LDLR Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description low density lipoprotein receptor|The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] (NCBI Entrez Gene Database, 3949)
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Genes

295 genes differentially expressed following the LDLR gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LIPK lipase, family member K 3.43612
FOXA2 forkhead box A2 3.43612
HORMAD1 HORMA domain containing 1 3.43612
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 3.43612
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.43612
TM4SF20 transmembrane 4 L six family member 20 3.43612
AFM afamin 3.43612
OR10A4 olfactory receptor, family 10, subfamily A, member 4 3.43612
OSR2 odd-skipped related transciption factor 2 3.43612
PDYN prodynorphin 3.43612
ANKRD22 ankyrin repeat domain 22 3.43612
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 3.43612
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.43612
RAET1G retinoic acid early transcript 1G 3.43612
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.43612
HLX H2.0-like homeobox 3.43612
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 3.43612
CFAP74 cilia and flagella associated protein 74 3.43612
MYBPHL myosin binding protein H-like 3.43612
LRRD1 leucine-rich repeats and death domain containing 1 3.43612
SKOR1 SKI family transcriptional corepressor 1 3.43612
TBR1 T-box, brain, 1 3.43612
RSPO1 R-spondin 1 3.43612
SPDYE11 speedy/RINGO cell cycle regulator family member E11 3.43612
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.43612
NPIPA8 nuclear pore complex interacting protein family, member A8 3.43612
LBX2 ladybird homeobox 2 3.43612
CORO6 coronin 6 3.43612
LGALS2 lectin, galactoside-binding, soluble, 2 3.43612
CPLX3 complexin 3 3.43612
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 3.43612
TTLL8 tubulin tyrosine ligase-like family member 8 3.43612
CRX cone-rod homeobox 3.43612
C9ORF152 chromosome 9 open reading frame 152 3.43612
GYPB glycophorin B (MNS blood group) 3.43612
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 3.43612
REN renin 3.43612
ANKRD34A ankyrin repeat domain 34A 3.43612
FAM221B family with sequence similarity 221, member B 3.43612
POSTN periostin, osteoblast specific factor 3.43612
TRPV6 transient receptor potential cation channel, subfamily V, member 6 3.43612
IQCF1 IQ motif containing F1 3.43612
SPACA3 sperm acrosome associated 3 3.43612
RAB41 RAB41, member RAS oncogene family 3.43612
LRTM3 leucine rich repeat transmembrane protein 3 3.43612
DNAI7 dynein axonemal intermediate chain 7 3.43612
TMEM275 transmembrane protein 275 3.43612
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.43612
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 3.43612
SELE selectin E 3.43612
MCHR2 melanin-concentrating hormone receptor 2 3.43612
ROPN1L rhophilin associated tail protein 1-like 3.43612
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.43612
SPATA46 spermatogenesis associated 46 3.43612
VXN vexin 3.43612
GARIN5B golgi associated RAB2 interactor family member 5B 3.43612
TEKTL1 tektin like 1 3.43612
PNMA6F PNMA family member 6F 3.43612
FAM246C family with sequence similarity 246 member C (gene/pseudogene) 3.43612
CD8B2 CD8b2 molecule 3.43612
SPAAR small regulatory polypeptide of amino acid response 3.43612
AKAIN1 A-kinase anchor inhibitor 1 3.43612
MYMK myomaker, myoblast fusion factor 3.43612
LHFPL7 LHFPL tetraspan subfamily member 7 3.43612
TRPC7 transient receptor potential cation channel, subfamily C, member 7 3.43612
OR9G1 olfactory receptor, family 9, subfamily G, member 1 3.43612
SMPX small muscle protein, X-linked 3.43612
OR2L2 olfactory receptor, family 2, subfamily L, member 2 3.43612
TBX3 T-box 3 3.43612
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.43612
SH3TC2 SH3 domain and tetratricopeptide repeats 2 3.43612
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.43612
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.43612
LDHAL6B lactate dehydrogenase A-like 6B 3.43612
AXDND1 axonemal dynein light chain domain containing 1 3.43612
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.43612
SBSN suprabasin 3.43612
FGFBP2 fibroblast growth factor binding protein 2 3.43612
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.43612
FOXC1 forkhead box C1 3.43612
SPATA22 spermatogenesis associated 22 3.43612
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.43612
LTA lymphotoxin alpha 3.43612
DLK2 delta-like 2 homolog (Drosophila) 3.43612
NPIPB8 nuclear pore complex interacting protein family, member B8 3.43612
FRK fyn-related Src family tyrosine kinase 3.43612
TRIM61 tripartite motif containing 61 3.43612
SPACA7 sperm acrosome associated 7 3.43612
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.43612
THTPA thiamine triphosphatase 3.43612
BTNL2 butyrophilin-like 2 3.43612
DPRX divergent-paired related homeobox 3.43612
CTAGE9 CTAGE family, member 9 3.43612
FAM163A family with sequence similarity 163, member A 3.43612
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.43612
KLF1 Kruppel-like factor 1 (erythroid) 3.43612
KLF2 Kruppel-like factor 2 3.43612
KLHL1 kelch-like family member 1 3.43612
EFCAB3 EF-hand calcium binding domain 3 3.43612
TSPAN32 tetraspanin 32 3.43612
LCN2 lipocalin 2 3.43612
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.43612
ERMN ermin, ERM-like protein 3.43612
IL17REL interleukin 17 receptor E-like 3.43612
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.43612
IL9R interleukin 9 receptor 3.43612
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.43612
MKRN3 makorin ring finger protein 3 3.43612
TPSB2 tryptase beta 2 (gene/pseudogene) 3.43612
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.43612
PRSS38 protease, serine, 38 3.43612
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 3.43612
GPR142 G protein-coupled receptor 142 3.43612
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 3.43612
FBXO15 F-box protein 15 3.43612
GOLGA8M golgin A8 family, member M 3.43612
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 3.43612
SAMD5 sterile alpha motif domain containing 5 3.43612
MRPL17 mitochondrial ribosomal protein L17 3.43612
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.43612
CD5L CD5 molecule-like 3.43612
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.43612
APOC4 apolipoprotein C-IV 3.43612
TLR10 toll-like receptor 10 3.43612
ODF4 outer dense fiber of sperm tails 4 3.43612
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 3.43612
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.43612
DMBT1 deleted in malignant brain tumors 1 3.43612
ECM1 extracellular matrix protein 1 3.43612
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.43612
TRPM1 transient receptor potential cation channel, subfamily M, member 1 3.43612
BOLA2 bolA family member 2 3.43612
FGF7 fibroblast growth factor 7 3.43612
GRAPL GRB2-related adaptor protein-like 3.43612
SLCO1C1 solute carrier organic anion transporter family, member 1C1 3.43612
ANGPTL3 angiopoietin-like 3 3.43612
ADRA1B adrenoceptor alpha 1B 3.43612
ANXA8 annexin A8 3.43612
MST1R macrophage stimulating 1 receptor 3.43612
MMP10 matrix metallopeptidase 10 3.43612
CCDC89 coiled-coil domain containing 89 3.43612
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.43612
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 3.43612
NLRP6 NLR family, pyrin domain containing 6 3.43612
IL23R interleukin 23 receptor 3.43612
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.43612
TSSK1B testis-specific serine kinase 1B 3.43612
STAP1 signal transducing adaptor family member 1 3.43612
SPAG8 sperm associated antigen 8 3.43612
EPO erythropoietin 3.43612
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.43612
RNF39 ring finger protein 39 3.43612
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.43612
VTCN1 V-set domain containing T cell activation inhibitor 1 3.43612
POU3F2 POU class 3 homeobox 2 3.43612
RERGL RERG/RAS-like 3.43612
MC5R melanocortin 5 receptor 3.43612
C1QTNF2 C1q and tumor necrosis factor related protein 2 3.35255
MAGIX MAGI family member, X-linked 3.35255
CMKLR2 chemerin chemokine-like receptor 2 3.35255
IGFBP3 insulin-like growth factor binding protein 3 3.16149
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 3.15677
COX14 COX14 cytochrome c oxidase assembly factor 3.1242
CLK1 CDC-like kinase 1 2.99883
HOOK1 hook microtubule-tethering protein 1 2.72709
GLI2 GLI family zinc finger 2 2.66933
STX4 syntaxin 4 2.64152
SRSF2 serine/arginine-rich splicing factor 2 2.62279
SDHAF1 succinate dehydrogenase complex assembly factor 1 2.62279
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.5875
SLFNL1 schlafen-like 1 2.51827
SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.503
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 2.46026
CALCOCO1 calcium binding and coiled-coil domain 1 2.45697
CCDC30 coiled-coil domain containing 30 2.43445
TRIM38 tripartite motif containing 38 2.43394
IRS4 insulin receptor substrate 4 2.38287
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.33773
WDR87 WD repeat domain 87 2.32718
BTC betacellulin 2.32718
OR2A42 olfactory receptor, family 2, subfamily A, member 42 2.32718
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 2.3257
NCKIPSD NCK interacting protein with SH3 domain 2.31918
C1ORF87 chromosome 1 open reading frame 87 2.31076
CALCA calcitonin-related polypeptide alpha 2.31076
GBX2 gastrulation brain homeobox 2 2.31076
NOL4L nucleolar protein 4-like 2.28824
MKNK2 MAP kinase interacting serine/threonine kinase 2 2.27907
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 2.27526
SPRYD4 SPRY domain containing 4 2.26653
MUC20 mucin 20, cell surface associated 2.25579
AKAP9 A kinase (PRKA) anchor protein 9 2.23698
PGAM1 phosphoglycerate mutase 1 (brain) 2.23131
HVCN1 hydrogen voltage gated channel 1 2.23131
ETV2 ets variant 2 2.20394
SLC7A14 solute carrier family 7, member 14 2.1966
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2.18474
MSI2 musashi RNA-binding protein 2 2.16366
TMEM260 transmembrane protein 260 2.12816
KNTC1 kinetochore associated 1 2.12816
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 2.10329
VAMP5 vesicle-associated membrane protein 5 2.09364
NSUN3 NOP2/Sun domain family, member 3 2.0813
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.07387
DEPDC1B DEP domain containing 1B 2.07129
BTBD2 BTB (POZ) domain containing 2 2.07017
TTC21A tetratricopeptide repeat domain 21A 2.07017
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.06058
COL16A1 collagen, type XVI, alpha 1 2.01427
KRT19 keratin 19, type I 2.0139
CCDC141 coiled-coil domain containing 141 2.0139
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.00758

decreased expression

Symbol Name Standardized Value
TNMD tenomodulin -3.43612
SPMAP2L sperm microtubule associated protein 2 like -3.43612
CHRND cholinergic receptor, nicotinic, delta (muscle) -3.43612
CXCR2 chemokine (C-X-C motif) receptor 2 -3.43612
OR56A3 olfactory receptor, family 56, subfamily A, member 3 -3.43612
APLNR apelin receptor -3.43612
LIPH lipase, member H -3.43612
GLUD2 glutamate dehydrogenase 2 -3.43612
ADTRP androgen-dependent TFPI-regulating protein -3.43612
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) -3.43612
TSHR thyroid stimulating hormone receptor -3.43612
RFPL3 ret finger protein-like 3 -3.43612
LCN10 lipocalin 10 -3.43612
TPPP tubulin polymerization promoting protein -3.43612
NR4A3 nuclear receptor subfamily 4, group A, member 3 -3.43612
FGF18 fibroblast growth factor 18 -3.43612
CLCF1 cardiotrophin-like cytokine factor 1 -3.43612
CALHM2 calcium homeostasis modulator 2 -3.43612
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 -3.43612
TRADD TNFRSF1A-associated via death domain -3.43612
GSDMA gasdermin A -3.43612
EVI2A ecotropic viral integration site 2A -3.43612
OR56B2 olfactory receptor family 56 subfamily B member 2 -3.43612
LTF lactotransferrin -3.43612
PLCD4 phospholipase C, delta 4 -3.43612
DUSP9 dual specificity phosphatase 9 -3.43612
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 -3.43612
HNF4A hepatocyte nuclear factor 4, alpha -3.43612
WDR93 WD repeat domain 93 -3.43612
KRTAP5-11 keratin associated protein 5-11 -3.38523
SPEF2 sperm flagellar 2 -3.20236
MUC19 mucin 19, oligomeric -3.20236
NONO non-POU domain containing, octamer-binding -3.1339
CHCT1 CHD1 helical C-terminal domain containing 1 -3.01943
SPIN2A spindlin family, member 2A -2.98524
COG2 component of oligomeric golgi complex 2 -2.93246
ATPSCKMT ATP synthase c subunit lysine N-methyltransferase -2.90021
NR1H2 nuclear receptor subfamily 1, group H, member 2 -2.83564
STXBP4 syntaxin binding protein 4 -2.73052
C19ORF12 chromosome 19 open reading frame 12 -2.72709
LIG4 ligase IV, DNA, ATP-dependent -2.64131
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -2.61209
MPHOSPH6 M-phase phosphoprotein 6 -2.50764
MOB1B MOB kinase activator 1B -2.50764
LAPTM4A lysosomal protein transmembrane 4 alpha -2.49399
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase -2.42391
LDLR low density lipoprotein receptor -2.38468
STARD5 StAR-related lipid transfer (START) domain containing 5 -2.38287
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B -2.38287
ZFYVE21 zinc finger, FYVE domain containing 21 -2.38204
ALAD aminolevulinate dehydratase -2.36609
TIGD3 tigger transposable element derived 3 -2.32718
PLSCR3 phospholipid scramblase 3 -2.32718
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -2.2849
ZSCAN16 zinc finger and SCAN domain containing 16 -2.27526
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -2.26519
CHADL chondroadherin-like -2.26245
SFPQ splicing factor proline/glutamine-rich -2.24908
ALDOA aldolase A, fructose-bisphosphate -2.23008
WDR45B WD repeat domain 45B -2.22213
SLC22A15 solute carrier family 22, member 15 -2.196
GALM galactose mutarotase (aldose 1-epimerase) -2.18985
TIPE1 TNF alpha induced protein 8 like 1 -2.18985
COTL1 coactosin-like F-actin binding protein 1 -2.18675
MYSM1 Myb-like, SWIRM and MPN domains 1 -2.14635
HDDC3 HD domain containing 3 -2.12816
SLC16A12 solute carrier family 16, member 12 -2.12816
LRRC49 leucine rich repeat containing 49 -2.1231
BABAM2 BRISC and BRCA1 A complex member 2 -2.09896
MNT MAX network transcriptional repressor -2.08988
LRRC4C leucine rich repeat containing 4C -2.07653
SIX5 SIX homeobox 5 -2.07653
ZNF322 zinc finger protein 322 -2.07612
TRAM2 translocation associated membrane protein 2 -2.07387
MRPS9 mitochondrial ribosomal protein S9 -2.06624
SDC4 syndecan 4 -2.06058
GPN1 GPN-loop GTPase 1 -2.06058
TXN2 thioredoxin 2 -2.03463
ANXA11 annexin A11 -2.0341
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C -2.02083
SDC2 syndecan 2 -2.01414
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.0139
ZNF746 zinc finger protein 746 -2.0139