| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | L-Thyroxine (sodium salt pentahydrate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.218909 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.118733 |
| CADM1 | cell adhesion molecule 1 | 0.118079 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0989896 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0764933 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0752118 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0639914 |
| PDE10A | phosphodiesterase 10A | 0.0639193 |
| VEGFA | vascular endothelial growth factor A | 0.0617964 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0588431 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0573831 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0541837 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0510174 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0447447 |
| MYO10 | myosin X | 0.0418387 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0411007 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0405992 |
| VIM | vimentin | 0.0405247 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0365742 |
| ADM | adrenomedullin | 0.03452 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0343647 |
| QKI | QKI, KH domain containing, RNA binding | 0.034309 |
| RPS2 | ribosomal protein S2 | 0.0322673 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.029683 |
| POTEF | POTE ankyrin domain family, member F | 0.0295001 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0292233 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.028996 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0289467 |
| SDC2 | syndecan 2 | 0.0288597 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0288519 |
| MRTFA | myocardin related transcription factor A | 0.0287377 |
| SETD5 | SET domain containing 5 | 0.0285515 |
| CDH13 | cadherin 13 | 0.0283256 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0271401 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0266785 |
| FMNL2 | formin-like 2 | 0.0263894 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0256023 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0255776 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0253348 |
| HDAC9 | histone deacetylase 9 | 0.0252477 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0251895 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0248946 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0248445 |
| FNDC3B | fibronectin type III domain containing 3B | 0.024703 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0244041 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0243712 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0241807 |
| NAV2 | neuron navigator 2 | 0.024079 |
| CCNY | cyclin Y | 0.0239705 |
| FAM13A | family with sequence similarity 13, member A | 0.0238103 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0234513 |
| MTDH | metadherin | 0.0232103 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0229746 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0229087 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.022621 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0226184 |
| TMEM165 | transmembrane protein 165 | 0.0225543 |
| FTL | ferritin, light polypeptide | 0.0223928 |
| OXR1 | oxidation resistance 1 | 0.0222276 |
| ARRDC3 | arrestin domain containing 3 | 0.0221634 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0221528 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0219324 |
| CD109 | CD109 molecule | 0.0217433 |
| MSN | moesin | 0.0216361 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0216015 |
| MEF2A | myocyte enhancer factor 2A | 0.0215772 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0215636 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0214406 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0213968 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0213377 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0211416 |
| FRMD6 | FERM domain containing 6 | 0.0206963 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0205342 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0204969 |
| IER3 | immediate early response 3 | 0.0204556 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0202885 |
| SPAG9 | sperm associated antigen 9 | 0.0201585 |
| HIP1 | huntingtin interacting protein 1 | 0.0200282 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0199405 |
| RYBP | RING1 and YY1 binding protein | 0.0196485 |
| KLF10 | Kruppel-like factor 10 | 0.0196452 |
| FAM162A | family with sequence similarity 162, member A | 0.0194282 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0194106 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0192615 |
| RPL37A | ribosomal protein L37a | 0.0192441 |
| SQSTM1 | sequestosome 1 | 0.0192051 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0191358 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0191054 |
| KIF13A | kinesin family member 13A | 0.0190334 |
| SNX9 | sorting nexin 9 | 0.0190325 |
| IRF1 | interferon regulatory factor 1 | 0.0188762 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0187808 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0186755 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0185894 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0185744 |
| LOX | lysyl oxidase | 0.0185241 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0185064 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0183477 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0182222 |
| PKM | pyruvate kinase, muscle | 0.0181742 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.176275 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.156232 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0810172 |
| HMGA2 | high mobility group AT-hook 2 | -0.0505608 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.048488 |
| STC1 | stanniocalcin 1 | -0.0448902 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0428723 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0415894 |
| TMSB10 | thymosin beta 10 | -0.0415676 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0389154 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0374499 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0357865 |
| RRBP1 | ribosome binding protein 1 | -0.0348208 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.034065 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0335373 |
| CD44 | CD44 molecule (Indian blood group) | -0.0334057 |
| PRELID2 | PRELI domain containing 2 | -0.0332127 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0314308 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0296917 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0278976 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0277296 |
| OSMR | oncostatin M receptor | -0.0265109 |
| COL1A1 | collagen, type I, alpha 1 | -0.0263743 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0258995 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0252793 |
| SMAD3 | SMAD family member 3 | -0.0226719 |
| VCL | vinculin | -0.0221646 |
| ACTN4 | actinin, alpha 4 | -0.0216764 |
| PLSCR1 | phospholipid scramblase 1 | -0.0216297 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0204259 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0201235 |
| RPL35A | ribosomal protein L35a | -0.0197867 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0196814 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0194657 |
| RIGI | RNA sensor RIG-I | -0.0189805 |
| PALLD | palladin, cytoskeletal associated protein | -0.0185198 |
| PLEC | plectin | -0.0184421 |
| FAM20C | family with sequence similarity 20, member C | -0.0179682 |
| CLIC4 | chloride intracellular channel 4 | -0.0179056 |
| LOXL2 | lysyl oxidase-like 2 | -0.0178275 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0178044 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0176761 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0176385 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.017569 |
| NRP1 | neuropilin 1 | -0.0175659 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0164631 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0164578 |
| SRGN | serglycin | -0.0161392 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0159685 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0158351 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0157334 |
| EBF1 | early B-cell factor 1 | -0.0153873 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0152106 |
| IL6 | interleukin 6 | -0.0151191 |
| EGR1 | early growth response 1 | -0.0149798 |
| MX2 | MX dynamin-like GTPase 2 | -0.0148855 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0148044 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0146705 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0146675 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.0145847 |
| INHBA | inhibin, beta A | -0.0145223 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0144175 |
| TUBB | tubulin, beta class I | -0.0141275 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0139403 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0139177 |
| JAK2 | Janus kinase 2 | -0.0138991 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0137065 |
| NABP1 | nucleic acid binding protein 1 | -0.0136762 |
| LIPG | lipase, endothelial | -0.0134371 |
| AHNAK | AHNAK nucleoprotein | -0.0132783 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0130791 |
| RPL19 | ribosomal protein L19 | -0.0129047 |
| GANAB | glucosidase, alpha; neutral AB | -0.0128218 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0124335 |
| POSTN | periostin, osteoblast specific factor | -0.0118944 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0118933 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0118799 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.011845 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0117614 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0115672 |
| AOPEP | aminopeptidase O (putative) | -0.011559 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0114797 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0114252 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0110851 |
| DUSP6 | dual specificity phosphatase 6 | -0.0110624 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.01101 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0108397 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0108391 |
| CFB | complement factor B | -0.0107824 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0106989 |
| COL12A1 | collagen, type XII, alpha 1 | -0.0105986 |
| BSG | basigin (Ok blood group) | -0.0104656 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0104361 |
| TMSB4X | thymosin beta 4, X-linked | -0.0104327 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.010396 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0103512 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0103008 |
| MACROD2 | MACRO domain containing 2 | -0.0102661 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0101995 |
| SMYD3 | SET and MYND domain containing 3 | -0.0101747 |
