LB-100_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LB-100 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LB-100_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.24947
TIMP3 TIMP metallopeptidase inhibitor 3 0.176672
LMO7 LIM domain 7 0.175412
PALM2AKAP2 PALM2 and AKAP2 fusion 0.134944
PDE4D phosphodiesterase 4D, cAMP-specific 0.132283
SLC35F3 solute carrier family 35, member F3 0.114066
LDHA lactate dehydrogenase A 0.108698
PDLIM5 PDZ and LIM domain 5 0.0940415
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0904149
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0877946
FTH1 ferritin, heavy polypeptide 1 0.0864165
CD44 CD44 molecule (Indian blood group) 0.0811946
EXT1 exostosin glycosyltransferase 1 0.0765639
SULF2 sulfatase 2 0.0749522
B2M beta-2-microglobulin 0.0689506
RASAL2 RAS protein activator like 2 0.068537
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0665767
TPT1 tumor protein, translationally-controlled 1 0.06343
MACF1 microtubule-actin crosslinking factor 1 0.063344
LAMC2 laminin, gamma 2 0.061529
HLA-B major histocompatibility complex, class I, B 0.0582694
SAMD9 sterile alpha motif domain containing 9 0.0580315
PRSS23 protease, serine, 23 0.0577992
HMGA2 high mobility group AT-hook 2 0.0573102
BCAR3 breast cancer anti-estrogen resistance 3 0.0564651
IFITM1 interferon induced transmembrane protein 1 0.0558081
AMOTL1 angiomotin like 1 0.0528823
ALCAM activated leukocyte cell adhesion molecule 0.0523746
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0521337
PALLD palladin, cytoskeletal associated protein 0.0505535
RPS8 ribosomal protein S8 0.0502705
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0488005
ANO1 anoctamin 1, calcium activated chloride channel 0.0471145
TMSB10 thymosin beta 10 0.0457915
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0451283
IFI6 interferon, alpha-inducible protein 6 0.0447932
KLF5 Kruppel-like factor 5 (intestinal) 0.0446539
PODXL podocalyxin-like 0.0444163
ANXA2 annexin A2 0.0440091
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0434446
ITGB4 integrin, beta 4 0.0432534
AKAP13 A kinase (PRKA) anchor protein 13 0.0430765
IFITM3 interferon induced transmembrane protein 3 0.0426624
HLA-E major histocompatibility complex, class I, E 0.0409815
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0407703
RNF217 ring finger protein 217 0.040451
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.039627
IFI44L interferon-induced protein 44-like 0.0394213
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0391919
MTSS1 metastasis suppressor 1 0.0391827
RPLP1 ribosomal protein, large, P1 0.0386992
ACTN4 actinin, alpha 4 0.0383162
EFNA5 ephrin-A5 0.0376268
SQSTM1 sequestosome 1 0.0374853
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.037481
PLS3 plastin 3 0.0371754
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0371046
HSPG2 heparan sulfate proteoglycan 2 0.0370884
INTS6 integrator complex subunit 6 0.0370119
SVIL supervillin 0.0366322
FTL ferritin, light polypeptide 0.0365854
RABGAP1L RAB GTPase activating protein 1-like 0.0365481
SP100 SP100 nuclear antigen 0.0363088
KLF6 Kruppel-like factor 6 0.0359439
MTAP methylthioadenosine phosphorylase 0.0354065
FAM107B family with sequence similarity 107, member B 0.0353129
ZSWIM6 zinc finger, SWIM-type containing 6 0.0344796
AOPEP aminopeptidase O (putative) 0.0342529
RPS3 ribosomal protein S3 0.0341616
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0340248
RPS4X ribosomal protein S4, X-linked 0.0336986
CALB1 calbindin 1, 28kDa 0.0336535
ENO1 enolase 1, (alpha) 0.033521
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0328335
MECOM MDS1 and EVI1 complex locus 0.0325942
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0325358
MPRIP myosin phosphatase Rho interacting protein 0.0325257
EGFR epidermal growth factor receptor 0.0322984
RPL35A ribosomal protein L35a 0.0322912
HDAC9 histone deacetylase 9 0.0320838
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0318037
RAD51B RAD51 paralog B 0.03159
THSD4 thrombospondin, type I, domain containing 4 0.0311661
IFI27 interferon, alpha-inducible protein 27 0.0311621
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0311242
RPL31 ribosomal protein L31 0.0307997
KIAA1671 KIAA1671 0.0306746
RPL26 ribosomal protein L26 0.0303538
VCL vinculin 0.0303505
PLXNA2 plexin A2 0.0302044
MKI67 marker of proliferation Ki-67 0.0298357
ECE1 endothelin converting enzyme 1 0.0297029
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0292808
UTRN utrophin 0.0292331
BZW1 basic leucine zipper and W2 domains 1 0.0289098
TJP1 tight junction protein 1 0.02861
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0285385
RACK1 receptor for activated C kinase 1 0.0282892
FOXP1 forkhead box P1 0.0282601
CSMD2 CUB and Sushi multiple domains 2 0.0282465

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.176659
NAMPT nicotinamide phosphoribosyltransferase -0.139647
MEF2A myocyte enhancer factor 2A -0.109231
GOLGA4 golgin A4 -0.0793769
KMT2E lysine (K)-specific methyltransferase 2E -0.0729903
CUL4B cullin 4B -0.0704442
RBM39 RNA binding motif protein 39 -0.0699229
ITCH itchy E3 ubiquitin protein ligase -0.0644637
ANLN anillin, actin binding protein -0.0631705
MYOF myoferlin -0.0612859
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0543931
RPS2 ribosomal protein S2 -0.0539136
SUCO SUN domain containing ossification factor -0.0506269
ESYT2 extended synaptotagmin-like protein 2 -0.0505318
KDM6A lysine (K)-specific demethylase 6A -0.0496861
CEMIP cell migration inducing protein, hyaluronan binding -0.0463951
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0454527
ARRDC3 arrestin domain containing 3 -0.0453294
ZNF292 zinc finger protein 292 -0.0452692
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0452536
TRIO trio Rho guanine nucleotide exchange factor -0.0448402
CANX calnexin -0.0448082
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0446449
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0441445
EFHD2 EF-hand domain family, member D2 -0.0432297
SPAG9 sperm associated antigen 9 -0.0419436
KTN1 kinectin 1 (kinesin receptor) -0.0418387
OGA O-GlcNAcase -0.0413441
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0396552
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.038939
RAB6A RAB6A, member RAS oncogene family -0.0385323
COG5 component of oligomeric golgi complex 5 -0.0383781
KDM3A lysine (K)-specific demethylase 3A -0.0372922
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0371145
FNIP1 folliculin interacting protein 1 -0.0367871
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.03663
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0363874
XPO1 exportin 1 -0.0360158
POTEF POTE ankyrin domain family, member F -0.0357855
ACBD3 acyl-CoA binding domain containing 3 -0.0357543
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0351883
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0350574
TPX2 TPX2, microtubule-associated -0.0348761
YBX3 Y box binding protein 3 -0.0346232
CLTC clathrin, heavy chain (Hc) -0.034282
KIF16B kinesin family member 16B -0.0342813
COG6 component of oligomeric golgi complex 6 -0.0340682
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0339744
AKAP9 A kinase (PRKA) anchor protein 9 -0.0338583
BZW2 basic leucine zipper and W2 domains 2 -0.0334894
DSTN destrin (actin depolymerizing factor) -0.0334552
COPA coatomer protein complex, subunit alpha -0.0333881
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0333351
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0328547
RLF rearranged L-myc fusion -0.0328175
SKIC3 SKI3 subunit of superkiller complex -0.032597
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0325054
NPEPPS aminopeptidase puromycin sensitive -0.0324602
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0322313
METTL15 methyltransferase like 15 -0.0321525
SRP54 signal recognition particle 54kDa -0.0320499
YAP1 Yes-associated protein 1 -0.0319962
RNF145 ring finger protein 145 -0.0313794
SBF2 SET binding factor 2 -0.0313424
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0307108
RNF19B ring finger protein 19B -0.0305192
KIAA1217 KIAA1217 -0.030501
MARCHF6 membrane associated ring-CH-type finger 6 -0.0301916
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0301626
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0301096
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0300665
GATA6 GATA binding protein 6 -0.0294675
COPB1 coatomer protein complex, subunit beta 1 -0.0294074
MSN moesin -0.0290076
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0286558
BRWD3 bromodomain and WD repeat domain containing 3 -0.0284333
MYH9 myosin, heavy chain 9, non-muscle -0.0280763
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0280381
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0279463
KDM7A lysine (K)-specific demethylase 7A -0.0277769
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0274932
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0274832
RIN2 Ras and Rab interactor 2 -0.0272612
NUP58 nucleoporin 58 -0.0271812
MORF4L2 mortality factor 4 like 2 -0.0270631
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.02689
ZFC3H1 zinc finger, C3H1-type containing -0.0267848
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0267094
ZMYM2 zinc finger, MYM-type 2 -0.0267001
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0266363
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0265727
PDLIM1 PDZ and LIM domain 1 -0.0264301
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0263928
DENND4C DENN/MADD domain containing 4C -0.0263755
PNISR PNN-interacting serine/arginine-rich protein -0.0258759
PTEN phosphatase and tensin homolog -0.0257065
TFG TRK-fused gene -0.0256699
GOLT1B golgi transport 1B -0.025562
GARS1 glycyl-tRNA synthetase 1 -0.025493
CDC73 cell division cycle 73 -0.0254843