LAMB1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description laminin, beta 1|Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 3912)
External Link http://www.ncbi.nlm.nih.gov/gene/3912
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Genes

169 interacting proteins for LAMB1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACHE acetylcholinesterase (Yt blood group)
ACSM2B acyl-CoA synthetase medium-chain family member 2B
ACTB actin, beta
AKAP8 A kinase (PRKA) anchor protein 8
ANTXR2 anthrax toxin receptor 2
ATXN7 ataxin 7
ATXN7L2 ataxin 7-like 2
BAIAP2L1 BAI1-associated protein 2-like 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCLAF1 BCL2-associated transcription factor 1
C19ORF68 chromosome 19 open reading frame 68
C9ORF114 chromosome 9 open reading frame 114
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CGN cingulin
CNTRL centriolin
COIL coilin
COL6A1 collagen, type VI, alpha 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CWC15 CWC15 spliceosome-associated protein
DBN1 drebrin 1
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DOK6 docking protein 6
DPY30 dpy-30 homolog (C. elegans)
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EIF3I eukaryotic translation initiation factor 3, subunit I
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ERBB2IP erbb2 interacting protein
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EXOSC10 exosome component 10
EXOSC4 exosome component 4
FBXO6 F-box protein 6
FMR1 fragile X mental retardation 1
FTSJ3 FtsJ homolog 3 (E. coli)
FXR2 fragile X mental retardation, autosomal homolog 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GCC2 GRIP and coiled-coil domain containing 2
GFI1B growth factor independent 1B transcription repressor
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GSN gelsolin
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
H2BFS H2B histone family, member S (pseudogene)
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
HIST1H4F histone cluster 1, H4f
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HSPA1B heat shock 70kDa protein 1B
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ITGA6 integrin, alpha 6
ITGB4 integrin, beta 4
KANK2 KN motif and ankyrin repeat domains 2
KARS lysyl-tRNA synthetase
KIAA1033 KIAA1033
LACTB lactamase, beta
LAMA1 laminin, alpha 1
LAMA2 laminin, alpha 2
LAMA5 laminin, alpha 5
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMC3 laminin, gamma 3
LAS1L LAS1-like (S. cerevisiae)
LIMA1 LIM domain and actin binding 1
LRRC59 leucine rich repeat containing 59
MED1 mediator complex subunit 1
MED17 mediator complex subunit 17
MED4 mediator complex subunit 4
MKI67 marker of proliferation Ki-67
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRPS15 mitochondrial ribosomal protein S15
MRPS22 mitochondrial ribosomal protein S22
MYBBP1A MYB binding protein (P160) 1a
MYH13 myosin, heavy chain 13, skeletal muscle
MYH14 myosin, heavy chain 14, non-muscle
MYH4 myosin, heavy chain 4, skeletal muscle
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYH7B myosin, heavy chain 7B, cardiac muscle, beta
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYLK2 myosin light chain kinase 2
MYO1C myosin IC
MYO1D myosin ID
NAT10 N-acetyltransferase 10 (GCN5-related)
NCOA3 nuclear receptor coactivator 3
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NID1 nidogen 1
NKRF NFKB repressing factor
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
OGG1 8-oxoguanine DNA glycosylase
PDIA3 protein disulfide isomerase family A, member 3
PELP1 proline, glutamate and leucine rich protein 1
PIP prolactin-induced protein
PKP3 plakophilin 3
POLR1E polymerase (RNA) I polypeptide E, 53kDa
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POM121 POM121 transmembrane nucleoporin
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTCD3 pentatricopeptide repeat domain 3
PTPN23 protein tyrosine phosphatase, non-receptor type 23
PTPRF protein tyrosine phosphatase, receptor type, F
PURA purine-rich element binding protein A
PURB purine-rich element binding protein B
PWP1 PWP1 homolog (S. cerevisiae)
RBM10 RNA binding motif protein 10
RBM14 RNA binding motif protein 14
RBM28 RNA binding motif protein 28
RFC1 replication factor C (activator 1) 1, 145kDa
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RIMS2 regulating synaptic membrane exocytosis 2
RPL10A ribosomal protein L10a
RPL17 ribosomal protein L17
RPL18A ribosomal protein L18a
RPL23 ribosomal protein L23
RPL29 ribosomal protein L29
RPL36AL ribosomal protein L36a-like
RPL7 ribosomal protein L7
RPL7A ribosomal protein L7a
RPLP0 ribosomal protein, large, P0
RPS11 ribosomal protein S11
RPS13 ribosomal protein S13
RPS16 ribosomal protein S16
RPS17 ribosomal protein S17
RPS18 ribosomal protein S18
RPS25 ribosomal protein S25
RPS26 ribosomal protein S26
RPS27L ribosomal protein S27-like
RPS3 ribosomal protein S3
RPS4X ribosomal protein S4, X-linked
RPS9 ribosomal protein S9
RRP1 ribosomal RNA processing 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP1B ribosomal RNA processing 1B
SEMG2 semenogelin II
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SHROOM3 shroom family member 3
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMN2 survival of motor neuron 2, centromeric
SPTBN2 spectrin, beta, non-erythrocytic 2
SRRM2 serine/arginine repetitive matrix 2
STAU1 staufen double-stranded RNA binding protein 1
STK31 serine/threonine kinase 31
SURF6 surfeit 6
TGFB1 transforming growth factor, beta 1
TTC21B tetratricopeptide repeat domain 21B
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBC ubiquitin C
UBN1 ubinuclein 1
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative)
VMAC vimentin-type intermediate filament associated coiled-coil protein
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WDR18 WD repeat domain 18
WNK4 WNK lysine deficient protein kinase 4
ZC3H18 zinc finger CCCH-type containing 18
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZFP91 ZFP91 zinc finger protein
ZFR zinc finger RNA binding protein
ZNF512B zinc finger protein 512B
ZNF638 zinc finger protein 638