAP9 Rho GTPase activating protein 9 0.0221942
RPTOR regulatory associated protein of MTOR, complex 1 0.0220429
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0220355
DNMBP dynamin binding protein 0.0219901
GLCCI1 glucocorticoid induced 1 0.0217528
CPNE8 copine VIII 0.021749
AKAP9 A kinase (PRKA) anchor protein 9 0.0216647
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0215214
DNAH14 dynein, axonemal, heavy chain 14 0.0215125
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0215038
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0211388
FRMD4A FERM domain containing 4A 0.0211318
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0210641
DTNA dystrobrevin, alpha 0.0209875
LIMCH1 LIM and calponin homology domains 1 0.0209065
BCAS3 breast carcinoma amplified sequence 3 0.0208071
EPAS1 endothelial PAS domain protein 1 0.0207826
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.020745
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0207344
DIAPH2 diaphanous-related formin 2 0.0204886
SHB Src homology 2 domain containing adaptor protein B 0.0202811
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0202746
ITPRID2 ITPR interacting domain containing 2 0.0196966
AVL9 AVL9 homolog (S. cerevisiase) 0.019565
FAM219A family with sequence similarity 219, member A 0.0194622
SETBP1 SET binding protein 1 0.0193478
ZCCHC7 zinc finger, CCHC domain containing 7 0.0192419
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0192399
GREM2 gremlin 2, DAN family BMP antagonist 0.0191966
PDE8B phosphodiesterase 8B 0.0189694
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0188641
SMC5 structural maintenance of chromosomes 5 0.018847
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0188349
AOPEP aminopeptidase O (putative) 0.0187595
GSE1 Gse1 coiled-coil protein 0.01856
FMNL2 formin-like 2 0.0183204

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.372455
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.184913
VIM vimentin -0.154823
PTMA prothymosin, alpha -0.126916
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0809929
RPLP1 ribosomal protein, large, P1 -0.0747632
RPL23 ribosomal protein L23 -0.0733241
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0658681
RPL19 ribosomal protein L19 -0.0651748
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0633225
RPS19 ribosomal protein S19 -0.0595124
TMSB10 thymosin beta 10 -0.0592762
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0577521
RPL35A ribosomal protein L35a -0.0572709
COL1A1 collagen, type I, alpha 1 -0.0536779
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0531995
RPS6 ribosomal protein S6 -0.0516596
MAP1B microtubule-associated protein 1B -0.0482996
ANXA2 annexin A2 -0.0477555
RPL34 ribosomal protein L34 -0.0475001
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0448903
B2M beta-2-microglobulin -0.043641
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0430934
S100A6 S100 calcium binding protein A6 -0.0426995
FTL ferritin, light polypeptide -0.0424387
PKM pyruvate kinase, muscle -0.0406277
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0403913
MED13 mediator complex subunit 13 -0.0387723
WDR45B WD repeat domain 45B -0.0384723
ACTG1 actin gamma 1 -0.0380311
KDM3A lysine (K)-specific demethylase 3A -0.0369163
LPIN1 lipin 1 -0.0368624
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0351691
USP3 ubiquitin specific peptidase 3 -0.0337025
IER3 immediate early response 3 -0.033429
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0330728
SLC38A2 solute carrier family 38, member 2 -0.0327805
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0327663
RPL32 ribosomal protein L32 -0.0322053
EIF1 eukaryotic translation initiation factor 1 -0.0320462
RPS21 ribosomal protein S21 -0.031585
COL3A1 collagen, type III, alpha 1 -0.0306908
RPL36 ribosomal protein L36 -0.0304495
RPS24 ribosomal protein S24 -0.0301698
ZMYM2 zinc finger, MYM-type 2 -0.0296356
LMNA lamin A/C -0.029201
TPI1 triosephosphate isomerase 1 -0.0291252
RAB1A RAB1A, member RAS oncogene family -0.0290888
CSNK1G1 casein kinase 1, gamma 1 -0.0287856
S100A10 S100 calcium binding protein A10 -0.0287834
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0279244
HILPDA hypoxia inducible lipid droplet-associated -0.0278455
RAD21 RAD21 homolog (S. pombe) -0.0276687
QKI QKI, KH domain containing, RNA binding -0.0276631
WAC WW domain containing adaptor with coiled-coil -0.027426
RNMT RNA (guanine-7-) methyltransferase -0.0269253
RPL26 ribosomal protein L26 -0.0268876
NIPBL Nipped-B homolog (Drosophila) -0.0265694
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0264546
HMGA1 high mobility group AT-hook 1 -0.0261839
EGR1 early growth response 1 -0.0260314
UBC ubiquitin C -0.0258511
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0258051
CANX calnexin -0.0250756
GNAS GNAS complex locus -0.0244477
NAMPT nicotinamide phosphoribosyltransferase -0.0239221
PDIA3 protein disulfide isomerase family A, member 3 -0.0237898
TOP1 topoisomerase (DNA) I -0.02373
MARCKS myristoylated alanine-rich protein kinase C substrate -0.023659
NPEPPS aminopeptidase puromycin sensitive -0.0235691
RPLP2 ribosomal protein, large, P2 -0.0232875
RPL31 ribosomal protein L31 -0.0230518
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0230399
LCORL ligand dependent nuclear receptor corepressor-like -0.0228506
LMAN1 lectin, mannose-binding, 1 -0.0226479
CCND1 cyclin D1 -0.0226033
BSG basigin (Ok blood group) -0.0224622
RPS11 ribosomal protein S11 -0.0223321
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0221193
MAP4 microtubule-associated protein 4 -0.0221074
TLK2 tousled-like kinase 2 -0.0220266
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0219707
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0218517
YBX1 Y box binding protein 1 -0.0216629
RPS29 ribosomal protein S29 -0.0216004
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.021494
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0214695
PITPNB phosphatidylinositol transfer protein, beta -0.0214215
RPL37A ribosomal protein L37a -0.0213784
KDM2A lysine (K)-specific demethylase 2A -0.0212005
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.020967
RTN4 reticulon 4 -0.0208921
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0206853
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0206585
MKI67 marker of proliferation Ki-67 -0.0206312
TTC3 tetratricopeptide repeat domain 3 -0.0205522
CHD6 chromodomain helicase DNA binding protein 6 -0.0204266
IARS1 isoleucyl-tRNA synthetase 1 -0.0203848
FTH1 ferritin, heavy polypeptide 1 -0.0200504
PFN1 profilin 1 -0.0200031