L1CAM Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description L1 cell adhesion molecule|The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013] (NCBI Entrez Gene Database, 3897)
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Genes

294 genes differentially expressed following the L1CAM gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FRMPD1 FERM and PDZ domain containing 1 3.12821
OSTN osteocrin 3.12821
ASIC4 acid sensing (proton gated) ion channel family member 4 3.12821
BOLA2 bolA family member 2 3.12821
SAMD15 sterile alpha motif domain containing 15 3.12821
CAPN8 calpain 8 3.12821
PLD4 phospholipase D family, member 4 3.12821
COPZ2 coatomer protein complex, subunit zeta 2 3.12821
CSN2 casein beta 3.12821
SMIM9 small integral membrane protein 9 3.12821
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.12821
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.12821
GCKR glucokinase (hexokinase 4) regulator 3.12821
NRSN1 neurensin 1 3.12821
DSPP dentin sialophosphoprotein 3.12821
KRTAP13-4 keratin associated protein 13-4 3.12821
TTR transthyretin 3.12821
GREM1 gremlin 1, DAN family BMP antagonist 3.12821
SSX1 synovial sarcoma, X breakpoint 1 3.12821
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.12821
KRT40 keratin 40, type I 3.12821
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.12821
C5ORF46 chromosome 5 open reading frame 46 3.12821
NEUROD2 neuronal differentiation 2 3.12821
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.12821
CD22 CD22 molecule 3.12821
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.12821
GATA3 GATA binding protein 3 3.12821
C16ORF89 chromosome 16 open reading frame 89 3.12821
SPRR1B small proline-rich protein 1B 3.12821
CCR3 chemokine (C-C motif) receptor 3 3.12821
CD160 CD160 molecule 3.12821
PRICKLE4 prickle homolog 4 (Drosophila) 3.12821
XAF1 XIAP associated factor 1 3.12821
WDR38 WD repeat domain 38 3.12821
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.12821
RAB44 RAB44, member RAS oncogene family 3.12821
ATP13A4 ATPase type 13A4 3.12821
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.12821
SOX1 SRY (sex determining region Y)-box 1 3.12821
GJA3 gap junction protein, alpha 3, 46kDa 3.12821
GJA9 gap junction protein, alpha 9, 59kDa 3.12821
TPBGL trophoblast glycoprotein-like 3.12821
RAX retina and anterior neural fold homeobox 3.12821
FOXA2 forkhead box A2 3.12821
CCDC17 coiled-coil domain containing 17 3.12821
LOC124906892 uncharacterized LOC124906892 3.12821
MIA melanoma inhibitory activity 3.12821
MUSK muscle, skeletal, receptor tyrosine kinase 3.12821
RSPO3 R-spondin 3 3.12821
LRG1 leucine-rich alpha-2-glycoprotein 1 3.12821
TLR7 toll-like receptor 7 3.12821
OLIG2 oligodendrocyte lineage transcription factor 2 3.12821
GJB4 gap junction protein, beta 4, 30.3kDa 3.12821
SH2D7 SH2 domain containing 7 3.12821
SLPI secretory leukocyte peptidase inhibitor 3.12821
MAL mal, T-cell differentiation protein 3.12821
RIMBP2 RIMS binding protein 2 3.12821
FAM153A family with sequence similarity 153, member A 3.12821
ADRA1B adrenoceptor alpha 1B 3.12821
BCL2A1 BCL2-related protein A1 3.12821
SPATA31H1 SPATA31 subfamily H member 1 3.12821
OR2I1 olfactory receptor family 2 subfamily I member 1 (gene/pseudogene) 3.12821
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.12821
GREP1 glycine rich extracellular protein 1 3.12821
PKDREJ polycystin (PKD) family receptor for egg jelly 3.12821
ROPN1L rhophilin associated tail protein 1-like 3.12821
DUOX2 dual oxidase 2 3.12821
GLOD5 glyoxalase domain containing 5 3.12821
CRYBB2 crystallin, beta B2 3.12821
AKAIN1 A-kinase anchor inhibitor 1 3.12821
EZHIP EZH inhibitory protein 3.12821
KLHL1 kelch-like family member 1 3.12821
SMIM31 small integral membrane protein 31 3.12821
MUC13 mucin 13, cell surface associated 3.12821
VWA7 von Willebrand factor A domain containing 7 3.12821
ART1 ADP-ribosyltransferase 1 3.12821
OR52N5 olfactory receptor, family 52, subfamily N, member 5 3.12821
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.12821
TTC22 tetratricopeptide repeat domain 22 3.12821
CCDC70 coiled-coil domain containing 70 3.12821
TRIM7 tripartite motif containing 7 3.12821
TMPPE transmembrane protein with metallophosphoesterase domain 3.12821
SIGLEC11 sialic acid binding Ig-like lectin 11 3.12821
CIMIP2B ciliary microtubule inner protein 2B 3.12821
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.12821
UTS2B urotensin 2B 3.12821
DRC5 dynein regulatory complex subunit 5 3.12821
HELT helt bHLH transcription factor 3.12821
UBQLNL ubiquilin-like 3.12821
TUBB8B tubulin beta 8B 3.12821
CERKL ceramide kinase-like 3.12821
TRPC7 transient receptor potential cation channel, subfamily C, member 7 3.12821
SLITRK1 SLIT and NTRK-like family, member 1 3.12821
FGF17 fibroblast growth factor 17 3.12821
LRRC74A leucine rich repeat containing 74A 3.12821
LRRC74B leucine rich repeat containing 74B 3.12821
LAMP3 lysosomal-associated membrane protein 3 3.12821
FYB1 FYN binding protein 1 3.12821
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3 3.12821
ZBED6 zinc finger, BED-type containing 6 3.12821
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.12821
FOXC2 forkhead box C2 3.12821
THEM5 thioesterase superfamily member 5 3.12821
ACSM4 acyl-CoA synthetase medium-chain family member 4 3.12821
C4BPA complement component 4 binding protein, alpha 3.12821
DNAAF6 dynein axonemal assembly factor 6 3.12821
PCARE photoreceptor cilium actin regulator 3.12821
HAMP hepcidin antimicrobial peptide 3.12821
ACOX2 acyl-CoA oxidase 2, branched chain 3.12821
FBXO39 F-box protein 39 3.12821
PLPP4 phospholipid phosphatase 4 3.12821
GMCL2 germ cell-less 2, spermatogenesis associated 3.12821
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.12821
SLFN12L schlafen family member 12-like 3.12821
HTD2 hydroxyacyl-thioester dehydratase type 2 3.12821
PLA2G4E phospholipase A2, group IVE 3.12821
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum) 3.01264
ERVH48-1 endogenous retrovirus group 48, member 1 2.97494
F8A1 coagulation factor VIII-associated 1 2.90177
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.90177
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 2.85976
TXN thioredoxin 2.72766
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.72137
ZNF548 zinc finger protein 548 2.69623
ALX3 ALX homeobox 3 2.67733
MED7 mediator complex subunit 7 2.66585
TCN2 transcobalamin II 2.65387
WDR76 WD repeat domain 76 2.59928
PCDHGA4 protocadherin gamma subfamily A, 4 2.55374
AXDND1 axonemal dynein light chain domain containing 1 2.55374
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.53478
FAM241A family with sequence similarity 241 member A 2.53478
TMEM229B transmembrane protein 229B 2.53375
TNRC6B trinucleotide repeat containing 6B 2.53152
CKS2 CDC28 protein kinase regulatory subunit 2 2.51152
SLIT1 slit homolog 1 (Drosophila) 2.48206
CTRL chymotrypsin-like 2.4505
FGF2 fibroblast growth factor 2 (basic) 2.44733
TEX9 testis expressed 9 2.44733
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.42871
FOSL2 FOS-like antigen 2 2.42871
PLXDC2 plexin domain containing 2 2.39708
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.38465
ZNF44 zinc finger protein 44 2.37782
RPS28 ribosomal protein S28 2.37782
REEP1 receptor accessory protein 1 2.35298
ADAM7 ADAM metallopeptidase domain 7 2.35298
AMBP alpha-1-microglobulin/bikunin precursor 2.35298
TTLL13 tubulin tyrosine ligase like 13 2.35298
SDSL serine dehydratase-like 2.33246
PLVAP plasmalemma vesicle associated protein 2.33246
DPRX divergent-paired related homeobox 2.33246
EYA2 EYA transcriptional coactivator and phosphatase 2 2.32612
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 2.32447
DCAF12 DDB1 and CUL4 associated factor 12 2.3165
CYB5RL cytochrome b5 reductase-like 2.29651
CCDC196 coiled-coil domain containing 196 2.28284
ANO1 anoctamin 1, calcium activated chloride channel 2.25535
TNN tenascin N 2.23964
PAIP2 poly(A) binding protein interacting protein 2 2.23416
RPL14 ribosomal protein L14 2.21653
DOK5 docking protein 5 2.21436
WDTC1 WD and tetratricopeptide repeats 1 2.16977
MORC4 MORC family CW-type zinc finger 4 2.16503
KYNU kynureninase 2.16503
MORN3 MORN repeat containing 3 2.16503
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 2.16503
PPL periplakin 2.16503
PIPOX pipecolic acid oxidase 2.16374
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.1443
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.1443
ZFP69B ZFP69 zinc finger protein B 2.1352
KANSL2 KAT8 regulatory NSL complex subunit 2 2.12695
TDG thymine-DNA glycosylase 2.1204
FBXL12 F-box and leucine-rich repeat protein 12 2.10874
IFT88 intraflagellar transport 88 2.10874
EYA1 EYA transcriptional coactivator and phosphatase 1 2.10381
KCTD21 potassium channel tetramerization domain containing 21 2.07315
PRSS27 protease, serine 27 2.06153
TMEM267 transmembrane protein 267 2.05233
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 2.05092
HDAC7 histone deacetylase 7 2.04205
SNAP25 synaptosomal-associated protein, 25kDa 2.02578
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.02578
SEC13 SEC13 homolog (S. cerevisiae) 2.02107
H2AC6 H2A clustered histone 6 2.00357
COX7C cytochrome c oxidase subunit VIIc 2.00334

decreased expression

Symbol Name Standardized Value
BTNL8 butyrophilin-like 8 -3.12821
CFAP100 cilia and flagella associated protein 100 -3.12821
GGT1 gamma-glutamyltransferase 1 -3.12821
ZNF843 zinc finger protein 843 -3.12821
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -3.12821
TMPRSS11D transmembrane protease, serine 11D -3.12821
AFAP1L1 actin filament associated protein 1-like 1 -3.12821
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B -3.12821
TMEM150C transmembrane protein 150C -3.12821
SCN1B sodium channel, voltage gated, type I beta subunit -3.12821
ZPBP zona pellucida binding protein -3.12821
EAF2 ELL associated factor 2 -3.12821
H2AZ1 H2A.Z variant histone 1 -2.8286
MANSC1 MANSC domain containing 1 -2.8033
BHLHA9 basic helix-loop-helix family, member a9 -2.76891
CLCN1 chloride channel, voltage-sensitive 1 -2.76891
ASGR2 asialoglycoprotein receptor 2 -2.76891
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 -2.76891
CLCF1 cardiotrophin-like cytokine factor 1 -2.76891
HIGD1C HIG1 hypoxia inducible domain family, member 1C -2.76891
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -2.76891
SNTN sentan, cilia apical structure protein -2.76891
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 -2.76891
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -2.76891
GYPE glycophorin E (MNS blood group) -2.76891
TMEM100 transmembrane protein 100 -2.76891
MSX2 msh homeobox 2 -2.76891
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.76891
PIWIL3 piwi-like RNA-mediated gene silencing 3 -2.76891
IRF4 interferon regulatory factor 4 -2.76891
PCDHB11 protocadherin beta 11 -2.76891
ITGAD integrin, alpha D -2.76891
TSPAN1 tetraspanin 1 -2.76891
ACER1 alkaline ceramidase 1 -2.76891
OR52A5 olfactory receptor, family 52, subfamily A, member 5 -2.76891
NME2 NME/NM23 nucleoside diphosphate kinase 2 -2.76891
FPR1 formyl peptide receptor 1 -2.76891
FNDC8 fibronectin type III domain containing 8 -2.76891
TRADD TNFRSF1A-associated via death domain -2.76891
EFCAB6 EF-hand calcium binding domain 6 -2.76891
POF1B premature ovarian failure, 1B -2.76891
F10 coagulation factor X -2.76891
TTC16 tetratricopeptide repeat domain 16 -2.76891
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) -2.76891
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.76891
ESPNL espin-like -2.76891
MSMP microseminoprotein, prostate associated -2.76891
TTLL3 tubulin tyrosine ligase-like family member 3 -2.73434
FILIP1 filamin A interacting protein 1 -2.70983
AIM2 absent in melanoma 2 -2.66689
LGMN legumain -2.66689
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -2.66585
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 -2.64207
E2F7 E2F transcription factor 7 -2.58965
RFXANK regulatory factor X-associated ankyrin-containing protein -2.56912
NPIPB15 nuclear pore complex interacting protein family, member B15 -2.53478
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.53478
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -2.53152
TADA1 transcriptional adaptor 1 -2.53121
SOWAHC sosondowah ankyrin repeat domain family member C -2.51156
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.44754
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 -2.44733
NFE2L3 nuclear factor, erythroid 2-like 3 -2.42871
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -2.37782
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 -2.37782
CD177 CD177 molecule -2.37782
NTNG2 netrin G2 -2.35597
DXO decapping exoribonuclease -2.35597
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.34427
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -2.34415
TUBGCP4 tubulin, gamma complex associated protein 4 -2.3165
CCDC157 coiled-coil domain containing 157 -2.3165
MKRN1 makorin ring finger protein 1 -2.27764
APH1A APH1A gamma secretase subunit -2.24158
YME1L1 YME1-like 1 ATPase -2.22799
ACOT1 acyl-CoA thioesterase 1 -2.22538
CLEC4C C-type lectin domain family 4, member C -2.22538
RDH16 retinol dehydrogenase 16 (all-trans) -2.22538
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 -2.19578
ZNF836 zinc finger protein 836 -2.18448
BGN biglycan -2.18048
TSPAN16 tetraspanin 16 -2.18048
LHFPL5 lipoma HMGIC fusion partner-like 5 -2.16503
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa -2.16503
TSLIG3A tRNA splicing ligase complex subunit 3A -2.16503
LINGO3 leucine rich repeat and Ig domain containing 3 -2.16503
SMAD1 SMAD family member 1 -2.10874
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.10548
RABEPK Rab9 effector protein with kelch motifs -2.09965
MTCP1 mature T-cell proliferation 1 -2.09661
CDCA2 cell division cycle associated 2 -2.09661
YIPF6 Yip1 domain family, member 6 -2.07964
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -2.05233
SSRP1 structure specific recognition protein 1 -2.05092
ODR4 odr-4 GPCR localization factor homolog -2.05092
RBM41 RNA binding motif protein 41 -2.04631
PFAS phosphoribosylformylglycinamidine synthase -2.04205
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 -2.04205
DEPDC1 DEP domain containing 1 -2.04205
CHN1 chimerin 1 -2.03324
ANKRD17 ankyrin repeat domain 17 -2.02291
SNRPN small nuclear ribonucleoprotein polypeptide N -2.01705
RPL39L ribosomal protein L39-like -2.01156
DES desmin -2.00542
FKBP1B FK506 binding protein 1B, 12.6 kDa -2.00533
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -2.00357