L-Thyroxine (sodium salt pentahydrate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Thyroxine (sodium salt pentahydrate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.15785
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0749528
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0711036
LDHA lactate dehydrogenase A 0.069951
FAM13A family with sequence similarity 13, member A 0.0696493
AKAP12 A kinase (PRKA) anchor protein 12 0.0696246
FTL ferritin, light polypeptide 0.0626297
CXCL8 chemokine (C-X-C motif) ligand 8 0.062204
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0567185
STC1 stanniocalcin 1 0.0552934
ANXA2 annexin A2 0.0517137
LMAN1 lectin, mannose-binding, 1 0.0477743
FNDC3B fibronectin type III domain containing 3B 0.0466062
CD44 CD44 molecule (Indian blood group) 0.0458946
CANX calnexin 0.0458569
ZNF395 zinc finger protein 395 0.0450857
GOLGA4 golgin A4 0.0442787
LOX lysyl oxidase 0.0442606
NAMPT nicotinamide phosphoribosyltransferase 0.0439794
NDRG1 N-myc downstream regulated 1 0.0429247
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0426688
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0398332
ATP13A3 ATPase type 13A3 0.0388555
LOC112694756 uncharaterized LOC112694756 0.0382316
TPM4 tropomyosin 4 0.0365721
PGK1 phosphoglycerate kinase 1 0.0363105
CALU calumenin 0.0361466
PKM pyruvate kinase, muscle 0.0357893
ELL2 elongation factor, RNA polymerase II, 2 0.0356378
SMAD3 SMAD family member 3 0.0356343
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0354014
COPA coatomer protein complex, subunit alpha 0.0351671
GOLGB1 golgin B1 0.0351375
SRP54 signal recognition particle 54kDa 0.0347971
ANKRD17 ankyrin repeat domain 17 0.0343229
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0334147
PRRC2C proline-rich coiled-coil 2C 0.031803
KTN1 kinectin 1 (kinesin receptor) 0.0317554
NOP58 NOP58 ribonucleoprotein 0.0315158
TNIP1 TNFAIP3 interacting protein 1 0.0314814
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0312832
HELZ helicase with zinc finger 0.0312674
MYO1B myosin IB 0.0311389
RTN4 reticulon 4 0.0311314
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.0310857
KPNB1 karyopherin (importin) beta 1 0.0309442
OGA O-GlcNAcase 0.0306739
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0303367
UBA6 ubiquitin-like modifier activating enzyme 6 0.0302618
RLF rearranged L-myc fusion 0.0301594
MXI1 MAX interactor 1, dimerization protein 0.0300517
LOXL2 lysyl oxidase-like 2 0.0300047
FOXJ3 forkhead box J3 0.0299722
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0294026
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0293289
ACBD3 acyl-CoA binding domain containing 3 0.0291689
CUL4B cullin 4B 0.0290733
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0289963
SEPTIN2 septin 2 0.028786
GYS1 glycogen synthase 1 (muscle) 0.0286668
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0280561
TLN1 talin 1 0.0277031
ERRFI1 ERBB receptor feedback inhibitor 1 0.0273763
DGKD diacylglycerol kinase, delta 130kDa 0.0272938
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0272822
RASA2 RAS p21 protein activator 2 0.027165
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0270569
COPB1 coatomer protein complex, subunit beta 1 0.0269571
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0269336
SMC5 structural maintenance of chromosomes 5 0.0269051
KDM3A lysine (K)-specific demethylase 3A 0.0268838
MARCHF6 membrane associated ring-CH-type finger 6 0.0268402
RNF220 ring finger protein 220 0.0268044
USP37 ubiquitin specific peptidase 37 0.0267493
ENO1 enolase 1, (alpha) 0.0266657
SEC24D SEC24 family member D 0.0265501
NAV2 neuron navigator 2 0.0264225
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0263703
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0262173
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0259805
CDC27 cell division cycle 27 0.0255527
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0251432
TUT4 terminal uridylyl transferase 4 0.0251171
BRWD3 bromodomain and WD repeat domain containing 3 0.025117
SRRM2 serine/arginine repetitive matrix 2 0.0250602
USP36 ubiquitin specific peptidase 36 0.0247961
YBX1 Y box binding protein 1 0.0247653
SPAG9 sperm associated antigen 9 0.0246379
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0244771
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0244015
TRIO trio Rho guanine nucleotide exchange factor 0.0243468
EIF4A2 eukaryotic translation initiation factor 4A2 0.0238943
TGFBI transforming growth factor, beta-induced, 68kDa 0.0237244
COL12A1 collagen, type XII, alpha 1 0.0234716
TM9SF3 transmembrane 9 superfamily member 3 0.0233522
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0233213
KMT2C lysine (K)-specific methyltransferase 2C 0.0232939
AKAP9 A kinase (PRKA) anchor protein 9 0.0232532
ANKRD28 ankyrin repeat domain 28 0.023201
CHD1 chromodomain helicase DNA binding protein 1 0.0230496

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.158374
NALF1 NALCN channel auxiliary factor 1 -0.108212
PDE4D phosphodiesterase 4D, cAMP-specific -0.09776
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0705002
GRB10 growth factor receptor-bound protein 10 -0.0559226
NLGN1 neuroligin 1 -0.0530516
TMSB10 thymosin beta 10 -0.048713
GLCCI1 glucocorticoid induced 1 -0.0460769
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0448041
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0426742
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0424349
SDK1 sidekick cell adhesion molecule 1 -0.0420977
PTK2 protein tyrosine kinase 2 -0.0392927
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.038127
SYT1 synaptotagmin I -0.0374342
ZNF804A zinc finger protein 804A -0.0348361
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0347526
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0314843
IGFBP5 insulin-like growth factor binding protein 5 -0.0308447
NAV1 neuron navigator 1 -0.0294948
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0293624
PAPPA2 pappalysin 2 -0.02838
KCTD16 potassium channel tetramerization domain containing 16 -0.0277963
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0275955
KYNU kynureninase -0.0274066
FN1 fibronectin 1 -0.0268778
PSD3 pleckstrin and Sec7 domain containing 3 -0.0264137
INTS6 integrator complex subunit 6 -0.0263544
RUNX1 runt-related transcription factor 1 -0.026066
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.026024
ZBTB20 zinc finger and BTB domain containing 20 -0.0258465
AUTS2 autism susceptibility candidate 2 -0.0254833
LYPD6B LY6/PLAUR domain containing 6B -0.0254588
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0247781
PTPRG protein tyrosine phosphatase, receptor type, G -0.0245829
EXT1 exostosin glycosyltransferase 1 -0.0243062
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0241281
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0240171
DGKI diacylglycerol kinase, iota -0.0240037
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0236192
THSD4 thrombospondin, type I, domain containing 4 -0.023353
POTEF POTE ankyrin domain family, member F -0.0231528
VCL vinculin -0.0229413
LRRC23 leucine rich repeat containing 23 -0.0228296
UBASH3B ubiquitin associated and SH3 domain containing B -0.0225037
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0224815
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) -0.0223196
DTNA dystrobrevin, alpha -0.0221901
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -0.0220275
KDM4C lysine (K)-specific demethylase 4C -0.0215863
GPR39 G protein-coupled receptor 39 -0.0215704
MYO9A myosin IXA -0.0215184
CLASP1 cytoplasmic linker associated protein 1 -0.0207823
ATXN1 ataxin 1 -0.0204653
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0203948
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0203576
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0200036
WWOX WW domain containing oxidoreductase -0.0198843
SUMF1 sulfatase modifying factor 1 -0.0198334
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0197929
HDAC4 histone deacetylase 4 -0.0196474
RNF213 ring finger protein 213 -0.0194857
CDK14 cyclin-dependent kinase 14 -0.0194012
DPYD dihydropyrimidine dehydrogenase -0.0192794
NPAS2 neuronal PAS domain protein 2 -0.0192575
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.019253
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0191226
RPL23 ribosomal protein L23 -0.0188705
PHF14 PHD finger protein 14 -0.0188277
MAML3 mastermind-like 3 (Drosophila) -0.0188025
LRP1B low density lipoprotein receptor-related protein 1B -0.0187518
XYLT1 xylosyltransferase I -0.0187473
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0182613
EGR1 early growth response 1 -0.0181842
FTO fat mass and obesity associated -0.018075
SMC4 structural maintenance of chromosomes 4 -0.0178636
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0177043
COL8A1 collagen, type VIII, alpha 1 -0.0176645
PALLD palladin, cytoskeletal associated protein -0.0174965
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0174246
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0173341
MSI2 musashi RNA-binding protein 2 -0.0173095
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0172092
PTCHD4 patched domain containing 4 -0.0171431
UBAP2 ubiquitin associated protein 2 -0.0171388
TENM3 teneurin transmembrane protein 3 -0.0171192
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0170558
PHACTR2 phosphatase and actin regulator 2 -0.0170133
WARS1 tryptophanyl-tRNA synthetase 1 -0.0169922
COL6A2 collagen, type VI, alpha 2 -0.0169807
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -0.0168301
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0168176
RABGAP1L RAB GTPase activating protein 1-like -0.0168101
COMMD10 COMM domain containing 10 -0.0166996
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0166877
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.0165216
PRR16 proline rich 16 -0.0164323
SOX5 SRY (sex determining region Y)-box 5 -0.0164082
TTYH3 tweety family member 3 -0.0163724
PIAS2 protein inhibitor of activated STAT, 2 -0.0162785