LATS2 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description large tumor suppressor kinase 2|This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 26524)
External Link http://www.ncbi.nlm.nih.gov/gene/26524
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Genes

8 substrates of the kinase LATS2 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AMOT angiomotin
AMOTL2 angiomotin like 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
KIF23 kinesin family member 23
SNAI1 snail family zinc finger 1
YAP1 Yes-associated protein 1
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma