L-Thyroxine (sodium salt pentahydrate)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Thyroxine (sodium salt pentahydrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.284046
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.132629
ELL2 elongation factor, RNA polymerase II, 2 0.127523
AKAP12 A kinase (PRKA) anchor protein 12 0.12201
FAM107B family with sequence similarity 107, member B 0.0846909
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.073945
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0707575
BCAR3 breast cancer anti-estrogen resistance 3 0.0694755
DOCK4 dedicator of cytokinesis 4 0.0691307
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0688685
FLNB filamin B, beta 0.0686081
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.067762
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0664597
WAC WW domain containing adaptor with coiled-coil 0.0656292
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0655622
FMNL2 formin-like 2 0.0611912
MCL1 myeloid cell leukemia 1 0.0570023
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0556942
UGCG UDP-glucose ceramide glucosyltransferase 0.0555067
VEZT vezatin, adherens junctions transmembrane protein 0.0518708
OSMR oncostatin M receptor 0.0515628
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0502168
LAMC2 laminin, gamma 2 0.0495097
COPA coatomer protein complex, subunit alpha 0.0481919
IGFBP3 insulin-like growth factor binding protein 3 0.047449
ERRFI1 ERBB receptor feedback inhibitor 1 0.0461967
PRRC2C proline-rich coiled-coil 2C 0.0459781
ACTN1 actinin, alpha 1 0.045961
TRIO trio Rho guanine nucleotide exchange factor 0.0457353
RBM39 RNA binding motif protein 39 0.044685
SMOC1 SPARC related modular calcium binding 1 0.0430532
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0429482
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0424558
ITGB5 integrin, beta 5 0.0406663
PYGL phosphorylase, glycogen, liver 0.040665
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0400813
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0400116
PLS3 plastin 3 0.0397487
NPC1 Niemann-Pick disease, type C1 0.0396497
THSD4 thrombospondin, type I, domain containing 4 0.0391382
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0385236
ZFAND3 zinc finger, AN1-type domain 3 0.0385178
EXT1 exostosin glycosyltransferase 1 0.0375486
NEMF nuclear export mediator factor 0.0365657
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0365303
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.036279
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0362712
NPEPPS aminopeptidase puromycin sensitive 0.0359382
FNDC3B fibronectin type III domain containing 3B 0.035461
APP amyloid beta (A4) precursor protein 0.0351548
ITCH itchy E3 ubiquitin protein ligase 0.0351099
HLA-B major histocompatibility complex, class I, B 0.035093
NOP58 NOP58 ribonucleoprotein 0.0348345
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0347442
KMT2C lysine (K)-specific methyltransferase 2C 0.034425
STC1 stanniocalcin 1 0.0341164
AKAP13 A kinase (PRKA) anchor protein 13 0.0340005
FGD6 FYVE, RhoGEF and PH domain containing 6 0.033915
CSNK1E casein kinase 1, epsilon 0.0338587
GOLGA4 golgin A4 0.0338352
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0337979
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0325332
PUM1 pumilio RNA-binding family member 1 0.0320809
PUM2 pumilio RNA-binding family member 2 0.03125
RBM25 RNA binding motif protein 25 0.0312425
CSNK1A1 casein kinase 1, alpha 1 0.0312069
RAB7A RAB7A, member RAS oncogene family 0.0310199
TJP1 tight junction protein 1 0.0309767
CHD1 chromodomain helicase DNA binding protein 1 0.0309166
FNBP1L formin binding protein 1-like 0.0306985
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0304359
TRA2A transformer 2 alpha homolog (Drosophila) 0.0302515
CDCP1 CUB domain containing protein 1 0.0299165
PTPRM protein tyrosine phosphatase, receptor type, M 0.0293282
STRN3 striatin, calmodulin binding protein 3 0.0292447
UBASH3B ubiquitin associated and SH3 domain containing B 0.0289546
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0289337
SAMD4A sterile alpha motif domain containing 4A 0.0286539
ITSN2 intersectin 2 0.0284956
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0277841
PARD3 par-3 family cell polarity regulator 0.0274853
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0274512
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0271286
DENND5A DENN/MADD domain containing 5A 0.0270081
USP36 ubiquitin specific peptidase 36 0.0269796
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0265946
IGF2 insulin-like growth factor 2 0.0263846
VMP1 vacuole membrane protein 1 0.026269
KDM5B lysine (K)-specific demethylase 5B 0.0261104
RAP1B RAP1B, member of RAS oncogene family 0.0260416
KLF6 Kruppel-like factor 6 0.0259306
USP53 ubiquitin specific peptidase 53 0.0259243
SLMAP sarcolemma associated protein 0.025578
ZC3H11A zinc finger CCCH-type containing 11A 0.0255719
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0253708
CASC3 cancer susceptibility candidate 3 0.025243
MACF1 microtubule-actin crosslinking factor 1 0.0250977
EEF2 eukaryotic translation elongation factor 2 0.0249519
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0249241
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0248027

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.118532
TFPI2 tissue factor pathway inhibitor 2 -0.104812
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100683
RPL19 ribosomal protein L19 -0.0884787
PTMA prothymosin, alpha -0.0834957
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.080111
PDE4D phosphodiesterase 4D, cAMP-specific -0.077276
DENND4A DENN/MADD domain containing 4A -0.0699586
VIM vimentin -0.0626495
ASPH aspartate beta-hydroxylase -0.0613343
USP34 ubiquitin specific peptidase 34 -0.0563123
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0545329
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0527772
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0488621
FGB fibrinogen beta chain -0.047141
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0438625
LRPPRC leucine-rich pentatricopeptide repeat containing -0.04197
FTL ferritin, light polypeptide -0.040669
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0406372
RPL4 ribosomal protein L4 -0.0394832
TM4SF1 transmembrane 4 L six family member 1 -0.0392244
RPL23 ribosomal protein L23 -0.0391167
CAMTA1 calmodulin binding transcription activator 1 -0.0384528
PM20D1 peptidase M20 domain containing 1 -0.0384272
TBC1D5 TBC1 domain family, member 5 -0.0375329
WWOX WW domain containing oxidoreductase -0.0362485
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0343947
CANX calnexin -0.034158
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0340666
RPS25 ribosomal protein S25 -0.0334975
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0332551
BICC1 BicC family RNA binding protein 1 -0.0330886
RPS8 ribosomal protein S8 -0.0329797
RAD21 RAD21 homolog (S. pombe) -0.0321053
SLC38A2 solute carrier family 38, member 2 -0.0311942
RPS2 ribosomal protein S2 -0.0292452
NEGR1 neuronal growth regulator 1 -0.029128
ADGRG6 adhesion G protein-coupled receptor G6 -0.0289603
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0289257
RPL8 ribosomal protein L8 -0.0288772
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0282797
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0282176
NHSL1 NHS-like 1 -0.0277879
RPL7 ribosomal protein L7 -0.0276948
NFIA nuclear factor I/A -0.0276793
SPIDR scaffolding protein involved in DNA repair -0.0268309
RPS27A ribosomal protein S27a -0.0264198
RPL35A ribosomal protein L35a -0.0262259
KANSL1L KAT8 regulatory NSL complex subunit 1-like -0.0261566
NAMPT nicotinamide phosphoribosyltransferase -0.0260889
RPS11 ribosomal protein S11 -0.025658
RPS21 ribosomal protein S21 -0.0252414
LDHB lactate dehydrogenase B -0.0250778
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0250001
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0248418
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0246265
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0245496
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0244421
CDK6 cyclin-dependent kinase 6 -0.0243772
RAB10 RAB10, member RAS oncogene family -0.0243388
RPS23 ribosomal protein S23 -0.0240872
RPS12 ribosomal protein S12 -0.0238517
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.023634
RPS5 ribosomal protein S5 -0.0236229
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0235939
NRDC nardilysin convertase -0.0235872
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0235866
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0233995
BPTF bromodomain PHD finger transcription factor -0.0233489
YBX1 Y box binding protein 1 -0.0232311
CYRIB CYFIP related Rac1 interactor B -0.023149
ANKRD28 ankyrin repeat domain 28 -0.0230763
MYOF myoferlin -0.0230158
RTN4 reticulon 4 -0.0228238
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0226899
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0226329
CPNE1 copine I -0.0225675
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0222161
SSB Sjogren syndrome antigen B (autoantigen La) -0.0221339
CBX5 chromobox homolog 5 -0.0219762
RAD51B RAD51 paralog B -0.0219732
LPP LIM domain containing preferred translocation partner in lipoma -0.021881
MEMO1 mediator of cell motility 1 -0.0218193
R3HDM1 R3H domain containing 1 -0.0217226
FAM168A family with sequence similarity 168, member A -0.0213716
ATP5F1B ATP synthase F1 subunit beta -0.0211717
RRM2 ribonucleotide reductase M2 -0.0211068
CCNG2 cyclin G2 -0.0210163
UTRN utrophin -0.0208252
INTS6 integrator complex subunit 6 -0.0207815
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0207159
GRAMD1B GRAM domain containing 1B -0.0207152
RPL9 ribosomal protein L9 -0.0206089
MIS18BP1 MIS18 binding protein 1 -0.0205584
RPS3 ribosomal protein S3 -0.0204867
CCDC88A coiled-coil domain containing 88A -0.0204521
DST dystonin -0.0203681
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0202644
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0202074
CCL5 chemokine (C-C motif) ligand 5 -0.0201334