| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | L-Thyroxine (sodium salt pentahydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.316793 |
| IGF2 | insulin-like growth factor 2 | 0.21979 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0897634 |
| C3 | complement component 3 | 0.081589 |
| DSPP | dentin sialophosphoprotein | 0.064364 |
| NDRG1 | N-myc downstream regulated 1 | 0.0627908 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0590157 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0557484 |
| VEGFA | vascular endothelial growth factor A | 0.0505105 |
| DTNA | dystrobrevin, alpha | 0.0501351 |
| MT2A | metallothionein 2A | 0.0439539 |
| ENO1 | enolase 1, (alpha) | 0.0432657 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0428002 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0419496 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0409309 |
| AFDN | afadin, adherens junction formation factor | 0.0405038 |
| INSIG2 | insulin induced gene 2 | 0.0392036 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0389257 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0388832 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0381545 |
| FAM13A | family with sequence similarity 13, member A | 0.0376668 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0368639 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0352174 |
| NPTN | neuroplastin | 0.0351359 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0341761 |
| GOLGA4 | golgin A4 | 0.0339026 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.032757 |
| RTN4 | reticulon 4 | 0.0324671 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0324503 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0323159 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0323111 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0319221 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.031171 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0310483 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0303473 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0301396 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0300624 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.029817 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0294716 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0293295 |
| OPTN | optineurin | 0.0283885 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0278799 |
| FBXO42 | F-box protein 42 | 0.0276686 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0274346 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0271741 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0271151 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0264774 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.026119 |
| NBAS | neuroblastoma amplified sequence | 0.0257465 |
| NKTR | natural killer cell triggering receptor | 0.0256457 |
| KIAA1217 | KIAA1217 | 0.0243825 |
| HELZ | helicase with zinc finger | 0.024255 |
| SETD5 | SET domain containing 5 | 0.023873 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | 0.0235884 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0235422 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0233718 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0232616 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0228124 |
| NGLY1 | N-glycanase 1 | 0.022805 |
| RPL3 | ribosomal protein L3 | 0.0227671 |
| CPE | carboxypeptidase E | 0.022579 |
| SPAG9 | sperm associated antigen 9 | 0.022333 |
| KIF1B | kinesin family member 1B | 0.022068 |
| ZNF292 | zinc finger protein 292 | 0.0220389 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0220186 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.021756 |
| TNS1 | tensin 1 | 0.0214259 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0211761 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0211027 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0210993 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0209216 |
| WDR45B | WD repeat domain 45B | 0.0209008 |
| SMAD5 | SMAD family member 5 | 0.0206468 |
| TPR | translocated promoter region, nuclear basket protein | 0.0204707 |
| SEPTIN2 | septin 2 | 0.0204639 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0203979 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.020325 |
| PER2 | period circadian clock 2 | 0.0201881 |
| LDHA | lactate dehydrogenase A | 0.0200332 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0200191 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0198307 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.019798 |
| ARFGEF3 | ARFGEF family member 3 | 0.0197916 |
| MYO1B | myosin IB | 0.0197034 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0196284 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0195313 |
| PCM1 | pericentriolar material 1 | 0.0194105 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0191722 |
| USP47 | ubiquitin specific peptidase 47 | 0.0190864 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.0189416 |
| MATR3 | matrin 3 | 0.0188446 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0188232 |
| RAB6A | RAB6A, member RAS oncogene family | 0.018369 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0182296 |
| RBM39 | RNA binding motif protein 39 | 0.0181003 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0180297 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0180213 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0176736 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0176648 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0176099 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EHBP1 | EH domain binding protein 1 | -0.133834 |
| SLC38A2 | solute carrier family 38, member 2 | -0.121156 |
| GPC6 | glypican 6 | -0.104144 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0980172 |
| GPC3 | glypican 3 | -0.0820885 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0763809 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0761422 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0744848 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0744155 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0740399 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0732829 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0710218 |
| FN1 | fibronectin 1 | -0.0670047 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0618316 |
| INTS6 | integrator complex subunit 6 | -0.0617324 |
| RPS24 | ribosomal protein S24 | -0.0614568 |
| RNF213 | ring finger protein 213 | -0.061124 |
| CP | ceruloplasmin (ferroxidase) | -0.0606268 |
| PTCHD4 | patched domain containing 4 | -0.0561029 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0532443 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0518335 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0501996 |
| PEG3 | paternally expressed 3 | -0.0499698 |
| APOA2 | apolipoprotein A-II | -0.0489173 |
| FOXP1 | forkhead box P1 | -0.0476951 |
| ATXN1 | ataxin 1 | -0.0475189 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0459811 |
| EGR1 | early growth response 1 | -0.0444079 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0440554 |
| SDC4 | syndecan 4 | -0.043158 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0424734 |
| GNAS | GNAS complex locus | -0.0412315 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0410263 |
| GK | glycerol kinase | -0.0409512 |
| KLF6 | Kruppel-like factor 6 | -0.0407669 |
| TMSB10 | thymosin beta 10 | -0.0407571 |
| PRKCA | protein kinase C, alpha | -0.040566 |
| RPL35A | ribosomal protein L35a | -0.0405137 |
| FRMD5 | FERM domain containing 5 | -0.0402404 |
| AHSG | alpha-2-HS-glycoprotein | -0.0395456 |
| RIGI | RNA sensor RIG-I | -0.0395007 |
| FMNL2 | formin-like 2 | -0.0375187 |
| CNKSR3 | CNKSR family member 3 | -0.037473 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0368772 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0368605 |
| PARD3 | par-3 family cell polarity regulator | -0.0361087 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.03605 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0356036 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0355165 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0349871 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0349526 |
| RPL34 | ribosomal protein L34 | -0.0345779 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0344707 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.034215 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0341173 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0340006 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0330868 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0328581 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0325283 |
| IER3 | immediate early response 3 | -0.0324916 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0317481 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0317087 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0316705 |
| VCL | vinculin | -0.0312758 |
| MYO1E | myosin IE | -0.0312684 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0308899 |
| RPS21 | ribosomal protein S21 | -0.0307979 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0307808 |
| SP100 | SP100 nuclear antigen | -0.0307482 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0305515 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0305199 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0303361 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0300905 |
| ZFHX3 | zinc finger homeobox 3 | -0.0289045 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.028699 |
| APOB | apolipoprotein B | -0.0286694 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0283893 |
| STK17A | serine/threonine kinase 17a | -0.0283797 |
| MCL1 | myeloid cell leukemia 1 | -0.0281182 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0277718 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0277197 |
| MSI2 | musashi RNA-binding protein 2 | -0.0276717 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0272617 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0271743 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0268356 |
| LYZ | lysozyme | -0.0267368 |
| FILIP1L | filamin A interacting protein 1-like | -0.0267149 |
| RPL23 | ribosomal protein L23 | -0.0266631 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0263635 |
| A2M | alpha-2-macroglobulin | -0.026243 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0258265 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0251721 |
| NPR2 | natriuretic peptide receptor 2 | -0.0247606 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0246413 |
| RPS19 | ribosomal protein S19 | -0.0245106 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0244855 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0243343 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.024216 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0241892 |
| HMGA2 | high mobility group AT-hook 2 | -0.0236486 |
