LCAT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description lecithin-cholesterol acyltransferase|This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3931)
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Genes

335 genes differentially expressed following the LCAT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TLE6 transducin-like enhancer of split 6 3.28264
IL11RA interleukin 11 receptor, alpha 3.28264
NPAP1 nuclear pore associated protein 1 3.28264
FGD2 FYVE, RhoGEF and PH domain containing 2 3.28264
ZNF503 zinc finger protein 503 3.28264
COLEC10 collectin sub-family member 10 (C-type lectin) 3.28264
GPR162 G protein-coupled receptor 162 3.28264
GPR52 G protein-coupled receptor 52 3.28264
SLC26A7 solute carrier family 26 (anion exchanger), member 7 3.28264
NPPB natriuretic peptide B 3.28264
MYBPHL myosin binding protein H-like 3.28264
CD6 CD6 molecule 3.28264
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 3.28264
GGT5 gamma-glutamyltransferase 5 3.28264
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 3.28264
RAB44 RAB44, member RAS oncogene family 3.28264
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.28264
FAM153A family with sequence similarity 153, member A 3.28264
TSSK4 testis-specific serine kinase 4 3.28264
CFHR3 complement factor H-related 3 3.28264
HRH1 histamine receptor H1 3.28264
RNF17 ring finger protein 17 3.28264
ZNF208 zinc finger protein 208 3.28264
SCN2B sodium channel, voltage gated, type II beta subunit 3.28264
SLC46A3 solute carrier family 46, member 3 3.28264
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.28264
TNS4 tensin 4 3.28264
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.28264
CRIPT cysteine-rich PDZ-binding protein 3.28264
MEIKIN meiotic kinetochore factor 3.28264
LGI3 leucine-rich repeat LGI family, member 3 3.28264
MYL4 myosin, light chain 4, alkali; atrial, embryonic 3.28264
TPPP tubulin polymerization promoting protein 3.28264
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 3.28264
SMTNL1 smoothelin-like 1 3.28264
RFPL2 ret finger protein-like 2 3.28264
ARSF arylsulfatase F 3.28264
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.28264
MC4R melanocortin 4 receptor 3.28264
ANKRD22 ankyrin repeat domain 22 3.28264
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.28264
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.28264
BTC betacellulin 3.28264
DSG3 desmoglein 3 3.28264
SLC15A5 solute carrier family 15, member 5 3.28264
SSTR4 somatostatin receptor 4 3.28264
ZNF804B zinc finger protein 804B 3.28264
ITK IL2-inducible T-cell kinase 3.28264
DEFB109B defensin beta 109B 3.28264
GPR35 G protein-coupled receptor 35 3.28264
MGAM maltase-glucoamylase 3.28264
MGAT4D MGAT4 family, member D 3.28264
RHCE Rh blood group, CcEe antigens 3.28264
DPP4 dipeptidyl-peptidase 4 3.28264
FIMP1 fertilization-influencing membrane protein 1 3.28264
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.28264
TBC1D3L TBC1 domain family, member 3L 3.28264
MYL10 myosin, light chain 10, regulatory 3.28264
BEND2 BEN domain containing 2 3.28264
AVPR1A arginine vasopressin receptor 1A 3.28264
ZAR1 zygote arrest 1 3.28264
LOC124902436 talanin 3.28264
DNAAF6 dynein axonemal assembly factor 6 3.28264
ODAPH odontogenesis associated phosphoprotein 3.28264
RTL5 retrotransposon Gag like 5 3.28264
KASH5 KASH domain containing 5 3.28264
AJM1 apical junction component 1 homolog 3.28264
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.28264
SQOR sulfide quinone oxidoreductase 3.28264
HBG1 hemoglobin, gamma A 3.28264
IMPG2 interphotoreceptor matrix proteoglycan 2 3.28264
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 3.28264
C15ORF62 chromosome 15 open reading frame 62 3.28264
GDF10 growth differentiation factor 10 3.28264
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.28264
TLR7 toll-like receptor 7 3.28264
NHLRC4 NHL repeat containing 4 3.28264
TACSTD2 tumor-associated calcium signal transducer 2 3.28264
NPIPB9 nuclear pore complex interacting protein family, member B9 3.28264
OR8D4 olfactory receptor, family 8, subfamily D, member 4 3.28264
ANKRD42-DT ANKRD42 divergent transcript 3.28264
DSG1 desmoglein 1 3.28264
IAPP islet amyloid polypeptide 3.28264
MIP major intrinsic protein of lens fiber 3.28264
UBL4B ubiquitin-like 4B 3.28264
CCDC42 coiled-coil domain containing 42 3.28264
DLK1 delta-like 1 homolog (Drosophila) 3.28264
TMEM119 transmembrane protein 119 3.28264
UTS2 urotensin 2 3.28264
CCR1 chemokine (C-C motif) receptor 1 3.28264
SPDYC speedy/RINGO cell cycle regulator family member C 3.28264
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 3.28264
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 3.28264
RUNX3 runt-related transcription factor 3 3.28264
CCR6 chemokine (C-C motif) receptor 6 3.28264
SSH2 slingshot protein phosphatase 2 3.28264
VTCN1 V-set domain containing T cell activation inhibitor 1 3.28264
GPR50 G protein-coupled receptor 50 3.28264
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 3.28264
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 3.28264
DES desmin 3.28264
C17ORF99 chromosome 17 open reading frame 99 3.28264
CSDC2 cold shock domain containing C2, RNA binding 3.28264
LRRC46 leucine rich repeat containing 46 3.28264
VWA3A von Willebrand factor A domain containing 3A 3.28264
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.28264
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.28264
MAEL maelstrom spermatogenic transposon silencer 3.28264
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 3.28264
SLITRK6 SLIT and NTRK-like family, member 6 3.28264
ADGRF1 adhesion G protein-coupled receptor F1 3.28264
EGR3 early growth response 3 3.28264
LRRK2 leucine-rich repeat kinase 2 3.28264
FADS6 fatty acid desaturase 6 3.28264
EPX eosinophil peroxidase 3.28264
PLGLB1 plasminogen-like B1 3.28264
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.28264
KCNK9 potassium channel, two pore domain subfamily K, member 9 3.28264
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 3.28264
WFDC9 WAP four-disulfide core domain 9 3.28264
C11ORF16 chromosome 11 open reading frame 16 3.28264
NIPAL4 NIPA-like domain containing 4 3.28264
TRIM55 tripartite motif containing 55 3.28264
FIBIN fin bud initiation factor homolog (zebrafish) 3.28264
DRD5 dopamine receptor D5 3.28264
BAHCC1 BAH domain and coiled-coil containing 1 3.28264
TAS2R50 taste receptor, type 2, member 50 3.28264
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.28264
TIGD3 tigger transposable element derived 3 3.28264
ERICH4 glutamate-rich 4 3.28264
RGS11 regulator of G-protein signaling 11 3.28264
LMOD2 leiomodin 2 (cardiac) 3.28264
GJE1 gap junction protein, epsilon 1, 23kDa 3.28264
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.28264
UBQLNL ubiquilin-like 3.28264
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.28264
AQP8 aquaporin 8 3.28264
C2CD4D C2 calcium-dependent domain containing 4D 3.28264
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.28264
IRX4 iroquois homeobox 4 3.28264
QRFP pyroglutamylated RFamide peptide 3.28264
POU5F2 POU domain class 5, transcription factor 2 3.28264
EVI2A ecotropic viral integration site 2A 3.28264
LRRC25 leucine rich repeat containing 25 3.28264
ICAM2 intercellular adhesion molecule 2 3.28264
KIF19 kinesin family member 19 3.28264
OR10G3 olfactory receptor, family 10, subfamily G, member 3 3.28264
C11ORF87 chromosome 11 open reading frame 87 3.28264
MOBP myelin-associated oligodendrocyte basic protein 3.28264
ANGPTL7 angiopoietin-like 7 3.28264
FAIM2 Fas apoptotic inhibitory molecule 2 3.28264
SOX30 SRY (sex determining region Y)-box 30 3.28264
TGM1 transglutaminase 1 3.28264
GFI1B growth factor independent 1B transcription repressor 3.28264
OR14A16 olfactory receptor, family 14, subfamily A, member 16 3.28264
ITPKA inositol-trisphosphate 3-kinase A 3.28264
CHAT choline O-acetyltransferase 3.28264
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 3.28264
FOXP3 forkhead box P3 3.28264
FKBP1C FK506 binding protein 1C 3.28264
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.28264
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.28264
SIGLEC15 sialic acid binding Ig-like lectin 15 3.28264
PRSS21 protease, serine, 21 (testisin) 3.28264
CCNO cyclin O 3.28264
CA5A carbonic anhydrase VA, mitochondrial 3.28264
OTP orthopedia homeobox 3.28264
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 3.20702
IGFBP7 insulin-like growth factor binding protein 7 3.1933
SRP54 signal recognition particle 54kDa 3.02355
SP6 Sp6 transcription factor 3.01932
PNMA1 paraneoplastic Ma antigen 1 2.90127
ACD adrenocortical dysplasia homolog (mouse) 2.85708
GINS2 GINS complex subunit 2 (Psf2 homolog) 2.82919
SF3B3 splicing factor 3b, subunit 3, 130kDa 2.82174
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 2.78107
PCDHB15 protocadherin beta 15 2.69024
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 2.68851
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 2.62491
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 2.59894
H3C6 H3 clustered histone 6 2.56004
RASGEF1C RasGEF domain family, member 1C 2.52499
ANTXR1 anthrax toxin receptor 1 2.51121
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.50515
TMPPE transmembrane protein with metallophosphoesterase domain 2.50515
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.50515
ARSJ arylsulfatase family, member J 2.4793
FBXL16 F-box and leucine-rich repeat protein 16 2.4791
ORC2 origin recognition complex, subunit 2 2.47861
NR4A1 nuclear receptor subfamily 4, group A, member 1 2.47565
RPL3L ribosomal protein L3-like 2.41051
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.41051
ZBTB42 zinc finger and BTB domain containing 42 2.41051
DCP2 decapping mRNA 2 2.39629
WSB2 WD repeat and SOCS box containing 2 2.37831
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.36797
ACTN4 actinin, alpha 4 2.36797
TDO2 tryptophan 2,3-dioxygenase 2.36797
SZRD1 SUZ RNA binding domain containing 1 2.33688
ZNHIT2 zinc finger, HIT-type containing 2 2.3061
TRMT10B tRNA methyltransferase 10 homolog B (S. cerevisiae) 2.30041
ATP11C ATPase, class VI, type 11C 2.29532
WDR41 WD repeat domain 41 2.28688
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.28435
FAT1 FAT atypical cadherin 1 2.27606
CADM2 cell adhesion molecule 2 2.26084
THPO thrombopoietin 2.25763
TGFB3 transforming growth factor, beta 3 2.25763
MEIS2 Meis homeobox 2 2.25763
ADAM33 ADAM metallopeptidase domain 33 2.25763
FBH1 F-box DNA helicase 1 2.25763
PCDHB13 protocadherin beta 13 2.25763
MAPK15 mitogen-activated protein kinase 15 2.25763
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.25763
ZNF561 zinc finger protein 561 2.20987
SORCS2 sortilin-related VPS10 domain containing receptor 2 2.17224
ARL8B ADP-ribosylation factor-like 8B 2.16827
A2ML1 alpha-2-macroglobulin-like 1 2.16827
TSEN15 TSEN15 tRNA splicing endonuclease subunit 2.1365
TPRG1L tumor protein p63 regulated 1-like 2.12245
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 2.11794
XPO6 exportin 6 2.10503
IFRD1 interferon-related developmental regulator 1 2.10064
CORO1B coronin, actin binding protein, 1B 2.1004
NCKAP1 NCK-associated protein 1 2.065
MACC1 metastasis associated in colon cancer 1 2.05101
ZBTB34 zinc finger and BTB domain containing 34 2.04629
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 2.04263
LAP3 leucine aminopeptidase 3 2.02981
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 2.02348
DAZAP2 DAZ associated protein 2 2.00076

decreased expression

Symbol Name Standardized Value
SLC39A5 solute carrier family 39 (zinc transporter), member 5 -3.28264
RXFP1 relaxin/insulin-like family peptide receptor 1 -3.28264
STKLD1 serine/threonine kinase-like domain containing 1 -3.28264
PCDHGA10 protocadherin gamma subfamily A, 10 -3.28264
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 -3.28264
SCRG1 stimulator of chondrogenesis 1 -3.28264
GREB1L growth regulation by estrogen in breast cancer-like -3.28264
TUBA3D tubulin, alpha 3d -3.28264
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -3.28264
PRAM1 PML-RARA regulated adaptor molecule 1 -3.28264
ZNF575 zinc finger protein 575 -3.28264
GJD3 gap junction protein, delta 3, 31.9kDa -3.28264
AZU1 azurocidin 1 -3.28264
MEIOB meiosis specific with OB domains -3.28264
RAPSN receptor-associated protein of the synapse -3.28264
GLIS1 GLIS family zinc finger 1 -3.28264
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 -3.28264
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit -3.28264
IFI6 interferon, alpha-inducible protein 6 -3.28264
PAX5 paired box 5 -3.28264
WAS Wiskott-Aldrich syndrome -3.28264
KRTAP13-4 keratin associated protein 13-4 -3.28264
VPREB3 pre-B lymphocyte 3 -3.28264
MUC6 mucin 6, oligomeric mucus/gel-forming -3.28264
FOXG1 forkhead box G1 -3.28264
ACE angiotensin I converting enzyme -3.28264
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -3.28264
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -3.28264
CSP2 CS pseudogene 2 -3.28264
DRC5 dynein regulatory complex subunit 5 -3.28264
RRH retinal pigment epithelium-derived rhodopsin homolog -3.28264
RAG1 recombination activating gene 1 -3.28264
PCDHAC1 protocadherin alpha subfamily C, 1 -3.28264
HJV hemojuvelin BMP co-receptor -3.28264
FMO1 flavin containing monooxygenase 1 -3.28264
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -3.28264
NPNT nephronectin -3.28264
F5 coagulation factor V (proaccelerin, labile factor) -3.28264
RNF157 ring finger protein 157 -3.26208
ZBTB49 zinc finger and BTB domain containing 49 -3.24979
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 -3.1217
SYT7 synaptotagmin VII -2.91407
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -2.91183
CENPF centromere protein F, 350/400kDa -2.88337
CAMKMT calmodulin-lysine N-methyltransferase -2.78652
STUM stum, mechanosensory transduction mediator homolog -2.78652
CALU calumenin -2.72783
CAMTA2 calmodulin binding transcription activator 2 -2.69496
DTNBP1 dystrobrevin binding protein 1 -2.6878
PTBP3 polypyrimidine tract binding protein 3 -2.498
ATMIN ATM interactor -2.47861
PLCG1 phospholipase C, gamma 1 -2.47861
ZNF706 zinc finger protein 706 -2.4761
FAM171A2 family with sequence similarity 171, member A2 -2.43194
LYG2 lysozyme G-like 2 -2.41176
PTH2R parathyroid hormone 2 receptor -2.40299
GPHA2 glycoprotein hormone alpha 2 -2.40299
DPH2 DPH2 homolog (S. cerevisiae) -2.39629
MYOM1 myomesin 1 -2.37761
ANKRD45 ankyrin repeat domain 45 -2.36797
RSAD1 radical S-adenosyl methionine domain containing 1 -2.36797
RPS25 ribosomal protein S25 -2.36797
RNF115 ring finger protein 115 -2.35529
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.33688
IFI16 interferon, gamma-inducible protein 16 -2.33688
C17ORF100 chromosome 17 open reading frame 100 -2.33688
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -2.33688
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.33688
SERINC5 serine incorporator 5 -2.33688
SCARF1 scavenger receptor class F, member 1 -2.33688
ANKRD65 ankyrin repeat domain 65 -2.33688
MIEF2 mitochondrial elongation factor 2 -2.33688
PNMT phenylethanolamine N-methyltransferase -2.3276
SH3GL3 SH3-domain GRB2-like 3 -2.31055
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -2.30204
EPB41L4B erythrocyte membrane protein band 4.1 like 4B -2.29384
SEPTIN7 septin 7 -2.26865
ZNF44 zinc finger protein 44 -2.26426
AHSG alpha-2-HS-glycoprotein -2.26084
ECE2 endothelin converting enzyme 2 -2.26084
BMI1 BMI1 proto-oncogene, polycomb ring finger -2.26084
TOR4A torsin family 4, member A -2.26084
GULP1 GULP, engulfment adaptor PTB domain containing 1 -2.25763
PRPF3 pre-mRNA processing factor 3 -2.22769
TMEM63A transmembrane protein 63A -2.21225
MCOLN2 mucolipin 2 -2.2045
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 -2.18183
PRSS50 protease, serine, 50 -2.16827
PIAS3 protein inhibitor of activated STAT, 3 -2.16827
GPNMB glycoprotein (transmembrane) nmb -2.16827
TMPRSS11E transmembrane protease, serine 11E -2.16827
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 -2.16827
POU2F3 POU class 2 homeobox 3 -2.16827
STIL SCL/TAL1 interrupting locus -2.14849
SCHIP1 schwannomin interacting protein 1 -2.1365
CCNQ cyclin Q -2.12738
TRERF1 transcriptional regulating factor 1 -2.12245
ATXN7L2 ataxin 7-like 2 -2.11794
UNC13D unc-13 homolog D (C. elegans) -2.11794
ASIC2 acid sensing (proton gated) ion channel 2 -2.11794
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.07357
FGD1 FYVE, RhoGEF and PH domain containing 1 -2.065
CYBA cytochrome b-245, alpha polypeptide -2.04203
KIF23 kinesin family member 23 -2.00967