LDLR Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description low density lipoprotein receptor|The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] (NCBI Entrez Gene Database, 3949)
External Link https://ncbi.nlm.nih.gov/gene/3949
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Genes

499 genes differentially expressed following the LDLR gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 0.0159431
SQLE squalene epoxidase 0.0157925
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0153892
ACAT2 acetyl-CoA acetyltransferase 2 0.0144291
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0139577
DHCR24 24-dehydrocholesterol reductase 0.0133078
NSDHL NAD(P) dependent steroid dehydrogenase-like 0.012338
SSBP2 single-stranded DNA binding protein 2 0.0121074
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0119388
TRIM16 tripartite motif containing 16 0.0116275
SLPI secretory leukocyte peptidase inhibitor 0.011096
ABLIM1 actin binding LIM protein 1 0.0109597
AKR1C2 aldo-keto reductase family 1, member C2 0.0107934
FGG fibrinogen gamma chain 0.0106135
KRT13 keratin 13, type I 0.0105133
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0104296
DHCR7 7-dehydrocholesterol reductase 0.0104135
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0103026
KRT15 keratin 15, type I 0.0102002
G6PD glucose-6-phosphate dehydrogenase 0.0100986
FDPS farnesyl diphosphate synthase 0.00985155
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.00975467
TRIM29 tripartite motif containing 29 0.00963735
L1CAM L1 cell adhesion molecule 0.00944828
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.00923167
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.00918553
LAMB3 laminin, beta 3 0.00912365
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.00905183
AKR1C1 aldo-keto reductase family 1, member C1 0.0090478
AHNAK2 AHNAK nucleoprotein 2 0.00901104
S100P S100 calcium binding protein P 0.00884958
HACD1 3-hydroxyacyl-CoA dehydratase 1 0.00868378
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 0.00864473
PGD phosphogluconate dehydrogenase 0.00849864
FN1 fibronectin 1 0.00847368
CES1 carboxylesterase 1 0.00838488
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.00833536
KRT7 keratin 7, type II 0.00830785
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.00827306
PPL periplakin 0.00815382
ZNF185 zinc finger protein 185 (LIM domain) 0.00813733
KRT6A keratin 6A, type II 0.00811455
ASS1 argininosuccinate synthase 1 0.0079305
TSPAN8 tetraspanin 8 0.00788321
KRT8 keratin 8, type II 0.00778363
ERG28 ergosterol biosynthesis 28 homolog 0.00773887
C3 complement component 3 0.007675
INHBB inhibin, beta B 0.00762542
C1S complement component 1, s subcomponent 0.00761929
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.00760386
NRCAM neuronal cell adhesion molecule 0.00755241
WNT5A wingless-type MMTV integration site family, member 5A 0.00754997
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.0075441
AQP3 aquaporin 3 (Gill blood group) 0.00749904
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.0074853
ATF4 activating transcription factor 4 0.00748246
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.00747974
KRT6B keratin 6B, type II 0.00745137
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.00744851
RAPSN receptor-associated protein of the synapse 0.00741962
NEBL nebulette 0.00741852
DDR2 discoidin domain receptor tyrosine kinase 2 0.00741727
S100A2 S100 calcium binding protein A2 0.00740728
INSIG1 insulin induced gene 1 0.00734294
KRT14 keratin 14, type I 0.007334
SIK1 salt-inducible kinase 1 0.00728042
KYNU kynureninase 0.00727804
NKX3-1 NK3 homeobox 1 0.00723209
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.00722945
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.0072042
FLNA filamin A, alpha 0.00717371
ABHD4 abhydrolase domain containing 4 0.0071679
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.00713888
HMOX1 heme oxygenase 1 0.00711876
FADS1 fatty acid desaturase 1 0.00709003
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.00698613
S100A14 S100 calcium binding protein A14 0.00695518
MAGEA3 melanoma antigen family A3 0.00692651
CETN2 centrin, EF-hand protein, 2 0.00692569
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.00689836
COL7A1 collagen, type VII, alpha 1 0.00688651
KRT17 keratin 17, type I 0.00682763
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.00679699
SC5D sterol-C5-desaturase 0.00675543
IRS2 insulin receptor substrate 2 0.00673578
FGFBP1 fibroblast growth factor binding protein 1 0.00667787
KRT5 keratin 5, type II 0.00665922
PRDX1 peroxiredoxin 1 0.00661152
S100A10 S100 calcium binding protein A10 0.00657456
CP ceruloplasmin (ferroxidase) 0.00656662
INAVA innate immunity activator 0.00654206
GNAS GNAS complex locus 0.00650102
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.00646705
SCEL sciellin 0.00644664
GPX2 glutathione peroxidase 2 0.00642388
C9ORF3 chromosome 9 open reading frame 3 0.00641019
CD9 CD9 molecule 0.00637964
CRNN cornulin 0.00637298
MATN2 matrilin 2 0.00635043
PI3 peptidase inhibitor 3, skin-derived 0.00631415
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.00630037
LDLR low density lipoprotein receptor 0.00629546
MEIS1 Meis homeobox 1 0.00627119
RFTN1 raftlin, lipid raft linker 1 0.00626566
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.00624982
RHCG Rh family, C glycoprotein 0.00617068
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 0.00616571
PALLD palladin, cytoskeletal associated protein 0.00614516
MAMLD1 mastermind-like domain containing 1 0.00614275
GUCY2C guanylate cyclase 2C 0.00611768
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.00611607
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.00605169
TLE4 transducin-like enhancer of split 4 0.00603999
HHEX hematopoietically expressed homeobox 0.00602752
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.00602502
FGB fibrinogen beta chain 0.00602288
MSMB microseminoprotein, beta- 0.00600549
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding) 0.00597664
COL9A3 collagen, type IX, alpha 3 0.00597285
CLU clusterin 0.0059698
KIF5C kinesin family member 5C 0.00586044
NQO1 NAD(P)H dehydrogenase, quinone 1 0.00584312
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.00583885
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.00581637
LPIN1 lipin 1 0.00581114
RIPK4 receptor-interacting serine-threonine kinase 4 0.00578783
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.00577879
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.00575628
ITGB4 integrin, beta 4 0.00575579
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 0.0057541
CBS cystathionine-beta-synthase 0.005744
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.00573948
PBX3 pre-B-cell leukemia homeobox 3 0.00571586
IL1RN interleukin 1 receptor antagonist 0.00571003
SYNM synemin, intermediate filament protein 0.00567354
CLDN1 claudin 1 0.00566079
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.00565495
SOX9 SRY (sex determining region Y)-box 9 0.00565104
HOPX HOP homeobox 0.00564914
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 0.00563542
BASP1 brain abundant, membrane attached signal protein 1 0.00561438
FGA fibrinogen alpha chain 0.00560873
COMT catechol-O-methyltransferase 0.00559625
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.00559609
TMOD1 tropomodulin 1 0.00558382
BLNK B-cell linker 0.00557245
AEBP1 AE binding protein 1 0.0055682
GSDME gasdermin E 0.0055603
C1R complement component 1, r subcomponent 0.00555108
CSTA cystatin A (stefin A) 0.00550749
HTRA1 HtrA serine peptidase 1 0.0054492
AGR2 anterior gradient 2 0.00544654
IRAK1 interleukin-1 receptor-associated kinase 1 0.0054203
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.00539712
KLF5 Kruppel-like factor 5 (intestinal) 0.00539153
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.00538599
PUF60 poly-U binding splicing factor 60KDa 0.00537932
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.00536688
PERP PERP, TP53 apoptosis effector 0.00535908
STC1 stanniocalcin 1 0.00534924
CRELD2 cysteine-rich with EGF-like domains 2 0.00534631
LAMC2 laminin, gamma 2 0.0053381
RRAGD Ras-related GTP binding D 0.00533339
KLK10 kallikrein-related peptidase 10 0.00533088
DMD dystrophin 0.00532701
PSCA prostate stem cell antigen 0.00532083
DEPTOR DEP domain containing MTOR-interacting protein 0.0053077
MMP10 matrix metallopeptidase 10 0.00528711
BTF3P11 basic transcription factor 3 pseudogene 11 0.00527237
SLC39A4 solute carrier family 39 (zinc transporter), member 4 0.00526462
DES desmin 0.00523744
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 0.00521768
FABP7 fatty acid binding protein 7, brain 0.00520935
TFRC transferrin receptor 0.00520633
PITX1 paired-like homeodomain 1 0.00518706
F3 coagulation factor III (thromboplastin, tissue factor) 0.00517734
TRIB3 tribbles pseudokinase 3 0.00517482
IGSF3 immunoglobulin superfamily, member 3 0.00517215
CHI3L2 chitinase 3-like 2 0.00515215
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.0051432
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.00512365
APOB apolipoprotein B 0.00511788
C1RL complement component 1, r subcomponent-like 0.00511246
REEP1 receptor accessory protein 1 0.00511153
TGM1 transglutaminase 1 0.00510048
TNIP1 TNFAIP3 interacting protein 1 0.0051002
SORD sorbitol dehydrogenase 0.00508534
LCN2 lipocalin 2 0.00508465
CXCL10 chemokine (C-X-C motif) ligand 10 0.00508264
IQCG IQ motif containing G 0.0050759
RFX5 regulatory factor X, 5 (influences HLA class II expression) 0.00501697
SCRG1 stimulator of chondrogenesis 1 0.00501591
LIPG lipase, endothelial 0.00501354
CDH13 cadherin 13 0.00500026
KRT16 keratin 16, type I 0.00499275
LYPD3 LY6/PLAUR domain containing 3 0.00497891
MAL mal, T-cell differentiation protein 0.00497621
CLIC3 chloride intracellular channel 3 0.004973
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.00496653
STXBP1 syntaxin binding protein 1 0.00496375
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.00491731
MACROH2A1 macroH2A.1 histone 0.0049098
GSTP1 glutathione S-transferase pi 1 0.00489929
LYN LYN proto-oncogene, Src family tyrosine kinase 0.00489225
AUTS2 autism susceptibility candidate 2 0.00489117
EPS8L2 EPS8-like 2 0.00488972
F12 coagulation factor XII (Hageman factor) 0.00486271
BCAP31 B-cell receptor-associated protein 31 0.00486127
COL11A1 collagen, type XI, alpha 1 0.00485889
ENO2 enolase 2 (gamma, neuronal) 0.00485436
VLDLR very low density lipoprotein receptor 0.00485355
GPR87 G protein-coupled receptor 87 0.00484462
COL9A2 collagen, type IX, alpha 2 0.00484175
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.00483767
CLTB clathrin, light chain B 0.00483039
APOA2 apolipoprotein A-II 0.00481614
PEG10 paternally expressed 10 0.00480501
HILPDA hypoxia inducible lipid droplet-associated 0.00480179
BIK BCL2-interacting killer (apoptosis-inducing) 0.00480171
TGFA transforming growth factor, alpha 0.00480074
PEG3 paternally expressed 3 0.00479786
RRAS related RAS viral (r-ras) oncogene homolog 0.00477424
TGM3 transglutaminase 3 0.00475995
CRIP1 cysteine-rich protein 1 (intestinal) 0.00475236
PIR pirin (iron-binding nuclear protein) 0.00475161
CLCA2 chloride channel accessory 2 0.00474977
SCPEP1 serine carboxypeptidase 1 0.00473829
TNS3 tensin 3 0.00473741
UGDH UDP-glucose 6-dehydrogenase 0.00473541
ACSL3 acyl-CoA synthetase long-chain family member 3 0.00472872
BLVRB biliverdin reductase B 0.00471521
H1-0 H1.0 linker histone 0.00468465
APOA1 apolipoprotein A-I 0.00467489
CTSV cathepsin V 0.00466518
VSNL1 visinin-like 1 0.00466463
KRT19 keratin 19, type I 0.00466228
SPRR3 small proline-rich protein 3 0.00465149
ALCAM activated leukocyte cell adhesion molecule 0.0046504
VCL vinculin 0.00464348
CORO1A coronin, actin binding protein, 1A 0.00463849
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.00463423
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.00462982
WASF1 WAS protein family, member 1 0.0046265
MMP11 matrix metallopeptidase 11 0.00462599
COL5A1 collagen, type V, alpha 1 0.00462309
SEPTIN6 septin 6 0.00461774
GSTA4 glutathione S-transferase alpha 4 0.00461717
EMP1 epithelial membrane protein 1 0.00461427
BRD1 bromodomain containing 1 0.00461102

decreased expression

Symbol Name Standardized Value
CXCL14 chemokine (C-X-C motif) ligand 14 -0.0172629
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0133221
MT1E metallothionein 1E -0.0111847
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.010836
JCHAIN joining chain of multimeric IgA and IgM -0.0107971
SRGN serglycin -0.0101571
ARMCX2 armadillo repeat containing, X-linked 2 -0.00909394
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 -0.00902497
CD36 CD36 molecule (thrombospondin receptor) -0.00898174
CRABP1 cellular retinoic acid binding protein 1 -0.00882865
TXNIP thioredoxin interacting protein -0.0085136
LXN latexin -0.00830703
PLIN2 perilipin 2 -0.00812669
SEPP1 selenoprotein P, plasma, 1 -0.00809971
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.00800844
MXRA8 matrix-remodelling associated 8 -0.00800571
ZBTB20 zinc finger and BTB domain containing 20 -0.00800469
ISG15 ISG15 ubiquitin-like modifier -0.00777317
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -0.00770317
CPVL carboxypeptidase, vitellogenic-like -0.00739797
CYCS cytochrome c, somatic -0.00739212
FGFR1 fibroblast growth factor receptor 1 -0.00721602
FKBP11 FK506 binding protein 11, 19 kDa -0.00717547
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -0.00714326
RNPS1 RNA binding protein S1, serine-rich domain -0.00712011
SELENBP1 selenium binding protein 1 -0.00704755
IFITM1 interferon induced transmembrane protein 1 -0.00702268
CYTIP cytohesin 1 interacting protein -0.0069546
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) -0.00684499
CD320 CD320 molecule -0.00684329
TXNDC9 thioredoxin domain containing 9 -0.00680137
KLF10 Kruppel-like factor 10 -0.00674268
IFI27 interferon, alpha-inducible protein 27 -0.00673457
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.00666703
SCGB1D2 secretoglobin, family 1D, member 2 -0.00661855
ADGRF5 adhesion G protein-coupled receptor F5 -0.00660376
CA2 carbonic anhydrase II -0.00659954
TUBB6 tubulin, beta 6 class V -0.0065652
RHOB ras homolog family member B -0.00639807
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) -0.00632509
CST7 cystatin F (leukocystatin) -0.00617378
TYROBP TYRO protein tyrosine kinase binding protein -0.00615123
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -0.00612573
BTG2 BTG family, member 2 -0.0060755
EGR3 early growth response 3 -0.00606311
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.0059952
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.00597204
RSAD2 radical S-adenosyl methionine domain containing 2 -0.00597066
CA4 carbonic anhydrase IV -0.00595743
PRDX2 peroxiredoxin 2 -0.00592514
GLIPR1 GLI pathogenesis-related 1 -0.00591385
F13A1 coagulation factor XIII, A1 polypeptide -0.00588691
MDFIC MyoD family inhibitor domain containing -0.00587792
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -0.00587241
ACSL5 acyl-CoA synthetase long-chain family member 5 -0.00585131
ESR1 estrogen receptor 1 -0.00575733
CDC20 cell division cycle 20 -0.00564638
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -0.00564128
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.00563573
ECI2 enoyl-CoA delta isomerase 2 -0.00562793
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.00562613
EVI2A ecotropic viral integration site 2A -0.00561366
CTSG cathepsin G -0.00561251
CASP1 caspase 1, apoptosis-related cysteine peptidase -0.00561205
DLX5 distal-less homeobox 5 -0.00558253
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 -0.00557865
FRZB frizzled-related protein -0.0055721
GADD45B growth arrest and DNA-damage-inducible, beta -0.00555604
RPL36 ribosomal protein L36 -0.00554844
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.00553291
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa -0.00552543
POSTN periostin, osteoblast specific factor -0.00551678
OLFM4 olfactomedin 4 -0.00548168
LPXN leupaxin -0.00538328
CCL4 chemokine (C-C motif) ligand 4 -0.00535626
CYBA cytochrome b-245, alpha polypeptide -0.00535284
PHACTR2 phosphatase and actin regulator 2 -0.0053428
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -0.00534218
EGR1 early growth response 1 -0.00533456
EDN3 endothelin 3 -0.00531358
ALPL alkaline phosphatase, liver/bone/kidney -0.00528111
TTC39A tetratricopeptide repeat domain 39A -0.00527554
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -0.00525792
CKS2 CDC28 protein kinase regulatory subunit 2 -0.00525285
LYZ lysozyme -0.0052508
PON2 paraoxonase 2 -0.00524267
ARID4A AT rich interactive domain 4A (RBP1-like) -0.00523123
CCDC92 coiled-coil domain containing 92 -0.00521811
CIRBP cold inducible RNA binding protein -0.00520969
ADGRL4 adhesion G protein-coupled receptor L4 -0.00516688
FAM46C family with sequence similarity 46, member C -0.00515204
ATP5F1D ATP synthase F1 subunit delta -0.00513901
METTL7A methyltransferase like 7A -0.0051055
HOXB6 homeobox B6 -0.00510297
CD209 CD209 molecule -0.00509241
HOXB2 homeobox B2 -0.00508503
EDNRB endothelin receptor type B -0.0050649
RNASE6 ribonuclease, RNase A family, k6 -0.00505814
GPR171 G protein-coupled receptor 171 -0.0050546
ISYNA1 inositol-3-phosphate synthase 1 -0.00499959
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 -0.00493912
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) -0.00492736
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.00491325
LDB2 LIM domain binding 2 -0.00488758
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.00485647
THAP12 THAP domain containing 12 -0.00483959
NPTX2 neuronal pentraxin II -0.00482864
BBX bobby sox homolog (Drosophila) -0.00481864
SNRPG small nuclear ribonucleoprotein polypeptide G -0.00481688
ATP5ME ATP synthase membrane subunit e -0.00480375
SKAP1 src kinase associated phosphoprotein 1 -0.00480292
AKAP12 A kinase (PRKA) anchor protein 12 -0.00478698
TARP TCR gamma alternate reading frame protein -0.004779
CHN2 chimerin 2 -0.0047771
MT1H metallothionein 1H -0.00477173
BPHL biphenyl hydrolase-like (serine hydrolase) -0.00475301
FAXDC2 fatty acid hydroxylase domain containing 2 -0.0047398
AQP8 aquaporin 8 -0.00472828
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -0.0047214
TLR4 toll-like receptor 4 -0.00471817
IER2 immediate early response 2 -0.00471605
TFF3 trefoil factor 3 (intestinal) -0.00470382
LEFTY1 left-right determination factor 1 -0.00470355
FGL2 fibrinogen-like 2 -0.00470326
TMEM106B transmembrane protein 106B -0.00469963
CDCA4 cell division cycle associated 4 -0.00468423
XCL1 chemokine (C motif) ligand 1 -0.00466035
ZBTB38 zinc finger and BTB domain containing 38 -0.00465704
EPCAM epithelial cell adhesion molecule -0.00464476
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.00462829
C1ORF54 chromosome 1 open reading frame 54 -0.00461624
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.00461345
ACP5 acid phosphatase 5, tartrate resistant -0.00460585
CTSK cathepsin K -0.00460188
FBXL5 F-box and leucine-rich repeat protein 5 -0.00459887
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 -0.00459791
PRF1 perforin 1 (pore forming protein) -0.00459761
CRYM crystallin, mu -0.00459553
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -0.00459039
OASL 2'-5'-oligoadenylate synthetase-like -0.00458139
ZNF562 zinc finger protein 562 -0.00457661
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -0.00457274
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -0.00456811
C19ORF53 chromosome 19 open reading frame 53 -0.00456671
TMEM176B transmembrane protein 176B -0.00455609
NANOG Nanog homeobox -0.00455444
EIF1AX eukaryotic translation initiation factor 1A, X-linked -0.00454952
MFAP2 microfibrillar-associated protein 2 -0.00453724
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -0.00453033
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -0.00451844
FNDC3A fibronectin type III domain containing 3A -0.00450525
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -0.00449391
CLCA1 chloride channel accessory 1 -0.0044897
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 -0.00447529
DNASE1L3 deoxyribonuclease I-like 3 -0.00447201
BSG basigin (Ok blood group) -0.00447109
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -0.00446028
IFI44L interferon-induced protein 44-like -0.00445995
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -0.00445414
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -0.00442775
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -0.00442379
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.00442305
HIST1H2AE histone cluster 1, H2ae -0.00440597
IL17RB interleukin 17 receptor B -0.00438385
BIRC2 baculoviral IAP repeat containing 2 -0.00437236
CISH cytokine inducible SH2-containing protein -0.00436342
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.00434759
PRKACB protein kinase, cAMP-dependent, catalytic, beta -0.0043412
ASRGL1 asparaginase like 1 -0.00433434
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -0.00432803
ZNF160 zinc finger protein 160 -0.00432635
TRIM22 tripartite motif containing 22 -0.00431975
SCGB2A2 secretoglobin, family 2A, member 2 -0.0043077
LIMA1 LIM domain and actin binding 1 -0.00430611
ASCL1 achaete-scute family bHLH transcription factor 1 -0.00428815
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 -0.00427357
TBX2 T-box 2 -0.00427332
TOX3 TOX high mobility group box family member 3 -0.0042722
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -0.00426166
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.00424579
CDK17 cyclin-dependent kinase 17 -0.00423195
ZNF586 zinc finger protein 586 -0.0042291
NKG7 natural killer cell granule protein 7 -0.00422121
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -0.0042019
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -0.00419249
FKBP14 FK506 binding protein 14, 22 kDa -0.00418987
HIST1H2BD histone cluster 1, H2bd -0.00418884
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -0.00417429
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -0.00416998
PUDP pseudouridine 5'-phosphatase -0.00416507
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -0.00415733
HNMT histamine N-methyltransferase -0.00415641
CHRDL1 chordin-like 1 -0.00414555
MT1HL1 metallothionein 1H-like 1 -0.00413789
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.00413468
DHDDS dehydrodolichyl diphosphate synthase -0.00413108
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -0.00411793
LRRC17 leucine rich repeat containing 17 -0.00411383
GUSBP3 glucuronidase, beta pseudogene 3 -0.00410115
KCTD12 potassium channel tetramerization domain containing 12 -0.0040967
KAT2B K(lysine) acetyltransferase 2B -0.00408465
AKAP7 A kinase (PRKA) anchor protein 7 -0.00408458
CCR2 chemokine (C-C motif) receptor 2 -0.00407766
FAM3C family with sequence similarity 3, member C -0.00405709
ZNF721 zinc finger protein 721 -0.00405296
RNF144A ring finger protein 144A -0.00404691
PDGFA platelet-derived growth factor alpha polypeptide -0.0040463
CD2 CD2 molecule -0.00401366
POU5F1B POU class 5 homeobox 1B -0.00400681
RESF1 retroelement silencing factor 1 -0.0040068
CPB1 carboxypeptidase B1 (tissue) -0.00400362
POU5F1P3 POU class 5 homeobox 1 pseudogene 3 -0.00400127
SFTPB surfactant protein B -0.00399657
CCDC91 coiled-coil domain containing 91 -0.00399342
CCL13 chemokine (C-C motif) ligand 13 -0.00398066
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -0.00397284
F2R coagulation factor II (thrombin) receptor -0.0039566
ECHDC3 enoyl CoA hydratase domain containing 3 -0.00393459
GIMAP4 GTPase, IMAP family member 4 -0.00393219
PDE9A phosphodiesterase 9A -0.00392236
COX7B cytochrome c oxidase subunit VIIb -0.00391156
PLA1A phospholipase A1 member A -0.00390711
RAB38 RAB38, member RAS oncogene family -0.00389993
SLFN12 schlafen family member 12 -0.00389402
CD93 CD93 molecule -0.00388921
CCNA2 cyclin A2 -0.00388339
RHOBTB3 Rho-related BTB domain containing 3 -0.00387985
HAUS2 HAUS augmin-like complex, subunit 2 -0.00387805
CCND2 cyclin D2 -0.00387705
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.00387582
LYRM4 LYR motif containing 4 -0.00386892
TRAPPC2L trafficking protein particle complex 2-like -0.00385883
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.00385579
ARMCX1 armadillo repeat containing, X-linked 1 -0.00384403
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor -0.00384234
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -0.00383964
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -0.0038395
DENND1B DENN/MADD domain containing 1B -0.00383753
SLAMF7 SLAM family member 7 -0.00383552
CASP4 caspase 4, apoptosis-related cysteine peptidase -0.00382739
COX17 COX17 cytochrome c oxidase copper chaperone -0.00382405
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.00382312
GPM6B glycoprotein M6B -0.00382194
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.00382154
ADIPOQ adiponectin, C1Q and collagen domain containing -0.00381799
GUCA2A guanylate cyclase activator 2A (guanylin) -0.00381109
AMD1 adenosylmethionine decarboxylase 1 -0.00381074
BEX1 brain expressed, X-linked 1 -0.00380879
TMEM204 transmembrane protein 204 -0.00380874
SETD6 SET domain containing 6 -0.00380818