LCK Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description LCK proto-oncogene, Src family tyrosine kinase|This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3932)
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100 substrates of the kinase LCK from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 99.91
CSNK2A2 casein kinase 2, alpha prime polypeptide 99.89
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 99.87
KAT2B K(lysine) acetyltransferase 2B 99.85
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 99.83
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 99.8
PCYOX1 prenylcysteine oxidase 1 99.72
ANKRD26 ankyrin repeat domain 26 99.71
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 99.65
LOC102725035 leukocyte immunoglobulin-like receptor subfamily B member 3 99.63
RFTN1 raftlin, lipid raft linker 1 99.59
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 99.56
VCP valosin containing protein 99.54
MCC mutated in colorectal cancers 99.5
PHKB phosphorylase kinase, beta 99.48
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 99.43
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 99.39
FHIT fragile histidine triad 99.37
RBM25 RNA binding motif protein 25 99.36
RRM1 ribonucleotide reductase M1 99.32
FBXO9 F-box protein 9 99.19
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 99.13
KAT2A K(lysine) acetyltransferase 2A 99.12
ELP3 elongator acetyltransferase complex subunit 3 98.87
UBE2E1 ubiquitin-conjugating enzyme E2E 1 98.86
UBE2E3 ubiquitin-conjugating enzyme E2E 3 98.86
UBE2E2 ubiquitin-conjugating enzyme E2E 2 98.86
EXPH5 exophilin 5 98.75
SCAF8 SR-related CTD-associated factor 8 98.73
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 98.71
ZCCHC3 zinc finger, CCHC domain containing 3 98.69
MACO1 macoilin 1 98.67
ZNF512 zinc finger protein 512 98.66
RABGAP1L RAB GTPase activating protein 1-like 98.6
DPH6 diphthamine biosynthesis 6 98.58
DOK3 docking protein 3 98.47
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 98.42
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 98.42
CHERP calcium homeostasis endoplasmic reticulum protein 98.39
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 98.25
TRIP11 thyroid hormone receptor interactor 11 98.23
PLCL2 phospholipase C-like 2 98.21
CLEC12B C-type lectin domain family 12, member B 98.03
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 97.88
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 97.79
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 97.76
JUN jun proto-oncogene 97.62
PILRA paired immunoglobin-like type 2 receptor alpha 97.55
FCRL6 Fc receptor-like 6 97.51
TCHP trichoplein, keratin filament binding 97.44
SIPA1L1 signal-induced proliferation-associated 1 like 1 97.42
RPL36AL ribosomal protein L36a-like 97.39
TEX2 testis expressed 2 97.37
PRMT3 protein arginine methyltransferase 3 97.37
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 97.26
TENT4A terminal nucleotidyltransferase 4A 97.24
SMG8 SMG8 nonsense mediated mRNA decay factor 97.15
EPB41L5 erythrocyte membrane protein band 4.1 like 5 97.13
FAM168A family with sequence similarity 168, member A 96.98
KLC3 kinesin light chain 3 96.96
GMPPA GDP-mannose pyrophosphorylase A 96.93
FKBP6 FK506 binding protein 6, 36kDa 96.89
MTMR10 myotubularin related protein 10 96.87
AHCY adenosylhomocysteinase 96.78
IKZF3 IKAROS family zinc finger 3 (Aiolos) 96.76
LY6G6F lymphocyte antigen 6 complex, locus G6F 96.72
CEP89 centrosomal protein 89kDa 96.69
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 96.63
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 96.58
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 96.58
CHD2 chromodomain helicase DNA binding protein 2 96.54
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 96.45
NCKAP5 NCK-associated protein 5 96.43
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 96.35
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 96.28
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 96.23
EPHA7 EPH receptor A7 96.17
ACBD3 acyl-CoA binding domain containing 3 96.1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 96.04
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 96.0
LNPEP leucyl/cystinyl aminopeptidase 95.985
TGFB1I1 transforming growth factor beta 1 induced transcript 1 95.95
LRPPRC leucine-rich pentatricopeptide repeat containing 95.95
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 95.93
RRM2 ribonucleotide reductase M2 95.84
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 95.84
RGS10 regulator of G-protein signaling 10 95.82
FCMR Fc fragment of IgM receptor 95.75
PBX2 pre-B-cell leukemia homeobox 2 95.71
N4BP3 NEDD4 binding protein 3 95.69
NFYA nuclear transcription factor Y, alpha 95.58
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 95.58
N4BP2 NEDD4 binding protein 2 95.51
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 95.49
AP1B1 adaptor-related protein complex 1, beta 1 subunit 95.47
DTD2 D-tyrosyl-tRNA deacylase 2 (putative) 95.36
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 95.34
COX4I1 cytochrome c oxidase subunit IV isoform 1 95.27
PRRC2B proline-rich coiled-coil 2B 95.25
PTPRB protein tyrosine phosphatase, receptor type, B 95.23