L-Thyroxine (sodium salt pentahydrate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Thyroxine (sodium salt pentahydrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.20509
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.172189
MT2A metallothionein 2A 0.144289
GOLGA4 golgin A4 0.124622
RPS6 ribosomal protein S6 0.123318
NDRG1 N-myc downstream regulated 1 0.116484
FTL ferritin, light polypeptide 0.112015
RPS2 ribosomal protein S2 0.108582
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0925382
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.083644
EEF2 eukaryotic translation elongation factor 2 0.081672
RPS8 ribosomal protein S8 0.080302
EIF1 eukaryotic translation initiation factor 1 0.0781511
POTEF POTE ankyrin domain family, member F 0.0754938
DSG2 desmoglein 2 0.073386
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0729928
SETD5 SET domain containing 5 0.0713689
ACTG1 actin gamma 1 0.0708605
TPM4 tropomyosin 4 0.0698795
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0690122
B2M beta-2-microglobulin 0.0683778
TPT1 tumor protein, translationally-controlled 1 0.0663284
SET SET nuclear proto-oncogene 0.0647842
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0609337
RPL12 ribosomal protein L12 0.0603352
ENO1 enolase 1, (alpha) 0.0585048
RPL11 ribosomal protein L11 0.0581492
CANX calnexin 0.0576992
PKM pyruvate kinase, muscle 0.0554093
TTC3 tetratricopeptide repeat domain 3 0.0553156
MYH9 myosin, heavy chain 9, non-muscle 0.0536335
PTMA prothymosin, alpha 0.0521197
CDCP1 CUB domain containing protein 1 0.0518702
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.051771
RPS12 ribosomal protein S12 0.0513989
ERRFI1 ERBB receptor feedback inhibitor 1 0.0510937
TMF1 TATA element modulatory factor 1 0.050774
RPS3 ribosomal protein S3 0.0499641
RACK1 receptor for activated C kinase 1 0.0493713
DDIT4 DNA-damage-inducible transcript 4 0.0483786
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0477963
RPL7A ribosomal protein L7a 0.0467692
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0467328
HSPA8 heat shock 70kDa protein 8 0.046715
HELZ helicase with zinc finger 0.0464169
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0459152
RPL37A ribosomal protein L37a 0.045558
UPP1 uridine phosphorylase 1 0.0446814
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.044083
RPL7 ribosomal protein L7 0.0436493
LDHA lactate dehydrogenase A 0.0433659
RPS27A ribosomal protein S27a 0.0428227
KTN1 kinectin 1 (kinesin receptor) 0.0427057
CALR calreticulin 0.0423465
RPL26 ribosomal protein L26 0.0420542
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0420471
OPTN optineurin 0.0413864
RPS13 ribosomal protein S13 0.0411233
RPL5 ribosomal protein L5 0.0410649
RPL9 ribosomal protein L9 0.0408198
DSPP dentin sialophosphoprotein 0.0405104
SPAG9 sperm associated antigen 9 0.040482
RPL15 ribosomal protein L15 0.0387905
RPL23 ribosomal protein L23 0.0386258
NRIP1 nuclear receptor interacting protein 1 0.0377906
FLNB filamin B, beta 0.0372486
GOLGB1 golgin B1 0.0370644
RPL31 ribosomal protein L31 0.0364694
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0363886
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0363112
RPS17 ribosomal protein S17 0.0361585
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.03614
SRRM2 serine/arginine repetitive matrix 2 0.0356544
MATR3 matrin 3 0.0356287
BHLHE40 basic helix-loop-helix family, member e40 0.0352229
ESYT2 extended synaptotagmin-like protein 2 0.0350305
YBX1 Y box binding protein 1 0.0345109
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0344703
APP amyloid beta (A4) precursor protein 0.0341875
AKAP12 A kinase (PRKA) anchor protein 12 0.0340918
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0339486
NKTR natural killer cell triggering receptor 0.0335209
RPL3 ribosomal protein L3 0.0334439
RPS16 ribosomal protein S16 0.0334195
RPL19 ribosomal protein L19 0.0333097
RPL35A ribosomal protein L35a 0.0330121
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0325833
WDR45B WD repeat domain 45B 0.0321187
RSL24D1 ribosomal L24 domain containing 1 0.0319066
PDIA6 protein disulfide isomerase family A, member 6 0.0316843
GARS1 glycyl-tRNA synthetase 1 0.0316612
ZNF292 zinc finger protein 292 0.0314324
AKAP9 A kinase (PRKA) anchor protein 9 0.0311886
LMAN1 lectin, mannose-binding, 1 0.0311171
RPS29 ribosomal protein S29 0.0310166
TPM3 tropomyosin 3 0.0310126
FNBP1L formin binding protein 1-like 0.0308979
SEPTIN7 septin 7 0.0306996
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0306768
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0304315

decreased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein -0.0837832
ITGB8 integrin, beta 8 -0.0760246
BICD1 bicaudal D homolog 1 (Drosophila) -0.0698278
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0657953
RHEX regulator of hemoglobinization and erythroid cell expansion -0.058673
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0581619
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0549625
HMGA2 high mobility group AT-hook 2 -0.0476028
MKI67 marker of proliferation Ki-67 -0.0455741
DLC1 DLC1 Rho GTPase activating protein -0.0439798
DIAPH3 diaphanous-related formin 3 -0.0427771
RFC3 replication factor C (activator 1) 3, 38kDa -0.0420207
ACTN4 actinin, alpha 4 -0.0417387
SMYD3 SET and MYND domain containing 3 -0.0394563
VCL vinculin -0.038821
ASPH aspartate beta-hydroxylase -0.0385388
LIMCH1 LIM and calponin homology domains 1 -0.0369307
ECT2 epithelial cell transforming 2 -0.0368385
TMSB10 thymosin beta 10 -0.036348
H1-0 H1.0 linker histone -0.0363479
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0360222
ATG7 autophagy related 7 -0.0358974
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0357428
TXNRD1 thioredoxin reductase 1 -0.0356002
EGFR epidermal growth factor receptor -0.0353891
BICC1 BicC family RNA binding protein 1 -0.0348796
ALCAM activated leukocyte cell adhesion molecule -0.0338856
MACROD2 MACRO domain containing 2 -0.0333281
RAD51B RAD51 paralog B -0.0330957
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0326448
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0322914
NSD2 nuclear receptor binding SET domain protein 2 -0.0316727
GPR39 G protein-coupled receptor 39 -0.0316192
PAX8 paired box 8 -0.0300997
TBC1D5 TBC1 domain family, member 5 -0.0298658
WWC1 WW and C2 domain containing 1 -0.0298081
SPATA13 spermatogenesis associated 13 -0.0297802
ANKRD10 ankyrin repeat domain 10 -0.0296321
SMC4 structural maintenance of chromosomes 4 -0.0293113
PCED1B PC-esterase domain containing 1B -0.0289695
WWOX WW domain containing oxidoreductase -0.0289075
PTPRK protein tyrosine phosphatase, receptor type, K -0.028787
STAU2 staufen double-stranded RNA binding protein 2 -0.0265653
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0261569
PRELID2 PRELI domain containing 2 -0.0253896
UTRN utrophin -0.0251517
EXOC4 exocyst complex component 4 -0.0251499
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0250991
PARD3B par-3 family cell polarity regulator beta -0.0249295
AEBP2 AE binding protein 2 -0.0246723
SUMF1 sulfatase modifying factor 1 -0.0246271
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0243788
TUBB tubulin, beta class I -0.0242786
BRCA1 breast cancer 1, early onset -0.0239722
ANXA2 annexin A2 -0.0239042
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.023798
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.0237942
FIGN fidgetin -0.02374
CD44 CD44 molecule (Indian blood group) -0.0237223
FHIT fragile histidine triad -0.023581
DLG1 discs, large homolog 1 (Drosophila) -0.0232368
DENND1A DENN/MADD domain containing 1A -0.0232292
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0225379
ANKRD28 ankyrin repeat domain 28 -0.0224954
ACACA acetyl-CoA carboxylase alpha -0.0224493
MTAP methylthioadenosine phosphorylase -0.0222545
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0221557
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0221243
APOLD1 apolipoprotein L domain containing 1 -0.0221176
SCLT1 sodium channel and clathrin linker 1 -0.0220917
LAMA4 laminin, alpha 4 -0.0216572
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.0213542
OSBPL10 oxysterol binding protein-like 10 -0.0212995
RANBP17 RAN binding protein 17 -0.0212916
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0212145
EHBP1 EH domain binding protein 1 -0.020764
HELLS helicase, lymphoid-specific -0.0202801
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0202497
MYOF myoferlin -0.0201374
DOCK1 dedicator of cytokinesis 1 -0.0199918
CFAP44 cilia and flagella associated protein 44 -0.0197392
KAZN kazrin, periplakin interacting protein -0.0197386
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0197355
PKP4 plakophilin 4 -0.0193282
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0192885
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0191365
ANLN anillin, actin binding protein -0.0189748
POU5F1 POU class 5 homeobox 1 -0.0187661
LPP LIM domain containing preferred translocation partner in lipoma -0.0186387
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0185892
DOCK3 dedicator of cytokinesis 3 -0.018589
BPTF bromodomain PHD finger transcription factor -0.0184141
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0183895
RRM2 ribonucleotide reductase M2 -0.0183786
SLC38A2 solute carrier family 38, member 2 -0.0183412
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0182879
NF1 neurofibromin 1 -0.0181928
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.0181713
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0181462
ENOSF1 enolase superfamily member 1 -0.0181129