LB-100_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LB-100 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LB-100_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP1 insulin-like growth factor binding protein 1 0.132446
IGF2 insulin-like growth factor 2 0.127004
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0727077
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.05526
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0541248
SVIL supervillin 0.0486223
SDC4 syndecan 4 0.035812
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0345781
TMED2 transmembrane emp24 domain trafficking protein 2 0.034545
EEF2 eukaryotic translation elongation factor 2 0.0344924
MACF1 microtubule-actin crosslinking factor 1 0.0335275
NSUN6 NOP2/Sun domain family, member 6 0.0324943
INTS6 integrator complex subunit 6 0.0323115
SMAD3 SMAD family member 3 0.0317502
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0317083
OSBPL8 oxysterol binding protein-like 8 0.0297606
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.0292779
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0287396
PDLIM5 PDZ and LIM domain 5 0.0278914
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0264237
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0263262
NRIP1 nuclear receptor interacting protein 1 0.0261896
SRRM1 serine/arginine repetitive matrix 1 0.0257716
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0250652
CCL20 chemokine (C-C motif) ligand 20 0.0246798
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0244857
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0240515
APOB apolipoprotein B 0.0239211
KLF6 Kruppel-like factor 6 0.0238379
ARHGAP26 Rho GTPase activating protein 26 0.0235529
TLE4 transducin-like enhancer of split 4 0.0234434
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0233227
KYNU kynureninase 0.0231506
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0226935
LDHA lactate dehydrogenase A 0.0213242
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0212619
ADARB1 adenosine deaminase, RNA-specific, B1 0.0210519
BCL2L1 BCL2-like 1 0.020781
SPOPL speckle-type POZ protein-like 0.0207228
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0207
CLU clusterin 0.0200944
RBM39 RNA binding motif protein 39 0.0200629
YTHDC1 YTH domain containing 1 0.0199578
TF transferrin 0.0199526
ASXL2 additional sex combs like transcriptional regulator 2 0.0195269
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0193919
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0192384
HSPA8 heat shock 70kDa protein 8 0.0192028
PAWR PRKC, apoptosis, WT1, regulator 0.0189898
SHB Src homology 2 domain containing adaptor protein B 0.0189845
LIMS1 LIM and senescent cell antigen-like domains 1 0.0189349
EPS8 epidermal growth factor receptor pathway substrate 8 0.0186255
NACA nascent polypeptide-associated complex alpha subunit 0.0185508
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0183608
AHR aryl hydrocarbon receptor 0.0182969
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0181582
ZFAND3 zinc finger, AN1-type domain 3 0.0179484
RPL3 ribosomal protein L3 0.0179246
ABTB3 ankyrin repeat and BTB domain containing 3 0.0178546
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0178447
EIF4B eukaryotic translation initiation factor 4B 0.0178178
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0178092
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0177438
CCNY cyclin Y 0.0176559
JAG1 jagged 1 0.0176208
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0175972
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0174615
KMT2E lysine (K)-specific methyltransferase 2E 0.0174515
GPHN gephyrin 0.0171889
HNMT histamine N-methyltransferase 0.0171425
WWC2 WW and C2 domain containing 2 0.0169166
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0166554
LRRC1 leucine rich repeat containing 1 0.0164342
SERTAD2 SERTA domain containing 2 0.0164235
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0162976
ACSL3 acyl-CoA synthetase long-chain family member 3 0.015861
SET SET nuclear proto-oncogene 0.0157022
GPBP1 GC-rich promoter binding protein 1 0.015612
MED13L mediator complex subunit 13-like 0.0155872
RBM33 RNA binding motif protein 33 0.0154663
CXCL8 chemokine (C-X-C motif) ligand 8 0.0152756
TOP1 topoisomerase (DNA) I 0.0151843
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.015013
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0150017
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.0149861
HSPA1A heat shock 70kDa protein 1A 0.0149557
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0148411
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0148133
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0147788
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0147312
KLF10 Kruppel-like factor 10 0.0146544
HSPH1 heat shock 105kDa/110kDa protein 1 0.0145431
RPL21 ribosomal protein L21 0.0145292
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0145097
PPARD peroxisome proliferator-activated receptor delta 0.0144792
BAIAP2L1 BAI1-associated protein 2-like 1 0.0143817
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0143812
RPL7 ribosomal protein L7 0.01438
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0142224
PHF3 PHD finger protein 3 0.0141894

decreased expression

Symbol Name Standardized Value
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.155308
APOA2 apolipoprotein A-II -0.151436
MT2A metallothionein 2A -0.138663
TMSB10 thymosin beta 10 -0.119469
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.115764
ERRFI1 ERBB receptor feedback inhibitor 1 -0.106961
ENO1 enolase 1, (alpha) -0.103895
TM4SF1 transmembrane 4 L six family member 1 -0.0986266
TPT1 tumor protein, translationally-controlled 1 -0.095636
MAML2 mastermind-like 2 (Drosophila) -0.093418
VCL vinculin -0.0899913
EHBP1 EH domain binding protein 1 -0.0898012
NPAS2 neuronal PAS domain protein 2 -0.0889029
GPC6 glypican 6 -0.0872357
HMGA1 high mobility group AT-hook 1 -0.083458
AKAP12 A kinase (PRKA) anchor protein 12 -0.0819314
FN1 fibronectin 1 -0.0798685
ASPH aspartate beta-hydroxylase -0.0789389
ZMYND8 zinc finger, MYND-type containing 8 -0.0778663
ZBTB20 zinc finger and BTB domain containing 20 -0.0744426
TPM4 tropomyosin 4 -0.0699962
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0673687
SLC38A2 solute carrier family 38, member 2 -0.0639877
GPC3 glypican 3 -0.0635821
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0612532
RPS24 ribosomal protein S24 -0.0571725
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0562921
RUNX1 runt-related transcription factor 1 -0.0556584
RNF213 ring finger protein 213 -0.0553209
PLIN2 perilipin 2 -0.0551553
EGR1 early growth response 1 -0.0524353
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0515354
SOX5 SRY (sex determining region Y)-box 5 -0.0489301
PEG3 paternally expressed 3 -0.0480521
IFITM1 interferon induced transmembrane protein 1 -0.0479147
CP ceruloplasmin (ferroxidase) -0.0468717
RPS21 ribosomal protein S21 -0.0465101
NDRG1 N-myc downstream regulated 1 -0.0462076
IFI6 interferon, alpha-inducible protein 6 -0.0451908
ISG15 ISG15 ubiquitin-like modifier -0.0448608
RPL35A ribosomal protein L35a -0.0439015
GNAS GNAS complex locus -0.0431393
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0427992
FNDC3B fibronectin type III domain containing 3B -0.0425379
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0424306
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0424132
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0423836
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0411112
PTCHD4 patched domain containing 4 -0.04088
GMDS GDP-mannose 4,6-dehydratase -0.0400604
DSPP dentin sialophosphoprotein -0.0398782
C3 complement component 3 -0.0388624
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0387811
RIGI RNA sensor RIG-I -0.0379199
ELL2 elongation factor, RNA polymerase II, 2 -0.0378995
RPL11 ribosomal protein L11 -0.0371709
RPL34 ribosomal protein L34 -0.0362731
PERP PERP, TP53 apoptosis effector -0.0362629
PTBP3 polypyrimidine tract binding protein 3 -0.0362028
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0361616
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0361258
MX2 MX dynamin-like GTPase 2 -0.035711
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0356844
TM9SF3 transmembrane 9 superfamily member 3 -0.0354644
LOC112694756 uncharaterized LOC112694756 -0.0349531
ACTG1 actin gamma 1 -0.0348293
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0345414
B2M beta-2-microglobulin -0.0344453
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0340614
RPL37A ribosomal protein L37a -0.0331109
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0329814
TMEM123 transmembrane protein 123 -0.0325573
PTMA prothymosin, alpha -0.0324729
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0323615
RPL31 ribosomal protein L31 -0.0323032
POTEF POTE ankyrin domain family, member F -0.0321876
NPR2 natriuretic peptide receptor 2 -0.0321539
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0321199
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0318253
ITGAV integrin, alpha V -0.031581
HLA-A major histocompatibility complex, class I, A -0.0315268
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.031343
S100A9 S100 calcium binding protein A9 -0.0306955
HMGA2 high mobility group AT-hook 2 -0.0306837
PGK1 phosphoglycerate kinase 1 -0.0306063
KPNB1 karyopherin (importin) beta 1 -0.0299827
GLG1 golgi glycoprotein 1 -0.0295384
IFI27 interferon, alpha-inducible protein 27 -0.0294696
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0293842
DST dystonin -0.0292804
DNAAF9 dynein axonemal assembly factor 9 -0.0288273
AMBP alpha-1-microglobulin/bikunin precursor -0.0285858
TRIM26 tripartite motif containing 26 -0.0284855
EML4 echinoderm microtubule associated protein like 4 -0.0282636
STAU1 staufen double-stranded RNA binding protein 1 -0.0281951
FRMD5 FERM domain containing 5 -0.0281057
IFIH1 interferon induced with helicase C domain 1 -0.0279167
KIZ kizuna centrosomal protein -0.0278152
AHSG alpha-2-HS-glycoprotein -0.0278092
DOCK4 dedicator of cytokinesis 4 -0.0278003