LCP2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)|SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3937)
External Link http://www.ncbi.nlm.nih.gov/gene/3937
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260 interacting proteins for LCP2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
ADAP1 ArfGAP with dual PH domains 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
APC adenomatous polyposis coli
APP amyloid beta (A4) precursor protein
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARF6 ADP-ribosylation factor 6
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
AXL AXL receptor tyrosine kinase
B2M beta-2-microglobulin
BCR breakpoint cluster region
BLNK B-cell linker
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BTC betacellulin
BTK Bruton agammaglobulinemia tyrosine kinase
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD19 CD19 molecule
CD22 CD22 molecule
CD247 CD247 molecule
CD28 CD28 molecule
CD2AP CD2-associated protein
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CD80 CD80 molecule
CD86 CD86 molecule
CD8A CD8a molecule
CD8B CD8b molecule
CDC37 cell division cycle 37
CDC42 cell division cycle 42
CLNK cytokine-dependent hematopoietic cell linker
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CNOT1 CCR4-NOT transcription complex, subunit 1
CNTRL centriolin
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTTN cortactin
CUX1 cut-like homeobox 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
CYTH2 cytohesin 2
CYTH3 cytohesin 3
DARS aspartyl-tRNA synthetase
DNM2 dynamin 2
DNM3 dynamin 3
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EP300 E1A binding protein p300
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
FAM175B family with sequence similarity 175, member B
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FER fer (fps/fes related) tyrosine kinase
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF16 fibroblast growth factor 16
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF20 fibroblast growth factor 20
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR1OP FGFR1 oncogene partner
FGFR1OP2 FGFR1 oncogene partner 2
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FRS2 fibroblast growth factor receptor substrate 2
FUS FUS RNA binding protein
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
GNB5 guanine nucleotide binding protein (G protein), beta 5
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG5 guanine nucleotide binding protein (G protein), gamma 5
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNG8 guanine nucleotide binding protein (G protein), gamma 8
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
GSN gelsolin
HBEGF heparin-binding EGF-like growth factor
HCK HCK proto-oncogene, Src family tyrosine kinase
HLA-A major histocompatibility complex, class I, A
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HLA-E major histocompatibility complex, class I, E
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPG2 heparan sulfate proteoglycan 2
IGHE immunoglobulin heavy constant epsilon
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)
IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker)
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLC1 immunoglobulin lambda constant 1 (Mcg marker)
IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)
IGLC3 immunoglobulin lambda constant 3 (Kern-Oz+ marker)
IGLC6 immunoglobulin lambda constant 6 (Kern+Oz- marker, gene/pseudogene)
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITK IL2-inducible T-cell kinase
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KL klotho
KLB klotho beta
KLRC2 killer cell lectin-like receptor subfamily C, member 2
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT33A keratin 33A, type I
KRT36 keratin 36, type I
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LRRK1 leucine-rich repeat kinase 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYO18A myosin XVIIIA
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
NCKAP1 NCK-associated protein 1
NCKIPSD NCK interacting protein with SH3 domain
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRG1 neuregulin 1
NRG2 neuregulin 2
NRG3 neuregulin 3
NRG4 neuregulin 4
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRAM1 PML-RARA regulated adaptor molecule 1
PRKCQ protein kinase C, theta
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN23 protein tyrosine phosphatase, non-receptor type 23
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRC protein tyrosine phosphatase, receptor type, C
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
SGK1 serum/glucocorticoid regulated kinase 1
SH2D2A SH2 domain containing 2A
SH3GL2 SH3-domain GRB2-like 2
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SKAP2 src kinase associated phosphoprotein 2
SOS1 son of sevenless homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
SYK spleen tyrosine kinase
TEC tec protein tyrosine kinase
TFG TRK-fused gene
TRA T cell receptor alpha locus
TRAC T cell receptor alpha constant
TRAT1 T cell receptor associated transmembrane adaptor 1
TRB T cell receptor beta locus
TRBC1 T cell receptor beta constant 1
TRBV12-3 T cell receptor beta variable 12-3
TREM2 triggering receptor expressed on myeloid cells 2
TRIM24 tripartite motif containing 24
TXK TXK tyrosine kinase
TYROBP TYRO protein tyrosine kinase binding protein
UBASH3B ubiquitin associated and SH3 domain containing B
UBC ubiquitin C
UBR4 ubiquitin protein ligase E3 component n-recognin 4
USP8 ubiquitin specific peptidase 8
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
WAS Wiskott-Aldrich syndrome
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WNK1 WNK lysine deficient protein kinase 1
YBX1 Y box binding protein 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZMYM2 zinc finger, MYM-type 2