LB-100_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LB-100 perturbation in SW 900 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the LB-100_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 0.053579
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0467446
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0393354
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.030289
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0295178
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0257282
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0245055
NFE2L2 nuclear factor, erythroid 2-like 2 0.0239334
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.022044
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.0212469
BZW1 basic leucine zipper and W2 domains 1 0.020457
RPH3AL rabphilin 3A-like (without C2 domains) 0.0180866
KDM3A lysine (K)-specific demethylase 3A 0.0178208
ZSWIM6 zinc finger, SWIM-type containing 6 0.0162924
ATF6 activating transcription factor 6 0.0149669
TMED2 transmembrane emp24 domain trafficking protein 2 0.0143661
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.014055
LRRC23 leucine rich repeat containing 23 0.0139279
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0135881
PDIA4 protein disulfide isomerase family A, member 4 0.0129314
POU2F2 POU class 2 homeobox 2 0.0129055
AHRR aryl-hydrocarbon receptor repressor 0.0128329
ANKRD28 ankyrin repeat domain 28 0.0124538
HSPH1 heat shock 105kDa/110kDa protein 1 0.0124397
GPHN gephyrin 0.0121414
TPT1 tumor protein, translationally-controlled 1 0.0121261
AGO2 argonaute RISC catalytic component 2 0.0120521
RPL26 ribosomal protein L26 0.0115973
ABLIM1 actin binding LIM protein 1 0.0114889
NPTN neuroplastin 0.0114821
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0114724
SMOC1 SPARC related modular calcium binding 1 0.0114541
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0114058
TOP1 topoisomerase (DNA) I 0.0112946
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0112198
EFNA5 ephrin-A5 0.0109562
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0109395
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0107532
IPMK inositol polyphosphate multikinase 0.0107401
TMEM263 transmembrane protein 263 0.0106991
LARP1B La ribonucleoprotein domain family, member 1B 0.0106538
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0105634
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0101861
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0101571
PALLD palladin, cytoskeletal associated protein 0.0101309
SDC4 syndecan 4 0.00977283
FAM193B family with sequence similarity 193, member B 0.00974969
TMF1 TATA element modulatory factor 1 0.00973867
TBCA tubulin folding cofactor A 0.00967398
LCORL ligand dependent nuclear receptor corepressor-like 0.00963195
UBE2O ubiquitin-conjugating enzyme E2O 0.00961712
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00959343
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.00956955
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.00953085
FAM107B family with sequence similarity 107, member B 0.0094775
FAT1 FAT atypical cadherin 1 0.0093666
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0092599
SRP72 signal recognition particle 72kDa 0.00923157
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.00909959
DGKI diacylglycerol kinase, iota 0.00909952
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0090919
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.00907232
PRRC2C proline-rich coiled-coil 2C 0.00906233
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.00905302
PTPRM protein tyrosine phosphatase, receptor type, M 0.00902316
DSCAM Down syndrome cell adhesion molecule 0.00902206
IFRD1 interferon-related developmental regulator 1 0.00899215
EMP1 epithelial membrane protein 1 0.00898699
TSLIG3A tRNA splicing ligase complex subunit 3A 0.00891131
FMNL2 formin-like 2 0.0088478
ELOVL5 ELOVL fatty acid elongase 5 0.00882917
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.00880094
FGF18 fibroblast growth factor 18 0.0087904
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.00877435
NRIP1 nuclear receptor interacting protein 1 0.00877003
CCDC138 coiled-coil domain containing 138 0.00876763
PEAK1 pseudopodium-enriched atypical kinase 1 0.00872042
GLCCI1 glucocorticoid induced 1 0.00869106
NFE2L1 nuclear factor, erythroid 2-like 1 0.00855661
DSG2 desmoglein 2 0.00853183
H1-0 H1.0 linker histone 0.00843357
EDRF1 erythroid differentiation regulatory factor 1 0.00843069
RPL13A ribosomal protein L13a 0.00832689
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.00828204
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.00826299
CSPP1 centrosome and spindle pole associated protein 1 0.00825483
RSRP1 arginine/serine-rich protein 1 0.00825153
KANK1 KN motif and ankyrin repeat domains 1 0.00824998
PRPF39 pre-mRNA processing factor 39 0.00819794
IGF1R insulin-like growth factor 1 receptor 0.00819209
STAT5B signal transducer and activator of transcription 5B 0.00811746
UBXN7 UBX domain protein 7 0.00800571
GOLGA4 golgin A4 0.00799382
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.00799252
NPAS1 neuronal PAS domain protein 1 0.00798475
PPARA peroxisome proliferator-activated receptor alpha 0.00795911
PDE7A phosphodiesterase 7A 0.00791902
GPC5 glypican 5 0.00787224
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.00781729
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0077384

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.213617
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.19058
NRG1 neuregulin 1 -0.147453
IFI27 interferon, alpha-inducible protein 27 -0.114288
TMSB10 thymosin beta 10 -0.0905821
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0871788
HMGA2 high mobility group AT-hook 2 -0.0809063
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0784553
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0782903
S100A6 S100 calcium binding protein A6 -0.0744711
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.073941
ITGA1 integrin, alpha 1 -0.0668182
VIM vimentin -0.0656853
TMEM156 transmembrane protein 156 -0.0641629
MT2A metallothionein 2A -0.0612436
MAP1B microtubule-associated protein 1B -0.0605719
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0592089
ENO2 enolase 2 (gamma, neuronal) -0.0569971
VCL vinculin -0.0560546
SYT1 synaptotagmin I -0.0537525
B2M beta-2-microglobulin -0.0534462
FTL ferritin, light polypeptide -0.0519179
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0508645
HLA-B major histocompatibility complex, class I, B -0.0473676
SFTPA2 surfactant protein A2 -0.04465
TMEM165 transmembrane protein 165 -0.0437076
HMGA1 high mobility group AT-hook 1 -0.042108
PKM pyruvate kinase, muscle -0.0413043
NRP1 neuropilin 1 -0.0411238
ETV1 ets variant 1 -0.0408829
ASPH aspartate beta-hydroxylase -0.0402396
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0398042
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0397677
NDRG1 N-myc downstream regulated 1 -0.0396648
GLIS3 GLIS family zinc finger 3 -0.0358735
PLIN2 perilipin 2 -0.0351487
RTN4 reticulon 4 -0.0348559
EGR1 early growth response 1 -0.0347904
POTEF POTE ankyrin domain family, member F -0.0328406
KLHL5 kelch-like family member 5 -0.0327077
GRB10 growth factor receptor-bound protein 10 -0.0326373
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0325791
IFI6 interferon, alpha-inducible protein 6 -0.0324265
MRPS6 mitochondrial ribosomal protein S6 -0.0315384
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0307802
TMSB4X thymosin beta 4, X-linked -0.0305612
LMNA lamin A/C -0.0305527
LY6E lymphocyte antigen 6 complex, locus E -0.0304759
TRIO trio Rho guanine nucleotide exchange factor -0.0299128
HLA-A major histocompatibility complex, class I, A -0.0297111
TPI1 triosephosphate isomerase 1 -0.0295172
TXNRD1 thioredoxin reductase 1 -0.0293627
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0293404
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0287948
LOC112694756 uncharaterized LOC112694756 -0.0287116
PTMA prothymosin, alpha -0.0286456
ZBTB20 zinc finger and BTB domain containing 20 -0.028532
ZMYND8 zinc finger, MYND-type containing 8 -0.0285032
CENPF centromere protein F, 350/400kDa -0.028147
RBM25 RNA binding motif protein 25 -0.027898
SOX5 SRY (sex determining region Y)-box 5 -0.0278786
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0277329
ENO1 enolase 1, (alpha) -0.0269592
MAML2 mastermind-like 2 (Drosophila) -0.0261762
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0260621
CLTC clathrin, heavy chain (Hc) -0.0257876
SFRP1 secreted frizzled-related protein 1 -0.0254813
SPAG9 sperm associated antigen 9 -0.0251787
SOX4 SRY (sex determining region Y)-box 4 -0.025131
TPM4 tropomyosin 4 -0.0251133
NTN4 netrin 4 -0.0250687
LOC102724023 ES1 protein homolog, mitochondrial -0.0250684
FNDC3B fibronectin type III domain containing 3B -0.0250305
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0245912
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0242776
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0241615
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0239652
RPS21 ribosomal protein S21 -0.0237471
RAI14 retinoic acid induced 14 -0.023603
PTBP3 polypyrimidine tract binding protein 3 -0.0234716
ITGB5 integrin, beta 5 -0.0233809
PGK1 phosphoglycerate kinase 1 -0.023326
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0230622
ACBD3 acyl-CoA binding domain containing 3 -0.0229981
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0228572
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0225869
FOSL1 FOS-like antigen 1 -0.0224181
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0223922
VEGFA vascular endothelial growth factor A -0.0223529
TAGLN2 transgelin 2 -0.0222917
CD44 CD44 molecule (Indian blood group) -0.0219661
PCBP2 poly(rC) binding protein 2 -0.0215354
OSMR oncostatin M receptor -0.0214249
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0213837
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0213009
TSC22D1 TSC22 domain family, member 1 -0.0212172
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0211718
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0208984
GLUL glutamate-ammonia ligase -0.0203508
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0201962