| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | L-Thyroxine (sodium salt pentahydrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.159109 |
| DSCAM | Down syndrome cell adhesion molecule | 0.138469 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.126542 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.102665 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0982207 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0942189 |
| PTMA | prothymosin, alpha | 0.0883047 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0875562 |
| RIGI | RNA sensor RIG-I | 0.0844525 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0820887 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0798171 |
| KYNU | kynureninase | 0.0796168 |
| ZNF292 | zinc finger protein 292 | 0.0781155 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0770613 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0744081 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0740683 |
| NDRG1 | N-myc downstream regulated 1 | 0.0731839 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.0699405 |
| TOP1 | topoisomerase (DNA) I | 0.0660363 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0650927 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0643876 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0616769 |
| LMO7 | LIM domain 7 | 0.0612472 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0607803 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0585407 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0552824 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0545775 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0534745 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.052867 |
| SGMS2 | sphingomyelin synthase 2 | 0.051756 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0487686 |
| APP | amyloid beta (A4) precursor protein | 0.0484286 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0474198 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0472299 |
| B3GALNT2 | beta-1,3-N-acetylgalactosaminyltransferase 2 | 0.0468736 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0464068 |
| TXNRD1 | thioredoxin reductase 1 | 0.0461969 |
| NPTN | neuroplastin | 0.0459316 |
| B2M | beta-2-microglobulin | 0.04564 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0455651 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0453528 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0449928 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0444256 |
| PTK2 | protein tyrosine kinase 2 | 0.0435585 |
| OXSR1 | oxidative stress responsive 1 | 0.0435567 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0433379 |
| WWC1 | WW and C2 domain containing 1 | 0.0431361 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0429968 |
| CSTB | cystatin B (stefin B) | 0.0429639 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0427794 |
| COLEC11 | collectin sub-family member 11 | 0.041619 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0407603 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0401853 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0399675 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0395719 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0394479 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0390787 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0388106 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0384091 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0383997 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0383156 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0382305 |
| PUM2 | pumilio RNA-binding family member 2 | 0.03813 |
| RAB8B | RAB8B, member RAS oncogene family | 0.03784 |
| SPNS2 | spinster homolog 2 (Drosophila) | 0.0375888 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0375706 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0370092 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0367683 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0362599 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0362008 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0359402 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0358287 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0356886 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0355731 |
| PDE10A | phosphodiesterase 10A | 0.0353758 |
| IFI44 | interferon-induced protein 44 | 0.0351588 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0346831 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0345776 |
| FTL | ferritin, light polypeptide | 0.0342252 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0340566 |
| RPL37 | ribosomal protein L37 | 0.0339859 |
| UBC | ubiquitin C | 0.0337506 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.033296 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.033281 |
| QKI | QKI, KH domain containing, RNA binding | 0.0328476 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.03281 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0327097 |
| NCKAP1 | NCK-associated protein 1 | 0.0324835 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0321871 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.032054 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0315793 |
| OFD1 | oral-facial-digital syndrome 1 | 0.0315256 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.031395 |
| TXNIP | thioredoxin interacting protein | 0.0312387 |
| JMJD1C | jumonji domain containing 1C | 0.0312362 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0311733 |
| OGA | O-GlcNAcase | 0.0311346 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0311073 |
| RNF103-CHMP3 | RNF103-CHMP3 readthrough | 0.0310105 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0309694 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.180156 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.149047 |
| COL6A3 | collagen, type VI, alpha 3 | -0.115163 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0950435 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0942923 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.093186 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0931614 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0902748 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0831978 |
| MMP1 | matrix metallopeptidase 1 | -0.0826772 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0821778 |
| ASPH | aspartate beta-hydroxylase | -0.0818083 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0805515 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0783841 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0725284 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0714633 |
| RUNX1 | runt-related transcription factor 1 | -0.0691136 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0685266 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0684651 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0672539 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0666743 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0661138 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0651744 |
| RBM47 | RNA binding motif protein 47 | -0.0649056 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0623385 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0620642 |
| AHNAK | AHNAK nucleoprotein | -0.0599862 |
| FRMD5 | FERM domain containing 5 | -0.0596347 |
| VMP1 | vacuole membrane protein 1 | -0.0591683 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0583181 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0567823 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0567703 |
| HOMER1 | homer scaffolding protein 1 | -0.0562242 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0561149 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0557751 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0548195 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.054379 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0533042 |
| HMGA2 | high mobility group AT-hook 2 | -0.0528785 |
| HPCAL1 | hippocalcin-like 1 | -0.0527631 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0523237 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0520015 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0519774 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0518196 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0515142 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.050671 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0490842 |
| CA12 | carbonic anhydrase XII | -0.0488503 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0487791 |
| MUC16 | mucin 16, cell surface associated | -0.0484072 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0482764 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0481386 |
| FN1 | fibronectin 1 | -0.0463098 |
| EFNA5 | ephrin-A5 | -0.0461459 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | -0.0461458 |
| RAB31 | RAB31, member RAS oncogene family | -0.0461172 |
| GLIS3 | GLIS family zinc finger 3 | -0.0454371 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0454245 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0454038 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0448287 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0447469 |
| SEPTIN10 | septin 10 | -0.043897 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.043855 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0432312 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0428063 |
| CD44 | CD44 molecule (Indian blood group) | -0.0427316 |
| MYO1E | myosin IE | -0.0424035 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0423784 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0423035 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0422718 |
| ACTG1 | actin gamma 1 | -0.0420258 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0419824 |
| TPR | translocated promoter region, nuclear basket protein | -0.0419418 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0415717 |
| HDLBP | high density lipoprotein binding protein | -0.0413723 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0413326 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0413144 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0412729 |
| DIAPH2 | diaphanous-related formin 2 | -0.0411631 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0406262 |
| FLNB | filamin B, beta | -0.0401657 |
| RASA2 | RAS p21 protein activator 2 | -0.0395175 |
| CUX1 | cut-like homeobox 1 | -0.03945 |
| CYTH1 | cytohesin 1 | -0.0379278 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0376809 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0374703 |
| SBF2 | SET binding factor 2 | -0.0366821 |
| INTS6 | integrator complex subunit 6 | -0.036467 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0358309 |
| NABP1 | nucleic acid binding protein 1 | -0.0349487 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0348952 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0345419 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.034515 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0341859 |
| CCNY | cyclin Y | -0.0340331 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0334128 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0333517 |
| TPM4 | tropomyosin 4 | -0.0327316 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0324288 |
| MAP4 | microtubule-associated protein 4 | -0.0323995 |
