LCK Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description LCK proto-oncogene, Src family tyrosine kinase|This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3932)
External Link http://www.ncbi.nlm.nih.gov/gene/3932
Similar Terms
Downloads & Tools

Genes

186 interacting proteins for hub protein LCK from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ACLY ATP citrate lyase
ACP1 acid phosphatase 1, soluble
ACTB actin, beta
ADAM10 ADAM metallopeptidase domain 10
ADAM15 ADAM metallopeptidase domain 15
ARHGAP17 Rho GTPase activating protein 17
AXL AXL receptor tyrosine kinase
BCAR1 breast cancer anti-estrogen resistance 1
BTK Bruton agammaglobulinemia tyrosine kinase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CCDC50 coiled-coil domain containing 50
CCDC88A coiled-coil domain containing 88A
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD2 CD2 molecule
CD247 CD247 molecule
CD28 CD28 molecule
CD33 CD33 molecule
CD34 CD34 molecule
CD38 CD38 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD48 CD48 molecule
CD5 CD5 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD8A CD8a molecule
CD8B CD8b molecule
CDC25C cell division cycle 25C
CDC42 cell division cycle 42
CDK5 cyclin-dependent kinase 5
CHN2 chimerin 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CSK c-src tyrosine kinase
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNND1 catenin (cadherin-associated protein), delta 1
CTNND2 catenin (cadherin-associated protein), delta 2
CYLD cylindromatosis (turban tumor syndrome)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGKA diacylglycerol kinase, alpha 80kDa
DLG1 discs, large homolog 1 (Drosophila)
DNM2 dynamin 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DOK3 docking protein 3
EFS embryonal Fyn-associated substrate
ELP3 elongator acetyltransferase complex subunit 3
EPHA3 EPH receptor A3
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZR ezrin
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FLNB filamin B, beta
FLT3 fms-related tyrosine kinase 3
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAB2 GRB2-associated binding protein 2
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GRAP GRB2-related adaptor protein
HCLS1 hematopoietic cell-specific Lyn substrate 1
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HLA-B major histocompatibility complex, class I, B
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL2RB interleukin 2 receptor, beta
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INPPL1 inositol polyphosphate phosphatase-like 1
INSR insulin receptor
ITK IL2-inducible T-cell kinase
ITSN2 intersectin 2
JAK1 Janus kinase 1
JAK3 Janus kinase 3
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAT linker for activation of T cells
LAX1 lymphocyte transmembrane adaptor 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIME1 Lck interacting transmembrane adaptor 1
LPP LIM domain containing preferred translocation partner in lipoma
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK9 mitogen-activated protein kinase 9
MED25 mediator complex subunit 25
MED28 mediator complex subunit 28
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MUC1 mucin 1, cell surface associated
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH1 notch 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRDX1 peroxiredoxin 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCQ protein kinase C, theta
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRH protein tyrosine phosphatase, receptor type, H
PVR poliovirus receptor
PXN paxillin
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RET ret proto-oncogene
RPS27A ribosomal protein S27a
RUNX3 runt-related transcription factor 3
S100B S100 calcium binding protein B
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SH2B3 SH2B adaptor protein 3
SH2D1A SH2 domain containing 1A
SH2D2A SH2 domain containing 2A
SH3BP2 SH3-domain binding protein 2
SH3KBP1 SH3-domain kinase binding protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIGLEC10 sialic acid binding Ig-like lectin 10
SIT1 signaling threshold regulating transmembrane adaptor 1
SKAP1 src kinase associated phosphoprotein 1
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSBP3 single stranded DNA binding protein 3
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
SYK spleen tyrosine kinase
TACC1 transforming, acidic coiled-coil containing protein 1
TEK TEK tyrosine kinase, endothelial
THY1 Thy-1 cell surface antigen
TRAT1 T cell receptor associated transmembrane adaptor 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TUB tubby bipartite transcription factor
TYROBP TYRO protein tyrosine kinase binding protein
UBC ubiquitin C
UBE3A ubiquitin protein ligase E3A
UNC119 unc-119 homolog (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZNF264 zinc finger protein 264