LB-100_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LB-100 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LB-100_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.33972
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.177109
PDE4D phosphodiesterase 4D, cAMP-specific 0.0826017
THSD4 thrombospondin, type I, domain containing 4 0.0819769
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0738081
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0711765
HMGA2 high mobility group AT-hook 2 0.0640071
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0599604
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0578677
ZSWIM6 zinc finger, SWIM-type containing 6 0.0563156
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0558892
GRAMD1B GRAM domain containing 1B 0.0557417
TRIO trio Rho guanine nucleotide exchange factor 0.0549763
DOCK5 dedicator of cytokinesis 5 0.0546198
DST dystonin 0.0542702
EEF2 eukaryotic translation elongation factor 2 0.0538523
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0534442
ANO6 anoctamin 6 0.0513572
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0512447
VIM vimentin 0.0498328
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0471555
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0466196
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0457641
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0450416
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0443678
YBX3 Y box binding protein 3 0.0427327
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0406624
MCL1 myeloid cell leukemia 1 0.0406182
OSMR oncostatin M receptor 0.0398118
SFPQ splicing factor proline/glutamine-rich 0.039799
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.039493
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0394373
SVIL supervillin 0.0382622
FMNL2 formin-like 2 0.0374201
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0369608
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0357345
HSPA8 heat shock 70kDa protein 8 0.0355933
PDLIM5 PDZ and LIM domain 5 0.0355537
IGF1R insulin-like growth factor 1 receptor 0.0355493
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0340254
SLC38A2 solute carrier family 38, member 2 0.0335232
HOMER1 homer scaffolding protein 1 0.033204
DENND5B DENN/MADD domain containing 5B 0.0328029
ZFAND3 zinc finger, AN1-type domain 3 0.0326162
JMJD1C jumonji domain containing 1C 0.0324261
KRT18 keratin 18, type I 0.0323586
RIMS2 regulating synaptic membrane exocytosis 2 0.0323151
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0321981
LDHA lactate dehydrogenase A 0.0307947
IL6ST interleukin 6 signal transducer 0.0305818
EXOC4 exocyst complex component 4 0.0302032
KTN1 kinectin 1 (kinesin receptor) 0.030146
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.030094
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.029735
TXNRD1 thioredoxin reductase 1 0.0295511
NIPBL Nipped-B homolog (Drosophila) 0.0293287
FBXO11 F-box protein 11 0.0292339
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0289531
TPM3 tropomyosin 3 0.0288262
RPS4X ribosomal protein S4, X-linked 0.0288198
CDK17 cyclin-dependent kinase 17 0.0283526
WWOX WW domain containing oxidoreductase 0.0283424
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0277988
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0275786
ATXN1 ataxin 1 0.0273861
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0272857
MCTP1 multiple C2 domains, transmembrane 1 0.0266446
BZW1 basic leucine zipper and W2 domains 1 0.0262714
ACTN1 actinin, alpha 1 0.026043
GPHN gephyrin 0.0260307
ELL2 elongation factor, RNA polymerase II, 2 0.0253946
ZCCHC7 zinc finger, CCHC domain containing 7 0.0252446
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0251472
AFF3 AF4/FMR2 family, member 3 0.0251143
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0250721
WDR70 WD repeat domain 70 0.0247771
AGO2 argonaute RISC catalytic component 2 0.0247421
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0245906
SNAP25 synaptosomal-associated protein, 25kDa 0.0244379
NF1 neurofibromin 1 0.024412
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0242764
FUS FUS RNA binding protein 0.0242503
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0240336
VMP1 vacuole membrane protein 1 0.0239623
PTK2 protein tyrosine kinase 2 0.0239465
WNT2B wingless-type MMTV integration site family, member 2B 0.0238871
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0238782
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0238212
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0237046
MYH9 myosin, heavy chain 9, non-muscle 0.0236596
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0235028
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0234974
SMYD3 SET and MYND domain containing 3 0.0231656
RBM39 RNA binding motif protein 39 0.0231354
TRIM59 tripartite motif containing 59 0.0227982
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0226497
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.022608
WNK1 WNK lysine deficient protein kinase 1 0.0225345
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0224809
PRRC2C proline-rich coiled-coil 2C 0.0221736

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.158145
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.131506
PTMA prothymosin, alpha -0.0533732
TFPI2 tissue factor pathway inhibitor 2 -0.0526746
RPL37A ribosomal protein L37a -0.0487117
RPL35A ribosomal protein L35a -0.045833
MT2A metallothionein 2A -0.0455926
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0399167
RPS21 ribosomal protein S21 -0.0366391
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.035985
GOLGA4 golgin A4 -0.0357566
RPS29 ribosomal protein S29 -0.0345666
WSB1 WD repeat and SOCS box containing 1 -0.0343853
NLGN1 neuroligin 1 -0.0304805
TMSB10 thymosin beta 10 -0.0294727
TPM2 tropomyosin 2 (beta) -0.0274006
USP36 ubiquitin specific peptidase 36 -0.0271069
RPL12 ribosomal protein L12 -0.0262934
RPL31 ribosomal protein L31 -0.0259919
TMEM165 transmembrane protein 165 -0.0258962
GLG1 golgi glycoprotein 1 -0.0249732
RPLP2 ribosomal protein, large, P2 -0.0243223
IER3 immediate early response 3 -0.0240087
RPL37 ribosomal protein L37 -0.0237709
HLA-B major histocompatibility complex, class I, B -0.0215326
ANKRD12 ankyrin repeat domain 12 -0.0203118
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0202062
EFNA1 ephrin-A1 -0.0191523
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0187943
CAVIN1 caveolae associated protein 1 -0.0187082
MON2 MON2 homolog (S. cerevisiae) -0.0186091
LRRC23 leucine rich repeat containing 23 -0.0185288
RPL11 ribosomal protein L11 -0.0184952
PCLO piccolo presynaptic cytomatrix protein -0.0183949
RPL36 ribosomal protein L36 -0.0183063
FSCN1 fascin actin-bundling protein 1 -0.0178519
RPL9 ribosomal protein L9 -0.0177242
ZFR zinc finger RNA binding protein -0.0171133
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0169549
RPL26 ribosomal protein L26 -0.0168978
OGA O-GlcNAcase -0.0163238
FBXO34 F-box protein 34 -0.0158384
TEX14 testis expressed 14 -0.0155002
PHF10 PHD finger protein 10 -0.0153413
TPT1 tumor protein, translationally-controlled 1 -0.0153298
RPL28 ribosomal protein L28 -0.0152537
RPS16 ribosomal protein S16 -0.0151165
RNF38 ring finger protein 38 -0.014992
RPS14 ribosomal protein S14 -0.0149644
WASF2 WAS protein family, member 2 -0.0145811
NDRG1 N-myc downstream regulated 1 -0.0145665
TRIM9 tripartite motif containing 9 -0.0145554
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -0.0144446
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0143948
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0142807
RPS25 ribosomal protein S25 -0.0142138
RPS17 ribosomal protein S17 -0.0141292
RNF169 ring finger protein 169 -0.0141157
RASA2 RAS p21 protein activator 2 -0.0140232
CEP95 centrosomal protein 95kDa -0.0140125
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0139763
RPS24 ribosomal protein S24 -0.0139462
ATP5F1B ATP synthase F1 subunit beta -0.013826
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0137741
RPL38 ribosomal protein L38 -0.0135951
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0134969
RPS19 ribosomal protein S19 -0.0133129
HLA-A major histocompatibility complex, class I, A -0.013179
UBE2K ubiquitin-conjugating enzyme E2K -0.0130794
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0130492
GCC2 GRIP and coiled-coil domain containing 2 -0.0129528
KDM2B lysine (K)-specific demethylase 2B -0.0128972
BBX bobby sox homolog (Drosophila) -0.0128606
GOLT1B golgi transport 1B -0.0127969
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0125815
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0125807
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.01254
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0125365
RPS10 ribosomal protein S10 -0.0124748
NHSL1 NHS-like 1 -0.0124604
RPL36A ribosomal protein L36a -0.0124549
RPL7A ribosomal protein L7a -0.0123989
MT1X metallothionein 1X -0.0123495
PNISR PNN-interacting serine/arginine-rich protein -0.012328
RPS12 ribosomal protein S12 -0.0122748
ANKRD36 ankyrin repeat domain 36 -0.0121232
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -0.0120353
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0119676
ENOSF1 enolase superfamily member 1 -0.0119298
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0119174
SENP6 SUMO1/sentrin specific peptidase 6 -0.0119005
TCEAL4 transcription elongation factor A (SII)-like 4 -0.0118866
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0118805
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0118173
VDAC1 voltage-dependent anion channel 1 -0.0116997
PER1 period circadian clock 1 -0.0114791
EBF2 early B-cell factor 2 -0.0112976
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0112789
LATS2 large tumor suppressor kinase 2 -0.0112443
NBEAL1 neurobeachin-like 1 -0.011203