L-Thyroxine (sodium salt pentahydrate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Thyroxine (sodium salt pentahydrate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0845538
NKD1 naked cuticle homolog 1 (Drosophila) 0.0457236
RPS2 ribosomal protein S2 0.0425416
HSPA8 heat shock 70kDa protein 8 0.0312987
INTS6 integrator complex subunit 6 0.022764
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0223285
SAMD4A sterile alpha motif domain containing 4A 0.0220857
ASPH aspartate beta-hydroxylase 0.0217049
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0174517
YAP1 Yes-associated protein 1 0.0151491
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0149897
LRMDA leucine rich melanocyte differentiation associated 0.0144498
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0141485
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0137891
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0136268
BCAR3 breast cancer anti-estrogen resistance 3 0.0134419
HDAC4 histone deacetylase 4 0.0133187
WWOX WW domain containing oxidoreductase 0.0131403
TRAF5 TNF receptor-associated factor 5 0.0124223
RAD51B RAD51 paralog B 0.0123374
ARHGAP9 Rho GTPase activating protein 9 0.0118003
ARL15 ADP-ribosylation factor-like 15 0.0117574
RPS18 ribosomal protein S18 0.011689
TTC17 tetratricopeptide repeat domain 17 0.0112348
FHIT fragile histidine triad 0.0102283
NTSR1 neurotensin receptor 1 (high affinity) 0.0102191
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0101994
GPATCH8 G patch domain containing 8 0.00993416
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.00955351
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.00943124
BACE2 beta-site APP-cleaving enzyme 2 0.00941385
AUH AU RNA binding protein/enoyl-CoA hydratase 0.00927122
ZBTB40 zinc finger and BTB domain containing 40 0.00919568
PCNX4 pecanex 4 0.00906728
PTPRG protein tyrosine phosphatase, receptor type, G 0.00895475
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.00873106
SMYD3 SET and MYND domain containing 3 0.00870176
EGFR epidermal growth factor receptor 0.00857486
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.00849603
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.00847231
PARP4 poly (ADP-ribose) polymerase family, member 4 0.00823692
ADARB1 adenosine deaminase, RNA-specific, B1 0.00819832
MCU mitochondrial calcium uniporter 0.00804882
CDK13 cyclin-dependent kinase 13 0.00802527
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.00798182
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00792394
NCBP3 nuclear cap binding subunit 3 0.00789739
ANKRD36 ankyrin repeat domain 36 0.00778413
RPS7 ribosomal protein S7 0.00768531
FAAH2 fatty acid amide hydrolase 2 0.00767789
ANO6 anoctamin 6 0.00762162
TAS2R14 taste receptor, type 2, member 14 0.00755676
VGLL4 vestigial-like family member 4 0.00751191
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.00744806
CEP290 centrosomal protein 290kDa 0.00743175
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.00742756
RAB28 RAB28, member RAS oncogene family 0.00740241
RAD50 RAD50 homolog (S. cerevisiae) 0.00737632
MCC mutated in colorectal cancers 0.00736647
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 0.00735532
GTF2I general transcription factor IIi 0.00731164
PRKN parkin RBR E3 ubiquitin protein ligase 0.00725931
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.00723505
AOPEP aminopeptidase O (putative) 0.00704798
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 0.00704508
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.00698956
PLAUR plasminogen activator, urokinase receptor 0.00694294
TNRC18 trinucleotide repeat containing 18 0.00692077
AEBP2 AE binding protein 2 0.006882
TMEM161B transmembrane protein 161B 0.00687601
HMGA2 high mobility group AT-hook 2 0.00683717
BBS9 Bardet-Biedl syndrome 9 0.00680824
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.00680438
BZW1 basic leucine zipper and W2 domains 1 0.00666503
STK38L serine/threonine kinase 38 like 0.00662293
ATXN7L1 ataxin 7-like 1 0.00661685
KDM4B lysine (K)-specific demethylase 4B 0.00651994
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.00650766
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.00647974
COPZ1 coatomer protein complex, subunit zeta 1 0.00647069
H1-4 H1.4 linker histone, cluster member 0.00639233
OCIAD1 OCIA domain containing 1 0.00634486
KLF9 Kruppel-like factor 9 0.00634454
FHL2 four and a half LIM domains 2 0.00634386
PPARD peroxisome proliferator-activated receptor delta 0.00631575
SELENOI selenoprotein I 0.0063061
FAM107B family with sequence similarity 107, member B 0.00629721
GPC5 glypican 5 0.00629187
RSPH3 radial spoke 3 homolog (Chlamydomonas) 0.00624209
DOCK4 dedicator of cytokinesis 4 0.00620852
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0062056
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 0.00620418
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0061772
AHNAK2 AHNAK nucleoprotein 2 0.00616204
AHCYL2 adenosylhomocysteinase-like 2 0.00615628
BIRC2 baculoviral IAP repeat containing 2 0.00611346
SCAPER S-phase cyclin A-associated protein in the ER 0.00609378
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.00609307
TLE4 transducin-like enhancer of split 4 0.00608155
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 0.00607033

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18503
TMSB10 thymosin beta 10 -0.165725
RPL35A ribosomal protein L35a -0.140689
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.11382
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.100042
VIM vimentin -0.0979934
PTMA prothymosin, alpha -0.0960367
KRT8 keratin 8, type II -0.0896959
RPS6 ribosomal protein S6 -0.0831158
KRT18 keratin 18, type I -0.0831077
RPL23 ribosomal protein L23 -0.0738959
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0723042
HMGA1 high mobility group AT-hook 1 -0.0714493
ACTG1 actin gamma 1 -0.0618705
ANXA2 annexin A2 -0.0615786
PFN1 profilin 1 -0.0605284
RPLP1 ribosomal protein, large, P1 -0.0604082
RPS19 ribosomal protein S19 -0.0602534
ITGA6 integrin, alpha 6 -0.0590743
EGR1 early growth response 1 -0.0574586
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0542159
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0540695
LDHA lactate dehydrogenase A -0.0532548
CCND1 cyclin D1 -0.0520576
NAV2 neuron navigator 2 -0.0512729
RPL19 ribosomal protein L19 -0.0504166
EZR ezrin -0.0501873
ENO1 enolase 1, (alpha) -0.0488187
PCBP2 poly(rC) binding protein 2 -0.0471564
PKM pyruvate kinase, muscle -0.0456605
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0455769
ACTN4 actinin, alpha 4 -0.0453399
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0451595
YBX1 Y box binding protein 1 -0.0448435
RPS21 ribosomal protein S21 -0.0447587
LOC102724023 ES1 protein homolog, mitochondrial -0.0444
KPNB1 karyopherin (importin) beta 1 -0.0441202
EEF2 eukaryotic translation elongation factor 2 -0.0440924
POTEF POTE ankyrin domain family, member F -0.0433535
PGK1 phosphoglycerate kinase 1 -0.0432199
RPLP0 ribosomal protein, large, P0 -0.0430443
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0419829
TPM4 tropomyosin 4 -0.0416312
MKI67 marker of proliferation Ki-67 -0.0415957
FTL ferritin, light polypeptide -0.0412383
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0408407
RPS14 ribosomal protein S14 -0.0403885
GLG1 golgi glycoprotein 1 -0.0403273
DEK DEK proto-oncogene -0.0392252
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0391407
MED13 mediator complex subunit 13 -0.0388601
CDK6 cyclin-dependent kinase 6 -0.0388139
RPL27A ribosomal protein L27a -0.0384822
LMNA lamin A/C -0.0384695
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0382374
TUBA1B tubulin, alpha 1b -0.0378794
BIRC6 baculoviral IAP repeat containing 6 -0.0374454
TPI1 triosephosphate isomerase 1 -0.0374291
ATP5F1B ATP synthase F1 subunit beta -0.0374124
RPL34 ribosomal protein L34 -0.0370818
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0370672
RPL12 ribosomal protein L12 -0.0366133
RPS24 ribosomal protein S24 -0.0365529
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0360406
RPL11 ribosomal protein L11 -0.0356729
SMC4 structural maintenance of chromosomes 4 -0.0354501
RPS4X ribosomal protein S4, X-linked -0.0351486
S100A10 S100 calcium binding protein A10 -0.03507
RPS23 ribosomal protein S23 -0.0349128
EIF1 eukaryotic translation initiation factor 1 -0.0348827
CBX3 chromobox homolog 3 -0.0346652
HMGB1 high mobility group box 1 -0.0340608
RPS5 ribosomal protein S5 -0.0337282
TMSB4X thymosin beta 4, X-linked -0.0334642
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.032884
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0327599
IARS1 isoleucyl-tRNA synthetase 1 -0.0326611
RPL5 ribosomal protein L5 -0.0325305
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0319663
S100A6 S100 calcium binding protein A6 -0.031796
H1-0 H1.0 linker histone -0.0317454
USP9X ubiquitin specific peptidase 9, X-linked -0.0317281
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0315503
ESYT2 extended synaptotagmin-like protein 2 -0.0311843
KRT19 keratin 19, type I -0.0311516
TMEM123 transmembrane protein 123 -0.0307602
CENPF centromere protein F, 350/400kDa -0.0307443
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0306613
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0303156
RPL31 ribosomal protein L31 -0.0299775
THOC2 THO complex 2 -0.0299675
SLC38A2 solute carrier family 38, member 2 -0.0298487
S100A9 S100 calcium binding protein A9 -0.0298245
GARS1 glycyl-tRNA synthetase 1 -0.0298091
TRIO trio Rho guanine nucleotide exchange factor -0.029734
PRRC2C proline-rich coiled-coil 2C -0.0290626
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0290265
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0288106
NAP1L1 nucleosome assembly protein 1-like 1 -0.0287403
GNAS GNAS complex locus -0.028726