L-Thyroxine (sodium salt pentahydrate)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Thyroxine (sodium salt pentahydrate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0908521
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0853813
NRG3 neuregulin 3 0.0660927
NLGN1 neuroligin 1 0.0642144
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0599892
LINGO2 leucine rich repeat and Ig domain containing 2 0.0569714
FNDC3B fibronectin type III domain containing 3B 0.0564704
DST dystonin 0.0387286
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0365982
FMNL2 formin-like 2 0.0338112
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0323601
FRMD4A FERM domain containing 4A 0.028323
RAD51B RAD51 paralog B 0.0279013
ASPH aspartate beta-hydroxylase 0.0276853
KAZN kazrin, periplakin interacting protein 0.0271341
MSI2 musashi RNA-binding protein 2 0.026562
MARCHF1 membrane associated ring-CH-type finger 1 0.0251264
DIAPH2 diaphanous-related formin 2 0.0246146
FMN1 formin 1 0.0245024
SLC39A11 solute carrier family 39, member 11 0.0244294
MAML3 mastermind-like 3 (Drosophila) 0.0238876
TAS2R14 taste receptor, type 2, member 14 0.0232196
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0230845
FHIT fragile histidine triad 0.0224984
PTPRM protein tyrosine phosphatase, receptor type, M 0.0222547
TENM3 teneurin transmembrane protein 3 0.0219444
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0219106
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0218742
LSAMP limbic system-associated membrane protein 0.0210579
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0205549
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0201778
SPAG9 sperm associated antigen 9 0.0193972
EHBP1 EH domain binding protein 1 0.0193718
EP300 E1A binding protein p300 0.019356
CFAP20DC CFAP20 domain containing 0.0193533
MEF2A myocyte enhancer factor 2A 0.0192268
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0184899
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0183919
TBC1D22A TBC1 domain family, member 22A 0.0181263
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0179815
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0177918
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0177293
LRMDA leucine rich melanocyte differentiation associated 0.0177079
LAMP2 lysosomal-associated membrane protein 2 0.0175941
ARB2A ARB2 cotranscriptional regulator A 0.0175649
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0175271
JMJD1C jumonji domain containing 1C 0.0171319
BACE2 beta-site APP-cleaving enzyme 2 0.0170758
RPS2 ribosomal protein S2 0.0170387
ZMIZ1 zinc finger, MIZ-type containing 1 0.0168667
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0162941
CDK19 cyclin-dependent kinase 19 0.016095
MMP12 matrix metallopeptidase 12 0.0160848
PMM2 phosphomannomutase 2 0.0158527
CDK13 cyclin-dependent kinase 13 0.0157834
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0156383
PRELID2 PRELI domain containing 2 0.0156022
AUTS2 autism susceptibility candidate 2 0.0155104
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0153891
USP53 ubiquitin specific peptidase 53 0.0153016
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 0.0152747
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0152501
EXOC4 exocyst complex component 4 0.0149412
CTTN cortactin 0.0148405
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0148251
CCDC91 coiled-coil domain containing 91 0.0148197
ATXN7 ataxin 7 0.0147877
IFI44L interferon-induced protein 44-like 0.0146493
ARHGAP5 Rho GTPase activating protein 5 0.0145048
NGLY1 N-glycanase 1 0.014414
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0143002
CLTC clathrin, heavy chain (Hc) 0.0141534
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0140602
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0139647
SETD5 SET domain containing 5 0.0139158
KLC1 kinesin light chain 1 0.0138706
SBF2 SET binding factor 2 0.0138529
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0136953
CHD1 chromodomain helicase DNA binding protein 1 0.0136278
PCBP3 poly(rC) binding protein 3 0.0136275
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.013425
STAG2 stromal antigen 2 0.0133194
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0132886
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0132661
KDM4C lysine (K)-specific demethylase 4C 0.0132515
HDAC8 histone deacetylase 8 0.0132095
PCNX1 pecanex 1 0.0131062
HSPA8 heat shock 70kDa protein 8 0.0129332
PEAK1 pseudopodium-enriched atypical kinase 1 0.0129297
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0128756
PRKD1 protein kinase D1 0.012647
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0125313
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0124859
SOS1 son of sevenless homolog 1 (Drosophila) 0.0124048
ANKHD1 ankyrin repeat and KH domain containing 1 0.0123159
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0122598
FRS2 fibroblast growth factor receptor substrate 2 0.0122469
LCORL ligand dependent nuclear receptor corepressor-like 0.0122074
ITCH itchy E3 ubiquitin protein ligase 0.0121812
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0119311

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.254474
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140794
MT2A metallothionein 2A -0.140552
TMSB10 thymosin beta 10 -0.0815669
RPLP1 ribosomal protein, large, P1 -0.0725834
ICAM1 intercellular adhesion molecule 1 -0.0630225
RPL35A ribosomal protein L35a -0.0605792
FTL ferritin, light polypeptide -0.0588019
RPL23 ribosomal protein L23 -0.0516364
EIF1 eukaryotic translation initiation factor 1 -0.0465721
RPS6 ribosomal protein S6 -0.0459099
FN1 fibronectin 1 -0.0456882
EEF2 eukaryotic translation elongation factor 2 -0.0409463
CCND1 cyclin D1 -0.0403229
TM4SF1 transmembrane 4 L six family member 1 -0.0370675
RPL34 ribosomal protein L34 -0.0363126
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0355037
RPS3 ribosomal protein S3 -0.0349318
RPL12 ribosomal protein L12 -0.0330761
LOC112694756 uncharaterized LOC112694756 -0.0323555
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0317185
PGK1 phosphoglycerate kinase 1 -0.0312364
RPS21 ribosomal protein S21 -0.0305332
RPL19 ribosomal protein L19 -0.0290719
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0290486
PKM pyruvate kinase, muscle -0.0285106
POTEF POTE ankyrin domain family, member F -0.0269113
RPS23 ribosomal protein S23 -0.0265707
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0264374
MT1X metallothionein 1X -0.0262671
ACTG1 actin gamma 1 -0.0259303
NDRG1 N-myc downstream regulated 1 -0.0253387
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0250433
RPS8 ribosomal protein S8 -0.0244596
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0241743
RPS19 ribosomal protein S19 -0.0241249
RACK1 receptor for activated C kinase 1 -0.0239995
RPL31 ribosomal protein L31 -0.0239684
RPS14 ribosomal protein S14 -0.0236963
RPS29 ribosomal protein S29 -0.0234455
RPL32 ribosomal protein L32 -0.0232434
RPLP2 ribosomal protein, large, P2 -0.0231739
ANGPTL4 angiopoietin-like 4 -0.0225066
S100A9 S100 calcium binding protein A9 -0.0218794
RPS5 ribosomal protein S5 -0.0214665
RPS20 ribosomal protein S20 -0.0213052
TFPI2 tissue factor pathway inhibitor 2 -0.0203933
RPL36 ribosomal protein L36 -0.0202049
RPS13 ribosomal protein S13 -0.0201215
FRMD5 FERM domain containing 5 -0.0199347
HMGA1 high mobility group AT-hook 1 -0.0198731
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0198601
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0195957
SQSTM1 sequestosome 1 -0.019256
ENO1 enolase 1, (alpha) -0.0192475
NAV2 neuron navigator 2 -0.0192019
S100A6 S100 calcium binding protein A6 -0.0187793
RPL27 ribosomal protein L27 -0.0184576
AHNAK AHNAK nucleoprotein -0.0184378
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0179179
RPLP0 ribosomal protein, large, P0 -0.0178685
VDAC1 voltage-dependent anion channel 1 -0.0178399
TUBB tubulin, beta class I -0.0177227
TXNRD1 thioredoxin reductase 1 -0.0176099
IER3 immediate early response 3 -0.0176037
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0175732
RPL28 ribosomal protein L28 -0.0173474
ANXA2 annexin A2 -0.0173116
CD44 CD44 molecule (Indian blood group) -0.0172188
SFTPA2 surfactant protein A2 -0.0170231
SLC38A1 solute carrier family 38, member 1 -0.0168659
APOD apolipoprotein D -0.0166848
RPS16 ribosomal protein S16 -0.0162711
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0161465
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0159749
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0158816
LMNA lamin A/C -0.0158585
RPS4X ribosomal protein S4, X-linked -0.0155933
EGR1 early growth response 1 -0.0155857
RPL8 ribosomal protein L8 -0.0153897
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0153542
CTSB cathepsin B -0.0153454
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0152711
RPL35 ribosomal protein L35 -0.0152162
ATP5F1E ATP synthase F1 subunit epsilon -0.0150869
WWTR1 WW domain containing transcription regulator 1 -0.0149132
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0148317
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.014724
EXT1 exostosin glycosyltransferase 1 -0.0145514
RPS27 ribosomal protein S27 -0.0144885
RPL5 ribosomal protein L5 -0.0141489
RPL11 ribosomal protein L11 -0.0140901
PLEC plectin -0.0140636
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0139342
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0139285
S100A10 S100 calcium binding protein A10 -0.0138998
RPS11 ribosomal protein S11 -0.0138323
TSC22D2 TSC22 domain family, member 2 -0.0135264
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0133541
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0133458