L33 Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
Description Human pancreatic cancer cell line. (BRENDA Tissue and Enzyme Source Ontology, BTO_0004571)
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Genes

553 gene knockdowns changing fitness of L33 relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
NCR1 natural cytotoxicity triggering receptor 1 3.13059
OR10R2 olfactory receptor, family 10, subfamily R, member 2 3.11913
PSIP1 PC4 and SFRS1 interacting protein 1 3.0342
ZNF621 zinc finger protein 621 3.0102
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 2.82366
ZSCAN5A zinc finger and SCAN domain containing 5A 2.6449
ZNF426 zinc finger protein 426 2.57062
DCP1A decapping mRNA 1A 2.48915
ANKFY1 ankyrin repeat and FYVE domain containing 1 2.37288
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.33404
RGS4 regulator of G-protein signaling 4 2.26536
DLG2 discs, large homolog 2 (Drosophila) 2.2236
RABIF RAB interacting factor 2.19734
UBE2J2 ubiquitin-conjugating enzyme E2, J2 2.15831
SLC16A6 solute carrier family 16, member 6 2.1034
MAPK9 mitogen-activated protein kinase 9 2.09414
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 2.07297
COTL1 coactosin-like F-actin binding protein 1 2.07278
FBXL5 F-box and leucine-rich repeat protein 5 2.06847
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 2.04942
GFOD2 glucose-fructose oxidoreductase domain containing 2 2.01634
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) 2.01352
CUL9 cullin 9 2.01342
PARP8 poly (ADP-ribose) polymerase family, member 8 1.98091
RRAGC Ras-related GTP binding C 1.97797
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 1.96931
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 1.939
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.9354
IKZF2 IKAROS family zinc finger 2 (Helios) 1.89749
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 1.89212
CPB1 carboxypeptidase B1 (tissue) 1.89129
PLXNB2 plexin B2 1.88546
RXFP4 relaxin/insulin-like family peptide receptor 4 1.88398
MEN1 multiple endocrine neoplasia I 1.883
LYRM2 LYR motif containing 2 1.88213
TBX5 T-box 5 1.86977
HSDL1 hydroxysteroid dehydrogenase like 1 1.86378
FTSJ2 FtsJ RNA methyltransferase homolog 2 (E. coli) 1.85927
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.79296
MAST2 microtubule associated serine/threonine kinase 2 1.79275
ZNF485 zinc finger protein 485 1.77116
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein 1.75123
EMD emerin 1.74688
ZNF860 zinc finger protein 860 1.74036
EIF2D eukaryotic translation initiation factor 2D 1.71314
LCK LCK proto-oncogene, Src family tyrosine kinase 1.71104
ZNF566 zinc finger protein 566 1.6928
USP21 ubiquitin specific peptidase 21 1.6809
HCAR1 hydroxycarboxylic acid receptor 1 1.66914
S100A13 S100 calcium binding protein A13 1.656
SHOX2 short stature homeobox 2 1.63373
RHAG Rh-associated glycoprotein 1.62984
MED16 mediator complex subunit 16 1.62837
UCK1 uridine-cytidine kinase 1 1.62585
LMO7 LIM domain 7 1.61822
HIST1H3G histone cluster 1, H3g 1.61032
TRIM6 tripartite motif containing 6 1.60736
ZNF529 zinc finger protein 529 1.60681
UBE2A ubiquitin-conjugating enzyme E2A 1.60511
IVNS1ABP influenza virus NS1A binding protein 1.5917
TFB2M transcription factor B2, mitochondrial 1.59012
C18ORF8 chromosome 18 open reading frame 8 1.58574
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 1.55523
RASL10B RAS-like, family 10, member B 1.54846
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 1.53988
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 1.52455
BMP2K BMP2 inducible kinase 1.52196
CTSD cathepsin D 1.51688
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 1.51645
SLC14A2 solute carrier family 14 (urea transporter), member 2 1.51452
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 1.51447
RASD2 RASD family, member 2 1.51315
UBE2H ubiquitin-conjugating enzyme E2H 1.51016
MVD mevalonate (diphospho) decarboxylase 1.50907
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 1.50047
CD72 CD72 molecule 1.4981
HIPK1 homeodomain interacting protein kinase 1 1.48507
SRPK1 SRSF protein kinase 1 1.4802
BRWD1 bromodomain and WD repeat domain containing 1 1.47247
TSHZ2 teashirt zinc finger homeobox 2 1.46724
ADK adenosine kinase 1.46105
POC1A POC1 centriolar protein A 1.45992
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.45457
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 1.45324
BAAT bile acid CoA:amino acid N-acyltransferase 1.44173
FGG fibrinogen gamma chain 1.43353
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 1.42447
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 1.4238
CAPN5 calpain 5 1.41617
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene 1.41224
EED embryonic ectoderm development 1.40628
CXCL16 chemokine (C-X-C motif) ligand 16 1.40442
HLX H2.0-like homeobox 1.40232
ZNF382 zinc finger protein 382 1.38839
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 1.38775
ALX3 ALX homeobox 3 1.37916
PTGR1 prostaglandin reductase 1 1.37505
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) 1.37414
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B) 1.37201
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 1.36706
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.36252
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.34303
PAQR3 progestin and adipoQ receptor family member III 1.3415
AHCYL2 adenosylhomocysteinase-like 2 1.33959
YEATS4 YEATS domain containing 4 1.33947
DEGS1 delta(4)-desaturase, sphingolipid 1 1.33449
CDO1 cysteine dioxygenase type 1 1.32577
STX5 syntaxin 5 1.32285
RBKS ribokinase 1.32088
EFCAB2 EF-hand calcium binding domain 2 1.32079
GIPR gastric inhibitory polypeptide receptor 1.31955
NOG noggin 1.31611
UGDH UDP-glucose 6-dehydrogenase 1.31174
RYK receptor-like tyrosine kinase 1.31123
CALU calumenin 1.2963
USP6 ubiquitin specific peptidase 6 1.28969
MRGPRD MAS-related GPR, member D 1.28964
ZNF236 zinc finger protein 236 1.28871
IFT54 intraflagellar transport 54 1.28171
ZFR zinc finger RNA binding protein 1.28062
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 1.27393
BRAP BRCA1 associated protein 1.27028
PDE9A phosphodiesterase 9A 1.27016
HNMT histamine N-methyltransferase 1.27007
UBE3B ubiquitin protein ligase E3B 1.26313
ZNF702P zinc finger protein 702, pseudogene 1.26312
BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 1.25927
ATF6 activating transcription factor 6 1.25562
SKIL SKI-like proto-oncogene 1.25328
IFNGR1 interferon gamma receptor 1 1.25321
AHCTF1 AT hook containing transcription factor 1 1.25294
GBX2 gastrulation brain homeobox 2 1.2507
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 1.25036
SIX4 SIX homeobox 4 1.24788
ESRRA estrogen-related receptor alpha 1.2469
RCOR3 REST corepressor 3 1.24425
CARS cysteinyl-tRNA synthetase 1.24055
STS steroid sulfatase (microsomal), isozyme S 1.23771
SH3TC1 SH3 domain and tetratricopeptide repeats 1 1.23452
CCL7 chemokine (C-C motif) ligand 7 1.23343
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 1.23259
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.22948
STARD8 StAR-related lipid transfer (START) domain containing 8 1.22936
PIR pirin (iron-binding nuclear protein) 1.22673
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 1.22665
ZNF433 zinc finger protein 433 1.22564
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 1.21222
TTLL1 tubulin tyrosine ligase-like family member 1 1.21097
CHD6 chromodomain helicase DNA binding protein 6 1.20792
MFN1 mitofusin 1 1.20737
MAPK1 mitogen-activated protein kinase 1 1.20501
HYAL1 hyaluronoglucosaminidase 1 1.20335
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 1.20327
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 1.19758
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 1.19626
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 1.18887
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.18681
RWDD2A RWD domain containing 2A 1.17637
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 1.17351
IL22 interleukin 22 1.16556
EGR1 early growth response 1 1.15945
KHSRP KH-type splicing regulatory protein 1.15913
SRM spermidine synthase 1.15871
TOM1 target of myb1 (chicken) 1.15305
HSPA4 heat shock 70kDa protein 4 1.14989
TGFA transforming growth factor, alpha 1.14921
NPEPPS aminopeptidase puromycin sensitive 1.13895
MSMO1 methylsterol monooxygenase 1 1.13636
CUTC cutC copper transporter 1.11861
FMNL1 formin-like 1 1.11835
CHST10 carbohydrate sulfotransferase 10 1.11439
ZNF581 zinc finger protein 581 1.10927
POLM polymerase (DNA directed), mu 1.10713
KIFC1 kinesin family member C1 1.10543
AKIP1 A kinase (PRKA) interacting protein 1 1.10487
EBF1 early B-cell factor 1 1.10343
BATF basic leucine zipper transcription factor, ATF-like 1.10071
ARNT aryl hydrocarbon receptor nuclear translocator 1.09946
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 1.0968
BRI3 brain protein I3 1.09592
MMP19 matrix metallopeptidase 19 1.09417
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.09347
GLUL glutamate-ammonia ligase 1.09249
TMEM234 transmembrane protein 234 1.09096
PLA2G3 phospholipase A2, group III 1.0906
OTUD7A OTU deubiquitinase 7A 1.09046
GMPS guanine monphosphate synthase 1.09022
CDX4 caudal type homeobox 4 1.08916
SRSF4 serine/arginine-rich splicing factor 4 1.08902
FADS6 fatty acid desaturase 6 1.08708
TBC1D2B TBC1 domain family, member 2B 1.08512
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase 1.0835
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 1.08256
RHOG ras homolog family member G 1.08231
TCOF1 Treacher Collins-Franceschetti syndrome 1 1.08024
GSTP1 glutathione S-transferase pi 1 1.07979
PNLIPRP1 pancreatic lipase-related protein 1 1.07974
MYEF2 myelin expression factor 2 1.07894
TGFB2 transforming growth factor, beta 2 1.07469
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 1.07159
MDH1 malate dehydrogenase 1, NAD (soluble) 1.07134
ADPRHL1 ADP-ribosylhydrolase like 1 1.06556
DIO2 deiodinase, iodothyronine, type II 1.06306
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.0594
EDA ectodysplasin A 1.05877
HARS histidyl-tRNA synthetase 1.05694
ARSA arylsulfatase A 1.05634
CXCL10 chemokine (C-X-C motif) ligand 10 1.05428
KRT3 keratin 3, type II 1.05283
CES1 carboxylesterase 1 1.05148
SAG S-antigen; retina and pineal gland (arrestin) 1.04737
MITF microphthalmia-associated transcription factor 1.04549
CAPN11 calpain 11 1.0454
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 1.04367
RNF144A ring finger protein 144A 1.04364
UBE3A ubiquitin protein ligase E3A 1.03882
MAPT microtubule-associated protein tau 1.03879
UMODL1 uromodulin-like 1 1.03764
USP20 ubiquitin specific peptidase 20 1.03393
KIR3DX1 killer cell immunoglobulin-like receptor, three domains, X1 1.033
RAB33A RAB33A, member RAS oncogene family 1.03176
CD274 CD274 molecule 1.02617
PRKCE protein kinase C, epsilon 1.02331
TFCP2L1 transcription factor CP2-like 1 1.02249
SLC26A11 solute carrier family 26 (anion exchanger), member 11 1.0186
NES nestin 1.01755
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.01716
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 1.01711
CTSH cathepsin H 1.0146
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 1.01413
CCNK cyclin K 1.01285
ODC1 ornithine decarboxylase 1 1.01255
TMPRSS5 transmembrane protease, serine 5 1.00587
ZNF645 zinc finger protein 645 1.00512
CNGA1 cyclic nucleotide gated channel alpha 1 1.00355
ZNF714 zinc finger protein 714 1.00351
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 1.00349
RNF17 ring finger protein 17 1.00049

decreased fitness

Symbol Name Standardized Value
ARHGAP35 Rho GTPase activating protein 35 -3.55825
FFAR3 free fatty acid receptor 3 -2.6113
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -2.43824
IGF2R insulin-like growth factor 2 receptor -2.41314
GDF10 growth differentiation factor 10 -2.38059
SIX6 SIX homeobox 6 -2.35166
ENC1 ectodermal-neural cortex 1 (with BTB domain) -2.32026
CRX cone-rod homeobox -2.29536
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 -2.29007
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -2.28856
ZFP62 ZFP62 zinc finger protein -2.2481
HPD 4-hydroxyphenylpyruvate dioxygenase -2.24214
SULT4A1 sulfotransferase family 4A, member 1 -2.22781
ARL13B ADP-ribosylation factor-like 13B -2.21747
CCDC146 coiled-coil domain containing 146 -2.1925
FOXD4L4 forkhead box D4-like 4 -2.18294
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) -2.1531
PLRG1 pleiotropic regulator 1 -2.14305
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.14018
PCDHB11 protocadherin beta 11 -2.12432
ISX intestine-specific homeobox -2.11789
FOXD4L5 forkhead box D4-like 5 -2.11179
MBD1 methyl-CpG binding domain protein 1 -2.08131
WDR54 WD repeat domain 54 -2.07928
BAZ1B bromodomain adjacent to zinc finger domain, 1B -2.05911
MNT MAX network transcriptional repressor -2.02479
IDE insulin-degrading enzyme -2.02058
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 -2.0165
LAMA3 laminin, alpha 3 -2.00676
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 -2.00307
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -1.99751
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -1.98746
DPP6 dipeptidyl-peptidase 6 -1.97447
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) -1.97062
C1QBP complement component 1, q subcomponent binding protein -1.96573
HELLS helicase, lymphoid-specific -1.96558
ADORA1 adenosine A1 receptor -1.94347
RPGR retinitis pigmentosa GTPase regulator -1.94284
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 -1.93486
EZR ezrin -1.91892
GSS glutathione synthetase -1.89609
REG3A regenerating islet-derived 3 alpha -1.89153
SLIT2 slit homolog 2 (Drosophila) -1.88687
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -1.87147
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B -1.83807
PAQR6 progestin and adipoQ receptor family member VI -1.82442
TRIM36 tripartite motif containing 36 -1.81318
SLC35F2 solute carrier family 35, member F2 -1.81017
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -1.80618
FGD5 FYVE, RhoGEF and PH domain containing 5 -1.79677
XYLB xylulokinase homolog (H. influenzae) -1.78707
HRH2 histamine receptor H2 -1.7856
TSC22D4 TSC22 domain family, member 4 -1.77623
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 -1.76666
PTGER3 prostaglandin E receptor 3 (subtype EP3) -1.74982
RARB retinoic acid receptor, beta -1.73557
ETNK1 ethanolamine kinase 1 -1.72063
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -1.71698
AP3S2 adaptor-related protein complex 3, sigma 2 subunit -1.71553
FETUB fetuin B -1.70261
CP ceruloplasmin (ferroxidase) -1.69898
KCNG4 potassium channel, voltage gated modifier subfamily G, member 4 -1.69886
PARP12 poly (ADP-ribose) polymerase family, member 12 -1.69526
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -1.68577
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -1.67902
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -1.67626
KLK1 kallikrein 1 -1.66247
ZNF600 zinc finger protein 600 -1.65791
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -1.65405
ZNF83 zinc finger protein 83 -1.63577
SYT3 synaptotagmin III -1.63572
ZNF217 zinc finger protein 217 -1.63464
GTF2A1 general transcription factor IIA, 1, 19/37kDa -1.62289
RNF149 ring finger protein 149 -1.61721
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -1.61672
ZNF41 zinc finger protein 41 -1.61115
RHD Rh blood group, D antigen -1.60462
OXCT1 3-oxoacid CoA transferase 1 -1.6044
FIP1L1 factor interacting with PAPOLA and CPSF1 -1.59915
STRN3 striatin, calmodulin binding protein 3 -1.5819
TNPO3 transportin 3 -1.58002
SLC25A27 solute carrier family 25, member 27 -1.57966
OC90 otoconin 90 -1.5758
ERCC1 excision repair cross-complementation group 1 -1.5732
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit -1.56858
GRSF1 G-rich RNA sequence binding factor 1 -1.5666
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -1.56571
AGA aspartylglucosaminidase -1.54845
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -1.54532
ZNF800 zinc finger protein 800 -1.54167
ICMT isoprenylcysteine carboxyl methyltransferase -1.53269
FLNB filamin B, beta -1.52922
OR2T1 olfactory receptor, family 2, subfamily T, member 1 -1.52878
UNKL unkempt family zinc finger-like -1.52858
SYT9 synaptotagmin IX -1.5266
ADGRE3 adhesion G protein-coupled receptor E3 -1.52523
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 -1.52487
PAQR4 progestin and adipoQ receptor family member IV -1.52098
IFT27 intraflagellar transport 27 -1.51752
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 -1.50412
ABLIM3 actin binding LIM protein family, member 3 -1.49662
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) -1.49655
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -1.49578
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma -1.49223
AQP3 aquaporin 3 (Gill blood group) -1.48411
B3GAT2 beta-1,3-glucuronyltransferase 2 -1.48315
ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene -1.46357
SRP19 signal recognition particle 19kDa -1.45689
PGRMC2 progesterone receptor membrane component 2 -1.44986
HDAC8 histone deacetylase 8 -1.4399
PHACTR1 phosphatase and actin regulator 1 -1.43699
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -1.4262
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -1.41649
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) -1.40876
GTPBP3 GTP binding protein 3 (mitochondrial) -1.40664
RACGAP1 Rac GTPase activating protein 1 -1.40495
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -1.40331
MET MET proto-oncogene, receptor tyrosine kinase -1.39683
DHRS4 dehydrogenase/reductase (SDR family) member 4 -1.39359
PITRM1 pitrilysin metallopeptidase 1 -1.39352
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 -1.39058
FUBP3 far upstream element (FUSE) binding protein 3 -1.38932
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.38488
H3F3C H3 histone, family 3C -1.38299
TRIM45 tripartite motif containing 45 -1.37859
BHMT2 betaine--homocysteine S-methyltransferase 2 -1.37172
RXRB retinoid X receptor, beta -1.37108
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 -1.36981
SGCE sarcoglycan, epsilon -1.36755
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 -1.36736
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -1.3641
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -1.36103
FBXO17 F-box protein 17 -1.35625
IL1RN interleukin 1 receptor antagonist -1.35604
MAP2K3 mitogen-activated protein kinase kinase 3 -1.35314
EXOC2 exocyst complex component 2 -1.34726
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -1.34066
DBN1 drebrin 1 -1.3367
ARHGAP24 Rho GTPase activating protein 24 -1.33102
ERBB3 erb-b2 receptor tyrosine kinase 3 -1.32976
SSB Sjogren syndrome antigen B (autoantigen La) -1.32952
BCL9L B-cell CLL/lymphoma 9-like -1.32893
COL5A2 collagen, type V, alpha 2 -1.3286
HMGB1 high mobility group box 1 -1.32793
CNGB3 cyclic nucleotide gated channel beta 3 -1.32781
HTRA4 HtrA serine peptidase 4 -1.32591
PEX1 peroxisomal biogenesis factor 1 -1.32305
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -1.31985
CALML3 calmodulin-like 3 -1.3178
THOC7 THO complex 7 -1.31336
TRAF4 TNF receptor-associated factor 4 -1.30641
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.30357
RAB43 RAB43, member RAS oncogene family -1.30186
PRICKLE4 prickle homolog 4 (Drosophila) -1.30156
CDH20 cadherin 20, type 2 -1.30131
SAE1 SUMO1 activating enzyme subunit 1 -1.30028
CALCR calcitonin receptor -1.29843
TRIM26 tripartite motif containing 26 -1.29812
PHF11 PHD finger protein 11 -1.29675
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -1.29566
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -1.29548
SF3B2 splicing factor 3b, subunit 2, 145kDa -1.29481
CLIP1 CAP-GLY domain containing linker protein 1 -1.29433
NPC1 Niemann-Pick disease, type C1 -1.29144
DKC1 dyskeratosis congenita 1, dyskerin -1.29001
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -1.28745
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -1.28415
EBNA1BP2 EBNA1 binding protein 2 -1.28172
KRT24 keratin 24, type I -1.27762
CANX calnexin -1.27741
COL11A1 collagen, type XI, alpha 1 -1.27667
TMLHE trimethyllysine hydroxylase, epsilon -1.27226
LIPM lipase, family member M -1.26696
UBAP1 ubiquitin associated protein 1 -1.2654
ZNF490 zinc finger protein 490 -1.26085
RNF130 ring finger protein 130 -1.25389
REXO2 RNA exonuclease 2 -1.25374
IL1R1 interleukin 1 receptor, type I -1.25343
KRT19 keratin 19, type I -1.25047
TASP1 taspase, threonine aspartase, 1 -1.24919
H2AFZ H2A histone family, member Z -1.24897
HAAO 3-hydroxyanthranilate 3,4-dioxygenase -1.24154
SOX14 SRY (sex determining region Y)-box 14 -1.23847
CLDN18 claudin 18 -1.23843
G6PC2 glucose-6-phosphatase, catalytic, 2 -1.23758
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -1.23681
FGF21 fibroblast growth factor 21 -1.23559
USP40 ubiquitin specific peptidase 40 -1.23007
CCNC cyclin C -1.22857
BCAR3 breast cancer anti-estrogen resistance 3 -1.22767
TBX21 T-box 21 -1.2216
GAL galanin/GMAP prepropeptide -1.21795
PPP1R15B protein phosphatase 1, regulatory subunit 15B -1.2168
MTA1 metastasis associated 1 -1.20812
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 -1.20686
KCMF1 potassium channel modulatory factor 1 -1.20588
NPTN neuroplastin -1.20541
OR1S1 olfactory receptor, family 1, subfamily S, member 1 (gene/pseudogene) -1.20352
ATG4B autophagy related 4B, cysteine peptidase -1.20043
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 -1.19979
CLDN14 claudin 14 -1.19399
EGFR epidermal growth factor receptor -1.19341
HBE1 hemoglobin, epsilon 1 -1.19293
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -1.19169
LBX1 ladybird homeobox 1 -1.18687
ADCK3 aarF domain containing kinase 3 -1.18369
CTSE cathepsin E -1.18061
BTF3P11 basic transcription factor 3 pseudogene 11 -1.17835
ASPH aspartate beta-hydroxylase -1.17605
BTF3L4 basic transcription factor 3-like 4 -1.17488
GIF gastric intrinsic factor (vitamin B synthesis) -1.17022
EP300 E1A binding protein p300 -1.16882
LY75 lymphocyte antigen 75 -1.16807
GSK3B glycogen synthase kinase 3 beta -1.16804
CDK11B cyclin-dependent kinase 11B -1.16786
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -1.16572
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -1.16098
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -1.15912
PBX2 pre-B-cell leukemia homeobox 2 -1.15655
ACAT2 acetyl-CoA acetyltransferase 2 -1.15593
AES amino-terminal enhancer of split -1.15531
LONP1 lon peptidase 1, mitochondrial -1.15439
RASAL1 RAS protein activator like 1 (GAP1 like) -1.15286
POLR1C polymerase (RNA) I polypeptide C, 30kDa -1.15272
TUSC1 tumor suppressor candidate 1 -1.1526
CLEC3B C-type lectin domain family 3, member B -1.15164
NME4 NME/NM23 nucleoside diphosphate kinase 4 -1.14761
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa -1.14562
CCR7 chemokine (C-C motif) receptor 7 -1.14546
DPRX divergent-paired related homeobox -1.14206
CHN1 chimerin 1 -1.13978
RPL7 ribosomal protein L7 -1.13676
ZNF788 zinc finger family member 788 -1.13628
RAB22A RAB22A, member RAS oncogene family -1.13606
ALG12 ALG12, alpha-1,6-mannosyltransferase -1.13478
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1 -1.13181
ATP10A ATPase, class V, type 10A -1.12878
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -1.12729
GCKR glucokinase (hexokinase 4) regulator -1.12669
LRP12 low density lipoprotein receptor-related protein 12 -1.12208
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa -1.12105
TMC7 transmembrane channel-like 7 -1.11969
UBL4B ubiquitin-like 4B -1.11812
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -1.11759
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -1.11635
ADGRD2 adhesion G protein-coupled receptor D2 -1.11563
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 -1.11142
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 -1.11037
GRK7 G protein-coupled receptor kinase 7 -1.10926
NAMPT nicotinamide phosphoribosyltransferase -1.10871
CWC22 CWC22 spliceosome-associated protein -1.10822
ERF Ets2 repressor factor -1.10707
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -1.10492
PCDHA8 protocadherin alpha 8 -1.10451
PLA2G4B phospholipase A2, group IVB (cytosolic) -1.10399
ZNF436 zinc finger protein 436 -1.10284
PGP phosphoglycolate phosphatase -1.09558
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -1.09537
THPO thrombopoietin -1.09499
COX7B2 cytochrome c oxidase subunit VIIb2 -1.09483
CKS2 CDC28 protein kinase regulatory subunit 2 -1.09366
SNRPC small nuclear ribonucleoprotein polypeptide C -1.09278
LENG8 leukocyte receptor cluster (LRC) member 8 -1.09135
ADRB2 adrenoceptor beta 2, surface -1.08877
NUPL1 nucleoporin like 1 -1.08623
PTCH1 patched 1 -1.08432
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -1.08402
COPS8 COP9 signalosome subunit 8 -1.08045
DMTF1 cyclin D binding myb-like transcription factor 1 -1.07971
NTSR2 neurotensin receptor 2 -1.07842
HIST1H2AE histone cluster 1, H2ae -1.07384
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle -1.07381
NPHP4 nephronophthisis 4 -1.07334
NELL1 NEL-like 1 (chicken) -1.07239
LRPPRC leucine-rich pentatricopeptide repeat containing -1.07238
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 -1.07227
ZFX zinc finger protein, X-linked -1.07064
FGFR1 fibroblast growth factor receptor 1 -1.06962
SGK1 serum/glucocorticoid regulated kinase 1 -1.06947
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) -1.06836
ACYP1 acylphosphatase 1, erythrocyte (common) type -1.06282
TRIM33 tripartite motif containing 33 -1.06267
APOM apolipoprotein M -1.06222
SREBF1 sterol regulatory element binding transcription factor 1 -1.06087
PHB2 prohibitin 2 -1.05982
ATG4C autophagy related 4C, cysteine peptidase -1.05758
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -1.05712
ZNF773 zinc finger protein 773 -1.05673
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein -1.05625
STK3 serine/threonine kinase 3 -1.05323
FOXC1 forkhead box C1 -1.05287
TMED3 transmembrane emp24 protein transport domain containing 3 -1.0526
PEX12 peroxisomal biogenesis factor 12 -1.05162
FNTA farnesyltransferase, CAAX box, alpha -1.05153
ZSCAN20 zinc finger and SCAN domain containing 20 -1.05068
RPS29 ribosomal protein S29 -1.04873
RBPJ recombination signal binding protein for immunoglobulin kappa J region -1.04703
RNF146 ring finger protein 146 -1.04078
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) -1.04019
DHRS4L2 dehydrogenase/reductase (SDR family) member 4 like 2 -1.03953
NUCLEOLIN nucleolin multifunctional protein -1.03904
PITX3 paired-like homeodomain 3 -1.03708
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) -1.03383
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -1.03068
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -1.03058
HSPA1B heat shock 70kDa protein 1B -1.02704
ZRANB2 zinc finger, RAN-binding domain containing 2 -1.02316
NEK5 NIMA-related kinase 5 -1.01895
ANTXR1 anthrax toxin receptor 1 -1.01248
PMPCB peptidase (mitochondrial processing) beta -1.01211
METAP2 methionyl aminopeptidase 2 -1.0083
C1QA complement component 1, q subcomponent, A chain -1.00812
MCHR2 melanin-concentrating hormone receptor 2 -1.00597
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -1.00307
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -1.0027