L-Valyl-L-phenylalanine Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/6993120
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Genes

200 proteins with high or low expression in L-Valyl-L-phenylalanine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
DHRS2 dehydrogenase/reductase (SDR family) member 2 4.29
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 4.21
CNTN1 contactin 1 3.26
AKR1C3 aldo-keto reductase family 1, member C3 2.93
MAP2 microtubule-associated protein 2 2.45
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.29
CRYM crystallin, mu 2.26
CLSTN3 calsyntenin 3 2.17
SORBS1 sorbin and SH3 domain containing 1 2.11
CA8 carbonic anhydrase VIII 2.09
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1.95
LTBP1 latent transforming growth factor beta binding protein 1 1.93
TRIM9 tripartite motif containing 9 1.9
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 1.86
CCN3 cellular communication network factor 3 1.78
CASZ1 castor zinc finger 1 1.76
VWA5B2 von Willebrand factor A domain containing 5B2 1.75
HYKK hydroxylysine kinase 1.71
KIAA0513 KIAA0513 1.7
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.7
PEG10 paternally expressed 10 1.62
HLA-F major histocompatibility complex, class I, F 1.58
PDE5A phosphodiesterase 5A, cGMP-specific 1.54
IQGAP2 IQ motif containing GTPase activating protein 2 1.5
VWA5A von Willebrand factor A domain containing 5A 1.47
BBS9 Bardet-Biedl syndrome 9 1.45
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7 1.45
ABAT 4-aminobutyrate aminotransferase 1.45
CLGN calmegin 1.43
SORT1 sortilin 1 1.43
DAAM1 dishevelled associated activator of morphogenesis 1 1.41
TMOD2 tropomodulin 2 (neuronal) 1.4
NMRK1 nicotinamide riboside kinase 1 1.37
GLRX glutaredoxin (thioltransferase) 1.37
OPTN optineurin 1.32
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 1.3
TPPP tubulin polymerization promoting protein 1.29
CCND3 cyclin D3 1.28
DEPTOR DEP domain containing MTOR-interacting protein 1.28
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 1.27
GCH1 GTP cyclohydrolase 1 1.27
LIPA lipase A, lysosomal acid, cholesterol esterase 1.26
KBTBD8 kelch repeat and BTB (POZ) domain containing 8 1.25
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 1.24
PGM2L1 phosphoglucomutase 2-like 1 1.22
CPEB4 cytoplasmic polyadenylation element binding protein 4 1.22
NEU1 sialidase 1 (lysosomal sialidase) 1.21
ATG4A autophagy related 4A, cysteine peptidase 1.2
MISP3 MISP family member 3 1.19
MT2A metallothionein 2A 1.19
ARG2 arginase 2 1.18
EPPK1 epiplakin 1 1.18
PLCD1 phospholipase C, delta 1 1.17
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 1.16
STX1A syntaxin 1A (brain) 1.15
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 1.15
CORO1A coronin, actin binding protein, 1A 1.14
MCF2L MCF.2 cell line derived transforming sequence-like 1.14
L1CAM L1 cell adhesion molecule 1.13
ANKRD22 ankyrin repeat domain 22 1.12
CGNL1 cingulin-like 1 1.12
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.12
OASL 2'-5'-oligoadenylate synthetase-like 1.12
GEM GTP binding protein overexpressed in skeletal muscle 1.12
GCA grancalcin, EF-hand calcium binding protein 1.11
NAGS N-acetylglutamate synthase 1.1
NOVA1 neuro-oncological ventral antigen 1 1.09
CAPN5 calpain 5 1.09
LGALS1 lectin, galactoside-binding, soluble, 1 1.09
TDRKH tudor and KH domain containing 1.09
LMCD1 LIM and cysteine-rich domains 1 1.08
KIAA1324L KIAA1324-like 1.08
RAB6B RAB6B, member RAS oncogene family 1.07
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 1.07
HPCAL4 hippocalcin like 4 1.07
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 1.06
PDLIM3 PDZ and LIM domain 3 1.06
STXBP1 syntaxin binding protein 1 1.04
REPS2 RALBP1 associated Eps domain containing 2 1.03
ARL15 ADP-ribosylation factor-like 15 1.03
PLCB4 phospholipase C, beta 4 1.03
CTIF CBP80/20-dependent translation initiation factor 1.02
ARL6 ADP-ribosylation factor-like 6 1.02
AAMDC adipogenesis associated, Mth938 domain containing 1.02
HID1 HID1 domain containing 1.02
H1-0 H1.0 linker histone 1.02
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 1.02
ITGA7 integrin, alpha 7 1.02
SULF2 sulfatase 2 1.02
SENP7 SUMO1/sentrin specific peptidase 7 1.01
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 1.0
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.0
KCTD12 potassium channel tetramerization domain containing 12 1.0
MYORG myogenesis regulating glycosidase (putative) 1.0
PRKCH protein kinase C, eta 0.99
KCTD21 potassium channel tetramerization domain containing 21 0.99
ELL2 elongation factor, RNA polymerase II, 2 0.99
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 0.99
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 0.99
EVI5L ecotropic viral integration site 5-like 0.98

low expression

Symbol Name Standardized Value
KLHL23 kelch-like family member 23 -3.49
ITGA1 integrin, alpha 1 -2.5
KMT2B lysine (K)-specific methyltransferase 2B -2.23
LAMA2 laminin, alpha 2 -1.98
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -1.68
IRX4 iroquois homeobox 4 -1.51
SUMO2 small ubiquitin-like modifier 2 -1.44
NPHP3 nephronophthisis 3 (adolescent) -1.4
CC2D2A coiled-coil and C2 domain containing 2A -1.39
TEN1 TEN1 CST complex subunit -1.39
EREG epiregulin -1.33
STC2 stanniocalcin 2 -1.22
SLC38A5 solute carrier family 38, member 5 -1.19
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -1.16
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -1.16
SLC38A2 solute carrier family 38, member 2 -1.1
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -1.08
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 -1.06
GMCL1 germ cell-less, spermatogenesis associated 1 -1.06
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -1.05
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -1.04
RARG retinoic acid receptor, gamma -1.03
PPHLN1 periphilin 1 -1.03
CARD8 caspase recruitment domain family, member 8 -1.03
TRIB1 tribbles pseudokinase 1 -1.02
ANO1 anoctamin 1, calcium activated chloride channel -1.01
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -1.0
LTBP3 latent transforming growth factor beta binding protein 3 -0.99
TRIM16 tripartite motif containing 16 -0.98
TNS2 tensin 2 -0.98
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) -0.98
PBRM1 polybromo 1 -0.97
ZNF142 zinc finger protein 142 -0.96
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -0.95
ERRFI1 ERBB receptor feedback inhibitor 1 -0.94
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.91
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -0.91
F3 coagulation factor III (thromboplastin, tissue factor) -0.9
IL27RA interleukin 27 receptor, alpha -0.89
SOCS2 suppressor of cytokine signaling 2 -0.89
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 -0.88
PHF19 PHD finger protein 19 -0.87
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.87
VIM vimentin -0.86
TYMS thymidylate synthetase -0.85
ZNF114 zinc finger protein 114 -0.85
SQSTM1 sequestosome 1 -0.85
M1AP meiosis 1 associated protein -0.83
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 -0.83
KEAP1 kelch-like ECH-associated protein 1 -0.82
ZBTB8A zinc finger and BTB domain containing 8A -0.82
ACTL8 actin-like 8 -0.81
ATN1 atrophin 1 -0.81
KANSL2 KAT8 regulatory NSL complex subunit 2 -0.81
KCTD15 potassium channel tetramerization domain containing 15 -0.81
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.81
SLC38A1 solute carrier family 38, member 1 -0.8
ZMYND19 zinc finger, MYND-type containing 19 -0.79
SCARA3 scavenger receptor class A, member 3 -0.78
KANSL3 KAT8 regulatory NSL complex subunit 3 -0.78
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -0.78
SLC19A1 solute carrier family 19 (folate transporter), member 1 -0.77
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -0.77
FIZ1 FLT3-interacting zinc finger 1 -0.77
CASP4 caspase 4, apoptosis-related cysteine peptidase -0.77
DOCK3 dedicator of cytokinesis 3 -0.77
ODC1 ornithine decarboxylase 1 -0.77
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.77
KLK6 kallikrein-related peptidase 6 -0.76
TMEM222 transmembrane protein 222 -0.76
BCL7B B-cell CLL/lymphoma 7B -0.75
NAV3 neuron navigator 3 -0.74
DDR1 discoidin domain receptor tyrosine kinase 1 -0.74
FBXW4 F-box and WD repeat domain containing 4 -0.74
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -0.74
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.73
UNC13D unc-13 homolog D (C. elegans) -0.73
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.73
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.72
PCNT pericentrin -0.71
UGCG UDP-glucose ceramide glucosyltransferase -0.71
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -0.71
ADGRF1 adhesion G protein-coupled receptor F1 -0.69
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) -0.69
MPZL2 myelin protein zero-like 2 -0.69
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.68
SENP6 SUMO1/sentrin specific peptidase 6 -0.68
ACIN1 apoptotic chromatin condensation inducer 1 -0.68
TRAIP TRAF interacting protein -0.68
HOXA9 homeobox A9 -0.68
ZFX zinc finger protein, X-linked -0.68
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial -0.68
NSD2 nuclear receptor binding SET domain protein 2 -0.67
PDE4B phosphodiesterase 4B, cAMP-specific -0.67
ZBTB20 zinc finger and BTB domain containing 20 -0.67
RCN1 reticulocalbin 1, EF-hand calcium binding domain -0.67
DUSP7 dual specificity phosphatase 7 -0.66
PHF20 PHD finger protein 20 -0.66
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase -0.66
HAS3 hyaluronan synthase 3 -0.66