L1CAM Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description L1 cell adhesion molecule|The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013] (NCBI Entrez Gene Database, 3897)
External Link http://www.ncbi.nlm.nih.gov/gene/3897
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Genes

155 interacting proteins for L1CAM from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
A2M alpha-2-macroglobulin
ACP2 acid phosphatase 2, lysosomal
ADGRE5 adhesion G protein-coupled receptor E5
ADNP activity-dependent neuroprotector homeobox
ANK1 ankyrin 1, erythrocytic
ANK2 ankyrin 2, neuronal
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
APMAP adipocyte plasma membrane associated protein
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BSG basigin (Ok blood group)
BTD biotinidase
BTN2A1 butyrophilin, subfamily 2, member A1
CANX calnexin
CD109 CD109 molecule
CD276 CD276 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CLN5 ceroid-lipofuscinosis, neuronal 5
CLPTM1 cleft lip and palate associated transmembrane protein 1
CLU clusterin
CNTN1 contactin 1
CNTN2 contactin 2 (axonal)
COL5A1 collagen, type V, alpha 1
COLGALT1 collagen beta(1-O)galactosyltransferase 1
CPM carboxypeptidase M
CRTAP cartilage associated protein
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CSPG4 chondroitin sulfate proteoglycan 4
CTSD cathepsin D
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DNASE2 deoxyribonuclease II, lysosomal
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DPP7 dipeptidyl-peptidase 7
DSG1 desmoglein 1
DSG2 desmoglein 2
ECE1 endothelin converting enzyme 1
EMC1 ER membrane protein complex subunit 1
ENG endoglin
EPHB2 EPH receptor B2
ERO1L ERO1-like (S. cerevisiae)
EYS eyes shut homolog (Drosophila)
EZR ezrin
FBN1 fibrillin 1
FBXO6 F-box protein 6
FKBP10 FK506 binding protein 10, 65 kDa
FKBP9 FK506 binding protein 9, 63 kDa
FOLR1 folate receptor 1 (adult)
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase)
GAA glucosidase, alpha; acid
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GBA glucosidase, beta, acid
GLMP glycosylated lysosomal membrane protein
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNS glucosamine (N-acetyl)-6-sulfatase
GUSB glucuronidase, beta
HEXA hexosaminidase A (alpha polypeptide)
HLA-A major histocompatibility complex, class I, A
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
IGF2R insulin-like growth factor 2 receptor
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JCHAIN joining chain of multimeric IgA and IgM
LAMA5 laminin, alpha 5
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LNPEP leucyl/cystinyl aminopeptidase
M6PR mannose-6-phosphate receptor (cation dependent)
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPK1 mitogen-activated protein kinase 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MPZL1 myelin protein zero-like 1
MSN moesin
NCAM1 neural cell adhesion molecule 1
NCAN neurocan
NCEH1 neutral cholesterol ester hydrolase 1
NCSTN nicastrin
NOMO1 NODAL modulator 1
NPC1 Niemann-Pick disease, type C1
NRP1 neuropilin 1
NUMB numb homolog (Drosophila)
NUP210 nucleoporin 210kDa
P3H1 prolyl 3-hydroxylase 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HB prolyl 4-hydroxylase, beta polypeptide
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCYOX1 prenylcysteine oxidase 1
PDIA6 protein disulfide isomerase family A, member 6
PEA15 phosphoprotein enriched in astrocytes 15
PIGR polymeric immunoglobulin receptor
PIGS phosphatidylinositol glycan anchor biosynthesis, class S
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PLA2G15 phospholipase A2, group XV
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
PLXNB2 plexin B2
PODXL2 podocalyxin-like 2
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPT1 palmitoyl-protein thioesterase 1
PRKCA protein kinase C, alpha
PROCR protein C receptor, endothelial
PSAP prosaposin
RAB10 RAB10, member RAS oncogene family
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RANBP9 RAN binding protein 9
RDX radixin
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SCARB1 scavenger receptor class B, member 1
SCARB2 scavenger receptor class B, member 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SETD3 SET domain containing 3
SGSH N-sulfoglucosamine sulfohydrolase
SIAE sialic acid acetylesterase
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSR1 signal sequence receptor, alpha
STOM stomatin
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
SUMF1 sulfatase modifying factor 1
SUN2 Sad1 and UNC84 domain containing 2
TFRC transferrin receptor
TMX3 thioredoxin-related transmembrane protein 3
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TREML2 triggering receptor expressed on myeloid cells-like 2
TSPEAR thrombospondin-type laminin G domain and EAR repeats
TUBB tubulin, beta class I
TUBB4A tubulin, beta 4A class IVa
TXNDC15 thioredoxin domain containing 15
UBC ubiquitin C
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
VTN vitronectin