LCK Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description LCK proto-oncogene, Src family tyrosine kinase|This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3932)
External Link http://www.ncbi.nlm.nih.gov/gene/3932
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Genes

51 substrates of the kinase LCK from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ACP1 acid phosphatase 1, soluble
ADAM15 ADAM metallopeptidase domain 15
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC50 coiled-coil domain containing 50
CD247 CD247 molecule
CD33 CD33 molecule
CD5 CD5 molecule
CHN2 chimerin 2
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DGKA diacylglycerol kinase, alpha 80kDa
ESR1 estrogen receptor 1
EZR ezrin
FOXP3 forkhead box P3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
IL2RB interleukin 2 receptor, beta
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITK IL2-inducible T-cell kinase
KSR1 kinase suppressor of ras 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIME1 Lck interacting transmembrane adaptor 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MED28 mediator complex subunit 28
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PECAM1 platelet/endothelial cell adhesion molecule 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRDX1 peroxiredoxin 1
PRKCQ protein kinase C, theta
PTEN phosphatase and tensin homolog
PTPN6 protein tyrosine phosphatase, non-receptor type 6
SH2B3 SH2B adaptor protein 3
SH2D2A SH2 domain containing 2A
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIGLEC10 sialic acid binding Ig-like lectin 10
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SOCS3 suppressor of cytokine signaling 3
SSBP3 single stranded DNA binding protein 3
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT5A signal transducer and activator of transcription 5A
STK11 serine/threonine kinase 11
SYK spleen tyrosine kinase
THEMIS thymocyte selection associated
VAV1 vav 1 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa