| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | L-Thyroxine (sodium salt pentahydrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.13864 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.130701 |
| EGFR | epidermal growth factor receptor | 0.12545 |
| FNDC3B | fibronectin type III domain containing 3B | 0.117661 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.114465 |
| MCL1 | myeloid cell leukemia 1 | 0.0917377 |
| LAMC2 | laminin, gamma 2 | 0.0875608 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0874964 |
| MT2A | metallothionein 2A | 0.0864131 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0811468 |
| MSN | moesin | 0.0701476 |
| SLTM | SAFB-like, transcription modulator | 0.0664867 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0627816 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0620256 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0609733 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0605516 |
| STC1 | stanniocalcin 1 | 0.0605291 |
| FAM13A | family with sequence similarity 13, member A | 0.0601554 |
| CAV2 | caveolin 2 | 0.059044 |
| NDRG1 | N-myc downstream regulated 1 | 0.0581292 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0576577 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0540197 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.053999 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0529335 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0494518 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0493877 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0493559 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0486623 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0477797 |
| SMAD3 | SMAD family member 3 | 0.046892 |
| RPS2 | ribosomal protein S2 | 0.0463413 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0457933 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0452914 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0424179 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0422581 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0420887 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0411281 |
| GOLGA4 | golgin A4 | 0.0405656 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0401142 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0400443 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0396517 |
| RPL37A | ribosomal protein L37a | 0.0387571 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0387001 |
| DTNA | dystrobrevin, alpha | 0.0383548 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0381427 |
| GRAMD1B | GRAM domain containing 1B | 0.0374308 |
| RPS6 | ribosomal protein S6 | 0.0371956 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0370762 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0368776 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0366397 |
| PDE8A | phosphodiesterase 8A | 0.0364707 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0361902 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0355132 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0351274 |
| CDCP1 | CUB domain containing protein 1 | 0.0344181 |
| RPS3 | ribosomal protein S3 | 0.0338215 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0332315 |
| INTS6 | integrator complex subunit 6 | 0.0328898 |
| TPM3 | tropomyosin 3 | 0.0317947 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0312266 |
| PYGL | phosphorylase, glycogen, liver | 0.0305964 |
| ANKRD37 | ankyrin repeat domain 37 | 0.0305589 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0301253 |
| RPLP1 | ribosomal protein, large, P1 | 0.0299892 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0295788 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0295409 |
| ITSN2 | intersectin 2 | 0.0291948 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0289451 |
| PLS3 | plastin 3 | 0.0284319 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0284095 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0280551 |
| ENO1 | enolase 1, (alpha) | 0.0277185 |
| SLK | STE20-like kinase | 0.0274604 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0273195 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0272106 |
| DSPP | dentin sialophosphoprotein | 0.0265868 |
| GPHN | gephyrin | 0.0265497 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0263432 |
| POTEF | POTE ankyrin domain family, member F | 0.0263059 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0261618 |
| ACTN1 | actinin, alpha 1 | 0.0261314 |
| FNIP1 | folliculin interacting protein 1 | 0.0257983 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.02567 |
| TPM4 | tropomyosin 4 | 0.0254999 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0252887 |
| CPE | carboxypeptidase E | 0.0248906 |
| RPL7 | ribosomal protein L7 | 0.0248428 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.024782 |
| RNF149 | ring finger protein 149 | 0.0246355 |
| SEC61G | Sec61 gamma subunit | 0.0245652 |
| RPS12 | ribosomal protein S12 | 0.0244688 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0244069 |
| KMT5B | lysine methyltransferase 5B | 0.0241587 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0241184 |
| SNX9 | sorting nexin 9 | 0.0240712 |
| SUMF1 | sulfatase modifying factor 1 | 0.023697 |
| MYO1E | myosin IE | 0.0234687 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0234163 |
| RPS17 | ribosomal protein S17 | 0.0233805 |
| SCEL | sciellin | 0.0232875 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.346327 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.169888 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.098902 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0985022 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0843911 |
| OSMR | oncostatin M receptor | -0.0826607 |
| CES1 | carboxylesterase 1 | -0.0799741 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0679648 |
| AHNAK | AHNAK nucleoprotein | -0.0661735 |
| UBC | ubiquitin C | -0.0634459 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0618229 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0595138 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0590724 |
| HDLBP | high density lipoprotein binding protein | -0.0566055 |
| H1-0 | H1.0 linker histone | -0.0560427 |
| ABLIM1 | actin binding LIM protein 1 | -0.0547076 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0522771 |
| TES | testin LIM domain protein | -0.0518562 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0517801 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0510623 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0493506 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0490226 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0485466 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0483067 |
| GM2A | GM2 ganglioside activator | -0.0477593 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0474054 |
| CANX | calnexin | -0.0461477 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0458848 |
| ANXA2 | annexin A2 | -0.0444193 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0441305 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0430884 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0430668 |
| LMO7 | LIM domain 7 | -0.0421352 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0417113 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0416282 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0408177 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0401688 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0387731 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0387564 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0383469 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0380457 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0357153 |
| MGAT4C | MGAT4 family, member C | -0.0354153 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0353877 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0341318 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.033048 |
| LAMA4 | laminin, alpha 4 | -0.032125 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0309825 |
| SMIM14 | small integral membrane protein 14 | -0.0307902 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0303333 |
| PGK1 | phosphoglycerate kinase 1 | -0.029986 |
| RNF169 | ring finger protein 169 | -0.0296952 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0296223 |
| EMP1 | epithelial membrane protein 1 | -0.0296096 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0296038 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0293128 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0291913 |
| MYO6 | myosin VI | -0.0290039 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0287552 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0278902 |
| TKT | transketolase | -0.0273718 |
| ECT2 | epithelial cell transforming 2 | -0.0273391 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0273175 |
| ARF1 | ADP-ribosylation factor 1 | -0.0270634 |
| FRMD4B | FERM domain containing 4B | -0.027026 |
| TOP1 | topoisomerase (DNA) I | -0.0270118 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0269217 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0267216 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0267142 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0265608 |
| TAOK1 | TAO kinase 1 | -0.0265394 |
| MKI67 | marker of proliferation Ki-67 | -0.0265354 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0263451 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0261883 |
| EXOC6B | exocyst complex component 6B | -0.0256036 |
| OGA | O-GlcNAcase | -0.0254996 |
| EFNA5 | ephrin-A5 | -0.0254157 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0253879 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0252031 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0249567 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.0247985 |
| WDR45B | WD repeat domain 45B | -0.0247423 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0246354 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0245451 |
| YTHDC1 | YTH domain containing 1 | -0.0242416 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0242113 |
| HBP1 | HMG-box transcription factor 1 | -0.0241531 |
| CCND1 | cyclin D1 | -0.0240613 |
| NF1 | neurofibromin 1 | -0.0239105 |
| FRY | furry homolog (Drosophila) | -0.0239023 |
| TRIM56 | tripartite motif containing 56 | -0.0238343 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0237813 |
| UBAP1 | ubiquitin associated protein 1 | -0.0237051 |
| HLA-B | major histocompatibility complex, class I, B | -0.023434 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0233339 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.023309 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0232063 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0231607 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0230489 |
| ASPH | aspartate beta-hydroxylase | -0.0230213 |
