| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | L-Thyroxine (sodium salt pentahydrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the L-Thyroxine (sodium salt pentahydrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.240769 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.182947 |
| CD44 | CD44 molecule (Indian blood group) | 0.179978 |
| MYO10 | myosin X | 0.17926 |
| STC1 | stanniocalcin 1 | 0.153379 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.114674 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.112727 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.104498 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0991652 |
| B2M | beta-2-microglobulin | 0.0940083 |
| ATP13A3 | ATPase type 13A3 | 0.0929457 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.085549 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0803735 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0800978 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0795068 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0776401 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0691048 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.06728 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0625805 |
| FAM13A | family with sequence similarity 13, member A | 0.0607708 |
| HLA-B | major histocompatibility complex, class I, B | 0.0580668 |
| PDE8A | phosphodiesterase 8A | 0.053288 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0519652 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0510941 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0469375 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0468287 |
| FMNL2 | formin-like 2 | 0.0464861 |
| MSN | moesin | 0.0453269 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.04465 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0445826 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0424881 |
| RNF145 | ring finger protein 145 | 0.041516 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0412414 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0407474 |
| RAI14 | retinoic acid induced 14 | 0.0407313 |
| TPM3 | tropomyosin 3 | 0.0404637 |
| RUNX1 | runt-related transcription factor 1 | 0.040434 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0399391 |
| SPAG9 | sperm associated antigen 9 | 0.0399066 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0397583 |
| TMEM165 | transmembrane protein 165 | 0.0394966 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0390352 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0384498 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0376089 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0375563 |
| SETD5 | SET domain containing 5 | 0.0372771 |
| FRMD6 | FERM domain containing 6 | 0.0371667 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0366008 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0365999 |
| EGFR | epidermal growth factor receptor | 0.0362612 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.034936 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0348501 |
| PKM | pyruvate kinase, muscle | 0.0346143 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0339939 |
| GPHN | gephyrin | 0.0338093 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0337172 |
| RPS2 | ribosomal protein S2 | 0.033412 |
| EMP1 | epithelial membrane protein 1 | 0.0331537 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0323356 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0323188 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0318281 |
| MCL1 | myeloid cell leukemia 1 | 0.0317493 |
| MT2A | metallothionein 2A | 0.0316434 |
| LOX | lysyl oxidase | 0.0315636 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0314332 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0312276 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0312109 |
| MMP12 | matrix metallopeptidase 12 | 0.0307578 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0303628 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0300986 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.029059 |
| TLN1 | talin 1 | 0.0281484 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0280001 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0279772 |
| SNX9 | sorting nexin 9 | 0.0278626 |
| NKTR | natural killer cell triggering receptor | 0.0277939 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0272827 |
| RPL3 | ribosomal protein L3 | 0.0264493 |
| BRD2 | bromodomain containing 2 | 0.0259329 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0259017 |
| DSPP | dentin sialophosphoprotein | 0.025827 |
| RPS8 | ribosomal protein S8 | 0.025034 |
| POTEF | POTE ankyrin domain family, member F | 0.0248527 |
| RASA2 | RAS p21 protein activator 2 | 0.0246681 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0245824 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0243943 |
| PRDM1 | PR domain containing 1, with ZNF domain | 0.0242308 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.024215 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0240478 |
| MED13L | mediator complex subunit 13-like | 0.0238685 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0238681 |
| FOSL1 | FOS-like antigen 1 | 0.0236717 |
| TMF1 | TATA element modulatory factor 1 | 0.0236618 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0236284 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0236087 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0235938 |
| TOP1 | topoisomerase (DNA) I | 0.0235733 |
| MEIS1 | Meis homeobox 1 | 0.0235699 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0234634 |
| IL6ST | interleukin 6 signal transducer | 0.0231438 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.304194 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.162283 |
| MMP1 | matrix metallopeptidase 1 | -0.160231 |
| VIM | vimentin | -0.0917312 |
| AHNAK | AHNAK nucleoprotein | -0.089544 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0779134 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0685107 |
| CDH13 | cadherin 13 | -0.058135 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0542924 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0442076 |
| OXR1 | oxidation resistance 1 | -0.0441566 |
| HDLBP | high density lipoprotein binding protein | -0.0438375 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0437843 |
| GLIS3 | GLIS family zinc finger 3 | -0.0436643 |
| NPTX1 | neuronal pentraxin I | -0.0426479 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0406948 |
| VCL | vinculin | -0.0370045 |
| INTS6 | integrator complex subunit 6 | -0.0362564 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0345741 |
| AEBP2 | AE binding protein 2 | -0.0343628 |
| TTC23L | tetratricopeptide repeat domain 23-like | -0.0342181 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0341132 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0333165 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0331611 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0328258 |
| NCKAP5 | NCK-associated protein 5 | -0.0320199 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0319297 |
| TMSB10 | thymosin beta 10 | -0.0319269 |
| EBF1 | early B-cell factor 1 | -0.0317272 |
| DGKI | diacylglycerol kinase, iota | -0.0314706 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.030454 |
| IER3 | immediate early response 3 | -0.0292327 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0291584 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0291558 |
| H1-0 | H1.0 linker histone | -0.0289691 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0284833 |
| HMGA2 | high mobility group AT-hook 2 | -0.0284212 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0275852 |
| COL5A1 | collagen, type V, alpha 1 | -0.0273306 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0270039 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.026945 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0265526 |
| RPLP1 | ribosomal protein, large, P1 | -0.0250611 |
| CAVIN1 | caveolae associated protein 1 | -0.0250497 |
| FTL | ferritin, light polypeptide | -0.0241554 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0236004 |
| TMEM263 | transmembrane protein 263 | -0.0232937 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0232285 |
| IPO9 | importin 9 | -0.0227697 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0224889 |
| FUS | FUS RNA binding protein | -0.0221174 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0218554 |
| CANX | calnexin | -0.0217797 |
| GNAS | GNAS complex locus | -0.0216586 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0215313 |
| ATG7 | autophagy related 7 | -0.0213935 |
| NREP | neuronal regeneration related protein | -0.0213503 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0212793 |
| RPL35A | ribosomal protein L35a | -0.0211715 |
| DNER | delta/notch-like EGF repeat containing | -0.0211062 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0209932 |
| RND3 | Rho family GTPase 3 | -0.020938 |
| ATXN1 | ataxin 1 | -0.0207187 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0205022 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0202128 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0201148 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0200593 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0196791 |
| LMNA | lamin A/C | -0.01963 |
| CALU | calumenin | -0.0195587 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.0195155 |
| SLCO1C1 | solute carrier organic anion transporter family, member 1C1 | -0.0193799 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0193549 |
| CUX1 | cut-like homeobox 1 | -0.0190032 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0188785 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.018515 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0184233 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0183578 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.018169 |
| COL4A1 | collagen, type IV, alpha 1 | -0.0181591 |
| NABP1 | nucleic acid binding protein 1 | -0.0178684 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0177985 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0177858 |
| ARF1 | ADP-ribosylation factor 1 | -0.0176905 |
| EXOC4 | exocyst complex component 4 | -0.0176585 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0176299 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0174293 |
| PRR16 | proline rich 16 | -0.0173986 |
| CCDC138 | coiled-coil domain containing 138 | -0.0171329 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0170739 |
| CCDC102B | coiled-coil domain containing 102B | -0.0170592 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0170102 |
| PDE7B | phosphodiesterase 7B | -0.0169409 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0166862 |
| TPM1 | tropomyosin 1 (alpha) | -0.0165947 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0165481 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0165343 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0164839 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0164193 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0161495 |
