| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LB-100 perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LB-100_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.14634 |
| CDH13 | cadherin 13 | 0.0820131 |
| MAP1B | microtubule-associated protein 1B | 0.0540997 |
| PLAT | plasminogen activator, tissue | 0.0534955 |
| LDHA | lactate dehydrogenase A | 0.0514561 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0429875 |
| HDAC9 | histone deacetylase 9 | 0.0392204 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0365998 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0359308 |
| ASPH | aspartate beta-hydroxylase | 0.0343605 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0332272 |
| EGFR | epidermal growth factor receptor | 0.0321863 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.030225 |
| SP100 | SP100 nuclear antigen | 0.0293598 |
| CENPF | centromere protein F, 350/400kDa | 0.0282968 |
| EFNA5 | ephrin-A5 | 0.0272708 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.026817 |
| PODXL | podocalyxin-like | 0.0256584 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0255684 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0255476 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0251657 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0244528 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0244275 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0240249 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0232661 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0231063 |
| MSN | moesin | 0.0227698 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0224552 |
| GOLGB1 | golgin B1 | 0.0222398 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.020982 |
| DST | dystonin | 0.0206549 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0204336 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.020093 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0198187 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0197898 |
| PLXNA2 | plexin A2 | 0.0193974 |
| PFN1 | profilin 1 | 0.0189867 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0189298 |
| MYADM | myeloid-associated differentiation marker | 0.0189096 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0187887 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0185179 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0184756 |
| CYTH3 | cytohesin 3 | 0.0181565 |
| INTS6 | integrator complex subunit 6 | 0.018017 |
| DSG2 | desmoglein 2 | 0.0177575 |
| NEK7 | NIMA-related kinase 7 | 0.0177149 |
| ANXA1 | annexin A1 | 0.0175635 |
| FSTL1 | follistatin-like 1 | 0.0161962 |
| DSPP | dentin sialophosphoprotein | 0.0158843 |
| ERBIN | erbb2 interacting protein | 0.0158283 |
| MKI67 | marker of proliferation Ki-67 | 0.0157928 |
| KIAA1549L | KIAA1549-like | 0.0157378 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0157377 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0153667 |
| RASAL2 | RAS protein activator like 2 | 0.0148787 |
| VCL | vinculin | 0.014758 |
| ADAM32 | ADAM metallopeptidase domain 32 | 0.0146941 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0146713 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0146127 |
| FOSL1 | FOS-like antigen 1 | 0.0143079 |
| FMN2 | formin 2 | 0.0142671 |
| CSTB | cystatin B (stefin B) | 0.0141424 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0140942 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0136777 |
| SET | SET nuclear proto-oncogene | 0.0134908 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0134627 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0133848 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0132658 |
| L1CAM | L1 cell adhesion molecule | 0.0132123 |
| PMP22 | peripheral myelin protein 22 | 0.012863 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0127195 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0126015 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0125975 |
| S100A10 | S100 calcium binding protein A10 | 0.0124558 |
| NAV3 | neuron navigator 3 | 0.0123311 |
| SON | SON DNA binding protein | 0.0122886 |
| FN1 | fibronectin 1 | 0.0122519 |
| TPM3 | tropomyosin 3 | 0.0121469 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | 0.0120313 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0120249 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0116354 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0116118 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0115178 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0115009 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0114026 |
| S100A11 | S100 calcium binding protein A11 | 0.011187 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0111807 |
| DSTN | destrin (actin depolymerizing factor) | 0.0109825 |
| VEGFC | vascular endothelial growth factor C | 0.0109152 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0107215 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0106845 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0106743 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.010672 |
| CDK6 | cyclin-dependent kinase 6 | 0.0106548 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.010608 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0105194 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0104746 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0104004 |
| KLF10 | Kruppel-like factor 10 | 0.0103089 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0102505 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.125734 |
| FBN1 | fibrillin 1 | -0.106043 |
| UBC | ubiquitin C | -0.0923597 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0784069 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0768216 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0764296 |
| TMSB10 | thymosin beta 10 | -0.0668604 |
| LOXL2 | lysyl oxidase-like 2 | -0.0650461 |
| COL1A2 | collagen, type I, alpha 2 | -0.0567725 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.054569 |
| LOX | lysyl oxidase | -0.0505667 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0503184 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0419385 |
| SBF2 | SET binding factor 2 | -0.0415351 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0400173 |
| NDRG1 | N-myc downstream regulated 1 | -0.039741 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0396957 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0371168 |
| GPC6 | glypican 6 | -0.0352268 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0347001 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0346866 |
| COL5A2 | collagen, type V, alpha 2 | -0.0339592 |
| AHNAK | AHNAK nucleoprotein | -0.0334703 |
| COL3A1 | collagen, type III, alpha 1 | -0.033157 |
| OGA | O-GlcNAcase | -0.0325969 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0312222 |
| NAV2 | neuron navigator 2 | -0.0305905 |
| RUNX1 | runt-related transcription factor 1 | -0.0304116 |
| SPAG9 | sperm associated antigen 9 | -0.0290816 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0281671 |
| AUTS2 | autism susceptibility candidate 2 | -0.0277223 |
| STC1 | stanniocalcin 1 | -0.0275866 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.027455 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0271945 |
| XPO1 | exportin 1 | -0.0270251 |
| ATP13A3 | ATPase type 13A3 | -0.0255428 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0254104 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0250632 |
| THBS2 | thrombospondin 2 | -0.0250182 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0250109 |
| APP | amyloid beta (A4) precursor protein | -0.0239325 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0232819 |
| PTMA | prothymosin, alpha | -0.0231245 |
| MYOF | myoferlin | -0.0228363 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0226825 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0225505 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0224974 |
| RTN4 | reticulon 4 | -0.0223489 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0223049 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0219907 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0217083 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0216844 |
| HLA-E | major histocompatibility complex, class I, E | -0.0216629 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0216344 |
| ZNF292 | zinc finger protein 292 | -0.0216024 |
| CD109 | CD109 molecule | -0.0214269 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0210863 |
| WTAP | Wilms tumor 1 associated protein | -0.0210783 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0207733 |
| MEIS2 | Meis homeobox 2 | -0.0207428 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0204472 |
| DENND5A | DENN/MADD domain containing 5A | -0.0203134 |
| PKM | pyruvate kinase, muscle | -0.0202221 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0198306 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0197775 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -0.0194327 |
| USP34 | ubiquitin specific peptidase 34 | -0.019279 |
| IGF2R | insulin-like growth factor 2 receptor | -0.0192749 |
| ZNF207 | zinc finger protein 207 | -0.0192712 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0190728 |
| CD99 | CD99 molecule | -0.0190479 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0190108 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0189999 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.018929 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0188754 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0188134 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0187926 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0186547 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0185723 |
| ACTN4 | actinin, alpha 4 | -0.0182352 |
| CANX | calnexin | -0.0181519 |
| TMOD1 | tropomodulin 1 | -0.0180184 |
| S100A6 | S100 calcium binding protein A6 | -0.0179687 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0179437 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0178936 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0178241 |
| FLNB | filamin B, beta | -0.0177507 |
| SH3PXD2B | SH3 and PX domains 2B | -0.017744 |
| APAF1 | apoptotic peptidase activating factor 1 | -0.0176421 |
| SP3 | Sp3 transcription factor | -0.0175511 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0173912 |
| RNF24 | ring finger protein 24 | -0.0173708 |
| YEATS2 | YEATS domain containing 2 | -0.017309 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0172633 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0168888 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0168033 |
| HLA-B | major histocompatibility complex, class I, B | -0.0167935 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0167242 |
| SLC22A23 | solute carrier family 22, member 23 | -0.0167024 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0166989 |
