LB-100_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LB-100 perturbation in SNU-423 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the LB-100_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0662108
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0637359
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.061712
KYNU kynureninase 0.048559
EEF2 eukaryotic translation elongation factor 2 0.0439214
MYH9 myosin, heavy chain 9, non-muscle 0.041884
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0368378
HDAC9 histone deacetylase 9 0.0349368
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0345929
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0343748
SOD2 superoxide dismutase 2, mitochondrial 0.0293467
SMAD3 SMAD family member 3 0.0283298
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0278506
PHF3 PHD finger protein 3 0.0274018
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0254461
GOLGB1 golgin B1 0.0251059
OGA O-GlcNAcase 0.024687
INTS6 integrator complex subunit 6 0.0244245
SQSTM1 sequestosome 1 0.02381
BICC1 BicC family RNA binding protein 1 0.0233479
ARRDC3 arrestin domain containing 3 0.0233135
HSPA8 heat shock 70kDa protein 8 0.0222951
OPTN optineurin 0.0217016
AHR aryl hydrocarbon receptor 0.0216524
LDHA lactate dehydrogenase A 0.0215102
NAV2 neuron navigator 2 0.0194015
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0193019
PRELID2 PRELI domain containing 2 0.0189091
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0187092
KDM3A lysine (K)-specific demethylase 3A 0.0178543
DUSP10 dual specificity phosphatase 10 0.0177236
ZBTB38 zinc finger and BTB domain containing 38 0.017629
USP9X ubiquitin specific peptidase 9, X-linked 0.0169663
MLPH melanophilin 0.0166005
TMED2 transmembrane emp24 domain trafficking protein 2 0.0163425
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0156521
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0156104
MBNL2 muscleblind-like splicing regulator 2 0.0152289
CANX calnexin 0.0151967
SOX9 SRY (sex determining region Y)-box 9 0.0141644
EIF4B eukaryotic translation initiation factor 4B 0.0139803
USP53 ubiquitin specific peptidase 53 0.0139458
TMF1 TATA element modulatory factor 1 0.0137344
NFE2L1 nuclear factor, erythroid 2-like 1 0.0137139
SPAG9 sperm associated antigen 9 0.0134367
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0132887
MXI1 MAX interactor 1, dimerization protein 0.0131716
OSBPL8 oxysterol binding protein-like 8 0.0131433
CUL4B cullin 4B 0.0130869
AHNAK AHNAK nucleoprotein 0.013038
RPL3 ribosomal protein L3 0.012969
ANXA1 annexin A1 0.0128951
ZMIZ1 zinc finger, MIZ-type containing 1 0.0127594
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.012728
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.012157
NRIP1 nuclear receptor interacting protein 1 0.012145
MACF1 microtubule-actin crosslinking factor 1 0.0120686
SHB Src homology 2 domain containing adaptor protein B 0.0120673
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0120176
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0117652
RPS2 ribosomal protein S2 0.0117512
UBE2O ubiquitin-conjugating enzyme E2O 0.011647
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0115339
NONO non-POU domain containing, octamer-binding 0.0113401
HOOK2 hook microtubule-tethering protein 2 0.0112326
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0112315
ARFGEF3 ARFGEF family member 3 0.0112151
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0111221
EEF1G eukaryotic translation elongation factor 1 gamma 0.0109254
FN1 fibronectin 1 0.0109062
FAM20C family with sequence similarity 20, member C 0.0107398
ZNF841 zinc finger protein 841 0.0107315
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0107249
BZW1 basic leucine zipper and W2 domains 1 0.0107034
RPL14 ribosomal protein L14 0.0106763
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0106593
ZNF608 zinc finger protein 608 0.0105343
OGFRL1 opioid growth factor receptor-like 1 0.0105162
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0104379
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0104338
TPR translocated promoter region, nuclear basket protein 0.0104303
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0103101
RSL1D1 ribosomal L1 domain containing 1 0.0102613
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.010175
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0100704
SAMD9 sterile alpha motif domain containing 9 0.0100664
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.010037
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0100327
EIF4H eukaryotic translation initiation factor 4H 0.0100281
SH3BP4 SH3-domain binding protein 4 0.00992668
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0098739
LNPEP leucyl/cystinyl aminopeptidase 0.00982585
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.00966541
BIRC3 baculoviral IAP repeat containing 3 0.00961744
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0096091
UBAP2L ubiquitin associated protein 2-like 0.00953255
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.00952608
SDCBP syndecan binding protein (syntenin) 0.0094493
SDC4 syndecan 4 0.00940712
AUH AU RNA binding protein/enoyl-CoA hydratase 0.00919921

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.321487
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.197934
FRMD4A FERM domain containing 4A -0.167123
HLA-B major histocompatibility complex, class I, B -0.149041
TMSB10 thymosin beta 10 -0.146147
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.127695
MARCKS myristoylated alanine-rich protein kinase C substrate -0.126399
FTL ferritin, light polypeptide -0.0984999
EGR1 early growth response 1 -0.0784704
ZMYND8 zinc finger, MYND-type containing 8 -0.0783776
IER3 immediate early response 3 -0.0781223
HLA-A major histocompatibility complex, class I, A -0.0778705
TPT1 tumor protein, translationally-controlled 1 -0.0769348
NAMPT nicotinamide phosphoribosyltransferase -0.0758883
CD44 CD44 molecule (Indian blood group) -0.0737646
ADM adrenomedullin -0.0711643
IGFBP3 insulin-like growth factor binding protein 3 -0.0702594
UGCG UDP-glucose ceramide glucosyltransferase -0.0622886
PTMA prothymosin, alpha -0.0607064
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0600622
CTSD cathepsin D -0.0600045
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0539703
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.053665
RPL35A ribosomal protein L35a -0.0527863
TPM4 tropomyosin 4 -0.0522643
GLIS3 GLIS family zinc finger 3 -0.0521363
VCL vinculin -0.051554
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0502658
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0500672
PGK1 phosphoglycerate kinase 1 -0.0495892
COL1A1 collagen, type I, alpha 1 -0.0495389
ENO2 enolase 2 (gamma, neuronal) -0.0477528
CADM1 cell adhesion molecule 1 -0.0473268
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0451809
DIAPH2 diaphanous-related formin 2 -0.0442201
NDRG1 N-myc downstream regulated 1 -0.0436666
C3 complement component 3 -0.0435639
RPS21 ribosomal protein S21 -0.0433208
GNAS GNAS complex locus -0.0430448
B2M beta-2-microglobulin -0.0430117
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0422244
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0416493
RPS24 ribosomal protein S24 -0.0413232
HMGA1 high mobility group AT-hook 1 -0.04072
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0405436
ARL4C ADP-ribosylation factor-like 4C -0.0402876
SFRP1 secreted frizzled-related protein 1 -0.0402448
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0398158
RTN4 reticulon 4 -0.0397452
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0393981
RPL23 ribosomal protein L23 -0.0381336
SDK1 sidekick cell adhesion molecule 1 -0.0379606
SLC38A1 solute carrier family 38, member 1 -0.0375376
ACTG1 actin gamma 1 -0.0373055
PLIN2 perilipin 2 -0.0363322
RPS23 ribosomal protein S23 -0.0359132
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0358392
RPLP2 ribosomal protein, large, P2 -0.0356991
RPL37A ribosomal protein L37a -0.0356395
CLMP CXADR-like membrane protein -0.0352554
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0349102
S100A9 S100 calcium binding protein A9 -0.0347677
IFITM3 interferon induced transmembrane protein 3 -0.0345027
FNDC3B fibronectin type III domain containing 3B -0.0341583
PKM pyruvate kinase, muscle -0.033731
AKAP12 A kinase (PRKA) anchor protein 12 -0.0336971
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.033542
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0335151
COL1A2 collagen, type I, alpha 2 -0.0334946
RPL11 ribosomal protein L11 -0.0333688
NAV1 neuron navigator 1 -0.0324308
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.032191
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0316168
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0315511
RAI14 retinoic acid induced 14 -0.0315144
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0313789
MT2A metallothionein 2A -0.0313238
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0312976
RPS6 ribosomal protein S6 -0.0312366
TAPBP TAP binding protein (tapasin) -0.0308602
RAB7A RAB7A, member RAS oncogene family -0.0308475
RPS19 ribosomal protein S19 -0.0307565
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0300701
BTG1 B-cell translocation gene 1, anti-proliferative -0.0298836
EGFR epidermal growth factor receptor -0.0294973
TGFBI transforming growth factor, beta-induced, 68kDa -0.02944
ERBIN erbb2 interacting protein -0.0294139
CDH13 cadherin 13 -0.0291733
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0289035
CD63 CD63 molecule -0.028882
SFTPA2 surfactant protein A2 -0.0285099
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0282882
BNC2 basonuclin 2 -0.0281885
RPL9 ribosomal protein L9 -0.0281827
RPS14 ribosomal protein S14 -0.0279377
PTBP3 polypyrimidine tract binding protein 3 -0.0276962
TMSB4X thymosin beta 4, X-linked -0.0276043
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0269381
RPS13 ribosomal protein S13 -0.0268389
BASP1 brain abundant, membrane attached signal protein 1 -0.0267494