L-Thyroxine (sodium salt pentahydrate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Thyroxine (sodium salt pentahydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.100612
ASPH aspartate beta-hydroxylase 0.0776236
NEK7 NIMA-related kinase 7 0.0611185
PDLIM5 PDZ and LIM domain 5 0.059484
COL8A1 collagen, type VIII, alpha 1 0.0591261
GDA guanine deaminase 0.0584993
COL5A2 collagen, type V, alpha 2 0.0563477
ZEB2 zinc finger E-box binding homeobox 2 0.0495159
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0475703
PM20D1 peptidase M20 domain containing 1 0.0455899
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0401939
GRAMD1B GRAM domain containing 1B 0.0377069
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0355024
TXNRD1 thioredoxin reductase 1 0.0337168
BCAR3 breast cancer anti-estrogen resistance 3 0.0326779
RPS2 ribosomal protein S2 0.0318567
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0314177
CD109 CD109 molecule 0.0313668
CENPF centromere protein F, 350/400kDa 0.0312119
PSD3 pleckstrin and Sec7 domain containing 3 0.0292993
TMX4 thioredoxin-related transmembrane protein 4 0.0289305
EFNA5 ephrin-A5 0.0284252
CTSC cathepsin C 0.0281975
ARHGAP29 Rho GTPase activating protein 29 0.0273795
PDE4D phosphodiesterase 4D, cAMP-specific 0.0258929
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0254877
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0251979
RAB3B RAB3B, member RAS oncogene family 0.0249139
KYNU kynureninase 0.0248877
GPRIN3 GPRIN family member 3 0.0248118
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0246426
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0243906
SPAG9 sperm associated antigen 9 0.0242788
MFF mitochondrial fission factor 0.023925
PUM2 pumilio RNA-binding family member 2 0.023375
TGFBR1 transforming growth factor, beta receptor 1 0.0231118
ENAH enabled homolog (Drosophila) 0.022861
DISP1 dispatched homolog 1 (Drosophila) 0.0227293
AGFG1 ArfGAP with FG repeats 1 0.0220857
DOCK4 dedicator of cytokinesis 4 0.0219827
SLF1 SMC5-SMC6 complex localization factor 1 0.0212253
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0212138
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0211599
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0210462
RTN4 reticulon 4 0.0202103
NRCAM neuronal cell adhesion molecule 0.0198147
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0197713
PTEN phosphatase and tensin homolog 0.0195659
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0194362
COL4A5 collagen, type IV, alpha 5 0.0193492
MKI67 marker of proliferation Ki-67 0.0192031
ITPRID2 ITPR interacting domain containing 2 0.0190519
MSN moesin 0.0190218
ATP13A3 ATPase type 13A3 0.0187941
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0184568
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0184005
HSPA8 heat shock 70kDa protein 8 0.0182898
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.017989
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0178553
TPM3 tropomyosin 3 0.0177373
CDK17 cyclin-dependent kinase 17 0.0177017
ANKRD28 ankyrin repeat domain 28 0.017203
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0169047
ZEB1 zinc finger E-box binding homeobox 1 0.016436
TGFB2 transforming growth factor, beta 2 0.0160806
CSNK1A1 casein kinase 1, alpha 1 0.0160221
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0159741
HEATR1 HEAT repeat containing 1 0.0158199
SRPK2 SRSF protein kinase 2 0.0156879
TNPO1 transportin 1 0.0154755
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0154662
ANKRD36 ankyrin repeat domain 36 0.0153316
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0153011
ZFC3H1 zinc finger, C3H1-type containing 0.01508
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0150738
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0150534
CCDC68 coiled-coil domain containing 68 0.0150454
BMP6 bone morphogenetic protein 6 0.0150242
NRIP1 nuclear receptor interacting protein 1 0.0149771
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0148294
DIAPH3 diaphanous-related formin 3 0.0147721
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0146295
NCKAP1 NCK-associated protein 1 0.014569
FNDC3B fibronectin type III domain containing 3B 0.0144251
RNF145 ring finger protein 145 0.0144246
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0144205
ATAD1 ATPase family, AAA domain containing 1 0.0142107
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0141729
CLTC clathrin, heavy chain (Hc) 0.0140574
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0139666
SP3 Sp3 transcription factor 0.0139216
CKAP5 cytoskeleton associated protein 5 0.0136886
MARCHF7 membrane associated ring-CH-type finger 7 0.0136353
SRPK1 SRSF protein kinase 1 0.0135228
AVL9 AVL9 homolog (S. cerevisiase) 0.0135202
RASA2 RAS p21 protein activator 2 0.0134706
CARD16 caspase recruitment domain family, member 16 0.0132695
RTN1 reticulon 1 0.0132356
PDE4B phosphodiesterase 4B, cAMP-specific 0.0131436
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0130817

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.230164
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.207814
VIM vimentin -0.177122
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.165891
FN1 fibronectin 1 -0.136612
TMSB10 thymosin beta 10 -0.136122
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.101275
RPLP1 ribosomal protein, large, P1 -0.0983177
FTL ferritin, light polypeptide -0.0871732
RPS6 ribosomal protein S6 -0.0816425
RPL35A ribosomal protein L35a -0.081493
IGFBP3 insulin-like growth factor binding protein 3 -0.0775884
PTMA prothymosin, alpha -0.069939
TPT1 tumor protein, translationally-controlled 1 -0.0698259
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0586094
RPS19 ribosomal protein S19 -0.0583134
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0556172
RPS23 ribosomal protein S23 -0.0550815
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0545265
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0527697
RPS24 ribosomal protein S24 -0.0513151
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0504191
RPL19 ribosomal protein L19 -0.0497242
RPL34 ribosomal protein L34 -0.0496154
RPL12 ribosomal protein L12 -0.0493392
RPL23 ribosomal protein L23 -0.0489363
MT2A metallothionein 2A -0.0478885
CXCL8 chemokine (C-X-C motif) ligand 8 -0.046892
RPL31 ribosomal protein L31 -0.0467632
RPS8 ribosomal protein S8 -0.0463033
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0458014
CDH13 cadherin 13 -0.0454753
RPLP0 ribosomal protein, large, P0 -0.0446326
RPS4X ribosomal protein S4, X-linked -0.0424442
RPL37A ribosomal protein L37a -0.0423388
HLA-A major histocompatibility complex, class I, A -0.0419534
S100A6 S100 calcium binding protein A6 -0.0416041
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0414582
RPL26 ribosomal protein L26 -0.0398176
EIF1 eukaryotic translation initiation factor 1 -0.0393924
RPS27 ribosomal protein S27 -0.0389282
RPS29 ribosomal protein S29 -0.0382692
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0376454
CANX calnexin -0.0372387
RPL7A ribosomal protein L7a -0.0366597
S100A10 S100 calcium binding protein A10 -0.0365676
HLA-B major histocompatibility complex, class I, B -0.0364985
SQSTM1 sequestosome 1 -0.0358822
RPL37 ribosomal protein L37 -0.035363
AUTS2 autism susceptibility candidate 2 -0.034787
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0346613
NDRG1 N-myc downstream regulated 1 -0.0344893
PDIA3 protein disulfide isomerase family A, member 3 -0.0342672
IL6 interleukin 6 -0.0341918
RPS14 ribosomal protein S14 -0.0341722
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0339198
RPL36A ribosomal protein L36a -0.0332749
BASP1 brain abundant, membrane attached signal protein 1 -0.0331379
RPL35 ribosomal protein L35 -0.0330503
RPS21 ribosomal protein S21 -0.0319252
FTH1 ferritin, heavy polypeptide 1 -0.0318396
B2M beta-2-microglobulin -0.0317001
IER3 immediate early response 3 -0.0316962
SLC38A2 solute carrier family 38, member 2 -0.0313979
RPLP2 ribosomal protein, large, P2 -0.0309379
EEF2 eukaryotic translation elongation factor 2 -0.03092
ACTG1 actin gamma 1 -0.0305933
GNAS GNAS complex locus -0.0305849
SOX4 SRY (sex determining region Y)-box 4 -0.0300454
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0300056
PGK1 phosphoglycerate kinase 1 -0.0298195
NPAS2 neuronal PAS domain protein 2 -0.0297931
DENND1A DENN/MADD domain containing 1A -0.0295268
RPL9 ribosomal protein L9 -0.0291378
RPL36 ribosomal protein L36 -0.0290736
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0290154
RPS16 ribosomal protein S16 -0.0290013
RPL28 ribosomal protein L28 -0.0289431
LMNA lamin A/C -0.0288927
EGR1 early growth response 1 -0.0286243
RPL13A ribosomal protein L13a -0.0283803
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0281631
NAP1L1 nucleosome assembly protein 1-like 1 -0.0272205
RPS25 ribosomal protein S25 -0.0271991
RPS27A ribosomal protein S27a -0.0269506
RPL27A ribosomal protein L27a -0.0268118
RPL11 ribosomal protein L11 -0.0261567
AGTPBP1 ATP/GTP binding protein 1 -0.0250965
WSB1 WD repeat and SOCS box containing 1 -0.0248911
RPL32 ribosomal protein L32 -0.0244693
LOC102724023 ES1 protein homolog, mitochondrial -0.0241944
RPS11 ribosomal protein S11 -0.0240778
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0238395
TFPI2 tissue factor pathway inhibitor 2 -0.0238241
MORF4L2 mortality factor 4 like 2 -0.0236794
CTBP2 C-terminal binding protein 2 -0.0235761
LMAN1 lectin, mannose-binding, 1 -0.0235643
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0234993
RPS20 ribosomal protein S20 -0.0231728
NRXN3 neurexin 3 -0.0229044