| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | LCK proto-oncogene, Src family tyrosine kinase|This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3932) |
| External Link | https://ncbi.nlm.nih.gov/gene/3932 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the LCK gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IFI27 | interferon, alpha-inducible protein 27 | 0.0202937 |
| THBS2 | thrombospondin 2 | 0.0170213 |
| MX1 | MX dynamin-like GTPase 1 | 0.0163965 |
| XIC | X chromosome inactivation center | 0.0162172 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0158886 |
| DEFB1 | defensin, beta 1 | 0.0153538 |
| GNAS | GNAS complex locus | 0.0143997 |
| RGCC | regulator of cell cycle | 0.0143441 |
| MUC16 | mucin 16, cell surface associated | 0.0139623 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.0136638 |
| SPON1 | spondin 1, extracellular matrix protein | 0.0135852 |
| DOK5 | docking protein 5 | 0.0135605 |
| TUBB2A | tubulin, beta 2A class IIa | 0.0133299 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.0131369 |
| XPO7 | exportin 7 | 0.0131037 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.0127673 |
| THBS1 | thrombospondin 1 | 0.0127419 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0127274 |
| CFI | complement factor I | 0.0123295 |
| MSLN | mesothelin | 0.0120296 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0117185 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0116265 |
| ANXA1 | annexin A1 | 0.0114918 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.0114706 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.0114561 |
| MFAP5 | microfibrillar associated protein 5 | 0.0114001 |
| TUBB2B | tubulin, beta 2B class IIb | 0.0111709 |
| EMX2 | empty spiracles homeobox 2 | 0.0110261 |
| CLIC5 | chloride intracellular channel 5 | 0.0108075 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0107615 |
| CD200 | CD200 molecule | 0.0106296 |
| QPRT | quinolinate phosphoribosyltransferase | 0.0105713 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | 0.0105139 |
| MEN1 | multiple endocrine neoplasia I | 0.0105086 |
| KLF6 | Kruppel-like factor 6 | 0.0104944 |
| OXTR | oxytocin receptor | 0.0103314 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | 0.0103229 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0102483 |
| DAXX | death-domain associated protein | 0.0102321 |
| PDZD2 | PDZ domain containing 2 | 0.0102222 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.0102045 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0101507 |
| AZIN1 | antizyme inhibitor 1 | 0.0099916 |
| MYO1B | myosin IB | 0.00997895 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00993718 |
| MXRA5 | matrix-remodelling associated 5 | 0.00987342 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.00978624 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 0.00976474 |
| GLDC | glycine dehydrogenase (decarboxylating) | 0.00976026 |
| ITM2C | integral membrane protein 2C | 0.00975694 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.00975216 |
| IFI44L | interferon-induced protein 44-like | 0.00974839 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 0.00965428 |
| OGDHL | oxoglutarate dehydrogenase-like | 0.00961341 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.00960764 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.00960305 |
| ESR1 | estrogen receptor 1 | 0.00949185 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0094707 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.00934652 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | 0.00934284 |
| PNMA2 | paraneoplastic Ma antigen 2 | 0.00933326 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.00933059 |
| MPDZ | multiple PDZ domain protein | 0.00926749 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.00925832 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00909305 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00906573 |
| CFB | complement factor B | 0.00905899 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0090469 |
| CSRP2 | cysteine and glycine-rich protein 2 | 0.00895879 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.00895831 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | 0.00895795 |
| SGCE | sarcoglycan, epsilon | 0.00894447 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00888016 |
| HSPB1 | heat shock 27kDa protein 1 | 0.00887994 |
| FCGBP | Fc fragment of IgG binding protein | 0.00887837 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.00885217 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.00884986 |
| EDN3 | endothelin 3 | 0.0088457 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.00883471 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.00882394 |
| TSPAN3 | tetraspanin 3 | 0.00881539 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.00879021 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 0.0087657 |
| PLAT | plasminogen activator, tissue | 0.00876527 |
| PNMA8A | PNMA family member 8A | 0.00874598 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.00870913 |
| LPPR4 | lipid phosphate phosphatase-related protein type 4 | 0.00858109 |
| TRIM22 | tripartite motif containing 22 | 0.00855088 |
| RUNX1 | runt-related transcription factor 1 | 0.00852819 |
| NPR1 | natriuretic peptide receptor 1 | 0.00852787 |
| IFI44 | interferon-induced protein 44 | 0.00850295 |
| RFTN1 | raftlin, lipid raft linker 1 | 0.00850287 |
| KLK10 | kallikrein-related peptidase 10 | 0.00849354 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.00842246 |
| IL6ST | interleukin 6 signal transducer | 0.00838995 |
| MVP | major vault protein | 0.00838708 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.00837097 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.00837087 |
| ZNF423 | zinc finger protein 423 | 0.00831995 |
| FGF1 | fibroblast growth factor 1 (acidic) | 0.00829527 |
| PLLP | plasmolipin | 0.00828804 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.00828355 |
| ATP6V1B1 | ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 | 0.0082364 |
| CA2 | carbonic anhydrase II | 0.0082307 |
| MT2A | metallothionein 2A | 0.00816052 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 0.0081319 |
| OGFOD1 | 2-oxoglutarate and iron-dependent oxygenase domain containing 1 | 0.00812911 |
| MT1E | metallothionein 1E | 0.00812642 |
| DRAM1 | DNA-damage regulated autophagy modulator 1 | 0.00812241 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.00811697 |
| ZYX | zyxin | 0.00810401 |
| CXADR | coxsackie virus and adenovirus receptor | 0.00805908 |
| MCL1 | myeloid cell leukemia 1 | 0.00803928 |
| MT1F | metallothionein 1F | 0.00800534 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.0079986 |
| TWIST1 | twist family bHLH transcription factor 1 | 0.00799129 |
| GAB2 | GRB2-associated binding protein 2 | 0.00796466 |
| C5AR1 | complement component 5a receptor 1 | 0.00789262 |
| PODXL | podocalyxin-like | 0.00784527 |
| ASPN | asporin | 0.00784296 |
| EMP2 | epithelial membrane protein 2 | 0.00784252 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | 0.00783031 |
| MGLL | monoglyceride lipase | 0.00780103 |
| BTG3 | BTG family, member 3 | 0.00778784 |
| CLDN10 | claudin 10 | 0.0077872 |
| SCG5 | secretogranin V | 0.00773037 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.00770956 |
| MECOM | MDS1 and EVI1 complex locus | 0.00768641 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.00766554 |
| SP100 | SP100 nuclear antigen | 0.00763514 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | 0.00758644 |
| NCALD | neurocalcin delta | 0.0075479 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00753026 |
| CYP27B1 | cytochrome P450, family 27, subfamily B, polypeptide 1 | 0.00748824 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.00747177 |
| PCOLCE | procollagen C-endopeptidase enhancer | 0.00745411 |
| PIPOX | pipecolic acid oxidase | 0.0074535 |
| FMO1 | flavin containing monooxygenase 1 | 0.00743998 |
| MT1X | metallothionein 1X | 0.00743569 |
| GRAMD2B | GRAM domain containing 2B | 0.00742908 |
| ZFHX4 | zinc finger homeobox 4 | 0.00742527 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.00742393 |
| PEG3 | paternally expressed 3 | 0.00741909 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.00741861 |
| PXDN | peroxidasin | 0.00739925 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.00738123 |
| UBXN7 | UBX domain protein 7 | 0.00737091 |
| KLK7 | kallikrein-related peptidase 7 | 0.00736242 |
| PABPC4 | poly(A) binding protein, cytoplasmic 4 (inducible form) | 0.00735455 |
| SYBU | syntabulin (syntaxin-interacting) | 0.00729863 |
| TPBG | trophoblast glycoprotein | 0.00727674 |
| HMGA1 | high mobility group AT-hook 1 | 0.0072671 |
| CFAP20 | cilia and flagella associated protein 20 | 0.00726386 |
| STK10 | serine/threonine kinase 10 | 0.00725677 |
| LCN2 | lipocalin 2 | 0.00725553 |
| ZNF512B | zinc finger protein 512B | 0.00724618 |
| FKBP5 | FK506 binding protein 5 | 0.00723804 |
| OAT | ornithine aminotransferase | 0.00723468 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.00720644 |
| CD93 | CD93 molecule | 0.00719919 |
| TGIF2 | TGFB-induced factor homeobox 2 | 0.00719876 |
| PNPLA3 | patatin-like phospholipase domain containing 3 | 0.0071898 |
| CSPG5 | chondroitin sulfate proteoglycan 5 (neuroglycan C) | 0.00716604 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00714824 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.00713504 |
| KLK8 | kallikrein-related peptidase 8 | 0.00710444 |
| FAIM | Fas apoptotic inhibitory molecule | 0.00708407 |
| MAB21L2 | mab-21-like 2 (C. elegans) | 0.00708124 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | 0.00707233 |
| ADD3 | adducin 3 (gamma) | 0.00705014 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | 0.00704231 |
| PPP2R2B | protein phosphatase 2, regulatory subunit B, beta | 0.00703774 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.00703584 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.00700566 |
| IL17RB | interleukin 17 receptor B | 0.00699691 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | 0.0069957 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.00698008 |
| WWC1 | WW and C2 domain containing 1 | 0.00697525 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.00696693 |
| ZNF706 | zinc finger protein 706 | 0.00695962 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.00693401 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | 0.00692829 |
| COL3A1 | collagen, type III, alpha 1 | 0.00692627 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | 0.0069245 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | 0.00692089 |
| HYAL1 | hyaluronoglucosaminidase 1 | 0.0068965 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.00688887 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.00687674 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0068409 |
| MX2 | MX dynamin-like GTPase 2 | 0.00683991 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00683193 |
| BFAR | bifunctional apoptosis regulator | 0.00680543 |
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | 0.00679358 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.00678914 |
| HTRA1 | HtrA serine peptidase 1 | 0.00678754 |
| AHCY | adenosylhomocysteinase | 0.00678665 |
| UMOD | uromodulin | 0.00677063 |
| MATN2 | matrilin 2 | 0.00676198 |
| MBD1 | methyl-CpG binding domain protein 1 | 0.00675886 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.00675422 |
| HOMER1 | homer scaffolding protein 1 | 0.00674902 |
| TOX | thymocyte selection-associated high mobility group box | 0.0067454 |
| ZNF281 | zinc finger protein 281 | 0.00674218 |
| ZW10 | zw10 kinetochore protein | 0.00672033 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00671871 |
| CCT2 | chaperonin containing TCP1, subunit 2 (beta) | 0.00671381 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | 0.00671172 |
| LARP1 | La ribonucleoprotein domain family, member 1 | 0.0066927 |
| KRT14 | keratin 14, type I | 0.00666636 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00665042 |
| ATP6V1H | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H | 0.00663522 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.00662178 |
| FOLR1 | folate receptor 1 (adult) | 0.00661053 |
| IQCK | IQ motif containing K | 0.00659115 |
| SP110 | SP110 nuclear body protein | 0.00658973 |
| HOXB2 | homeobox B2 | 0.00658077 |
| ASS1 | argininosuccinate synthase 1 | 0.00657491 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.00656005 |
| FZD3 | frizzled class receptor 3 | 0.00655472 |
| BCL3 | B-cell CLL/lymphoma 3 | 0.0065528 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.00653089 |
| GPR137B | G protein-coupled receptor 137B | 0.00650232 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.00649313 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 0.00646933 |
| SORBS3 | sorbin and SH3 domain containing 3 | 0.00645847 |
| IFT38 | intraflagellar transport 38 | 0.00645411 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.00645296 |
| GTF2H2B | general transcription factor IIH, polypeptide 2B (pseudogene) | 0.0064365 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor | 0.00643601 |
| AKIRIN1 | akirin 1 | 0.00643095 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.00643012 |
| IL1R1 | interleukin 1 receptor, type I | 0.00640627 |
| SYT17 | synaptotagmin XVII | 0.0064025 |
| KLF9 | Kruppel-like factor 9 | 0.00638366 |
| METTL7A | methyltransferase like 7A | 0.00637422 |
| PDLIM2 | PDZ and LIM domain 2 (mystique) | 0.00637415 |
| EBNA1BP2 | EBNA1 binding protein 2 | 0.00637242 |
| OSMR | oncostatin M receptor | 0.0063665 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.00636365 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.00635935 |
| RNASET2 | ribonuclease T2 | 0.00635792 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.00635063 |
| IL10RB | interleukin 10 receptor, beta | 0.00633869 |
| RBM39 | RNA binding motif protein 39 | 0.00633682 |
| RAB21 | RAB21, member RAS oncogene family | 0.00632874 |
| EMP1 | epithelial membrane protein 1 | 0.00632683 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00630521 |
| ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | 0.00629379 |
| LAMB1 | laminin, beta 1 | 0.00629232 |
| CCDC102B | coiled-coil domain containing 102B | 0.00628594 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.0183154 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0160483 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.0138848 |
| TPSAB1 | tryptase alpha/beta 1 | -0.0136562 |
| MAP7 | microtubule-associated protein 7 | -0.0135705 |
| AGR2 | anterior gradient 2 | -0.0133436 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.0133212 |
| LTF | lactotransferrin | -0.0128685 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | -0.0125044 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0124122 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -0.0123103 |
| DES | desmin | -0.0116057 |
| NTS | neurotensin | -0.0115872 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0111668 |
| CKM | creatine kinase, muscle | -0.0110526 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.0108636 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.0108184 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.0107004 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.0106759 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0104742 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.0104571 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.0103324 |
| EREG | epiregulin | -0.0102538 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0100953 |
| GPX2 | glutathione peroxidase 2 | -0.0100091 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00998228 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | -0.00997823 |
| RXRA | retinoid X receptor, alpha | -0.00991084 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.00986386 |
| MLPH | melanophilin | -0.00985998 |
| TFF3 | trefoil factor 3 (intestinal) | -0.00975737 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.00975064 |
| CHKB | choline kinase beta | -0.00967014 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | -0.00954632 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -0.00922726 |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist | -0.00915617 |
| TTN | titin | -0.00912768 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0090906 |
| CD8A | CD8a molecule | -0.00905013 |
| PCP4 | Purkinje cell protein 4 | -0.00900491 |
| MB | myoglobin | -0.00896374 |
| PDLIM5 | PDZ and LIM domain 5 | -0.00895429 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.00886934 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | -0.00881827 |
| ACP3 | acid phosphatase 3 | -0.00879737 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.00859741 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00856422 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.00854045 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.00851769 |
| CLGN | calmegin | -0.00849976 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -0.0084729 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | -0.00846114 |
| NEFH | neurofilament, heavy polypeptide | -0.00844304 |
| MTCL1 | microtubule crosslinking factor 1 | -0.00843093 |
| CPA3 | carboxypeptidase A3 (mast cell) | -0.00837555 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0083624 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.00831257 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.00831157 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -0.00830152 |
| NDRG1 | N-myc downstream regulated 1 | -0.00829603 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | -0.0082843 |
| CST3 | cystatin C | -0.00826241 |
| KLK2 | kallikrein-related peptidase 2 | -0.00826042 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.00823588 |
| MYBPC1 | myosin binding protein C, slow type | -0.00823002 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | -0.00819609 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | -0.00810318 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.0080961 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.00805946 |
| AKAP7 | A kinase (PRKA) anchor protein 7 | -0.00803961 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.00799912 |
| TNNC1 | troponin C type 1 (slow) | -0.00797823 |
| CDC20 | cell division cycle 20 | -0.00797527 |
| NPY | neuropeptide Y | -0.00796909 |
| CST7 | cystatin F (leukocystatin) | -0.00796657 |
| GZMK | granzyme K (granzyme 3; tryptase II) | -0.00794659 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.00791195 |
| TNNC2 | troponin C type 2 (fast) | -0.00789344 |
| RPA3 | replication protein A3, 14kDa | -0.00789242 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00787338 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | -0.00786624 |
| MIOS | missing oocyte, meiosis regulator, homolog (Drosophila) | -0.00783984 |
| MALL | mal, T-cell differentiation protein-like | -0.00783528 |
| UBE2M | ubiquitin-conjugating enzyme E2M | -0.00776145 |
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | -0.00775849 |
| LMNB2 | lamin B2 | -0.00768675 |
| EFHD2 | EF-hand domain family, member D2 | -0.00767899 |
| HBD | hemoglobin, delta | -0.00767707 |
| PCNA | proliferating cell nuclear antigen | -0.00767001 |
| FBXO11 | F-box protein 11 | -0.00766016 |
| BMP4 | bone morphogenetic protein 4 | -0.00760888 |
| TPD52L1 | tumor protein D52-like 1 | -0.00760043 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | -0.00759992 |
| MYOT | myotilin | -0.00757825 |
| CAMKK2 | calcium/calmodulin-dependent protein kinase kinase 2, beta | -0.00754011 |
| TST | thiosulfate sulfurtransferase (rhodanese) | -0.0075327 |
| VEGFC | vascular endothelial growth factor C | -0.00751973 |
| KCNMB1 | potassium channel subfamily M regulatory beta subunit 1 | -0.0075164 |
| TFF1 | trefoil factor 1 | -0.00747505 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | -0.00743259 |
| GSTT1 | glutathione S-transferase theta 1 | -0.00742517 |
| NKG7 | natural killer cell granule protein 7 | -0.00732657 |
| COCH | cochlin | -0.00730998 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.00728871 |
| PGD | phosphogluconate dehydrogenase | -0.00726613 |
| PRKCZ | protein kinase C, zeta | -0.00725616 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | -0.00721578 |
| CLIC3 | chloride intracellular channel 3 | -0.00719327 |
| TECR | trans-2,3-enoyl-CoA reductase | -0.00715641 |
| PRF1 | perforin 1 (pore forming protein) | -0.00713501 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00710783 |
| ZNF518A | zinc finger protein 518A | -0.00709228 |
| NKX3-1 | NK3 homeobox 1 | -0.0070768 |
| HSPB7 | heat shock 27kDa protein family, member 7 (cardiovascular) | -0.00706524 |
| TMEM165 | transmembrane protein 165 | -0.00704817 |
| CA9 | carbonic anhydrase IX | -0.00699051 |
| TNNI2 | troponin I type 2 (skeletal, fast) | -0.00697267 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | -0.00695808 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.00695685 |
| SMTN | smoothelin | -0.0069482 |
| SFN | stratifin | -0.00694374 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | -0.0069351 |
| XCL1 | chemokine (C motif) ligand 1 | -0.00692831 |
| ADRB2 | adrenoceptor beta 2, surface | -0.00692128 |
| TMEM106C | transmembrane protein 106C | -0.00689285 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.00686861 |
| GALE | UDP-galactose-4-epimerase | -0.00686792 |
| CD2 | CD2 molecule | -0.00686025 |
| TGFB1 | transforming growth factor, beta 1 | -0.00684503 |
| MYBPC2 | myosin binding protein C, fast type | -0.0068344 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.00681978 |
| RABAC1 | Rab acceptor 1 (prenylated) | -0.00678274 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.00677997 |
| MAGED1 | melanoma antigen family D1 | -0.00673535 |
| TGM3 | transglutaminase 3 | -0.00673307 |
| LMOD1 | leiomodin 1 (smooth muscle) | -0.00672354 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00671931 |
| GATA2 | GATA binding protein 2 | -0.00670733 |
| PNKP | polynucleotide kinase 3'-phosphatase | -0.0066924 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.00665869 |
| CDK8 | cyclin-dependent kinase 8 | -0.00665544 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.00664289 |
| DPM3 | dolichyl-phosphate mannosyltransferase polypeptide 3 | -0.00664034 |
| MGST2 | microsomal glutathione S-transferase 2 | -0.00660511 |
| CRCT1 | cysteine-rich C-terminal 1 | -0.00659556 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -0.00659059 |
| GPX3 | glutathione peroxidase 3 | -0.00656993 |
| LYZ | lysozyme | -0.00656861 |
| LDB3 | LIM domain binding 3 | -0.00654903 |
| RANBP1 | RAN binding protein 1 | -0.00654174 |
| OLFM4 | olfactomedin 4 | -0.00653037 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.00652795 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.00651255 |
| TMPRSS2 | transmembrane protease, serine 2 | -0.00650548 |
| G6PD | glucose-6-phosphate dehydrogenase | -0.0064935 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | -0.00648978 |
| CDK19 | cyclin-dependent kinase 19 | -0.00646112 |
| SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | -0.00645794 |
| COQ8A | coenzyme Q8A | -0.00645616 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.00644471 |
| XYLT1 | xylosyltransferase I | -0.00638582 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.00637515 |
| PYGB | phosphorylase, glycogen; brain | -0.00635609 |
| ENO3 | enolase 3 (beta, muscle) | -0.00635031 |
| TFF2 | trefoil factor 2 | -0.00634148 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | -0.00633736 |
| MET | MET proto-oncogene, receptor tyrosine kinase | -0.00632211 |
| VCAM1 | vascular cell adhesion molecule 1 | -0.00631701 |
| ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | -0.00627711 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.00627175 |
| CLU | clusterin | -0.00623708 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.00622749 |
| PPA2 | pyrophosphatase (inorganic) 2 | -0.00621728 |
| PYGM | phosphorylase, glycogen, muscle | -0.00621117 |
| TTC37 | tetratricopeptide repeat domain 37 | -0.00620688 |
| APMAP | adipocyte plasma membrane associated protein | -0.00620268 |
| FBLN1 | fibulin 1 | -0.00618693 |
| CD9 | CD9 molecule | -0.00617019 |
| CRTAM | cytotoxic and regulatory T cell molecule | -0.00616518 |
| GLB1L2 | galactosidase, beta 1-like 2 | -0.00616397 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.00615165 |
| CENPU | centromere protein U | -0.00614551 |
| NOTCH2 | notch 2 | -0.00608357 |
| STMN1 | stathmin 1 | -0.00607554 |
| CYP11A1 | cytochrome P450, family 11, subfamily A, polypeptide 1 | -0.00606221 |
| EPHX2 | epoxide hydrolase 2, cytoplasmic | -0.00604866 |
| BAD | BCL2-associated agonist of cell death | -0.00604619 |
| TMEM106B | transmembrane protein 106B | -0.00604032 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.00603664 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | -0.00603132 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00602872 |
| CTNNBIP1 | catenin, beta interacting protein 1 | -0.00602222 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.00600415 |
| ALOX12 | arachidonate 12-lipoxygenase | -0.00600058 |
| SUN2 | Sad1 and UNC84 domain containing 2 | -0.00599636 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | -0.005986 |
| BIRC5 | baculoviral IAP repeat containing 5 | -0.00597741 |
| NEK2 | NIMA-related kinase 2 | -0.00597243 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -0.00594455 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | -0.00594419 |
| SLN | sarcolipin | -0.00593507 |
| CWH43 | cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) | -0.00593066 |
| NR0B1 | nuclear receptor subfamily 0, group B, member 1 | -0.00592834 |
| NAV3 | neuron navigator 3 | -0.00592003 |
| HDC | histidine decarboxylase | -0.00591042 |
| GPR18 | G protein-coupled receptor 18 | -0.0059044 |
| CDC34 | cell division cycle 34 | -0.00590207 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.00589826 |
| STAT4 | signal transducer and activator of transcription 4 | -0.00588772 |
| DUSP5 | dual specificity phosphatase 5 | -0.00588269 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -0.0058808 |
| CD151 | CD151 molecule (Raph blood group) | -0.00588011 |
| PTPN22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | -0.00587614 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.00586402 |
| KLHL41 | kelch-like family member 41 | -0.00585915 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -0.00585831 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | -0.0058536 |
| CSRP1 | cysteine and glycine-rich protein 1 | -0.00584985 |
| NUDCD3 | NudC domain containing 3 | -0.00583928 |
| TBX3 | T-box 3 | -0.00582064 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.00581505 |
| WTAP | Wilms tumor 1 associated protein | -0.0058085 |
| RTN3 | reticulon 3 | -0.00580628 |
| CYB5A | cytochrome b5 type A (microsomal) | -0.00578553 |
| TSPAN13 | tetraspanin 13 | -0.00578415 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.0057766 |
| CKMT2 | creatine kinase, mitochondrial 2 (sarcomeric) | -0.00576811 |
| SPEN | spen family transcriptional repressor | -0.00576411 |
| CNN1 | calponin 1, basic, smooth muscle | -0.00575852 |
| LBR | lamin B receptor | -0.00575658 |
| NADK | NAD kinase | -0.00574573 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.00574281 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00574071 |
| GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | -0.00574 |
| CCDC92 | coiled-coil domain containing 92 | -0.00573413 |
| TMED3 | transmembrane emp24 protein transport domain containing 3 | -0.00570115 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00569624 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -0.00569243 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.00569156 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0056908 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.00567778 |
| RRAGA | Ras-related GTP binding A | -0.00567623 |
| MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle | -0.00566946 |
| GSAP | gamma-secretase activating protein | -0.00565706 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -0.00564254 |
| FOXA1 | forkhead box A1 | -0.00564151 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0056344 |
| KLK3 | kallikrein-related peptidase 3 | -0.00562055 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -0.00561538 |
