| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | L-Thyroxine (sodium salt pentahydrate) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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168 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.338089 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.173839 |
| RPS3 | ribosomal protein S3 | 0.160811 |
| EGFR | epidermal growth factor receptor | 0.12488 |
| SLTM | SAFB-like, transcription modulator | 0.123147 |
| JMJD1C | jumonji domain containing 1C | 0.113421 |
| KIZ | kizuna centrosomal protein | 0.11207 |
| YAP1 | Yes-associated protein 1 | 0.111996 |
| IGF2 | insulin-like growth factor 2 | 0.109569 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.10673 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.106513 |
| RPL37 | ribosomal protein L37 | 0.0981581 |
| FN1 | fibronectin 1 | 0.0952314 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0910085 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0903693 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0858281 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0857562 |
| ASPH | aspartate beta-hydroxylase | 0.0720537 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0714788 |
| FTL | ferritin, light polypeptide | 0.0658757 |
| RPS6 | ribosomal protein S6 | 0.0605702 |
| CDK13 | cyclin-dependent kinase 13 | 0.059062 |
| ATXN1 | ataxin 1 | 0.0584713 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0559712 |
| FLNB | filamin B, beta | 0.0539714 |
| WWOX | WW domain containing oxidoreductase | 0.0530797 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0500079 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0497578 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0494872 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0475606 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0467686 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0456501 |
| RPL11 | ribosomal protein L11 | 0.0435586 |
| BPTF | bromodomain PHD finger transcription factor | 0.0399782 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0371978 |
| PDE8A | phosphodiesterase 8A | 0.0368623 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0365585 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.036082 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0356472 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0353573 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0333981 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0324822 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0316059 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0313411 |
| VCL | vinculin | 0.0313199 |
| MYO1E | myosin IE | 0.0277237 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.027631 |
| AUTS2 | autism susceptibility candidate 2 | 0.026275 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0258737 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0251168 |
| RTN4 | reticulon 4 | 0.0245613 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0244754 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0230844 |
| APP | amyloid beta (A4) precursor protein | 0.0223781 |
| NRXN3 | neurexin 3 | 0.0223264 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0217696 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0212633 |
| NEK7 | NIMA-related kinase 7 | 0.0210985 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0207679 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0180654 |
| RPS12 | ribosomal protein S12 | 0.0176427 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0153293 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0104909 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0100079 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.00950062 |
| PTK2 | protein tyrosine kinase 2 | 0.0092227 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.00919391 |
| TPR | translocated promoter region, nuclear basket protein | 0.00887795 |
| MTDH | metadherin | 0.00821833 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00790249 |
| MT2A | metallothionein 2A | 0.00584431 |
| CLTC | clathrin, heavy chain (Hc) | 0.00554399 |
| RPS8 | ribosomal protein S8 | 0.00451821 |
| DOCK4 | dedicator of cytokinesis 4 | 0.00372878 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.00337632 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.00215357 |
| PDLIM5 | PDZ and LIM domain 5 | 0.00208504 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00160891 |
| GOLGB1 | golgin B1 | 0.001576 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 6.18563E-4 |
| ENO2 | enolase 2 (gamma, neuronal) | 4.56411E-4 |
| MYL12B | myosin, light chain 12B, regulatory | 1.05413E-4 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 3.12077E-5 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | -0.232808 |
| EXT1 | exostosin glycosyltransferase 1 | -0.201538 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.184008 |
| HMGA2 | high mobility group AT-hook 2 | -0.163681 |
| VIM | vimentin | -0.159369 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.138839 |
| EFNA5 | ephrin-A5 | -0.137503 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.111209 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0955629 |
| CDH13 | cadherin 13 | -0.0909105 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0873293 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0831779 |
| RORA | RAR-related orphan receptor A | -0.0819869 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0818009 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0785298 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0783379 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0769553 |
| PDE10A | phosphodiesterase 10A | -0.0750194 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0747288 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0730395 |
| INHBA | inhibin, beta A | -0.0728004 |
| NDRG1 | N-myc downstream regulated 1 | -0.0715089 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0713517 |
| RPL23 | ribosomal protein L23 | -0.0672589 |
| CD44 | CD44 molecule (Indian blood group) | -0.0623764 |
| LDHA | lactate dehydrogenase A | -0.0592553 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0534895 |
| SMYD3 | SET and MYND domain containing 3 | -0.0533548 |
| RBMX | RNA binding motif protein, X-linked | -0.0511436 |
| MYOF | myoferlin | -0.0511319 |
| DIAPH2 | diaphanous-related formin 2 | -0.0491111 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0488686 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0452305 |
| RPL37A | ribosomal protein L37a | -0.0444185 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0437941 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0433292 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0421997 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0411242 |
| RPLP1 | ribosomal protein, large, P1 | -0.0403219 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0397515 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0365729 |
| PTMA | prothymosin, alpha | -0.0361922 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0345626 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0333123 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0328519 |
| GPATCH8 | G patch domain containing 8 | -0.0325924 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0323659 |
| VMP1 | vacuole membrane protein 1 | -0.0305329 |
| DST | dystonin | -0.0285422 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0280118 |
| TMSB10 | thymosin beta 10 | -0.0279576 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.026649 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0259508 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0258317 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0244565 |
| PCBP3 | poly(rC) binding protein 3 | -0.022918 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0224707 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0217838 |
| ENO1 | enolase 1, (alpha) | -0.0210383 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0191546 |
| STC1 | stanniocalcin 1 | -0.019053 |
| RBM39 | RNA binding motif protein 39 | -0.0187434 |
| RPL10A | ribosomal protein L10a | -0.018418 |
| RBM25 | RNA binding motif protein 25 | -0.0178289 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0159253 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0154956 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0142522 |
| RPL32 | ribosomal protein L32 | -0.0133786 |
| RPS27A | ribosomal protein S27a | -0.0130495 |
| RPL31 | ribosomal protein L31 | -0.0130427 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0120723 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0114626 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0109202 |
| CDC27 | cell division cycle 27 | -0.0102596 |
| RPL19 | ribosomal protein L19 | -0.0093263 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.00903225 |
| KYNU | kynureninase | -0.00863467 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | -0.00719133 |
| GPC6 | glypican 6 | -0.00695693 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.00468029 |
| SQSTM1 | sequestosome 1 | -0.00320186 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.00280797 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.00198874 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.001137 |
| SRPK2 | SRSF protein kinase 2 | -4.97254E-4 |
